Reference mutational signatures and their aetiologies, mainly obtained from COSMIC database (SigProfiler results) and cleaned before saving into sigminer package. You can obtain:
COSMIC legacy SBS signatures.
COSMIC v3 SBS signatures.
COSMIC v3 DBS signatures.
COSMIC v3 ID (indel) signatures.
SBS and RS (rearrangement) signatures from Nik lab 2020 Nature Cancer paper.
RS signatures from BRCA560 and USARC cohorts.
Copy number signatures from USARC cohort and TCGA.
Copy number signatures from Liu lab 2023. It supports both PCAWG and TCGA cohort.
get_sig_db(sig_db = "legacy")default 'legacy', it can be 'legacy' (for COSMIC v2 'SBS'),
'SBS', 'DBS', 'ID' and 'TSB' (for COSMIV v3.1 signatures)
for small scale mutations.
For more specific details, it can also be 'SBS_hg19', 'SBS_hg38',
'SBS_mm9', 'SBS_mm10', 'DBS_hg19', 'DBS_hg38', 'DBS_mm9', 'DBS_mm10' to use
COSMIC v3 reference signatures from Alexandrov, Ludmil B., et al. (2020) (reference #1).
In addition, it can be one of "SBS_Nik_lab_Organ", "RS_Nik_lab_Organ",
"SBS_Nik_lab", "RS_Nik_lab" to refer reference signatures from
Degasperi, Andrea, et al. (2020) (reference #2);
"RS_BRCA560", "RS_USARC" to reference signatures from BRCA560 and USARC cohorts;
"CNS_USARC" (40 categories), "CNS_TCGA" (48 categories) to reference copy number signatures from USARC cohort and TCGA;
"CNS_TCGA176" (176 categories) and "CNS_PCAWG176" (176 categories) to reference copy number signatures from PCAWG and TCGA separately.
UPDATE, the latest version of reference version can be automatically
downloaded and loaded from https://cancer.sanger.ac.uk/signatures/downloads/
when a option with latest_ prefix is specified (e.g. "latest_SBS_GRCh37").
Note: the signature profile for different genome builds are basically same.
And specific database (e.g. 'SBS_mm10') contains less signatures than all COSMIC
signatures (because some signatures are not detected from Alexandrov, Ludmil B., et al. (2020)).
For all available options, check the parameter setting.
a list.
Steele, Christopher D., et al. "Signatures of copy number alterations in human cancer." Nature 606.7916 (2022): 984-991.
Alexandrov, Ludmil B., et al. "The repertoire of mutational signatures in human cancer." Nature 578.7793 (2020): 94-101.
Steele, Christopher D., et al. "Undifferentiated sarcomas develop through distinct evolutionary pathways." Cancer Cell 35.3 (2019): 441-456.
Ziyu Tao, et al. "The repertoire of copy number alteration signatures in human cancer." Briefings in Bioinformatics (2023): bbad053.
s1 <- get_sig_db()
s2 <- get_sig_db("SBS")
s3 <- get_sig_db("DBS")
s4 <- get_sig_db("DBS_mm10")
s5 <- get_sig_db("SBS_Nik_lab")
s6 <- get_sig_db("ID")
s7 <- get_sig_db("RS_BRCA560")
s8 <- get_sig_db("RS_USARC")
s9 <- get_sig_db("RS_Nik_lab")
s10 <- get_sig_db("CNS_USARC")
s11 <- get_sig_db("CNS_TCGA")
s12 <- get_sig_db("CNS_TCGA176")
s13 <- get_sig_db("CNS_PCAWG176")
s1
#> $db
#> COSMIC_1 COSMIC_2 COSMIC_3 COSMIC_4 COSMIC_5 COSMIC_6
#> A[C>A]A 1.109833e-02 6.827080e-04 0.022172307 0.0365 0.014941548 0.0017
#> A[C>A]C 9.149341e-03 6.191070e-04 0.017871675 0.0309 0.008960918 0.0028
#> A[C>A]G 1.490070e-03 9.927900e-05 0.002138340 0.0183 0.002207846 0.0005
#> A[C>A]T 6.233885e-03 3.238910e-04 0.016265146 0.0243 0.009206905 0.0019
#> A[C>G]A 1.801068e-03 2.634810e-04 0.024002615 0.0097 0.011671022 0.0013
#> A[C>G]C 2.580909e-03 2.698660e-04 0.012160304 0.0054 0.007292089 0.0012
#> A[C>G]G 5.925480e-04 2.192340e-04 0.005275419 0.0031 0.002303839 0.0000
#> A[C>G]T 2.963986e-03 6.109730e-04 0.023277656 0.0054 0.011696246 0.0018
#> A[C>T]A 2.951453e-02 7.441557e-03 0.017872171 0.0120 0.021839188 0.0312
#> A[C>T]C 1.432275e-02 2.726312e-03 0.008896034 0.0075 0.012756106 0.0163
#> A[C>T]G 1.716469e-01 3.322083e-03 0.003572708 0.0028 0.016760177 0.0908
#> A[C>T]T 1.262376e-02 3.326528e-03 0.014797612 0.0059 0.016477955 0.0149
#> A[T>A]A 4.021520e-03 1.323770e-07 0.008428564 0.0048 0.008902904 0.0006
#> A[T>A]C 2.371144e-03 1.130700e-04 0.007373097 0.0039 0.007399202 0.0033
#> A[T>A]G 2.810910e-03 5.329290e-04 0.007357300 0.0100 0.011508051 0.0000
#> A[T>A]T 8.360909e-03 1.491110e-04 0.008753939 0.0030 0.011193623 0.0053
#> A[T>C]A 1.391577e-02 1.303510e-03 0.013035709 0.0084 0.035366735 0.0075
#> A[T>C]C 6.274961e-03 4.255770e-04 0.009186290 0.0020 0.013771102 0.0056
#> A[T>C]G 1.013764e-02 5.754730e-04 0.011716920 0.0081 0.028449052 0.0217
#> A[T>C]T 9.256316e-03 1.488164e-03 0.016978871 0.0036 0.027302974 0.0023
#> A[T>G]A 1.587636e-03 3.371840e-05 0.002351368 0.0000 0.003462152 0.0000
#> A[T>G]C 1.784091e-03 2.484480e-05 0.001464231 0.0002 0.002246593 0.0017
#> A[T>G]G 1.385831e-03 2.734540e-04 0.009053778 0.0015 0.005490217 0.0007
#> A[T>G]T 3.158539e-03 2.176950e-04 0.007030976 0.0002 0.003821227 0.0029
#> C[C>A]A 6.595870e-03 6.774450e-04 0.018781726 0.0461 0.009674904 0.0101
#> C[C>A]C 7.342368e-03 2.136810e-04 0.015760458 0.0614 0.004952301 0.0241
#> C[C>A]G 8.928400e-04 6.770460e-06 0.001963390 0.0088 0.002800627 0.0091
#> C[C>A]T 7.186582e-03 4.163330e-04 0.014722861 0.0432 0.011013466 0.0571
#> C[C>G]A 1.284983e-03 2.777210e-05 0.016832572 0.0105 0.007537523 0.0000
#> C[C>G]C 7.021350e-04 2.796440e-04 0.013531442 0.0097 0.007633227 0.0000
#> C[C>G]G 5.062900e-04 1.916160e-05 0.004176458 0.0063 0.002613760 0.0000
#> C[C>G]T 1.381543e-03 3.127820e-04 0.024046390 0.0094 0.009417098 0.0002
#> C[C>T]A 2.089645e-02 1.501951e-02 0.014395059 0.0210 0.022769209 0.0085
#> C[C>T]C 1.850171e-02 3.516918e-03 0.008544781 0.0144 0.017509476 0.0099
#> C[C>T]G 9.557722e-02 4.979276e-03 0.003518466 0.0076 0.012862238 0.0901
#> C[C>T]T 1.711331e-02 8.956553e-03 0.016075546 0.0201 0.020429513 0.0087
#> C[T>A]A 1.182587e-03 1.545990e-04 0.007571320 0.0075 0.005043164 0.0001
#> C[T>A]C 1.903167e-03 4.640190e-04 0.012725464 0.0111 0.006208844 0.0026
#> C[T>A]G 1.487961e-03 2.304100e-04 0.011508562 0.0342 0.010507569 0.0008
#> C[T>A]T 2.179344e-03 5.748860e-04 0.016456178 0.0115 0.009784641 0.0011
#> C[T>C]A 4.176675e-03 5.466190e-04 0.007895013 0.0052 0.014238630 0.0062
#> C[T>C]C 5.252593e-03 3.923330e-04 0.014431170 0.0026 0.012489500 0.0040
#> C[T>C]G 7.013225e-03 3.620250e-04 0.008422972 0.0100 0.018741631 0.0270
#> C[T>C]T 6.713813e-03 5.609000e-04 0.011932430 0.0054 0.019054083 0.0033
#> C[T>G]A 3.026910e-04 1.137850e-04 0.001974181 0.0000 0.002041649 0.0001
#> C[T>G]C 2.098502e-03 2.209510e-05 0.005824296 0.0013 0.003478502 0.0040
#> C[T>G]G 1.599549e-03 2.282460e-04 0.010464655 0.0046 0.007147456 0.0050
#> C[T>G]T 2.758538e-03 6.711130e-05 0.008724387 0.0012 0.011486812 0.0086
#> G[C>A]A 8.232604e-03 3.520130e-04 0.009696540 0.0376 0.011892169 0.0024
#> G[C>A]C 5.758021e-03 1.338170e-04 0.010843341 0.0399 0.009247857 0.0058
#> G[C>A]G 6.163350e-04 1.784420e-04 0.000929141 0.0227 0.002809188 0.0021
#> G[C>A]T 4.459080e-03 1.228320e-04 0.012215383 0.0258 0.010301267 0.0087
#> G[C>G]A 6.021230e-04 4.483850e-05 0.011916845 0.0070 0.005559423 0.0000
#> G[C>G]C 2.393352e-03 1.452010e-05 0.009823653 0.0091 0.005388801 0.0030
#> G[C>G]G 2.485340e-07 4.066590e-05 0.001671054 0.0062 0.001100590 0.0000
#> G[C>G]T 8.900810e-04 2.684290e-04 0.017914334 0.0060 0.006041248 0.0017
#> G[C>T]A 2.494381e-02 6.390808e-03 0.016127273 0.0087 0.020038259 0.0653
#> G[C>T]C 2.716149e-02 1.995817e-03 0.008208632 0.0080 0.018022312 0.0773
#> G[C>T]G 1.035708e-01 3.030210e-04 0.001212923 0.0023 0.013193818 0.1339
#> G[C>T]T 1.768985e-02 3.265818e-03 0.010611649 0.0082 0.019502915 0.0524
#> G[T>A]A 6.892890e-04 1.149940e-04 0.004434783 0.0069 0.006740388 0.0000
#> G[T>A]C 5.524100e-04 2.938620e-04 0.005615432 0.0052 0.004021596 0.0028
#> G[T>A]G 1.200229e-03 8.872130e-05 0.008070136 0.0133 0.006814352 0.0006
#> G[T>A]T 2.107137e-03 2.157550e-04 0.008679122 0.0045 0.005101033 0.0021
#> G[T>C]A 1.124784e-02 4.673850e-06 0.006850056 0.0061 0.016294983 0.0122
#> G[T>C]C 6.999724e-03 1.860660e-04 0.006260749 0.0016 0.009574561 0.0059
#> G[T>C]G 4.977593e-03 4.950440e-07 0.006098763 0.0042 0.014103929 0.0115
#> G[T>C]T 1.066741e-02 5.785980e-04 0.007509344 0.0024 0.015666875 0.0042
#> G[T>G]A 9.904500e-05 9.555240e-05 0.004144488 0.0000 0.001627665 0.0000
#> G[T>G]C 2.023660e-04 4.700240e-05 0.004501985 0.0000 0.000327735 0.0016
#> G[T>G]G 1.188353e-03 1.099260e-04 0.016391453 0.0018 0.005948880 0.0010
#> G[T>G]T 8.007230e-04 8.647720e-05 0.007067237 0.0002 0.003307467 0.0035
#> T[C>A]A 1.225006e-02 1.512743e-02 0.011653225 0.0330 0.014774016 0.0017
#> T[C>A]C 1.116223e-02 6.532492e-03 0.016606775 0.0538 0.012043465 0.0029
#> T[C>A]G 2.275496e-03 1.656455e-03 0.001357239 0.0104 0.003902362 0.0011
#> T[C>A]T 1.525910e-02 1.239461e-02 0.016328076 0.0370 0.018243396 0.0058
#> T[C>G]A 1.874853e-03 3.724185e-02 0.016041405 0.0032 0.002681057 0.0000
#> T[C>G]C 2.067419e-03 1.941340e-05 0.020149920 0.0105 0.007924048 0.0002
#> T[C>G]G 3.048970e-04 1.625465e-03 0.002527911 0.0031 0.001319076 0.0000
#> T[C>G]T 3.151574e-03 6.687990e-02 0.032673641 0.0050 0.006644596 0.0001
#> T[C>T]A 1.449210e-02 4.199414e-01 0.008880209 0.0035 0.010997560 0.0074
#> T[C>T]C 1.768078e-02 8.197250e-02 0.013529573 0.0070 0.020644965 0.0067
#> T[C>T]G 7.600222e-02 4.772019e-02 0.001705409 0.0011 0.007534490 0.0391
#> T[C>T]T 1.376170e-02 2.286749e-01 0.010304417 0.0077 0.011787462 0.0047
#> T[T>A]A 5.600155e-03 8.075250e-05 0.007132681 0.0045 0.009205637 0.0002
#> T[T>A]C 1.999079e-03 4.802900e-06 0.009102798 0.0046 0.006835344 0.0008
#> T[T>A]G 1.090066e-03 6.660500e-05 0.006565863 0.0082 0.007144209 0.0000
#> T[T>A]T 3.981023e-03 2.763160e-04 0.014712135 0.0045 0.010240850 0.0007
#> T[T>C]A 8.073616e-03 1.019320e-04 0.009115495 0.0028 0.017059641 0.0059
#> T[T>C]C 4.857381e-03 4.703440e-04 0.010953791 0.0016 0.014195709 0.0035
#> T[T>C]G 8.325454e-03 1.923540e-04 0.006113033 0.0036 0.012596502 0.0106
#> T[T>C]T 6.257106e-03 5.853300e-04 0.010774336 0.0022 0.017375139 0.0029
#> T[T>G]A 1.397554e-03 7.173700e-05 0.005427184 0.0000 0.005202874 0.0009
#> T[T>G]C 1.291737e-03 1.428150e-05 0.006160250 0.0003 0.005131608 0.0019
#> T[T>G]G 2.031077e-03 2.066150e-04 0.011076526 0.0030 0.006055254 0.0011
#> T[T>G]T 4.030128e-03 2.359820e-05 0.013000984 0.0011 0.013369936 0.0072
#> COSMIC_7 COSMIC_8 COSMIC_9 COSMIC_10 COSMIC_11 COSMIC_12
#> A[C>A]A 0.0004 0.036718004 0.0120 0.0007 0.0002 0.0077
#> A[C>A]C 0.0005 0.033245722 0.0067 0.0010 0.0010 0.0047
#> A[C>A]G 0.0000 0.002525311 0.0005 0.0003 0.0000 0.0017
#> A[C>A]T 0.0004 0.033598550 0.0068 0.0092 0.0002 0.0046
#> A[C>G]A 0.0000 0.008356845 0.0048 0.0005 0.0007 0.0031
#> A[C>G]C 0.0000 0.004306380 0.0023 0.0003 0.0003 0.0015
#> A[C>G]G 0.0000 0.000584415 0.0000 0.0000 0.0000 0.0000
#> A[C>G]T 0.0001 0.008634907 0.0038 0.0002 0.0009 0.0025
#> A[C>T]A 0.0000 0.018066687 0.0093 0.0000 0.0225 0.0121
#> A[C>T]C 0.0197 0.005650015 0.0056 0.0032 0.1099 0.0054
#> A[C>T]G 0.0001 0.019265105 0.0125 0.0126 0.0072 0.0019
#> A[C>T]T 0.0043 0.020805967 0.0076 0.0047 0.0639 0.0067
#> A[T>A]A 0.0010 0.013365083 0.0121 0.0000 0.0002 0.0058
#> A[T>A]C 0.0008 0.012431202 0.0042 0.0002 0.0001 0.0065
#> A[T>A]G 0.0009 0.014036657 0.0068 0.0000 0.0007 0.0046
#> A[T>A]T 0.0035 0.024109917 0.0185 0.0012 0.0003 0.0060
#> A[T>C]A 0.0005 0.016206510 0.0252 0.0031 0.0006 0.0466
#> A[T>C]C 0.0001 0.007787803 0.0105 0.0052 0.0015 0.0317
#> A[T>C]G 0.0007 0.009852584 0.0176 0.0026 0.0008 0.0487
#> A[T>C]T 0.0011 0.021829464 0.0247 0.0040 0.0003 0.0250
#> A[T>G]A 0.0000 0.004219719 0.0335 0.0000 0.0000 0.0012
#> A[T>G]C 0.0000 0.000793671 0.0051 0.0040 0.0000 0.0010
#> A[T>G]G 0.0009 0.006865800 0.0052 0.0015 0.0001 0.0018
#> A[T>G]T 0.0000 0.002939922 0.0193 0.0137 0.0000 0.0030
#> C[C>A]A 0.0012 0.031723757 0.0098 0.0031 0.0007 0.0135
#> C[C>A]C 0.0006 0.025505407 0.0057 0.0009 0.0017 0.0112
#> C[C>A]G 0.0000 0.001159624 0.0000 0.0007 0.0010 0.0028
#> C[C>A]T 0.0013 0.028791173 0.0091 0.0160 0.0014 0.0071
#> C[C>G]A 0.0001 0.006619077 0.0018 0.0000 0.0000 0.0019
#> C[C>G]C 0.0004 0.006077703 0.0020 0.0000 0.0002 0.0019
#> C[C>G]G 0.0006 0.000656033 0.0000 0.0000 0.0008 0.0000
#> C[C>G]T 0.0003 0.007805027 0.0039 0.0000 0.0002 0.0019
#> C[C>T]A 0.0754 0.004865810 0.0098 0.0012 0.0310 0.0187
#> C[C>T]C 0.1007 0.003980150 0.0069 0.0024 0.1518 0.0094
#> C[C>T]G 0.0208 0.008338639 0.0076 0.0109 0.0135 0.0046
#> C[C>T]T 0.0788 0.018843627 0.0097 0.0043 0.0816 0.0205
#> C[T>A]A 0.0000 0.012024218 0.0055 0.0000 0.0004 0.0017
#> C[T>A]C 0.0014 0.017881092 0.0049 0.0001 0.0011 0.0086
#> C[T>A]G 0.0007 0.016356775 0.0051 0.0003 0.0006 0.0031
#> C[T>A]T 0.0018 0.026247802 0.0069 0.0009 0.0004 0.0054
#> C[T>C]A 0.0010 0.005173842 0.0154 0.0005 0.0001 0.0312
#> C[T>C]C 0.0008 0.010936894 0.0118 0.0019 0.0004 0.0385
#> C[T>C]G 0.0010 0.005657774 0.0154 0.0015 0.0001 0.0415
#> C[T>C]T 0.0045 0.011120389 0.0275 0.0020 0.0009 0.0324
#> C[T>G]A 0.0000 0.002424051 0.0216 0.0022 0.0000 0.0013
#> C[T>G]C 0.0008 0.002096211 0.0064 0.0018 0.0001 0.0049
#> C[T>G]G 0.0009 0.006604046 0.0126 0.0037 0.0011 0.0045
#> C[T>G]T 0.0013 0.004866714 0.0509 0.0182 0.0009 0.0063
#> G[C>A]A 0.0003 0.023682329 0.0118 0.0014 0.0004 0.0062
#> G[C>A]C 0.0001 0.015821896 0.0092 0.0022 0.0010 0.0056
#> G[C>A]G 0.0000 0.000850914 0.0000 0.0002 0.0000 0.0015
#> G[C>A]T 0.0001 0.021061236 0.0085 0.0088 0.0006 0.0027
#> G[C>G]A 0.0000 0.003724568 0.0011 0.0000 0.0000 0.0012
#> G[C>G]C 0.0004 0.003046597 0.0029 0.0002 0.0002 0.0011
#> G[C>G]G 0.0000 0.000321213 0.0000 0.0000 0.0000 0.0000
#> G[C>G]T 0.0000 0.005775664 0.0044 0.0004 0.0000 0.0009
#> G[C>T]A 0.0000 0.002261263 0.0062 0.0000 0.0261 0.0124
#> G[C>T]C 0.0210 0.001616649 0.0069 0.0134 0.0975 0.0092
#> G[C>T]G 0.0002 0.011606712 0.0088 0.0270 0.0090 0.0023
#> G[C>T]T 0.0161 0.006284929 0.0101 0.0152 0.0522 0.0115
#> G[T>A]A 0.0000 0.008139179 0.0030 0.0000 0.0003 0.0015
#> G[T>A]C 0.0000 0.007910080 0.0029 0.0001 0.0003 0.0039
#> G[T>A]G 0.0006 0.009057263 0.0028 0.0000 0.0004 0.0019
#> G[T>A]T 0.0010 0.017812239 0.0036 0.0004 0.0001 0.0031
#> G[T>C]A 0.0002 0.005720779 0.0091 0.0064 0.0010 0.0573
#> G[T>C]C 0.0001 0.005181052 0.0097 0.0101 0.0016 0.0274
#> G[T>C]G 0.0003 0.005040707 0.0094 0.0054 0.0019 0.0410
#> G[T>C]T 0.0081 0.008488220 0.0126 0.0124 0.0023 0.0405
#> G[T>G]A 0.0000 0.000974579 0.0072 0.0000 0.0000 0.0000
#> G[T>G]C 0.0000 0.000524822 0.0006 0.0020 0.0000 0.0004
#> G[T>G]G 0.0017 0.006087753 0.0050 0.0009 0.0010 0.0011
#> G[T>G]T 0.0009 0.005427434 0.0185 0.0030 0.0000 0.0032
#> T[C>A]A 0.0010 0.027032383 0.0222 0.0374 0.0009 0.0066
#> T[C>A]C 0.0020 0.018089773 0.0043 0.0103 0.0025 0.0099
#> T[C>A]G 0.0002 0.001694875 0.0000 0.0031 0.0001 0.0019
#> T[C>A]T 0.0013 0.038141331 0.0322 0.3083 0.0004 0.0049
#> T[C>G]A 0.0002 0.004117879 0.0033 0.0000 0.0001 0.0024
#> T[C>G]C 0.0010 0.003799650 0.0025 0.0000 0.0011 0.0027
#> T[C>G]G 0.0003 0.000025653 0.0000 0.0000 0.0003 0.0000
#> T[C>G]T 0.0007 0.006247554 0.0049 0.0001 0.0008 0.0015
#> T[C>T]A 0.1202 0.007180669 0.0050 0.0037 0.0302 0.0138
#> T[C>T]C 0.2887 0.004061033 0.0084 0.0211 0.1589 0.0095
#> T[C>T]G 0.0992 0.005535122 0.0047 0.2141 0.0080 0.0010
#> T[C>T]T 0.0844 0.012209070 0.0096 0.0392 0.0954 0.0090
#> T[T>A]A 0.0010 0.015139996 0.0215 0.0000 0.0003 0.0057
#> T[T>A]C 0.0015 0.012093555 0.0027 0.0008 0.0000 0.0132
#> T[T>A]G 0.0010 0.008362547 0.0140 0.0000 0.0000 0.0037
#> T[T>A]T 0.0050 0.027653296 0.0139 0.0028 0.0008 0.0094
#> T[T>C]A 0.0023 0.004901072 0.0156 0.0030 0.0002 0.0500
#> T[T>C]C 0.0018 0.006081011 0.0137 0.0097 0.0009 0.0342
#> T[T>C]G 0.0019 0.001712485 0.0098 0.0065 0.0007 0.0320
#> T[T>C]T 0.0024 0.010003442 0.0309 0.0099 0.0005 0.0371
#> T[T>G]A 0.0000 0.001743221 0.0502 0.0050 0.0000 0.0019
#> T[T>G]C 0.0010 0.002549838 0.0081 0.0092 0.0000 0.0027
#> T[T>G]G 0.0010 0.006030395 0.0088 0.0022 0.0003 0.0011
#> T[T>G]T 0.0014 0.007223999 0.0545 0.0633 0.0003 0.0032
#> COSMIC_13 COSMIC_14 COSMIC_15 COSMIC_16 COSMIC_17 COSMIC_18
#> A[C>A]A 3.347570e-04 0.0001 0.0013 0.0161 1.832019e-03 5.053642e-02
#> A[C>A]C 6.487360e-04 0.0042 0.0040 0.0097 3.422360e-04 1.093982e-02
#> A[C>A]G 3.814460e-05 0.0005 0.0000 0.0022 1.576230e-06 2.288073e-03
#> A[C>A]T 8.466580e-04 0.0296 0.0057 0.0088 3.179665e-03 1.942409e-02
#> A[C>G]A 3.775165e-03 0.0001 0.0011 0.0048 1.661704e-03 1.516888e-03
#> A[C>G]C 9.208250e-04 0.0000 0.0001 0.0024 1.626898e-03 2.498785e-03
#> A[C>G]G 1.989050e-05 0.0000 0.0006 0.0000 2.580190e-05 2.614509e-03
#> A[C>G]T 3.860632e-03 0.0001 0.0010 0.0073 1.328508e-03 3.983011e-03
#> A[C>T]A 1.480181e-03 0.0293 0.0117 0.0135 9.350488e-03 3.825624e-03
#> A[C>T]C 4.050870e-05 0.0321 0.0169 0.0076 4.224289e-03 2.465214e-03
#> A[C>T]G 3.165950e-04 0.0496 0.0309 0.0035 9.229213e-03 8.463957e-03
#> A[C>T]T 0.000000e+00 0.0277 0.0066 0.0101 5.735961e-03 5.605740e-03
#> A[T>A]A 1.243618e-03 0.0000 0.0021 0.0081 6.130020e-04 3.037211e-03
#> A[T>A]C 1.060002e-03 0.0008 0.0090 0.0073 1.878587e-03 8.111670e-04
#> A[T>A]G 1.025540e-04 0.0000 0.0009 0.0080 1.087350e-03 4.503207e-03
#> A[T>A]T 9.718120e-04 0.0009 0.0079 0.0084 2.045494e-03 2.736523e-03
#> A[T>C]A 5.494540e-04 0.0026 0.0115 0.0717 2.697314e-03 2.933054e-03
#> A[T>C]C 1.455070e-04 0.0046 0.0073 0.0171 8.078150e-03 1.513285e-03
#> A[T>C]G 2.791780e-04 0.0035 0.0073 0.0348 4.432871e-03 3.329669e-03
#> A[T>C]T 2.674610e-04 0.0025 0.0063 0.0497 3.140370e-03 5.491318e-03
#> A[T>G]A 3.862000e-04 0.0000 0.0000 0.0052 5.313920e-05 3.861380e-04
#> A[T>G]C 1.123830e-04 0.0020 0.0006 0.0042 6.468661e-03 1.254982e-03
#> A[T>G]G 3.600070e-05 0.0007 0.0012 0.0061 3.481549e-03 2.369216e-03
#> A[T>G]T 1.924940e-04 0.0056 0.0029 0.0076 3.092638e-02 3.386030e-04
#> C[C>A]A 1.710090e-03 0.0056 0.0106 0.0159 1.032430e-03 8.876811e-02
#> C[C>A]C 1.159257e-03 0.0102 0.0084 0.0100 4.218800e-04 2.064139e-02
#> C[C>A]G 2.441670e-04 0.0009 0.0015 0.0022 2.974630e-04 1.717840e-02
#> C[C>A]T 1.256768e-03 0.1257 0.0228 0.0084 3.147940e-05 3.767696e-02
#> C[C>G]A 5.333651e-03 0.0000 0.0009 0.0040 1.924979e-03 4.584640e-04
#> C[C>G]C 9.123030e-04 0.0000 0.0003 0.0050 7.093680e-04 3.654228e-03
#> C[C>G]G 2.854670e-04 0.0000 0.0004 0.0028 3.517870e-06 5.405774e-03
#> C[C>G]T 6.383098e-03 0.0000 0.0017 0.0080 9.537760e-04 5.519605e-03
#> C[C>T]A 3.647278e-03 0.0060 0.0051 0.0210 2.126521e-02 9.767511e-03
#> C[C>T]C 1.004229e-03 0.0167 0.0088 0.0098 3.847235e-03 5.654828e-03
#> C[C>T]G 1.292020e-04 0.0293 0.0155 0.0016 1.317611e-02 1.618322e-02
#> C[C>T]T 6.117700e-04 0.0186 0.0096 0.0211 9.648025e-03 5.153319e-03
#> C[T>A]A 2.851590e-04 0.0000 0.0016 0.0054 3.007920e-05 4.123460e-04
#> C[T>A]C 2.222870e-04 0.0034 0.0043 0.0128 1.022375e-02 2.491411e-03
#> C[T>A]G 2.869520e-04 0.0002 0.0027 0.0130 4.467036e-03 5.523046e-03
#> C[T>A]T 8.004460e-07 0.0020 0.0007 0.0096 3.124488e-02 3.313713e-03
#> C[T>C]A 4.275150e-05 0.0006 0.0032 0.0146 7.427000e-03 1.921690e-04
#> C[T>C]C 4.330750e-05 0.0053 0.0050 0.0194 3.965700e-02 3.050193e-03
#> C[T>C]G 5.427250e-05 0.0016 0.0128 0.0190 2.860970e-02 2.596464e-03
#> C[T>C]T 7.639440e-07 0.0027 0.0035 0.0263 1.018697e-01 1.310029e-03
#> C[T>G]A 1.509420e-05 0.0000 0.0000 0.0002 9.146980e-05 6.100250e-05
#> C[T>G]C 1.476250e-04 0.0020 0.0019 0.0082 1.981429e-02 2.015697e-03
#> C[T>G]G 4.598730e-05 0.0005 0.0007 0.0067 1.344984e-02 5.311967e-03
#> C[T>G]T 4.637150e-04 0.0063 0.0045 0.0186 2.614566e-01 2.341629e-03
#> G[C>A]A 1.321100e-04 0.0018 0.0024 0.0096 6.535405e-03 1.287242e-01
#> G[C>A]C 7.542440e-04 0.0114 0.0099 0.0094 1.293804e-03 1.609288e-02
#> G[C>A]G 9.682080e-05 0.0011 0.0013 0.0036 1.283663e-03 9.271417e-03
#> G[C>A]T 5.511040e-04 0.0736 0.0309 0.0063 3.103767e-03 7.201707e-02
#> G[C>G]A 1.349420e-03 0.0002 0.0022 0.0031 1.296324e-03 9.238800e-04
#> G[C>G]C 7.888080e-04 0.0001 0.0005 0.0032 2.607610e-04 6.486480e-04
#> G[C>G]G 8.179120e-05 0.0000 0.0006 0.0000 4.377550e-06 5.428400e-04
#> G[C>G]T 2.680123e-03 0.0003 0.0018 0.0029 1.820393e-03 1.376725e-03
#> G[C>T]A 2.934138e-03 0.0557 0.0476 0.0125 2.068755e-03 2.703069e-03
#> G[C>T]C 2.515171e-03 0.0618 0.1345 0.0092 3.254830e-04 4.199308e-03
#> G[C>T]G 3.205265e-03 0.0978 0.1829 0.0009 7.511101e-03 1.189736e-02
#> G[C>T]T 1.687731e-03 0.0555 0.0800 0.0116 9.256970e-04 1.913381e-03
#> G[T>A]A 1.379600e-04 0.0000 0.0000 0.0030 8.545690e-06 1.875434e-03
#> G[T>A]C 2.528670e-04 0.0025 0.0038 0.0040 2.573467e-03 1.510310e-03
#> G[T>A]G 1.535170e-04 0.0000 0.0026 0.0051 3.538823e-03 1.505369e-03
#> G[T>A]T 1.227460e-04 0.0009 0.0043 0.0033 3.879010e-03 3.611025e-03
#> G[T>C]A 1.054081e-03 0.0078 0.0195 0.0161 1.140130e-05 5.291260e-04
#> G[T>C]C 5.299000e-04 0.0127 0.0499 0.0099 9.657713e-03 2.279131e-03
#> G[T>C]G 6.300960e-04 0.0082 0.0154 0.0148 4.654129e-03 5.871057e-03
#> G[T>C]T 6.761880e-04 0.0086 0.0094 0.0142 8.149235e-03 4.771566e-03
#> G[T>G]A 1.848990e-05 0.0000 0.0000 0.0000 3.919380e-05 1.341532e-03
#> G[T>G]C 9.337350e-05 0.0019 0.0022 0.0032 9.078462e-03 9.204310e-07
#> G[T>G]G 1.057920e-05 0.0012 0.0037 0.0008 4.782775e-03 9.695000e-03
#> G[T>G]T 5.374120e-05 0.0038 0.0190 0.0044 6.349776e-02 2.890554e-03
#> T[C>A]A 4.816605e-02 0.0005 0.0057 0.0122 1.824558e-03 6.708064e-02
#> T[C>A]C 1.732956e-02 0.0166 0.0062 0.0145 1.286518e-03 4.186901e-02
#> T[C>A]G 2.293157e-03 0.0000 0.0025 0.0040 2.172942e-03 1.516238e-02
#> T[C>A]T 1.863458e-02 0.0516 0.0145 0.0157 5.012316e-03 1.178778e-01
#> T[C>G]A 2.802349e-01 0.0000 0.0009 0.0050 3.926850e-04 1.802969e-03
#> T[C>G]C 6.388529e-02 0.0000 0.0026 0.0064 6.556020e-04 7.863007e-03
#> T[C>G]G 9.528486e-03 0.0000 0.0000 0.0000 1.364150e-05 1.513223e-03
#> T[C>G]T 3.302255e-01 0.0001 0.0015 0.0169 2.852380e-03 3.567102e-03
#> T[C>T]A 1.138421e-01 0.0092 0.0112 0.0172 1.610079e-02 1.492339e-02
#> T[C>T]C 1.502484e-02 0.0283 0.0156 0.0131 1.677998e-02 9.962744e-03
#> T[C>T]G 6.102098e-03 0.0094 0.0104 0.0036 1.627210e-02 1.154971e-02
#> T[C>T]T 2.814066e-02 0.0229 0.0076 0.0193 1.982742e-02 5.398014e-03
#> T[T>A]A 4.032610e-04 0.0000 0.0008 0.0085 6.988120e-04 4.663278e-03
#> T[T>A]C 7.718130e-04 0.0016 0.0019 0.0087 2.579359e-03 2.578156e-03
#> T[T>A]G 2.451940e-04 0.0000 0.0006 0.0063 2.113360e-05 2.016738e-03
#> T[T>A]T 1.603460e-04 0.0012 0.0003 0.0080 3.883131e-03 2.818679e-03
#> T[T>C]A 7.840560e-04 0.0018 0.0068 0.0246 1.708587e-03 3.023040e-04
#> T[T>C]C 1.329750e-04 0.0056 0.0099 0.0183 1.107415e-02 6.260791e-03
#> T[T>C]G 3.740240e-05 0.0034 0.0039 0.0165 5.932003e-03 1.541265e-03
#> T[T>C]T 1.797030e-04 0.0026 0.0047 0.0174 7.208218e-03 1.357797e-03
#> T[T>G]A 5.465820e-04 0.0000 0.0000 0.0068 1.334110e-04 3.631840e-05
#> T[T>G]C 2.353470e-04 0.0015 0.0004 0.0069 9.613345e-03 3.233838e-03
#> T[T>G]G 4.790220e-07 0.0002 0.0009 0.0049 4.522462e-03 7.546020e-04
#> T[T>G]T 6.705880e-04 0.0025 0.0033 0.0163 5.804041e-02 2.126442e-03
#> COSMIC_19 COSMIC_20 COSMIC_21 COSMIC_22 COSMIC_23 COSMIC_24
#> A[C>A]A 0.0107 1.179962e-03 0.0001 0.001504070 0.0004533610 2.864599e-02
#> A[C>A]C 0.0074 2.211505e-03 0.0007 0.002451011 0.0003668000 2.021464e-02
#> A[C>A]G 0.0005 1.616910e-07 0.0000 0.000000000 0.0000000000 2.047900e-02
#> A[C>A]T 0.0074 3.008010e-03 0.0006 0.000922453 0.0000000000 2.460014e-02
#> A[C>G]A 0.0058 6.970410e-04 0.0005 0.000527644 0.0000000000 1.199304e-02
#> A[C>G]C 0.0019 2.059310e-03 0.0008 0.000000000 0.0000000000 8.425120e-03
#> A[C>G]G 0.0000 1.273500e-05 0.0000 0.000000000 0.0000000000 0.000000e+00
#> A[C>G]T 0.0072 8.485870e-04 0.0018 0.000299455 0.0000000000 3.881383e-03
#> A[C>T]A 0.0221 3.285805e-02 0.0051 0.003113390 0.0197671540 6.315518e-03
#> A[C>T]C 0.0203 2.219605e-02 0.0062 0.001524860 0.0818805799 3.844327e-03
#> A[C>T]G 0.0368 3.457201e-02 0.0256 0.003625641 0.0092487150 3.110664e-03
#> A[C>T]T 0.0266 1.881956e-02 0.0030 0.000000000 0.0332096519 3.420419e-03
#> A[T>A]A 0.0011 5.744010e-04 0.0083 0.049619230 0.0000000000 1.166747e-03
#> A[T>A]C 0.0053 1.971462e-03 0.0292 0.011666740 0.0000000000 1.517310e-05
#> A[T>A]G 0.0045 1.905870e-04 0.0027 0.067915453 0.0002374190 6.332456e-03
#> A[T>A]T 0.0033 7.421104e-03 0.0043 0.014599918 0.0000000000 4.967220e-06
#> A[T>C]A 0.0145 1.639506e-02 0.0265 0.016839931 0.0010684490 4.726009e-03
#> A[T>C]C 0.0048 1.925179e-02 0.0165 0.001108262 0.0002215730 6.279490e-04
#> A[T>C]G 0.0135 5.478492e-02 0.0224 0.004913616 0.0004988020 2.723759e-03
#> A[T>C]T 0.0160 7.341270e-03 0.0189 0.002630524 0.0003132410 7.122368e-03
#> A[T>G]A 0.0014 1.765290e-06 0.0000 0.001651999 0.0000000000 0.000000e+00
#> A[T>G]C 0.0000 3.813880e-04 0.0031 0.000000000 0.0000000000 1.463951e-03
#> A[T>G]G 0.0010 6.587580e-04 0.0016 0.001086873 0.0000000000 8.476130e-04
#> A[T>G]T 0.0017 5.321250e-04 0.0018 0.000000000 0.0000000000 1.075455e-03
#> C[C>A]A 0.0112 1.737711e-02 0.0020 0.004549693 0.0001647390 6.355928e-02
#> C[C>A]C 0.0159 3.650246e-02 0.0014 0.003764474 0.0007368750 3.375700e-02
#> C[C>A]G 0.0018 1.248259e-02 0.0027 0.000900163 0.0001639540 2.242899e-02
#> C[C>A]T 0.0096 1.034012e-01 0.0056 0.004439846 0.0007227320 2.008651e-02
#> C[C>G]A 0.0002 1.331630e-05 0.0001 0.000582018 0.0001990490 1.347682e-02
#> C[C>G]C 0.0028 5.481450e-04 0.0000 0.000825300 0.0002837760 1.610569e-02
#> C[C>G]G 0.0002 0.000000e+00 0.0000 0.000382115 0.0000000000 7.974720e-04
#> C[C>G]T 0.0008 1.207310e-04 0.0003 0.001760646 0.0001957750 1.038867e-02
#> C[C>T]A 0.0438 1.114518e-02 0.0034 0.007731350 0.0605726279 6.035447e-03
#> C[C>T]C 0.0753 1.815275e-02 0.0091 0.007110851 0.1863756337 0.000000e+00
#> C[C>T]G 0.0238 4.438494e-02 0.0318 0.005502031 0.0151490830 2.924419e-03
#> C[C>T]T 0.1159 1.384714e-02 0.0040 0.004169777 0.1560153968 3.971202e-03
#> C[T>A]A 0.0043 4.504240e-05 0.0000 0.086898545 0.0005945280 2.766635e-03
#> C[T>A]C 0.0053 4.389056e-03 0.0037 0.053706847 0.0000000000 2.694462e-03
#> C[T>A]G 0.0021 1.127836e-03 0.0025 0.213220865 0.0001731200 6.911165e-03
#> C[T>A]T 0.0022 2.385541e-03 0.0010 0.061827507 0.0004578130 2.915200e-03
#> C[T>C]A 0.0066 1.486770e-02 0.0219 0.004027346 0.0000000000 1.848877e-03
#> C[T>C]C 0.0070 1.835616e-02 0.0100 0.001352444 0.0000000000 4.453690e-03
#> C[T>C]G 0.0040 7.415056e-02 0.0211 0.002749666 0.0003207050 0.000000e+00
#> C[T>C]T 0.0053 1.100112e-02 0.0204 0.002363354 0.0000000000 1.597389e-03
#> C[T>G]A 0.0000 2.326410e-05 0.0000 0.001120357 0.0000000000 0.000000e+00
#> C[T>G]C 0.0011 8.476495e-03 0.0005 0.001064584 0.0001901440 2.185437e-03
#> C[T>G]G 0.0013 1.538378e-02 0.0004 0.004188568 0.0000000000 1.139100e-04
#> C[T>G]T 0.0019 2.185395e-03 0.0032 0.001629410 0.0002108350 2.533718e-03
#> G[C>A]A 0.0032 1.116124e-03 0.0001 0.001298370 0.0003499070 5.467645e-02
#> G[C>A]C 0.0031 3.271429e-03 0.0038 0.001809622 0.0005683380 1.099460e-01
#> G[C>A]G 0.0000 3.751613e-03 0.0003 0.000333838 0.0001494180 4.652487e-02
#> G[C>A]T 0.0072 1.293719e-02 0.0023 0.000519148 0.0000000000 5.042871e-02
#> G[C>G]A 0.0020 1.339769e-03 0.0004 0.000000000 0.0000000000 4.945061e-03
#> G[C>G]C 0.0000 1.811151e-03 0.0042 0.000000000 0.0001375010 9.369876e-03
#> G[C>G]G 0.0000 6.375380e-07 0.0000 0.000214696 0.0000000000 5.625727e-03
#> G[C>G]T 0.0000 1.238264e-03 0.0004 0.000538439 0.0000000000 3.055770e-03
#> G[C>T]A 0.0374 5.679395e-02 0.0163 0.001915371 0.0532820589 2.367905e-02
#> G[C>T]C 0.0614 5.442986e-02 0.0392 0.003229134 0.1629183437 1.591920e-02
#> G[C>T]G 0.0278 4.592689e-03 0.0019 0.003300599 0.0130464950 1.264808e-02
#> G[C>T]T 0.0917 4.958086e-02 0.0166 0.001114060 0.1075903998 1.812978e-02
#> G[T>A]A 0.0026 1.631300e-04 0.0000 0.053709146 0.0000000000 2.225127e-03
#> G[T>A]C 0.0000 3.799180e-03 0.0142 0.009489397 0.0001832040 4.853149e-03
#> G[T>A]G 0.0016 8.283340e-04 0.0031 0.050293902 0.0000000000 1.957590e-04
#> G[T>A]T 0.0052 1.900747e-03 0.0041 0.010601457 0.0000000000 0.000000e+00
#> G[T>C]A 0.0039 2.469317e-03 0.1426 0.004217454 0.0002511690 1.269750e-03
#> G[T>C]C 0.0030 1.565633e-03 0.0665 0.000000000 0.0005382180 6.710340e-03
#> G[T>C]G 0.0060 2.734175e-02 0.0884 0.001474885 0.0000000000 2.776850e-04
#> G[T>C]T 0.0099 1.498265e-03 0.1003 0.001561043 0.0009957700 4.238478e-03
#> G[T>G]A 0.0000 3.579150e-06 0.0000 0.000000000 0.0000000000 0.000000e+00
#> G[T>G]C 0.0000 2.830575e-03 0.0006 0.000000000 0.0000000000 1.073632e-03
#> G[T>G]G 0.0043 2.733219e-03 0.0004 0.001877589 0.0001871320 2.924697e-03
#> G[T>G]T 0.0025 3.558559e-03 0.0008 0.000000000 0.0000000000 8.250980e-04
#> T[C>A]A 0.0051 6.883000e-04 0.0001 0.004051635 0.0020712900 3.145126e-02
#> T[C>A]C 0.0063 4.058229e-03 0.0005 0.002739771 0.0006964100 6.253829e-02
#> T[C>A]G 0.0018 1.001102e-03 0.0000 0.000513151 0.0000993936 1.280259e-02
#> T[C>A]T 0.0087 1.222910e-02 0.0004 0.003605651 0.0002074300 3.029768e-02
#> T[C>G]A 0.0005 2.429850e-05 0.0002 0.000225491 0.0002306090 1.022086e-02
#> T[C>G]C 0.0011 1.519990e-04 0.0003 0.000628695 0.0001657870 7.578365e-03
#> T[C>G]G 0.0000 0.000000e+00 0.0000 0.000395808 0.0000000000 1.592714e-03
#> T[C>G]T 0.0105 6.830600e-04 0.0003 0.000257375 0.0004389560 6.100727e-03
#> T[C>T]A 0.0218 1.071032e-02 0.0064 0.002016722 0.0145586140 2.657189e-02
#> T[C>T]C 0.0330 8.175510e-03 0.0086 0.001990834 0.0435104469 1.205569e-02
#> T[C>T]G 0.0090 2.316390e-02 0.0126 0.001498473 0.0027526410 5.363360e-03
#> T[C>T]T 0.0267 9.540087e-03 0.0064 0.001182227 0.0243287850 5.532499e-03
#> T[T>A]A 0.0039 9.245480e-04 0.0027 0.040810503 0.0000000000 0.000000e+00
#> T[T>A]C 0.0048 7.082070e-04 0.0045 0.025570396 0.0000000000 7.994129e-03
#> T[T>A]G 0.0052 9.700310e-05 0.0000 0.069845217 0.0002315260 1.120214e-02
#> T[T>A]T 0.0085 2.313489e-03 0.0008 0.023579062 0.0000000000 2.705790e-04
#> T[T>C]A 0.0052 5.734230e-03 0.0389 0.004803670 0.0000000000 1.682291e-03
#> T[T>C]C 0.0020 1.123425e-02 0.0313 0.000912158 0.0002306090 2.344528e-03
#> T[T>C]G 0.0057 2.376761e-02 0.0249 0.001781736 0.0002395140 4.812740e-04
#> T[T>C]T 0.0038 5.395186e-03 0.0274 0.000000000 0.0000000000 3.581480e-04
#> T[T>G]A 0.0032 2.691470e-07 0.0000 0.001651699 0.0000000000 0.000000e+00
#> T[T>G]C 0.0018 3.772340e-04 0.0018 0.000000000 0.0000000000 0.000000e+00
#> T[T>G]G 0.0011 5.154220e-04 0.0003 0.002572752 0.0002475020 1.360505e-03
#> T[T>G]T 0.0013 6.156570e-04 0.0003 0.000000000 0.0000000000 6.951580e-05
#> COSMIC_25 COSMIC_26 COSMIC_27 COSMIC_28 COSMIC_29
#> A[C>A]A 0.009896768 2.039773e-03 0.0052056270 0.0013974390 0.069981987
#> A[C>A]C 0.006998929 1.487162e-03 0.0047382270 0.0009171880 0.055152357
#> A[C>A]G 0.001448443 2.839460e-04 0.0007826980 0.0000000000 0.017846984
#> A[C>A]T 0.004966565 5.978660e-04 0.0027182420 0.0005134100 0.026804716
#> A[C>G]A 0.008032568 1.272881e-03 0.0013241630 0.0002551950 0.009301971
#> A[C>G]C 0.001635970 1.528195e-03 0.0017710840 0.0002688990 0.003479049
#> A[C>G]G 0.000000000 3.072460e-04 0.0000000000 0.0000000000 0.000154434
#> A[C>G]T 0.003428450 2.498252e-03 0.0013227200 0.0003076980 0.003976790
#> A[C>T]A 0.020987618 5.907232e-03 0.0137232861 0.0054337920 0.005197221
#> A[C>T]C 0.013141284 1.062646e-02 0.0054243060 0.0018154150 0.008976470
#> A[C>T]G 0.019659894 1.993032e-02 0.0067064290 0.0054320390 0.031638996
#> A[C>T]T 0.005728519 1.133453e-02 0.0044756140 0.0016292130 0.004769667
#> A[T>A]A 0.020430527 4.459340e-03 0.1430763896 0.0009640310 0.000000000
#> A[T>A]C 0.008892561 1.282224e-02 0.0014640850 0.0033656680 0.003049596
#> A[T>A]G 0.006241948 1.172344e-03 0.0012262810 0.0017857540 0.003909982
#> A[T>A]T 0.014850878 3.993138e-03 0.0025351980 0.0056530890 0.005105527
#> A[T>C]A 0.020663283 5.502865e-02 0.0050473010 0.0040927470 0.010119181
#> A[T>C]C 0.009502478 2.759460e-02 0.0018456910 0.0078807290 0.006349683
#> A[T>C]G 0.019911492 5.179104e-02 0.0056888140 0.0055208340 0.014659610
#> A[T>C]T 0.014488390 3.907224e-02 0.0025927550 0.0032324840 0.007892413
#> A[T>G]A 0.005281680 8.065340e-05 0.0011363370 0.0063646760 0.000000000
#> A[T>G]C 0.000000000 1.631710e-04 0.0009589760 0.0166109060 0.000000000
#> A[T>G]G 0.007136422 1.255080e-03 0.0000676606 0.0065928420 0.002925171
#> A[T>G]T 0.000000000 1.850383e-03 0.0002560280 0.0863928968 0.000000000
#> C[C>A]A 0.014832948 3.705850e-03 0.0050650730 0.0011685160 0.051410212
#> C[C>A]C 0.007822175 3.980723e-03 0.0022341530 0.0003342920 0.025825651
#> C[C>A]G 0.001276977 8.117420e-04 0.0002663120 0.0000536520 0.014496183
#> C[C>A]T 0.012563655 1.903843e-02 0.0031005700 0.0001866720 0.040355074
#> C[C>G]A 0.007200790 1.279106e-03 0.0047306490 0.0001033660 0.002618863
#> C[C>G]C 0.004598473 1.214977e-03 0.0012616450 0.0001443110 0.001111512
#> C[C>G]G 0.000823709 2.078330e-04 0.0003608570 0.0000000000 0.001520047
#> C[C>G]T 0.000196360 2.297026e-03 0.0002680260 0.0002910000 0.000139751
#> C[C>T]A 0.014333995 6.594445e-03 0.0174384851 0.0043915330 0.009126472
#> C[C>T]C 0.005936644 6.510632e-03 0.0071448700 0.0026476610 0.007067603
#> C[C>T]G 0.011559392 1.190494e-02 0.0075035620 0.0022845640 0.019875180
#> C[C>T]T 0.013632597 6.238556e-03 0.0071480280 0.0024239840 0.001634059
#> C[T>A]A 0.026296323 3.561423e-03 0.3306010183 0.0025665800 0.001765448
#> C[T>A]C 0.015799883 3.901611e-03 0.0028135990 0.0196108970 0.000383359
#> C[T>A]G 0.062860606 2.390304e-03 0.0043968570 0.0088336000 0.003556845
#> C[T>A]T 0.036622351 1.635923e-03 0.0054308920 0.0109426100 0.002232755
#> C[T>C]A 0.009028015 3.788938e-02 0.0048990790 0.0207380030 0.000000000
#> C[T>C]C 0.010771632 2.174074e-02 0.0057244480 0.0432837969 0.002774954
#> C[T>C]G 0.013350661 4.724010e-02 0.0056614790 0.0370882619 0.006902415
#> C[T>C]T 0.008961030 2.074062e-02 0.0039005890 0.0050527160 0.003041425
#> C[T>G]A 0.000000000 9.539630e-05 0.0000000000 0.0095898420 0.001116855
#> C[T>G]C 0.002886454 3.919455e-03 0.0003812450 0.0339132239 0.000000000
#> C[T>G]G 0.011769492 5.497357e-03 0.0004032570 0.0185164820 0.002169693
#> C[T>G]T 0.008550807 6.788719e-03 0.0014390960 0.1189671027 0.001143663
#> G[C>A]A 0.013465295 1.375312e-03 0.0107558720 0.0021366290 0.078046610
#> G[C>A]C 0.006468298 1.961639e-03 0.0124423350 0.0004292080 0.073460915
#> G[C>A]G 0.000658103 1.322970e-05 0.0016296280 0.0000000000 0.017383297
#> G[C>A]T 0.010473080 1.934996e-03 0.0074123550 0.0013185070 0.059602472
#> G[C>G]A 0.004169656 1.320607e-03 0.0014181660 0.0000815914 0.000265760
#> G[C>G]C 0.002392805 1.845501e-03 0.0013467170 0.0001052190 0.000945013
#> G[C>G]G 0.000418194 2.050610e-04 0.0000000000 0.0000000000 0.000000000
#> G[C>G]T 0.001994012 1.225533e-03 0.0045606860 0.0001596790 0.004796745
#> G[C>T]A 0.010038112 9.606515e-03 0.0142153141 0.0033842410 0.011638793
#> G[C>T]C 0.006953875 1.950743e-02 0.0201436461 0.0016874140 0.003781752
#> G[C>T]G 0.010468363 2.250272e-02 0.0093684680 0.0021893090 0.019684388
#> G[C>T]T 0.009823821 1.730747e-02 0.0075896260 0.0010439940 0.005761337
#> G[T>A]A 0.036217801 2.242887e-03 0.1098518724 0.0005514610 0.002930098
#> G[T>A]C 0.005847110 5.207287e-03 0.0000234557 0.0031639880 0.000000000
#> G[T>A]G 0.038241179 1.358122e-03 0.0015659370 0.0021528470 0.000533632
#> G[T>A]T 0.020167954 2.513113e-03 0.0000000000 0.0020077330 0.000000000
#> G[T>C]A 0.017489824 9.805283e-02 0.0047773800 0.0036550480 0.007090804
#> G[T>C]C 0.004045612 4.022636e-02 0.0019649540 0.0070711750 0.007111328
#> G[T>C]G 0.013402246 4.462070e-02 0.0012291680 0.0082322380 0.005643064
#> G[T>C]T 0.014159694 5.552807e-02 0.0037472250 0.0004078850 0.011237674
#> G[T>G]A 0.005546227 3.739320e-05 0.0000000000 0.0000000000 0.000000000
#> G[T>G]C 0.000000000 2.460705e-03 0.0000507906 0.0000000000 0.000000000
#> G[T>G]G 0.008685244 8.172020e-04 0.0047429190 0.0042178080 0.003640594
#> G[T>G]T 0.002768572 7.833561e-03 0.0022984760 0.0316489969 0.006181024
#> T[C>A]A 0.006938147 2.680062e-03 0.0070792850 0.0007759030 0.026894407
#> T[C>A]C 0.010246607 2.031644e-03 0.0062688010 0.0008292920 0.031608137
#> T[C>A]G 0.000000000 2.650720e-04 0.0014464030 0.0000000000 0.012500468
#> T[C>A]T 0.024625787 3.017187e-03 0.0098062780 0.0019980740 0.041207176
#> T[C>G]A 0.009798725 4.201897e-03 0.0028704340 0.0005213700 0.000820445
#> T[C>G]C 0.003266507 2.807762e-03 0.0031079680 0.0006673260 0.000444119
#> T[C>G]G 0.002057437 6.197000e-09 0.0000128104 0.0000000000 0.000143297
#> T[C>G]T 0.016400917 8.019383e-03 0.0021305880 0.0012457800 0.001369869
#> T[C>T]A 0.011077521 1.130329e-02 0.0187577761 0.0076222580 0.012076583
#> T[C>T]C 0.006448788 1.080753e-02 0.0079891840 0.0051166190 0.000000000
#> T[C>T]G 0.014083416 1.036433e-02 0.0046091310 0.0019180280 0.015830197
#> T[C>T]T 0.012418586 7.249145e-03 0.0118809320 0.0061931590 0.013462137
#> T[T>A]A 0.021830329 6.281450e-04 0.0528138872 0.0002032380 0.001191207
#> T[T>A]C 0.003405687 5.073754e-03 0.0000470918 0.0101809650 0.001682664
#> T[T>A]G 0.010191520 2.013840e-05 0.0000000000 0.0032504270 0.002438756
#> T[T>A]T 0.014527539 1.235538e-03 0.0019297710 0.0164928120 0.000000000
#> T[T>C]A 0.014515050 2.878968e-02 0.0017210150 0.0099295520 0.011498666
#> T[T>C]C 0.007406083 3.663949e-02 0.0034892130 0.0290105629 0.003584215
#> T[T>C]G 0.004892531 1.914369e-02 0.0011528470 0.0156832190 0.001694297
#> T[T>C]T 0.017014781 2.307169e-02 0.0015279570 0.0172915640 0.003799706
#> T[T>G]A 0.002081480 8.534940e-06 0.0011890220 0.0093896590 0.000000000
#> T[T>G]C 0.000578979 2.718510e-03 0.0002802950 0.0301170769 0.000000000
#> T[T>G]G 0.009429196 1.369161e-03 0.0023530560 0.0126987510 0.000353696
#> T[T>G]T 0.007869672 2.568077e-03 0.0001395610 0.2336597824 0.006104834
#> COSMIC_30
#> A[C>A]A 0.0000000
#> A[C>A]C 0.0000000
#> A[C>A]G 0.0019673
#> A[C>A]T 0.0000000
#> A[C>G]A 0.0000000
#> A[C>G]C 0.0000000
#> A[C>G]G 0.0048200
#> A[C>G]T 0.0000000
#> A[C>T]A 0.0651190
#> A[C>T]C 0.0543970
#> A[C>T]G 0.0204604
#> A[C>T]T 0.0219359
#> A[T>A]A 0.0075743
#> A[T>A]C 0.0037380
#> A[T>A]G 0.0065906
#> A[T>A]T 0.0093447
#> A[T>C]A 0.0000000
#> A[T>C]C 0.0087547
#> A[T>C]G 0.0090498
#> A[T>C]T 0.0000000
#> A[T>G]A 0.0053118
#> A[T>G]C 0.0024592
#> A[T>G]G 0.0062955
#> A[T>G]T 0.0095416
#> C[C>A]A 0.0000000
#> C[C>A]C 0.0000000
#> C[C>A]G 0.0022624
#> C[C>A]T 0.0000000
#> C[C>G]A 0.0000000
#> C[C>G]C 0.0000000
#> C[C>G]G 0.0032461
#> C[C>G]T 0.0000000
#> C[C>T]A 0.0694472
#> C[C>T]C 0.0638403
#> C[C>T]G 0.0173126
#> C[C>T]T 0.0342318
#> C[T>A]A 0.0053118
#> C[T>A]C 0.0067873
#> C[T>A]G 0.0082628
#> C[T>A]T 0.0000000
#> C[T>C]A 0.0000000
#> C[T>C]C 0.0000000
#> C[T>C]G 0.0000000
#> C[T>C]T 0.0000000
#> C[T>G]A 0.0046233
#> C[T>G]C 0.0060004
#> C[T>G]G 0.0073775
#> C[T>G]T 0.0091481
#> G[C>A]A 0.0088530
#> G[C>A]C 0.0093449
#> G[C>A]G 0.0008853
#> G[C>A]T 0.0081645
#> G[C>G]A 0.0073775
#> G[C>G]C 0.0065906
#> G[C>G]G 0.0015739
#> G[C>G]T 0.0000000
#> G[C>T]A 0.0485934
#> G[C>T]C 0.0494787
#> G[C>T]G 0.0157387
#> G[C>T]T 0.0188865
#> G[T>A]A 0.0037380
#> G[T>A]C 0.0033445
#> G[T>A]G 0.0050167
#> G[T>A]T 0.0063939
#> G[T>C]A 0.0000000
#> G[T>C]C 0.0065906
#> G[T>C]G 0.0078694
#> G[T>C]T 0.0084596
#> G[T>G]A 0.0032461
#> G[T>G]C 0.0018690
#> G[T>G]G 0.0033445
#> G[T>G]T 0.0056069
#> T[C>A]A 0.0000000
#> T[C>A]C 0.0000000
#> T[C>A]G 0.0016722
#> T[C>A]T 0.0000000
#> T[C>G]A 0.0000000
#> T[C>G]C 0.0000000
#> T[C>G]G 0.0019673
#> T[C>G]T 0.0000000
#> T[C>T]A 0.0849892
#> T[C>T]C 0.0903010
#> T[C>T]G 0.0151485
#> T[C>T]T 0.0455440
#> T[T>A]A 0.0076726
#> T[T>A]C 0.0064922
#> T[T>A]G 0.0036396
#> T[T>A]T 0.0000000
#> T[T>C]A 0.0000000
#> T[T>C]C 0.0091481
#> T[T>C]G 0.0060004
#> T[T>C]T 0.0000000
#> T[T>G]A 0.0086563
#> T[T>G]C 0.0043282
#> T[T>G]G 0.0082628
#> T[T>G]T 0.0000000
#>
#> $aetiology
#> aetiology
#> COSMIC_1 spontaneous deamination of 5-methylcytosine
#> COSMIC_2 APOBEC Cytidine Deaminase (C>T)
#> COSMIC_3 defects in DNA-DSB repair by HR
#> COSMIC_4 exposure to tobacco (smoking) mutagens
#> COSMIC_5 Unknown
#> COSMIC_6 defective DNA mismatch repair
#> COSMIC_7 UV exposure
#> COSMIC_8 Unknown
#> COSMIC_9 defects in polymerase-eta
#> COSMIC_10 defects in polymerase POLE
#> COSMIC_11 exposure to alkylating agents
#> COSMIC_12 Unknown
#> COSMIC_13 APOBEC Cytidine Deaminase (C>G)
#> COSMIC_14 Unknown
#> COSMIC_15 defective DNA mismatch repair
#> COSMIC_16 Unknown
#> COSMIC_17 Unknown
#> COSMIC_18 Unknown
#> COSMIC_19 Unknown
#> COSMIC_20 defective DNA mismatch repair
#> COSMIC_21 unknown
#> COSMIC_22 exposure to aristolochic acid
#> COSMIC_23 Unknown
#> COSMIC_24 exposures to aflatoxin
#> COSMIC_25 Unknown
#> COSMIC_26 defective DNA mismatch repair
#> COSMIC_27 Unknown
#> COSMIC_28 Unknown
#> COSMIC_29 exposure to tobacco (chewing) mutagens
#> COSMIC_30 Unknown
#>
s2
#> $db
#> SBS1 SBS2 SBS3 SBS4 SBS5
#> A[C>A]A 8.861572e-04 5.800168e-07 0.0208083233 0.0421964977 0.011997600
#> A[C>A]C 2.280405e-03 1.480043e-04 0.0165066026 0.0332972363 0.009438112
#> A[C>A]G 1.770314e-04 5.230151e-05 0.0017507003 0.0155987053 0.001849630
#> A[C>A]T 1.280227e-03 9.780282e-05 0.0122048820 0.0294975517 0.006608678
#> A[C>G]A 1.860330e-03 2.230064e-16 0.0197078832 0.0068894282 0.010097980
#> A[C>G]C 1.220217e-03 1.330038e-04 0.0117046819 0.0028397643 0.005698860
#> A[C>G]G 1.150204e-04 1.520044e-05 0.0002531012 0.0012798938 0.001719656
#> A[C>G]T 1.140202e-03 9.120263e-05 0.0174069628 0.0035497054 0.010097980
#> A[C>T]A 2.500444e-02 6.110176e-05 0.0142056823 0.0086992780 0.032593481
#> A[C>T]C 6.321122e-03 1.380040e-03 0.0124049620 0.0041796531 0.017896421
#> A[C>T]G 3.650648e-01 3.270094e-05 0.0025710284 0.0007829350 0.006178764
#> A[C>T]T 9.581700e-03 1.860054e-03 0.0121048419 0.0042496473 0.021995601
#> A[T>A]A 8.001420e-04 9.590277e-05 0.0054921969 0.0094192182 0.007378524
#> A[T>A]C 2.230396e-03 8.780254e-04 0.0072128852 0.0035297070 0.006928614
#> A[T>A]G 1.140202e-03 2.550074e-05 0.0096438575 0.0123989709 0.009118176
#> A[T>A]T 1.830325e-04 2.230064e-16 0.0061124450 0.0042096506 0.006198760
#> A[T>C]A 1.090193e-03 6.170178e-05 0.0165066026 0.0079493402 0.046190762
#> A[T>C]C 3.040539e-03 2.150062e-05 0.0077631052 0.0007149407 0.013397321
#> A[T>C]G 1.060188e-04 1.320038e-05 0.0123049220 0.0049995850 0.038192362
#> A[T>C]T 5.741019e-03 1.550045e-04 0.0173069228 0.0015598705 0.038292342
#> A[T>G]A 1.720305e-04 2.380069e-04 0.0039515806 0.0010499129 0.003859228
#> A[T>G]C 2.070367e-04 7.460215e-05 0.0026010404 0.0001589868 0.002599480
#> A[T>G]G 2.680476e-04 2.050059e-06 0.0063025210 0.0014198821 0.007938412
#> A[T>G]T 1.120199e-04 3.760109e-06 0.0039715886 0.0002159821 0.004829034
#> C[C>A]A 3.120554e-04 2.080060e-04 0.0225090036 0.0806933025 0.007428514
#> C[C>A]C 1.790318e-03 9.530275e-05 0.0253101240 0.0796933854 0.006138772
#> C[C>A]G 9.321654e-05 2.230064e-16 0.0025110044 0.0244979667 0.003459308
#> C[C>A]T 2.230396e-16 4.210122e-04 0.0154061625 0.0689942735 0.006488702
#> C[C>G]A 2.410428e-05 2.230064e-16 0.0193077231 0.0078293502 0.006958608
#> C[C>G]C 7.681363e-05 3.510101e-04 0.0141056423 0.0068694298 0.009068186
#> C[C>G]G 3.520625e-04 4.870141e-05 0.0015006002 0.0033997178 0.002489502
#> C[C>G]T 2.230396e-16 6.360184e-05 0.0223089236 0.0068194340 0.009528094
#> C[C>T]A 2.000355e-03 4.320125e-03 0.0161064426 0.0126989460 0.019396121
#> C[C>T]C 2.700479e-04 1.700049e-04 0.0202080832 0.0114990456 0.018996201
#> C[C>T]G 1.960348e-01 2.770080e-03 0.0022408964 0.0033097253 0.017496501
#> C[C>T]T 1.960348e-04 1.450042e-03 0.0230092037 0.0159986721 0.023095381
#> C[T>A]A 4.300763e-05 2.430070e-04 0.0079431773 0.0143988049 0.003539292
#> C[T>A]C 3.930697e-04 2.440070e-04 0.0178071228 0.0121989875 0.005188962
#> C[T>A]G 3.240575e-04 1.490043e-04 0.0132052821 0.0324973027 0.005008998
#> C[T>A]T 2.600461e-04 2.230064e-16 0.0127050820 0.0117990207 0.004299140
#> C[T>C]A 2.230396e-16 3.020087e-04 0.0088335334 0.0051795701 0.013297341
#> C[T>C]C 2.500444e-03 2.850082e-05 0.0145058023 0.0023598041 0.010397920
#> C[T>C]G 3.600639e-04 2.230064e-16 0.0101040416 0.0054995435 0.020795841
#> C[T>C]T 4.260756e-05 1.860054e-04 0.0158063225 0.0025597875 0.014897021
#> C[T>G]A 3.550630e-05 1.530044e-04 0.0043717487 0.0008699278 0.002589482
#> C[T>G]C 2.120376e-04 1.550045e-04 0.0070428171 0.0004409634 0.004609078
#> C[T>G]G 1.280227e-04 1.210035e-04 0.0107042817 0.0037896855 0.006128774
#> C[T>G]T 1.710303e-04 2.030059e-04 0.0070328131 0.0011999004 0.007298540
#> G[C>A]A 1.580280e-03 8.620249e-05 0.0071328531 0.0315973774 0.010197960
#> G[C>A]C 3.390602e-04 2.230064e-16 0.0109043617 0.0347971118 0.007648470
#> G[C>A]G 5.871042e-04 1.390040e-05 0.0014305722 0.0152987302 0.002339532
#> G[C>A]T 2.230396e-16 5.120148e-05 0.0100040016 0.0211982405 0.006818636
#> G[C>G]A 9.591702e-06 6.540189e-05 0.0127050820 0.0052895610 0.004679064
#> G[C>G]C 1.640291e-04 2.610075e-04 0.0086334534 0.0057495228 0.005078984
#> G[C>G]G 1.660295e-04 2.230064e-16 0.0024209684 0.0032997261 0.001509698
#> G[C>G]T 2.230396e-16 1.340039e-04 0.0147058824 0.0030397477 0.006718656
#> G[C>T]A 4.440788e-03 2.230064e-16 0.0164065626 0.0040896606 0.019396121
#> G[C>T]C 9.281647e-05 1.290037e-07 0.0134053621 0.0044596299 0.021595681
#> G[C>T]G 2.180387e-01 2.230064e-16 0.0005282113 0.0004819600 0.012297540
#> G[C>T]T 3.840681e-05 5.040146e-05 0.0113045218 0.0038096838 0.018596281
#> G[T>A]A 8.121441e-05 2.230064e-16 0.0070628251 0.0092192348 0.003669266
#> G[T>A]C 1.290229e-04 1.310038e-04 0.0074829932 0.0035997012 0.002909418
#> G[T>A]G 2.460437e-04 6.380184e-05 0.0116046419 0.0130989128 0.004109178
#> G[T>A]T 2.580458e-04 6.280181e-05 0.0123049220 0.0055195419 0.003219356
#> G[T>C]A 1.050186e-03 2.230064e-16 0.0099839936 0.0028997593 0.014097181
#> G[T>C]C 1.900337e-03 2.740079e-05 0.0056422569 0.0011799021 0.007938412
#> G[T>C]G 1.170208e-03 1.070031e-04 0.0109043617 0.0023698033 0.014997001
#> G[T>C]T 7.131265e-05 1.250036e-05 0.0102040816 0.0007549373 0.013697261
#> G[T>G]A 2.230396e-16 2.090060e-04 0.0044217687 0.0005979504 0.002519496
#> G[T>G]C 2.230396e-16 1.330038e-04 0.0023409364 0.0002529790 0.001709658
#> G[T>G]G 3.480618e-04 3.710107e-05 0.0109043617 0.0024297983 0.005298940
#> G[T>G]T 1.460259e-05 2.230064e-16 0.0058323329 0.0002519791 0.002349530
#> T[C>A]A 6.581168e-05 6.390185e-04 0.0084133653 0.0397966969 0.007858428
#> T[C>A]C 2.530449e-03 1.700049e-04 0.0168067227 0.0468961076 0.009168166
#> T[C>A]G 2.230396e-16 8.530246e-05 0.0014105642 0.0108990954 0.002299540
#> T[C>A]T 5.881043e-06 4.400127e-04 0.0099739896 0.0412965724 0.012697461
#> T[C>G]A 2.230396e-16 2.230064e-16 0.0133053221 0.0035797029 0.007808438
#> T[C>G]C 2.030360e-04 9.870285e-05 0.0203081232 0.0059495062 0.007598480
#> T[C>G]G 6.941232e-05 4.120119e-05 0.0005202081 0.0018298481 0.001709658
#> T[C>G]T 1.560277e-03 1.180034e-03 0.0235094038 0.0033797195 0.012497500
#> T[C>T]A 1.110197e-03 5.360155e-01 0.0057623049 0.0037396896 0.020295941
#> T[C>T]C 3.730662e-05 9.730281e-02 0.0133053221 0.0069894199 0.022995401
#> T[C>T]G 1.100195e-01 4.420128e-02 0.0009893958 0.0002809767 0.015896821
#> T[C>T]T 2.230396e-16 3.000087e-01 0.0081732693 0.0072194008 0.020995801
#> T[T>A]A 6.721193e-03 4.220122e-04 0.0065126050 0.0088792630 0.006308738
#> T[T>A]C 2.230396e-16 1.920055e-04 0.0105042017 0.0043096423 0.004139172
#> T[T>A]G 2.800497e-05 5.010145e-05 0.0067126851 0.0095392082 0.004789042
#> T[T>A]T 2.250399e-03 2.050059e-04 0.0130052021 0.0056195336 0.008748250
#> T[T>C]A 2.550453e-04 2.230064e-16 0.0152060824 0.0024098000 0.017996401
#> T[T>C]C 3.390602e-03 4.350126e-05 0.0089935974 0.0005029583 0.009708058
#> T[T>C]G 4.160738e-04 1.170034e-04 0.0069327731 0.0017398556 0.012697461
#> T[T>C]T 4.330768e-03 3.580103e-05 0.0139055622 0.0006359472 0.018496301
#> T[T>G]A 2.230396e-16 1.670048e-05 0.0072529012 0.0003769687 0.005218956
#> T[T>G]C 5.510978e-05 7.040203e-05 0.0062825130 0.0001739856 0.006558688
#> T[T>G]G 5.831035e-04 9.540276e-05 0.0080532213 0.0023198075 0.006938612
#> T[T>G]T 2.230396e-16 2.230064e-16 0.0105042017 0.0005679529 0.013497301
#> SBS6 SBS7a SBS7b SBS7c SBS7d
#> A[C>A]A 4.252330e-04 6.704351e-05 2.329386e-03 4.830406e-03 4.039380e-05
#> A[C>A]C 5.242873e-04 1.791162e-04 4.608785e-04 1.150097e-03 7.648826e-04
#> A[C>A]G 5.202851e-05 7.124623e-05 1.859510e-04 3.770317e-04 2.499616e-04
#> A[C>A]T 1.800987e-04 2.481610e-04 7.098129e-04 1.960165e-03 4.049378e-03
#> A[C>G]A 4.712582e-04 6.494214e-05 8.557745e-06 1.120094e-03 1.179819e-03
#> A[C>G]C 2.891584e-04 2.161403e-05 1.889502e-04 3.190268e-04 2.549609e-03
#> A[C>G]G 2.221217e-16 5.083299e-05 5.048669e-04 2.220187e-16 9.058610e-04
#> A[C>G]T 2.541393e-04 9.566208e-05 2.849249e-04 1.930162e-03 2.909553e-03
#> A[C>T]A 6.413514e-02 1.220792e-04 1.409629e-03 1.330112e-03 3.329489e-03
#> A[C>T]C 2.291255e-02 1.771149e-02 3.808996e-02 7.680645e-03 1.399785e-03
#> A[C>T]G 1.200658e-01 2.231448e-16 5.428569e-04 9.270779e-04 1.209814e-03
#> A[C>T]T 2.131168e-02 7.424818e-03 1.079715e-02 7.480629e-03 3.289495e-02
#> A[T>A]A 9.825384e-05 1.941260e-03 2.489344e-03 1.240104e-02 8.888636e-05
#> A[T>A]C 5.462993e-04 6.704351e-04 4.668770e-04 3.420287e-03 1.079834e-03
#> A[T>A]G 2.221217e-16 5.873812e-04 1.559589e-03 2.110177e-04 3.699432e-03
#> A[T>A]T 1.660910e-03 3.712409e-03 8.287816e-03 5.070426e-02 4.109369e-02
#> A[T>C]A 2.211212e-03 4.903182e-04 1.019731e-03 2.880242e-04 4.359331e-03
#> A[T>C]C 1.130620e-03 2.271474e-04 4.558799e-04 5.330448e-04 3.929397e-03
#> A[T>C]G 4.242325e-03 1.871214e-04 1.499605e-03 1.070090e-03 9.188590e-03
#> A[T>C]T 5.022752e-04 6.153994e-04 2.149434e-03 2.650223e-03 5.099217e-02
#> A[T>G]A 2.571409e-05 4.733071e-04 8.437776e-05 1.190100e-02 3.699432e-03
#> A[T>G]C 2.041118e-04 2.471604e-04 9.317544e-04 1.050088e-03 2.659592e-03
#> A[T>G]G 1.070587e-04 2.761792e-04 1.469613e-03 6.040508e-04 1.059837e-02
#> A[T>G]T 3.862116e-04 3.092006e-04 7.328069e-04 2.220187e-16 1.429781e-02
#> C[C>A]A 1.820998e-03 4.552955e-04 1.139700e-03 1.090092e-04 1.449777e-02
#> C[C>A]C 4.092242e-03 2.401558e-04 1.549592e-03 3.090260e-03 3.219506e-03
#> C[C>A]G 1.650905e-03 2.231448e-16 4.078925e-04 1.910161e-03 8.508694e-05
#> C[C>A]T 9.605263e-03 3.722416e-04 1.489607e-03 1.350113e-02 1.169820e-04
#> C[C>G]A 4.112253e-05 2.231448e-16 4.578793e-04 2.060173e-04 1.319797e-03
#> C[C>G]C 3.722039e-05 1.310851e-04 9.597471e-04 2.260190e-03 2.859561e-04
#> C[C>G]G 8.434622e-05 7.755032e-05 7.907916e-04 2.620220e-04 1.319797e-03
#> C[C>G]T 1.440789e-05 9.566208e-05 8.897655e-04 4.240356e-03 2.219659e-16
#> C[C>T]A 1.360746e-02 5.003247e-02 1.069718e-01 2.710228e-03 3.559454e-02
#> C[C>T]C 1.480811e-02 5.533591e-02 1.819520e-01 5.970502e-03 2.599601e-03
#> C[C>T]G 1.220669e-01 6.714357e-03 2.209418e-02 8.940751e-03 2.639595e-03
#> C[C>T]T 1.380757e-02 5.663675e-02 1.259668e-01 2.060173e-02 1.379788e-04
#> C[T>A]A 6.663651e-05 1.771149e-04 1.119705e-03 3.470292e-03 1.609753e-03
#> C[T>A]C 5.513021e-04 2.611695e-04 9.577476e-04 1.340113e-02 8.128752e-05
#> C[T>A]G 1.150630e-04 1.120727e-04 8.827674e-04 9.610808e-04 1.199816e-03
#> C[T>A]T 1.790981e-04 3.712409e-04 1.119705e-04 4.870409e-02 1.149824e-03
#> C[T>C]A 1.660910e-03 4.512929e-04 1.529597e-03 7.570636e-03 1.019843e-02
#> C[T>C]C 1.030565e-03 2.591682e-04 8.397787e-04 3.580301e-03 8.888636e-05
#> C[T>C]G 5.322917e-03 1.040675e-04 7.298077e-04 2.170182e-03 9.348565e-04
#> C[T>C]T 1.270696e-03 1.821182e-03 5.728490e-03 4.310362e-02 3.969391e-02
#> C[T>G]A 4.952714e-05 8.425468e-05 3.589054e-04 3.280276e-03 1.479773e-03
#> C[T>G]C 7.844298e-04 1.721117e-04 7.917913e-04 5.580469e-03 4.979236e-05
#> C[T>G]G 9.245066e-04 2.231448e-16 1.289660e-03 1.190100e-03 2.579604e-05
#> C[T>G]T 1.300713e-03 2.651721e-05 3.679030e-06 3.400286e-03 1.559761e-04
#> G[C>A]A 4.272341e-04 4.062636e-05 7.458035e-04 1.050088e-03 1.679742e-04
#> G[C>A]C 9.135006e-04 1.380896e-04 2.149434e-04 7.420624e-04 2.219659e-16
#> G[C>A]G 3.571957e-04 4.252760e-05 7.288079e-05 2.220187e-16 1.819721e-05
#> G[C>A]T 1.230674e-03 2.231448e-16 1.469613e-04 3.630305e-04 7.398864e-05
#> G[C>G]A 1.941064e-05 1.961273e-05 5.108654e-05 1.820153e-04 1.959699e-04
#> G[C>G]C 6.853756e-04 3.322156e-05 4.518809e-04 4.730398e-04 2.219659e-16
#> G[C>G]G 2.221217e-16 4.512929e-05 3.369112e-04 1.800151e-04 5.449164e-04
#> G[C>G]T 3.211760e-04 4.202727e-05 2.769270e-04 1.280108e-03 8.818646e-04
#> G[C>T]A 9.365132e-02 8.495513e-05 8.547747e-04 1.570132e-04 3.649440e-04
#> G[C>T]C 1.110609e-01 1.170760e-02 2.629307e-02 9.510799e-06 1.809722e-04
#> G[C>T]G 1.780976e-01 5.523584e-06 1.759536e-04 3.430288e-05 1.569759e-04
#> G[C>T]T 7.444079e-02 1.611045e-02 5.388580e-03 7.580637e-04 4.209354e-02
#> G[T>A]A 5.102796e-05 4.012604e-04 5.258614e-04 1.730145e-03 2.369636e-05
#> G[T>A]C 4.892681e-04 2.241455e-04 2.559326e-04 2.270191e-03 1.119828e-04
#> G[T>A]G 1.951069e-04 2.901883e-04 6.558272e-04 2.220187e-16 1.349793e-03
#> G[T>A]T 2.481360e-04 3.061987e-04 5.588527e-05 2.030171e-02 8.758656e-03
#> G[T>C]A 2.571409e-03 1.010656e-04 2.659299e-04 2.220187e-16 7.998772e-04
#> G[T>C]C 1.110609e-03 7.414812e-05 2.219415e-16 4.230356e-04 2.319644e-03
#> G[T>C]G 2.451343e-03 7.254708e-05 5.288606e-04 2.320195e-04 2.569606e-03
#> G[T>C]T 9.064967e-04 8.115266e-04 6.848195e-03 7.070594e-03 3.179512e-01
#> G[T>G]A 4.352385e-05 9.065883e-05 3.229149e-04 2.480208e-03 7.478852e-05
#> G[T>G]C 2.131168e-04 1.210786e-04 3.209154e-04 1.660140e-03 2.229658e-05
#> G[T>G]G 2.741502e-04 3.252110e-04 2.409365e-03 6.030507e-03 3.799417e-03
#> G[T>G]T 7.874315e-04 8.355422e-04 1.829518e-03 6.750567e-03 6.838950e-03
#> T[C>A]A 3.561952e-04 3.902532e-04 2.899236e-03 2.520212e-03 1.139825e-02
#> T[C>A]C 4.982730e-04 6.364130e-04 3.519073e-03 1.420119e-02 7.758809e-03
#> T[C>A]G 2.001097e-04 3.442234e-05 2.999210e-04 2.220187e-16 2.219659e-16
#> T[C>A]T 7.474095e-04 6.133981e-04 1.409629e-03 3.730313e-03 1.909707e-04
#> T[C>G]A 4.972725e-05 2.231448e-16 2.539331e-04 1.940163e-03 3.739426e-03
#> T[C>G]C 1.130620e-04 5.093305e-05 1.619573e-03 4.610387e-03 5.879098e-04
#> T[C>G]G 1.951069e-06 6.354123e-06 3.639041e-04 8.750735e-06 8.728660e-04
#> T[C>G]T 1.280702e-04 2.811825e-04 7.138119e-04 1.230103e-02 8.528691e-05
#> T[C>T]A 1.200658e-02 2.381545e-01 6.608258e-03 1.730145e-02 2.069682e-04
#> T[C>T]C 1.050576e-02 3.312149e-01 2.109444e-01 1.370115e-02 5.649133e-03
#> T[C>T]G 5.202851e-02 7.414812e-02 5.738488e-02 4.640390e-05 1.749731e-03
#> T[C>T]T 6.993832e-03 1.070695e-01 1.019731e-01 2.320195e-03 4.999233e-02
#> T[T>A]A 4.542489e-04 3.562312e-04 3.239146e-03 1.540129e-02 1.669744e-02
#> T[T>A]C 1.140625e-04 3.892526e-04 2.239410e-03 3.420287e-02 1.229811e-03
#> T[T>A]G 2.951617e-05 2.231448e-16 1.699552e-03 1.220103e-02 5.599141e-03
#> T[T>A]T 4.262336e-04 7.985182e-04 2.219415e-16 2.790234e-01 2.729581e-02
#> T[T>C]A 1.480811e-03 2.151396e-03 5.998419e-03 3.020254e-02 8.118754e-02
#> T[T>C]C 1.090598e-03 5.963870e-04 1.729544e-03 2.090176e-02 1.429781e-02
#> T[T>C]G 2.131168e-03 3.192071e-04 3.808996e-03 1.290108e-02 2.279650e-02
#> T[T>C]T 1.740954e-03 8.125273e-04 2.969217e-03 8.810740e-02 4.309339e-02
#> T[T>G]A 1.050576e-04 1.280831e-04 9.547484e-04 1.930162e-02 2.109676e-04
#> T[T>G]C 2.871573e-04 1.160753e-04 1.549592e-03 1.740146e-02 1.149824e-04
#> T[T>G]G 3.241776e-04 2.231448e-16 1.349644e-03 7.640642e-03 1.249808e-04
#> T[T>G]T 1.010554e-03 8.295383e-05 1.769534e-03 2.170182e-02 1.659745e-04
#> SBS8 SBS9 SBS10a SBS10b SBS11
#> A[C>A]A 4.409822e-02 0.0005579537 2.190170e-03 1.819975e-04 1.462079e-04
#> A[C>A]C 4.779807e-02 0.0040896606 1.770137e-03 6.539908e-03 5.527862e-04
#> A[C>A]G 4.619813e-03 0.0004259646 1.500116e-04 5.349925e-05 9.423402e-05
#> A[C>A]T 4.699810e-02 0.0030497469 1.700132e-02 1.629977e-05 2.663788e-04
#> A[C>G]A 4.329825e-03 0.0048395983 2.230173e-16 3.049957e-04 1.702421e-04
#> A[C>G]C 2.949881e-03 0.0019598373 2.430189e-05 1.339981e-04 2.904130e-04
#> A[C>G]G 2.859884e-04 0.0013598871 2.230173e-16 2.219969e-16 5.968488e-05
#> A[C>G]T 5.709769e-03 0.0064094680 2.230173e-16 2.219969e-16 5.357620e-04
#> A[C>T]A 6.809725e-03 0.0080993278 1.040081e-03 5.489923e-04 2.583674e-02
#> A[C>T]C 2.819886e-03 0.0054195502 8.340648e-04 5.249927e-03 1.472094e-01
#> A[C>T]G 3.229870e-03 0.0043796365 5.570433e-03 4.139942e-04 7.590796e-03
#> A[C>T]T 1.249950e-02 0.0064894614 2.990232e-03 7.929889e-03 1.091552e-01
#> A[T>A]A 1.949921e-02 0.0126989460 5.070394e-05 1.819975e-03 4.175939e-04
#> A[T>A]C 2.129914e-02 0.0028197660 1.940151e-04 3.369953e-04 4.416281e-04
#> A[T>A]G 2.279908e-02 0.0027597709 2.230173e-16 2.339967e-05 3.935597e-05
#> A[T>A]T 2.499899e-02 0.0188984314 6.660517e-03 2.849960e-03 3.404842e-06
#> A[T>C]A 9.769605e-03 0.0202983152 7.450579e-04 9.349869e-03 1.141624e-03
#> A[T>C]C 5.009798e-03 0.0104991286 3.620281e-03 5.099929e-04 9.393359e-04
#> A[T>C]G 6.979718e-03 0.0142988132 2.140166e-03 5.309926e-04 3.204557e-04
#> A[T>C]T 1.489940e-02 0.0289975932 3.360261e-03 1.499979e-04 1.191695e-03
#> A[T>G]A 1.639934e-03 0.0450962570 1.920149e-03 3.469951e-05 2.183105e-04
#> A[T>G]C 6.679730e-04 0.0069294249 1.240096e-03 5.329925e-05 4.676651e-05
#> A[T>G]G 4.769807e-03 0.0053295576 3.200248e-04 5.229927e-04 1.792549e-04
#> A[T>G]T 7.399701e-04 0.0238980165 9.220716e-03 2.219969e-16 2.854059e-04
#> C[C>A]A 4.009838e-02 0.0047996016 3.180247e-03 5.209927e-04 6.188802e-04
#> C[C>A]C 3.879843e-02 0.0019198407 2.020157e-04 3.179955e-03 9.874043e-04
#> C[C>A]G 3.409862e-03 0.0013698863 4.640360e-05 8.379883e-05 9.213103e-06
#> C[C>A]T 3.299867e-02 0.0030597460 1.730134e-02 8.329883e-03 1.502136e-04
#> C[C>G]A 4.999798e-03 0.0008929259 4.570355e-05 2.989958e-05 2.613717e-04
#> C[C>G]C 5.459779e-03 0.0015398722 2.230173e-16 2.219969e-16 1.772521e-04
#> C[C>G]G 1.049958e-05 0.0004369637 2.010156e-05 2.219969e-16 1.121595e-05
#> C[C>G]T 5.489778e-03 0.0030297485 3.010234e-05 2.219969e-16 9.653729e-06
#> C[C>T]A 2.669892e-03 0.0072393991 3.680286e-05 1.509979e-04 4.075797e-03
#> C[C>T]C 4.019838e-03 0.0087592730 2.230173e-16 8.439882e-05 1.261795e-01
#> C[C>T]G 1.489940e-03 0.0065094597 2.230173e-16 3.699948e-03 9.213103e-04
#> C[C>T]T 1.449941e-02 0.0110990788 1.030080e-04 5.949917e-04 6.519272e-02
#> C[T>A]A 1.899923e-02 0.0047896025 2.230173e-16 7.089901e-05 1.842621e-04
#> C[T>A]C 2.919882e-02 0.0031297402 2.230173e-16 1.059985e-04 2.123019e-04
#> C[T>A]G 2.759889e-02 0.0053095593 2.230173e-16 2.219969e-16 3.054344e-04
#> C[T>A]T 4.179831e-02 0.0044396315 3.760292e-04 2.339967e-04 1.622307e-04
#> C[T>C]A 2.389903e-03 0.0136988630 1.220095e-04 1.319982e-03 3.284671e-04
#> C[T>C]C 6.999717e-03 0.0152987302 4.120320e-05 1.239983e-04 7.140155e-04
#> C[T>C]G 1.259949e-03 0.0153987219 1.050082e-03 2.529965e-05 1.311866e-04
#> C[T>C]T 6.459739e-03 0.0328972695 2.440189e-06 8.149886e-04 8.462035e-05
#> C[T>G]A 1.219951e-03 0.0259978422 1.550120e-04 2.269968e-04 2.223162e-16
#> C[T>G]C 1.949921e-03 0.0074093850 2.230173e-16 1.149984e-03 2.223162e-16
#> C[T>G]G 4.699810e-03 0.0141988215 5.350415e-05 4.789933e-04 2.223162e-16
#> C[T>G]T 5.739768e-04 0.0564953109 1.300101e-03 5.229927e-03 1.331894e-04
#> G[C>A]A 2.419902e-02 0.0077193593 1.210094e-03 7.309898e-04 1.652350e-04
#> G[C>A]C 2.619894e-02 0.0066794456 4.410342e-04 2.549964e-03 4.055768e-04
#> G[C>A]G 2.739889e-03 0.0001709858 1.050082e-05 8.519881e-05 1.391980e-05
#> G[C>A]T 2.689891e-02 0.0085592896 1.110086e-02 2.799961e-03 2.223162e-16
#> G[C>G]A 2.579896e-03 0.0013598871 1.500116e-05 1.719976e-05 4.676651e-05
#> G[C>G]C 2.389903e-03 0.0028297651 8.310645e-05 1.359981e-04 1.141624e-04
#> G[C>G]G 4.879803e-04 0.0005209568 2.230173e-16 2.219969e-16 3.244614e-06
#> G[C>G]T 4.859804e-03 0.0085692887 3.540275e-05 1.129984e-04 1.862649e-04
#> G[C>T]A 2.759889e-04 0.0069794207 4.220328e-05 3.629949e-04 1.972806e-02
#> G[C>T]C 2.449901e-04 0.0065294581 1.250097e-02 1.509979e-02 1.151638e-01
#> G[C>T]G 1.909923e-03 0.0047596050 1.490116e-02 1.259982e-02 1.782535e-03
#> G[C>T]T 4.609814e-03 0.0106991120 1.350105e-02 3.189955e-02 6.969913e-02
#> G[T>A]A 1.279948e-02 0.0026497801 3.310257e-06 2.219969e-16 1.542193e-06
#> G[T>A]C 1.349945e-02 0.0021198241 2.230173e-16 1.229983e-04 3.755341e-04
#> G[T>A]G 1.559937e-02 0.0007879346 7.300567e-05 2.219969e-16 1.191695e-04
#> G[T>A]T 2.809886e-02 0.0025597875 4.260331e-04 1.079985e-04 1.642336e-04
#> G[T>C]A 2.599895e-03 0.0095192099 2.200171e-03 1.469979e-02 8.101522e-04
#> G[T>C]C 2.619894e-03 0.0097791883 6.280488e-03 5.329925e-03 8.612248e-04
#> G[T>C]G 2.809886e-03 0.0063094763 2.230173e-16 1.379981e-03 5.617990e-04
#> G[T>C]T 6.289746e-03 0.0098591817 5.290411e-03 1.149984e-02 2.373375e-04
#> G[T>G]A 1.309947e-03 0.0082993112 2.040158e-04 4.809933e-04 9.583630e-05
#> G[T>G]C 6.559735e-04 0.0058495145 8.330647e-04 9.419868e-04 2.223162e-16
#> G[T>G]G 3.969840e-03 0.0039696705 2.230173e-16 1.729976e-03 1.301851e-04
#> G[T>G]T 1.289948e-03 0.0193983899 2.210172e-03 5.159928e-03 1.542193e-04
#> T[C>A]A 2.979880e-02 0.0169985891 9.400730e-02 4.459938e-04 1.802564e-04
#> T[C>A]C 2.509899e-02 0.0024597958 9.970774e-03 3.799947e-03 9.393359e-04
#> T[C>A]G 1.899923e-03 0.0004449631 1.160090e-03 5.729920e-04 2.223162e-16
#> T[C>A]T 3.189871e-02 0.0272977343 6.700520e-01 8.159886e-02 4.736737e-05
#> T[C>G]A 1.469941e-03 0.0026897767 5.550431e-05 2.219969e-16 1.562222e-05
#> T[C>G]C 1.339946e-03 0.0019998340 2.230173e-16 2.219969e-16 2.243190e-04
#> T[C>G]G 7.819684e-05 0.0004039665 2.230173e-16 2.219969e-16 2.223162e-16
#> T[C>G]T 2.489899e-04 0.0056295327 5.450423e-05 4.339939e-05 1.852635e-04
#> T[C>T]A 5.039796e-03 0.0042696456 3.660284e-04 2.729962e-03 9.793929e-03
#> T[C>T]C 2.519898e-04 0.0073293917 2.760214e-03 4.849932e-02 1.582250e-01
#> T[C>T]G 4.169832e-05 0.0032597294 2.790217e-03 4.369939e-01 2.944187e-07
#> T[C>T]T 5.269787e-03 0.0054595469 2.280177e-02 1.279982e-01 1.191695e-01
#> T[T>A]A 1.149954e-02 0.0259978422 2.040158e-03 3.059957e-03 1.862649e-04
#> T[T>A]C 1.949921e-02 0.0018498465 3.600280e-04 6.649907e-04 2.022877e-04
#> T[T>A]G 1.289948e-02 0.0166986140 6.930538e-04 7.059901e-05 2.012863e-04
#> T[T>A]T 3.789847e-02 0.0169985891 5.290411e-03 1.519979e-03 6.749599e-04
#> T[T>C]A 2.079916e-03 0.0139988381 7.300567e-04 8.859876e-03 1.131609e-04
#> T[T>C]C 2.639893e-03 0.0135988713 5.170401e-03 8.099887e-05 4.676651e-04
#> T[T>C]G 2.219910e-16 0.0093092273 3.630282e-04 6.679906e-04 1.552208e-04
#> T[T>C]T 4.569815e-03 0.0383968131 3.250252e-03 2.509965e-05 1.061510e-04
#> T[T>G]A 2.219910e-16 0.0656945474 2.690209e-03 1.129984e-02 8.522120e-05
#> T[T>G]C 1.139954e-03 0.0086192846 2.230173e-16 5.549922e-03 6.739585e-05
#> T[T>G]G 3.089875e-03 0.0108990954 2.160168e-05 2.759961e-03 1.011438e-04
#> T[T>G]T 9.959598e-04 0.0638946967 1.890147e-02 9.089873e-02 5.557904e-05
#> SBS12 SBS13 SBS14 SBS15 SBS16
#> A[C>A]A 4.520592e-03 1.819920e-03 1.120492e-03 9.442022e-04 1.599504e-02
#> A[C>A]C 1.130148e-03 7.209682e-04 1.310575e-02 4.971064e-04 2.899100e-03
#> A[C>A]G 5.400707e-04 2.639884e-04 4.131813e-04 4.610987e-05 1.019684e-03
#> A[C>A]T 1.220160e-03 3.479847e-04 8.263626e-02 1.110238e-03 1.059671e-02
#> A[C>G]A 1.220160e-03 3.869830e-03 2.220974e-16 1.130242e-04 1.739460e-03
#> A[C>G]C 6.420841e-04 9.509581e-04 5.782537e-06 2.690576e-04 2.009376e-03
#> A[C>G]G 7.510984e-05 2.639884e-04 3.911716e-05 3.070657e-05 8.467373e-04
#> A[C>G]T 1.440189e-03 3.999824e-03 2.040895e-04 3.250696e-04 1.149643e-02
#> A[C>T]A 5.510722e-03 7.179684e-03 1.240544e-02 5.051081e-03 1.759454e-03
#> A[C>T]C 2.120278e-03 2.219902e-16 1.010443e-02 6.911480e-03 3.728843e-03
#> A[C>T]G 1.180155e-04 3.029867e-04 2.651163e-02 7.451595e-02 3.268986e-03
#> A[C>T]T 2.380312e-03 3.179860e-04 1.610707e-02 1.780381e-03 5.998139e-03
#> A[T>A]A 5.170677e-03 2.219902e-16 6.132691e-04 2.040437e-03 2.309283e-02
#> A[T>A]C 2.710355e-03 6.519713e-05 3.721633e-04 8.411801e-04 7.737599e-03
#> A[T>A]G 3.120409e-03 5.899740e-04 3.541554e-04 5.401156e-04 8.807267e-03
#> A[T>A]T 2.820369e-03 6.059733e-04 1.850812e-03 9.542043e-03 1.099659e-02
#> A[T>C]A 7.360964e-02 1.909916e-03 1.260553e-02 3.890833e-03 2.419249e-01
#> A[T>C]C 4.030528e-02 1.419937e-04 6.302765e-03 1.960420e-03 1.289600e-02
#> A[T>C]G 7.050924e-02 4.279812e-04 1.240544e-02 2.400514e-04 6.388018e-02
#> A[T>C]T 6.380836e-02 9.589578e-04 5.972620e-03 9.291989e-04 1.359578e-01
#> A[T>G]A 2.010263e-03 6.139730e-05 2.120931e-04 4.681002e-04 1.119653e-02
#> A[T>G]C 6.640870e-04 2.219902e-16 2.971304e-03 4.150889e-04 4.408632e-03
#> A[T>G]G 8.081059e-04 8.249637e-05 7.093112e-04 1.850396e-04 4.618567e-03
#> A[T>G]T 1.280168e-03 3.199859e-04 1.110487e-02 3.630777e-03 7.957531e-03
#> C[C>A]A 5.420710e-03 1.399938e-03 1.630715e-02 4.180895e-02 1.039677e-02
#> C[C>A]C 4.280561e-03 9.679574e-04 1.970865e-02 5.051081e-03 9.027199e-03
#> C[C>A]G 1.170153e-03 4.329809e-06 1.380606e-03 6.621418e-05 1.739460e-03
#> C[C>A]T 1.100144e-03 2.219902e-16 2.601141e-01 2.870615e-02 2.489228e-03
#> C[C>G]A 1.340176e-03 5.609753e-03 8.553753e-05 8.361790e-05 3.548899e-03
#> C[C>G]C 8.911167e-04 6.479715e-04 7.863450e-05 1.700364e-05 4.538592e-03
#> C[C>G]G 1.730227e-04 4.879785e-04 1.910838e-05 5.021075e-05 1.459547e-03
#> C[C>G]T 1.560204e-03 6.399718e-03 1.780781e-04 8.451810e-05 9.617016e-03
#> C[C>T]A 6.590863e-03 1.929915e-05 2.731198e-03 1.080231e-02 7.167776e-03
#> C[C>T]C 2.540333e-04 1.349941e-03 1.380606e-03 1.110238e-02 2.839119e-03
#> C[C>T]G 4.090536e-05 1.989912e-03 1.160509e-02 2.480531e-02 6.907856e-04
#> C[C>T]T 3.380443e-03 1.449936e-03 1.360597e-03 1.560334e-02 1.929401e-02
#> C[T>A]A 5.460715e-04 2.089908e-04 1.550680e-04 3.480745e-04 3.209004e-03
#> C[T>A]C 5.600734e-03 3.419849e-04 2.951295e-03 2.440523e-04 5.698232e-03
#> C[T>A]G 1.410185e-03 2.259900e-04 3.171391e-04 8.201756e-05 1.029680e-03
#> C[T>A]T 1.500197e-03 5.229770e-04 1.380606e-03 1.050225e-03 6.527974e-03
#> C[T>C]A 4.540595e-02 4.739791e-05 3.161387e-03 7.501606e-04 1.069668e-02
#> C[T>C]C 4.970651e-02 1.219946e-04 5.342344e-03 2.150460e-03 3.169017e-03
#> C[T>C]G 3.740490e-02 2.219902e-16 4.471962e-03 1.390298e-03 9.607019e-03
#> C[T>C]T 4.590601e-02 1.119951e-04 2.060904e-03 1.750375e-03 1.549519e-02
#> C[T>G]A 8.931170e-04 4.139818e-05 4.852129e-05 2.060441e-04 3.958772e-03
#> C[T>G]C 1.140149e-03 2.819876e-06 1.210531e-03 1.570336e-04 1.079665e-03
#> C[T>G]G 5.930777e-04 2.219902e-16 4.351909e-04 2.720582e-04 2.239305e-03
#> C[T>G]T 3.440451e-04 5.549756e-05 9.624223e-04 2.490533e-03 2.539212e-03
#> G[C>A]A 1.980259e-03 9.489582e-04 2.080913e-03 2.290490e-03 8.607329e-03
#> G[C>A]C 4.170546e-04 4.509801e-04 2.240983e-02 2.490533e-03 4.248682e-03
#> G[C>A]G 4.470586e-04 1.639928e-04 1.110487e-03 4.040865e-04 1.359578e-03
#> G[C>A]T 2.750360e-05 6.149729e-05 1.260553e-01 1.820390e-02 5.798201e-03
#> G[C>G]A 5.640739e-04 1.499934e-03 2.220974e-16 9.942129e-04 1.049674e-03
#> G[C>G]C 2.890379e-04 4.789789e-04 4.331901e-05 6.081302e-04 3.089041e-03
#> G[C>G]G 9.541250e-05 2.409894e-04 2.220974e-16 1.010216e-05 8.127478e-05
#> G[C>G]T 5.040660e-04 2.699881e-03 8.033525e-05 4.510966e-04 3.228998e-03
#> G[C>T]A 4.480587e-03 7.179684e-03 1.710751e-02 7.371578e-02 6.497984e-03
#> G[C>T]C 1.820238e-03 9.209594e-04 8.163582e-03 1.290276e-01 5.288359e-03
#> G[C>T]G 7.460977e-05 1.779922e-04 1.920843e-05 2.770593e-01 1.169637e-03
#> G[C>T]T 2.670350e-03 1.269944e-03 1.050461e-02 7.721653e-02 6.717915e-03
#> G[T>A]A 8.261082e-04 6.699705e-06 5.772533e-05 5.111094e-04 9.397084e-04
#> G[T>A]C 1.810237e-03 1.299943e-04 2.731198e-03 5.891261e-04 6.078114e-04
#> G[T>A]G 2.510329e-03 4.699793e-05 1.200527e-04 1.870400e-04 5.548278e-03
#> G[T>A]T 9.151199e-04 3.579842e-04 8.573762e-04 8.401799e-04 9.657003e-04
#> G[T>C]A 7.110932e-02 2.869874e-04 1.100483e-02 1.290276e-02 2.059361e-03
#> G[T>C]C 3.040398e-02 1.819920e-04 6.542871e-03 1.160248e-02 1.189631e-03
#> G[T>C]G 4.150544e-02 1.949914e-04 1.100483e-02 5.951274e-03 4.278672e-03
#> G[T>C]T 4.630607e-02 2.219902e-16 1.120492e-02 5.861255e-03 2.399256e-03
#> G[T>G]A 4.120540e-04 8.769614e-05 7.793419e-05 2.030435e-04 9.017202e-04
#> G[T>G]C 2.130279e-04 2.219902e-16 2.100922e-03 5.801242e-04 9.007205e-04
#> G[T>G]G 4.960650e-04 4.259812e-04 7.813428e-04 3.470743e-04 6.747906e-04
#> G[T>G]T 1.650216e-04 2.889873e-06 2.250988e-03 1.390298e-03 2.389259e-03
#> T[C>A]A 3.480456e-03 7.899652e-02 3.471523e-04 1.720368e-02 1.079665e-02
#> T[C>A]C 2.880377e-03 2.939871e-02 2.431067e-02 5.811244e-03 5.868179e-03
#> T[C>A]G 5.050662e-04 1.209947e-02 7.083108e-06 7.691647e-05 1.489538e-03
#> T[C>A]T 2.350308e-03 3.549844e-02 1.510663e-01 8.051724e-03 9.247131e-03
#> T[C>G]A 9.691270e-04 3.169860e-01 1.970865e-05 2.140458e-04 2.509221e-03
#> T[C>G]C 1.550203e-03 6.349720e-02 1.500658e-04 6.121311e-05 5.228378e-03
#> T[C>G]G 2.140280e-04 1.379939e-02 1.830803e-05 5.841251e-05 4.388638e-04
#> T[C>G]T 3.050400e-03 3.689837e-01 3.211409e-04 1.740373e-04 2.849116e-02
#> T[C>T]A 5.520723e-03 6.929695e-03 3.541554e-03 2.650567e-02 6.358027e-03
#> T[C>T]C 2.640346e-03 4.479803e-03 1.370601e-04 9.562047e-03 3.678858e-03
#> T[C>T]G 8.851160e-05 1.189948e-03 5.322335e-03 2.120454e-02 3.019063e-03
#> T[C>T]T 6.120802e-03 1.419937e-03 3.591576e-04 1.740373e-03 2.209314e-02
#> T[T>A]A 3.750491e-03 2.959870e-04 2.000878e-04 1.090233e-03 1.229618e-02
#> T[T>A]C 6.450845e-03 2.319898e-04 1.730759e-03 1.570336e-04 4.668551e-03
#> T[T>A]G 2.770363e-03 1.879917e-04 3.571567e-04 1.490319e-04 5.178393e-03
#> T[T>A]T 5.250688e-03 6.199727e-05 1.820799e-03 4.751017e-04 7.157779e-03
#> T[T>C]A 8.611128e-02 2.209903e-05 6.272752e-03 3.420732e-03 1.299597e-02
#> T[T>C]C 4.630607e-02 2.489890e-05 2.881264e-03 5.921268e-03 3.668862e-03
#> T[T>C]G 4.000524e-02 9.979561e-05 4.311892e-03 1.320283e-03 7.227757e-03
#> T[T>C]T 5.970782e-02 5.309766e-04 2.921282e-03 1.350289e-03 8.387397e-03
#> T[T>G]A 1.630214e-03 1.839919e-04 9.924354e-05 2.310495e-04 9.776966e-03
#> T[T>G]C 1.130148e-03 2.219902e-16 1.200527e-03 2.940630e-04 5.508291e-03
#> T[T>G]G 8.751146e-04 3.669838e-05 1.140500e-04 1.480317e-04 5.238375e-03
#> T[T>G]T 2.210290e-03 1.889917e-05 6.052656e-04 5.991283e-03 1.579510e-02
#> SBS17a SBS17b SBS18 SBS19 SBS20
#> A[C>A]A 2.070261e-03 6.079583e-04 5.153386e-02 1.269382e-03 6.192834e-04
#> A[C>A]C 9.181159e-04 1.289912e-04 1.581039e-02 6.406882e-04 1.390636e-03
#> A[C>A]G 4.760601e-05 5.819601e-05 2.431598e-03 2.458803e-04 2.180998e-05
#> A[C>A]T 6.180780e-05 4.559687e-04 2.141407e-02 5.707222e-04 1.240568e-03
#> A[C>G]A 1.010128e-03 1.459900e-04 1.731137e-03 3.188448e-03 8.774015e-03
#> A[C>G]C 5.690719e-04 4.339702e-05 2.591703e-03 1.789129e-03 1.510691e-03
#> A[C>G]G 1.520192e-04 2.229847e-16 1.921262e-03 6.157003e-04 4.692147e-04
#> A[C>G]T 1.960248e-05 3.189781e-04 4.082682e-03 2.138959e-03 4.422024e-03
#> A[C>T]A 1.220154e-03 5.709608e-04 9.206048e-03 2.798638e-02 4.932257e-02
#> A[C>T]C 1.710216e-03 7.029518e-05 4.653057e-03 1.409314e-02 1.300595e-02
#> A[C>T]G 3.950499e-05 2.869803e-04 1.220802e-02 1.549246e-03 1.330609e-02
#> A[C>T]T 7.370931e-04 1.469899e-04 7.975240e-03 3.678210e-02 1.300595e-02
#> A[T>A]A 1.010128e-03 6.259571e-05 2.491637e-03 7.856176e-04 5.112340e-04
#> A[T>A]C 9.971259e-04 2.889802e-04 8.785772e-04 2.548760e-04 5.192376e-03
#> A[T>A]G 2.000253e-04 6.569549e-05 2.601709e-03 9.515369e-04 3.031387e-04
#> A[T>A]T 1.460184e-03 6.329566e-04 7.845154e-03 6.536819e-04 2.561172e-02
#> A[T>C]A 9.651219e-05 9.729333e-05 2.021328e-03 2.588740e-03 1.070490e-02
#> A[T>C]C 1.270160e-02 2.519827e-04 2.091374e-03 5.937110e-04 4.552083e-03
#> A[T>C]G 3.760475e-04 2.229847e-16 2.081367e-03 2.308876e-03 1.860852e-02
#> A[T>C]T 7.790984e-03 5.439627e-04 4.242788e-03 1.739154e-03 1.030472e-04
#> A[T>G]A 8.511075e-04 1.409903e-03 7.214740e-04 2.328867e-03 1.050481e-05
#> A[T>G]C 7.000884e-04 4.479693e-03 8.585641e-04 1.889081e-03 2.130975e-05
#> A[T>G]G 7.190908e-04 9.899321e-04 1.991308e-03 1.769139e-03 2.691232e-05
#> A[T>G]T 1.250158e-02 6.909526e-02 1.841210e-03 1.619212e-03 5.822665e-05
#> C[C>A]A 2.950373e-04 2.709814e-04 7.404865e-02 1.319358e-03 3.761721e-02
#> C[C>A]C 1.160146e-03 4.109718e-05 1.961289e-02 7.666269e-04 9.894528e-02
#> C[C>A]G 2.220280e-16 2.229847e-16 1.200789e-02 2.358852e-04 7.433402e-03
#> C[C>A]T 1.370173e-04 1.819875e-04 3.632386e-02 3.438327e-05 2.521154e-01
#> C[C>G]A 5.530698e-04 1.939867e-04 6.134030e-04 1.769139e-03 7.693521e-05
#> C[C>G]C 2.350297e-04 4.659680e-05 2.261486e-03 1.809120e-03 4.382005e-06
#> C[C>G]G 2.320293e-04 2.229847e-16 3.582354e-03 4.807660e-05 1.880861e-04
#> C[C>G]T 3.900492e-05 1.929868e-04 3.792492e-03 3.218434e-03 1.010462e-05
#> C[C>T]A 8.211037e-04 4.569687e-04 1.170769e-02 1.189421e-01 1.060485e-02
#> C[C>T]C 1.720217e-03 5.889596e-05 6.764444e-03 9.195525e-02 1.300595e-02
#> C[C>T]G 1.900240e-03 5.429628e-04 1.681104e-02 1.569236e-02 1.650755e-02
#> C[C>T]T 1.740220e-03 1.359907e-04 6.654372e-03 2.578745e-01 1.170536e-02
#> C[T>A]A 4.340548e-04 9.359358e-05 5.423563e-04 9.595330e-05 1.440659e-04
#> C[T>A]C 4.050511e-02 2.239846e-03 3.062012e-03 4.028040e-04 6.482967e-03
#> C[T>A]G 1.240157e-02 7.169508e-04 3.212110e-03 2.938570e-04 1.230563e-04
#> C[T>A]T 7.230913e-02 7.789466e-03 2.261486e-03 2.178940e-04 1.020467e-04
#> C[T>C]A 1.110140e-02 6.469556e-04 3.862538e-04 4.517801e-04 1.170536e-02
#> C[T>C]C 1.730218e-01 6.459557e-03 2.461617e-03 8.136040e-05 4.832211e-03
#> C[T>C]G 8.731102e-02 3.919731e-03 1.621065e-03 4.977577e-04 2.611195e-02
#> C[T>C]T 4.260538e-01 1.829875e-02 2.561683e-03 3.908098e-04 6.903159e-03
#> C[T>G]A 3.100391e-04 2.049859e-03 1.110730e-04 7.136527e-04 9.634409e-04
#> C[T>G]C 1.040131e-03 3.139785e-02 1.991308e-03 2.088983e-03 1.600733e-03
#> C[T>G]G 1.940245e-06 1.369906e-02 2.931926e-03 1.329353e-03 2.711241e-03
#> C[T>G]T 5.310671e-03 5.499623e-01 4.142722e-03 2.198930e-03 5.112340e-03
#> G[C>A]A 1.780225e-03 9.979316e-04 1.090717e-01 8.136040e-04 1.080494e-02
#> G[C>A]C 1.280162e-03 2.779809e-06 1.731137e-02 2.718677e-04 5.652587e-03
#> G[C>A]G 1.060134e-04 9.239366e-05 7.564970e-03 2.049003e-04 1.570719e-03
#> G[C>A]T 4.700593e-05 5.339634e-04 6.234096e-02 2.728672e-04 2.491140e-03
#> G[C>G]A 8.781109e-04 5.989589e-05 6.354175e-04 1.309363e-03 6.693063e-04
#> G[C>G]C 8.351054e-04 5.549619e-05 1.340881e-03 1.289372e-03 2.861309e-03
#> G[C>G]G 2.370299e-05 2.229847e-16 6.394201e-04 5.967096e-04 6.923168e-04
#> G[C>G]T 7.870994e-04 2.229847e-16 1.230809e-03 3.198443e-04 3.021383e-03
#> G[C>T]A 1.640207e-03 6.109581e-05 9.686364e-03 6.097033e-02 4.221932e-02
#> G[C>T]C 2.220280e-16 1.569892e-04 8.175371e-03 3.968069e-02 5.322436e-02
#> G[C>T]G 1.610203e-03 8.549414e-04 1.480973e-02 3.208438e-03 2.050939e-02
#> G[C>T]T 6.600833e-05 2.229847e-16 6.694398e-03 1.089470e-01 3.311515e-02
#> G[T>A]A 6.460816e-05 9.729333e-05 1.601052e-03 1.889081e-04 5.562546e-05
#> G[T>A]C 3.400429e-03 3.469762e-04 1.951282e-03 7.776215e-05 2.561172e-03
#> G[T>A]G 6.950878e-04 2.409835e-04 1.831203e-03 4.857636e-04 2.130975e-03
#> G[T>A]T 4.800606e-03 1.579892e-03 3.462275e-03 2.828623e-04 4.301969e-03
#> G[T>C]A 1.230155e-04 5.949592e-05 7.084655e-04 9.535359e-04 2.761264e-03
#> G[T>C]C 1.490188e-02 1.499897e-03 2.261486e-03 3.708195e-04 2.261035e-03
#> G[T>C]G 3.570451e-03 1.009931e-03 3.982617e-03 9.525364e-04 4.061859e-03
#> G[T>C]T 5.240662e-03 1.469899e-03 3.152071e-03 2.358852e-03 9.284249e-04
#> G[T>G]A 4.950625e-04 2.809807e-04 8.705720e-04 6.356906e-04 2.221016e-16
#> G[T>G]C 2.040258e-04 6.249571e-03 3.702432e-05 7.026580e-04 6.653045e-05
#> G[T>G]G 8.351054e-04 1.479899e-03 5.833833e-03 5.097519e-04 8.703983e-05
#> G[T>G]T 7.240914e-03 1.139922e-01 2.141407e-03 3.408341e-04 3.561630e-03
#> T[C>A]A 1.900240e-04 1.239915e-05 7.384852e-02 1.379329e-03 1.710783e-03
#> T[C>A]C 2.590327e-05 2.229847e-16 4.362866e-02 1.129450e-03 3.371543e-03
#> T[C>A]G 2.220280e-16 9.509348e-05 1.270835e-02 2.848614e-04 2.221016e-16
#> T[C>A]T 2.880364e-04 2.569824e-03 1.220802e-01 1.379329e-03 9.044139e-04
#> T[C>G]A 3.750474e-03 1.599890e-04 2.141407e-03 1.749149e-03 1.290591e-04
#> T[C>G]C 7.230913e-04 6.179576e-05 4.643050e-03 3.118482e-03 2.821291e-05
#> T[C>G]G 3.800480e-04 1.549894e-05 8.995910e-04 4.407855e-04 1.240568e-04
#> T[C>G]T 2.830357e-04 1.499897e-03 3.182091e-03 1.609217e-03 1.120513e-03
#> T[C>T]A 5.320672e-04 1.079926e-04 1.140749e-02 4.387864e-02 8.073695e-03
#> T[C>T]C 9.061144e-05 6.039586e-04 1.140749e-02 2.498784e-02 9.194207e-03
#> T[C>T]G 1.770224e-04 6.239572e-05 1.180776e-02 4.317898e-03 2.641209e-03
#> T[C>T]T 3.480439e-04 8.949386e-04 3.752465e-03 6.286940e-02 5.002289e-05
#> T[T>A]A 1.190150e-04 1.189918e-03 1.080710e-02 4.937597e-04 1.200549e-02
#> T[T>A]C 5.700720e-03 2.419834e-04 2.731795e-03 4.747689e-04 3.181456e-04
#> T[T>A]G 1.830231e-03 2.229847e-16 1.791177e-03 3.728185e-04 1.760806e-04
#> T[T>A]T 1.980250e-03 1.309910e-03 7.104668e-03 6.726726e-04 6.713072e-03
#> T[T>C]A 2.090264e-03 1.059927e-03 1.801183e-03 1.239397e-03 1.380632e-02
#> T[T>C]C 1.530193e-02 1.099925e-03 6.184063e-03 5.527310e-04 1.660760e-02
#> T[T>C]G 2.350297e-03 1.209917e-03 3.262143e-03 1.079475e-03 1.200549e-02
#> T[T>C]T 2.100265e-02 9.999314e-04 3.372216e-03 1.469285e-03 1.930884e-02
#> T[T>G]A 2.220280e-16 1.219916e-05 6.964576e-04 1.659192e-03 2.221016e-16
#> T[T>G]C 1.160146e-04 8.749400e-03 2.101381e-03 2.019017e-03 2.221016e-16
#> T[T>G]G 9.201162e-04 4.779672e-03 1.450953e-03 2.068993e-03 2.791277e-03
#> T[T>G]T 4.580578e-03 1.219916e-01 5.163392e-03 4.227942e-03 1.510691e-03
#> SBS21 SBS22 SBS23 SBS24 SBS25
#> A[C>A]A 1.569926e-04 6.012763e-03 8.355229e-04 0.0364134001 0.0098984657
#> A[C>A]C 2.359889e-03 9.544387e-05 3.992499e-04 0.0265097556 0.0069989152
#> A[C>A]G 2.939862e-04 7.653518e-04 9.856168e-08 0.0148054484 0.0014497753
#> A[C>A]T 6.209709e-04 1.720791e-03 5.613513e-18 0.0220080990 0.0049692298
#> A[C>G]A 1.689921e-05 1.660763e-03 5.743594e-18 0.0033412296 0.0080287555
#> A[C>G]C 7.189663e-04 1.950897e-04 4.082555e-05 0.0036713511 0.0016397458
#> A[C>G]G 2.219896e-16 2.311062e-04 2.861791e-18 0.0009203387 0.0000000000
#> A[C>G]T 6.189709e-05 6.202851e-05 5.613513e-18 0.0028510492 0.0034294684
#> A[C>T]A 2.169898e-03 1.760809e-03 2.261415e-02 0.0118043440 0.0209967455
#> A[C>T]C 3.919816e-03 2.201012e-04 8.095066e-02 0.0112041231 0.0130979698
#> A[C>T]G 7.399653e-03 1.360625e-03 8.725460e-03 0.0005141892 0.0196969470
#> A[C>T]T 4.169804e-05 6.162832e-04 3.502192e-02 0.0091533684 0.0057291120
#> A[T>A]A 3.459838e-03 6.392938e-02 8.285185e-18 0.0015805817 0.0203968385
#> A[T>A]C 5.649735e-03 7.013223e-03 5.563482e-18 0.0022508283 0.0088886223
#> A[T>A]G 2.479884e-04 6.062786e-02 3.542217e-04 0.0020007363 0.0062390329
#> A[T>A]T 1.599925e-03 2.511154e-03 1.611008e-04 0.0018006626 0.0148976909
#> A[T>C]A 1.669922e-02 2.501150e-02 8.865548e-04 0.0064023561 0.0206967920
#> A[T>C]C 9.999531e-03 8.994134e-04 1.781115e-04 0.0021808025 0.0094985277
#> A[T>C]G 3.879818e-03 7.753564e-03 4.702943e-04 0.0017606479 0.0198969160
#> A[T>C]T 2.559880e-02 7.553472e-04 2.611634e-04 0.0024408983 0.0144977528
#> A[T>G]A 3.919816e-04 2.331071e-03 8.285185e-18 0.0032111817 0.0052791817
#> A[T>G]C 4.369795e-04 5.092340e-05 5.433400e-18 0.0014005154 0.0000000000
#> A[T>G]G 1.869912e-04 2.951356e-03 5.683557e-18 0.0020607584 0.0071388935
#> A[T>G]T 6.949674e-05 4.181922e-05 7.434653e-18 0.0047117339 0.0000000000
#> C[C>A]A 2.219896e-16 1.830841e-03 1.510946e-04 0.0254093506 0.0147977064
#> C[C>A]C 2.599878e-03 4.432037e-03 6.303945e-04 0.0349128479 0.0078187881
#> C[C>A]G 1.979907e-03 1.360625e-04 1.300814e-04 0.0160058902 0.0012798016
#> C[C>A]T 1.909910e-02 1.100506e-04 5.803632e-04 0.0171062951 0.0125980473
#> C[C>G]A 1.969908e-05 1.050483e-03 1.741090e-04 0.0026109608 0.0071988842
#> C[C>G]C 2.729872e-04 7.853610e-04 2.551597e-04 0.0052219217 0.0045992871
#> C[C>G]G 1.009953e-05 2.391099e-04 1.861165e-18 0.0009453479 0.0008238723
#> C[C>G]T 1.729919e-04 3.201471e-04 2.271421e-04 0.0047117339 0.0001959696
#> C[C>T]A 1.349937e-03 1.210556e-03 6.223895e-02 0.0053819806 0.0142977838
#> C[C>T]C 5.159758e-03 3.191467e-03 1.891184e-01 0.0088532580 0.0059390794
#> C[C>T]G 6.219708e-03 4.261959e-04 1.420889e-02 0.0063523377 0.0115982023
#> C[C>T]T 3.249847e-04 1.600736e-03 1.560977e-01 0.0042915793 0.0135978923
#> C[T>A]A 6.189709e-06 1.280589e-01 4.622893e-04 0.0013204859 0.0262959241
#> C[T>A]C 6.879677e-04 5.512534e-02 4.472799e-18 0.0018706884 0.0157975514
#> C[T>A]G 1.249941e-04 1.680772e-01 1.320827e-04 0.0050318517 0.0628902520
#> C[T>A]T 2.219896e-16 6.032773e-02 3.752348e-04 0.0048017671 0.0365943279
#> C[T>C]A 1.149946e-02 6.743099e-03 6.864296e-18 0.0022708357 0.0090286006
#> C[T>C]C 2.819868e-03 1.340616e-03 4.472799e-18 0.0022408246 0.0107983263
#> C[T>C]G 1.439932e-02 2.030933e-03 3.892436e-04 0.0042215535 0.0133979233
#> C[T>C]T 2.169898e-02 5.362465e-04 4.712949e-05 0.0036313363 0.0089586114
#> C[T>G]A 4.349796e-06 4.912258e-03 6.854289e-18 0.0014305264 0.0000000000
#> C[T>G]C 5.439745e-05 8.804046e-04 1.480927e-04 0.0008803240 0.0028895521
#> C[T>G]G 2.009906e-05 8.033692e-03 6.524083e-05 0.0030411191 0.0117981713
#> C[T>G]T 1.849913e-04 1.190547e-03 2.471547e-04 0.0047117339 0.0085486750
#> G[C>A]A 2.139900e-03 2.231025e-03 3.372110e-04 0.0622228980 0.0134979078
#> G[C>A]C 7.069668e-03 1.730795e-03 5.413388e-04 0.1280471213 0.0064689973
#> G[C>A]G 1.689921e-03 5.152368e-04 1.190745e-04 0.0659242601 0.0006578980
#> G[C>A]T 8.899582e-03 5.512534e-04 3.091935e-05 0.0544200266 0.0104983728
#> G[C>G]A 3.879818e-04 1.400644e-03 4.322705e-18 0.0027210013 0.0041693538
#> G[C>G]C 1.419933e-03 9.304276e-04 1.270795e-04 0.0057921315 0.0023896296
#> G[C>G]G 1.169945e-04 2.110970e-04 1.831146e-18 0.0031411559 0.0004179352
#> G[C>G]T 2.069903e-04 4.552092e-04 4.042530e-18 0.0033812443 0.0019896916
#> G[C>T]A 9.319563e-03 2.381094e-03 5.373363e-02 0.0299110073 0.0099984502
#> G[C>T]C 1.959908e-02 1.870860e-03 1.540964e-01 0.0437160875 0.0069489229
#> G[C>T]G 4.339796e-05 2.221021e-16 1.230770e-02 0.0254093506 0.0104983728
#> G[C>T]T 8.049622e-03 1.760809e-03 1.070670e-01 0.0203074732 0.0098184781
#> G[T>A]A 1.169945e-03 5.372469e-02 6.263920e-18 0.0015705780 0.0361943899
#> G[T>A]C 3.259847e-03 1.020469e-02 1.400877e-04 0.0023508651 0.0058490934
#> G[T>A]G 7.419652e-04 3.751724e-02 4.682931e-18 0.0024909167 0.0381940799
#> G[T>A]T 9.369560e-04 9.324285e-03 5.783619e-18 0.0013104823 0.0201968695
#> G[T>C]A 2.229895e-01 7.213315e-04 2.181365e-04 0.0037013621 0.0174972879
#> G[T>C]C 6.629689e-02 1.240570e-03 4.182617e-04 0.0036513437 0.0040493723
#> G[T>C]G 1.169945e-01 5.812672e-04 4.682931e-18 0.0026709829 0.0133979233
#> G[T>C]T 1.329938e-01 8.343835e-04 7.995003e-04 0.0039914689 0.0141977993
#> G[T>G]A 2.859866e-04 1.590731e-03 6.263920e-18 0.0010703939 0.0055491399
#> G[T>G]C 5.329750e-04 2.361085e-04 8.695442e-05 0.0015305632 0.0000000000
#> G[T>G]G 2.129900e-04 4.502069e-04 1.570983e-04 0.0031311523 0.0086886533
#> G[T>G]T 2.589878e-03 1.960901e-05 5.783619e-18 0.0026809866 0.0027695707
#> T[C>A]A 1.459931e-03 7.843605e-04 2.131334e-03 0.0298109704 0.0069389245
#> T[C>A]C 2.359889e-04 1.740800e-03 6.644158e-04 0.0519191062 0.0101984192
#> T[C>A]G 6.829679e-05 2.221021e-16 9.125711e-05 0.0097936040 0.0000000000
#> T[C>A]T 2.219896e-16 3.961821e-04 2.401503e-04 0.0228083935 0.0245961876
#> T[C>G]A 6.539693e-04 3.561637e-03 2.111321e-04 0.0037513805 0.0097984812
#> T[C>G]C 6.309704e-04 1.520699e-03 2.661666e-04 0.0055820542 0.0032694932
#> T[C>G]G 6.269706e-05 3.811752e-04 2.561603e-18 0.0013504970 0.0020596807
#> T[C>G]T 6.869678e-04 3.881784e-04 4.662918e-04 0.0040714983 0.0163974584
#> T[C>T]A 3.599831e-03 1.590731e-03 1.530958e-02 0.0024008835 0.0110982798
#> T[C>T]C 8.069621e-05 1.320607e-03 4.362730e-02 0.0122044913 0.0064490004
#> T[C>T]G 3.169851e-04 3.771733e-05 2.871797e-03 0.0026909903 0.0140978148
#> T[C>T]T 7.309657e-05 2.221021e-16 2.631647e-02 0.0047117339 0.0123980783
#> T[T>A]A 2.569879e-04 7.183301e-02 7.774866e-18 0.0041215167 0.0217966215
#> T[T>A]C 7.949627e-04 2.361085e-02 5.273300e-18 0.0032712038 0.0034094715
#> T[T>A]G 9.849538e-05 7.323366e-02 1.851158e-04 0.0019907326 0.0101984192
#> T[T>A]T 7.639641e-05 3.011384e-02 7.324584e-18 0.0021908062 0.0144977528
#> T[T>C]A 8.419605e-02 4.632129e-03 7.774866e-18 0.0014605375 0.0144977528
#> T[T>C]C 5.479743e-02 2.221021e-16 1.901190e-04 0.0030011044 0.0074088516
#> T[T>C]G 2.759870e-02 1.220561e-03 3.021891e-04 0.0020307473 0.0048892422
#> T[T>C]T 4.069809e-02 2.221021e-16 7.324584e-18 0.0036713511 0.0169973654
#> T[T>G]A 4.649782e-04 5.062327e-03 1.861165e-04 0.0001230453 0.0020796776
#> T[T>G]C 3.789822e-04 7.523458e-04 5.273300e-18 0.0026409719 0.0005789103
#> T[T>G]G 1.309939e-04 5.572561e-03 1.821140e-04 0.0030411191 0.0094285386
#> T[T>G]T 2.219896e-16 5.952736e-04 7.324584e-18 0.0039614578 0.0078687803
#> SBS26 SBS27 SBS28 SBS29 SBS30
#> A[C>A]A 8.731180e-04 5.207818e-03 7.839051e-04 6.320926e-02 1.799681e-03
#> A[C>A]C 5.280713e-04 4.738015e-03 2.529694e-03 5.120750e-02 5.059103e-04
#> A[C>A]G 1.140154e-04 7.826721e-04 3.529573e-04 1.920281e-02 9.128381e-05
#> A[C>A]T 6.190836e-04 2.718861e-03 3.969520e-03 3.560522e-02 5.559014e-04
#> A[C>G]A 4.270577e-04 1.319447e-03 1.539814e-04 3.140460e-03 1.069810e-03
#> A[C>G]C 3.780511e-04 1.769259e-03 2.239729e-04 2.630385e-03 4.669172e-04
#> A[C>G]G 6.830923e-05 0.000000e+00 2.219731e-16 8.961313e-04 1.309768e-04
#> A[C>G]T 7.280984e-04 1.319447e-03 8.328992e-05 2.490365e-03 7.308703e-04
#> A[C>T]A 2.660359e-03 1.369426e-02 7.769060e-04 5.090746e-03 1.059812e-01
#> A[C>T]C 2.540343e-03 5.417731e-03 3.379591e-03 4.310632e-03 9.038397e-02
#> A[C>T]G 5.330720e-03 6.707190e-03 7.049147e-03 2.010295e-02 1.439745e-02
#> A[C>T]T 2.790377e-03 4.478124e-03 5.059388e-03 1.830268e-03 2.929480e-02
#> A[T>A]A 1.520205e-03 1.429401e-01 1.719792e-04 6.190907e-04 3.629356e-04
#> A[T>A]C 3.520476e-03 1.459389e-03 4.779422e-04 2.000293e-03 3.929303e-04
#> A[T>A]G 6.250844e-04 1.229485e-03 1.519816e-04 2.480363e-03 6.378868e-04
#> A[T>A]T 3.070415e-03 2.538936e-03 1.699794e-03 1.960287e-03 4.899131e-04
#> A[T>C]A 8.481146e-02 5.047885e-03 5.489336e-04 1.960287e-03 6.108916e-04
#> A[T>C]C 2.610353e-02 1.849225e-03 4.409466e-04 2.290336e-03 4.579188e-04
#> A[T>C]G 7.851061e-02 5.687617e-03 4.049510e-04 2.750403e-03 2.769509e-04
#> A[T>C]T 3.720503e-02 2.588916e-03 5.949280e-04 1.150169e-03 5.449033e-04
#> A[T>G]A 2.920395e-03 1.139523e-03 9.868806e-03 4.070596e-04 3.899308e-05
#> A[T>G]C 2.530342e-03 9.585984e-04 1.729791e-02 8.171197e-04 1.099805e-04
#> A[T>G]G 2.290309e-03 6.767165e-05 7.679071e-03 4.200616e-04 4.099273e-04
#> A[T>G]T 5.930801e-03 2.558928e-04 1.149861e-01 8.101187e-04 7.938592e-04
#> C[C>A]A 1.410191e-03 5.067877e-03 2.029754e-03 5.420794e-02 7.678638e-04
#> C[C>A]C 1.510204e-03 2.229066e-03 1.089868e-04 3.690541e-02 3.879312e-04
#> C[C>A]G 3.620489e-04 2.658886e-04 2.219731e-16 1.480217e-02 4.069278e-04
#> C[C>A]T 7.140965e-03 3.098702e-03 2.029754e-04 5.190761e-02 2.969473e-04
#> C[C>G]A 3.640492e-04 4.728019e-03 1.439826e-05 3.290482e-03 1.269775e-03
#> C[C>G]C 3.220435e-04 1.259472e-03 7.549087e-05 6.340929e-03 7.928593e-04
#> C[C>G]G 4.170563e-05 3.608488e-04 2.219731e-16 1.300191e-03 1.199787e-04
#> C[C>G]T 6.250844e-04 2.678878e-04 2.219731e-16 6.690980e-03 1.019819e-03
#> C[C>T]A 1.690228e-03 1.739271e-02 2.919647e-04 7.611115e-03 1.099805e-01
#> C[C>T]C 2.830382e-03 7.137010e-03 2.099746e-04 1.640240e-03 1.029817e-01
#> C[C>T]G 3.340451e-03 7.496860e-03 2.549691e-03 1.530224e-02 1.679702e-02
#> C[C>T]T 1.650223e-03 7.147006e-03 3.319598e-03 6.730986e-04 4.619181e-02
#> C[T>A]A 9.441276e-04 3.308614e-01 1.399831e-04 1.950286e-03 2.139620e-04
#> C[T>A]C 1.450196e-03 2.808823e-03 1.349837e-03 1.410207e-03 7.768622e-04
#> C[T>A]G 1.140154e-03 4.398158e-03 8.059025e-04 1.980290e-03 5.868959e-04
#> C[T>A]T 6.420867e-04 5.427726e-03 1.029875e-03 1.980290e-03 6.118915e-04
#> C[T>C]A 5.200703e-02 4.897948e-03 1.319840e-03 1.180173e-03 1.269775e-03
#> C[T>C]C 3.120422e-02 5.717605e-03 2.619683e-03 1.840270e-03 1.379755e-03
#> C[T>C]G 7.871063e-02 5.657630e-03 2.489699e-03 3.910573e-03 1.269775e-03
#> C[T>C]T 5.550750e-02 3.898367e-03 3.669556e-04 1.780261e-03 4.099273e-03
#> C[T>G]A 1.420192e-03 0.000000e+00 1.459823e-02 7.811145e-04 1.979649e-04
#> C[T>G]C 4.940667e-03 3.808405e-04 2.209733e-02 5.690834e-06 2.149619e-04
#> C[T>G]G 5.560751e-03 4.028313e-04 1.549812e-02 3.320487e-04 7.848608e-05
#> C[T>G]T 7.801054e-03 1.439397e-03 1.009878e-01 7.671124e-04 2.649530e-04
#> G[C>A]A 4.960670e-04 1.079548e-02 1.559811e-04 9.711423e-02 9.428327e-04
#> G[C>A]C 6.660900e-04 1.239481e-02 1.019877e-03 9.031323e-02 4.939124e-04
#> G[C>A]G 1.290174e-04 1.629317e-03 3.949522e-05 2.300337e-02 2.219606e-16
#> G[C>A]T 8.171104e-04 7.406897e-03 1.579809e-04 8.461240e-02 8.618471e-04
#> G[C>G]A 3.950534e-04 1.419405e-03 1.829779e-04 2.270333e-03 5.149087e-04
#> G[C>G]C 5.790782e-04 1.349435e-03 2.219731e-16 1.640240e-03 2.559546e-04
#> G[C>G]G 7.380997e-05 0.000000e+00 2.219731e-16 6.881008e-06 1.169792e-04
#> G[C>G]T 3.050412e-04 4.558091e-03 2.219731e-16 3.210470e-03 3.989292e-04
#> G[C>T]A 2.750372e-03 1.419405e-02 3.249607e-03 1.040152e-02 4.969118e-02
#> G[C>T]C 5.450736e-03 2.009158e-02 1.879773e-04 7.961167e-03 6.098918e-02
#> G[C>T]G 6.680903e-03 9.366077e-03 2.149740e-04 1.830268e-02 5.239071e-03
#> G[C>T]T 4.980673e-03 7.586822e-03 1.019877e-04 5.120750e-03 1.769686e-02
#> G[T>A]A 7.831058e-04 1.099539e-01 1.159860e-04 3.430503e-03 3.289416e-04
#> G[T>A]C 1.150155e-03 2.349016e-05 1.179857e-04 7.891156e-04 1.819677e-04
#> G[T>A]G 6.080822e-04 1.569343e-03 7.169133e-05 3.660536e-03 9.858251e-05
#> G[T>A]T 8.341127e-04 0.000000e+00 3.239608e-04 1.070157e-03 1.909661e-04
#> G[T>C]A 8.351128e-02 4.777998e-03 4.909406e-04 1.080158e-03 9.348342e-04
#> G[T>C]C 2.480335e-02 1.959179e-03 5.869290e-04 3.590526e-03 5.549016e-04
#> G[T>C]G 7.120962e-02 1.229485e-03 7.309116e-04 2.990438e-03 5.009111e-04
#> G[T>C]T 5.520746e-02 3.748430e-03 8.508970e-04 1.550227e-03 4.449211e-04
#> G[T>G]A 1.370185e-03 0.000000e+00 1.159860e-03 4.490658e-05 1.879667e-04
#> G[T>G]C 1.210163e-03 5.077873e-05 1.929766e-03 9.171344e-05 3.529374e-04
#> G[T>G]G 2.350318e-03 4.738015e-03 3.129621e-03 7.701128e-04 1.379755e-03
#> G[T>G]T 6.050817e-03 2.299037e-03 2.059751e-02 1.150169e-03 1.599716e-04
#> T[C>A]A 9.381267e-04 7.077035e-03 1.429827e-02 4.520662e-02 6.958766e-04
#> T[C>A]C 6.300851e-04 6.267375e-03 4.519453e-04 4.110602e-02 2.429569e-04
#> T[C>A]G 1.230166e-04 1.449393e-03 1.289844e-04 1.740255e-02 8.258535e-05
#> T[C>A]T 1.400189e-03 9.805892e-03 5.569326e-04 4.110602e-02 6.648820e-04
#> T[C>G]A 1.310177e-03 2.868798e-03 1.149861e-04 1.070157e-04 1.269775e-04
#> T[C>G]C 7.451007e-04 3.108698e-03 1.359835e-04 6.831001e-03 9.858251e-04
#> T[C>G]G 9.411271e-05 1.279464e-05 2.459702e-05 8.971315e-04 1.059812e-04
#> T[C>G]T 2.210299e-03 2.129108e-03 1.429827e-04 3.360492e-04 1.089807e-04
#> T[C>T]A 3.290445e-03 1.879213e-02 4.839414e-03 6.390936e-03 9.798262e-02
#> T[C>T]C 2.530342e-03 7.986654e-03 4.129500e-03 3.610529e-18 1.339762e-01
#> T[C>T]G 2.630355e-03 4.608070e-03 1.739789e-03 1.440211e-02 1.469739e-02
#> T[C>T]T 2.130288e-03 1.189502e-02 1.989759e-03 4.280627e-03 5.249069e-02
#> T[T>A]A 1.130153e-03 5.277789e-02 1.879773e-04 7.641120e-04 2.819500e-04
#> T[T>A]C 1.260170e-03 4.708028e-05 1.249849e-03 1.930283e-03 2.409573e-04
#> T[T>A]G 2.780376e-04 0.000000e+00 3.209612e-04 9.241354e-04 1.899663e-04
#> T[T>A]T 1.310177e-03 1.929192e-03 5.719308e-03 1.200176e-03 7.008757e-04
#> T[T>C]A 4.230572e-02 1.719280e-03 1.309842e-03 2.590380e-03 5.439035e-04
#> T[T>C]C 3.140424e-02 3.488539e-03 2.049752e-03 1.500220e-03 2.859493e-04
#> T[T>C]G 3.030409e-02 1.149518e-03 1.409829e-03 3.790555e-04 2.029640e-04
#> T[T>C]T 5.740776e-02 1.529359e-03 2.059751e-03 8.221205e-04 4.449211e-04
#> T[T>G]A 1.430193e-03 1.189502e-03 4.229488e-02 4.670684e-04 1.179791e-04
#> T[T>G]C 1.720232e-03 2.798828e-04 3.569568e-02 9.931455e-05 9.638290e-05
#> T[T>G]G 2.840384e-03 2.349016e-03 1.399831e-02 1.800264e-04 8.128558e-04
#> T[T>G]T 9.451277e-03 1.399414e-04 4.789420e-01 9.281360e-04 8.888423e-03
#> SBS31 SBS32 SBS33 SBS34 SBS35
#> A[C>A]A 0.0095349846 2.229777e-02 3.111360e-03 4.867950e-03 8.826949e-03
#> A[C>A]C 0.0184902741 1.879812e-02 2.230975e-03 6.957071e-03 4.618403e-02
#> A[C>A]G 0.0016591273 4.459554e-03 4.141810e-04 5.197811e-05 1.389520e-03
#> A[C>A]T 0.0062766985 1.459854e-02 1.900831e-03 1.229482e-03 2.159254e-02
#> A[C>G]A 0.0083156260 1.989801e-03 1.410616e-03 7.616793e-04 3.578763e-03
#> A[C>G]C 0.0031583387 2.029797e-03 1.300568e-03 1.129524e-03 4.548428e-03
#> A[C>G]G 0.0029984228 1.129887e-03 2.531106e-04 2.219066e-16 3.458804e-04
#> A[C>G]T 0.0037780128 1.749825e-03 1.300568e-03 2.029146e-03 9.476724e-03
#> A[C>T]A 0.0176906947 8.639137e-02 5.312321e-03 3.518518e-03 2.209236e-03
#> A[C>T]C 0.0092751213 1.229877e-01 2.130931e-03 3.708438e-03 3.988621e-03
#> A[C>T]G 0.0075860098 3.659634e-02 7.163130e-03 1.179503e-04 5.797996e-04
#> A[C>T]T 0.0100946902 1.519848e-01 3.071342e-03 3.868371e-03 8.996890e-04
#> A[T>A]A 0.0078558678 7.129288e-04 8.683795e-04 1.029566e-01 4.888310e-03
#> A[T>A]C 0.0060668089 8.869114e-04 1.140498e-03 4.438131e-02 7.357457e-03
#> A[T>A]G 0.0050273556 7.119289e-04 6.963043e-04 3.458544e-02 1.329540e-03
#> A[T>A]T 0.0041578130 8.439157e-04 5.072217e-03 3.158670e-01 7.367453e-03
#> A[T>C]A 0.0203892752 9.359065e-04 1.250546e-02 4.618055e-03 2.039295e-03
#> A[T>C]C 0.0073961096 7.009300e-04 3.751639e-03 1.229482e-03 8.207163e-04
#> A[T>C]G 0.0081157311 1.089891e-03 7.343209e-02 1.949179e-05 9.196821e-04
#> A[T>C]T 0.0084655471 6.099391e-04 9.214027e-03 2.339015e-03 2.029298e-03
#> A[T>G]A 0.0036780653 3.859614e-04 9.794280e-04 2.818813e-03 3.048946e-03
#> A[T>G]C 0.0024786962 4.289571e-04 3.021320e-04 4.618055e-04 9.656662e-04
#> A[T>G]G 0.0040178866 1.269873e-03 4.752077e-04 1.969171e-04 4.478452e-03
#> A[T>G]T 0.0007825884 6.449356e-18 7.583314e-04 1.149516e-03 2.629091e-03
#> C[C>A]A 0.0106943748 1.239876e-03 2.701180e-03 1.949179e-03 2.988967e-02
#> C[C>A]C 0.0115939016 4.919509e-03 1.910835e-03 3.668455e-05 3.298860e-02
#> C[C>A]G 0.0003288270 1.659834e-05 3.711622e-04 2.978746e-04 2.199240e-03
#> C[C>A]T 0.0278853323 2.669733e-03 2.531106e-03 6.197390e-04 8.247149e-02
#> C[C>G]A 0.0020489223 1.149885e-03 1.500656e-03 1.189499e-04 3.858666e-03
#> C[C>G]C 0.0018590222 8.239177e-04 4.101792e-04 1.179503e-04 6.297823e-03
#> C[C>G]G 0.0008535510 5.369464e-04 3.181390e-04 1.899200e-04 8.696993e-04
#> C[C>G]T 0.0034182020 4.949506e-04 6.622894e-04 7.356902e-05 1.619440e-02
#> C[C>T]A 0.0411783402 1.689831e-02 4.592007e-03 4.748001e-03 5.098238e-03
#> C[C>T]C 0.1639137814 2.839716e-02 1.530669e-03 5.137837e-04 8.317125e-02
#> C[C>T]G 0.0081956891 1.119888e-02 5.882571e-03 9.446023e-03 2.669077e-03
#> C[C>T]T 0.1449237701 4.279572e-02 2.701180e-03 3.528514e-05 4.698376e-02
#> C[T>A]A 0.0205891701 3.249675e-04 7.463261e-04 2.369002e-02 5.258182e-02
#> C[T>A]C 0.0210889072 6.499351e-04 9.924337e-04 4.088279e-04 3.298860e-02
#> C[T>A]G 0.0186901690 1.409859e-03 4.792094e-04 1.169508e-03 5.817989e-02
#> C[T>A]T 0.0309837026 6.629338e-04 1.120490e-03 2.678872e-04 6.637705e-02
#> C[T>C]A 0.0081457154 5.929408e-04 1.510660e-02 5.937500e-04 1.329540e-03
#> C[T>C]C 0.0099047901 9.269074e-04 3.011316e-02 4.038300e-05 2.019302e-03
#> C[T>C]G 0.0044576553 1.839816e-03 4.001749e-02 8.106587e-04 1.559461e-03
#> C[T>C]T 0.0137927450 1.089891e-03 3.071342e-03 1.589331e-03 3.178901e-03
#> C[T>G]A 0.0019689643 5.809420e-05 7.283183e-04 1.059554e-03 3.708718e-03
#> C[T>G]C 0.0014292482 4.499550e-04 9.494149e-04 2.219066e-16 5.178210e-04
#> C[T>G]G 0.0014992114 1.089891e-03 1.070468e-03 4.358165e-04 6.357802e-03
#> C[T>G]T 0.0009485011 6.759325e-04 1.920839e-04 6.547243e-07 2.709063e-03
#> G[C>A]A 0.0130931130 4.509549e-03 4.411928e-03 2.808817e-03 9.866589e-03
#> G[C>A]C 0.0214886969 3.619638e-03 9.684232e-04 4.678030e-04 5.018265e-02
#> G[C>A]G 0.0009714890 8.769124e-04 3.421495e-04 2.269045e-04 5.068248e-04
#> G[C>A]T 0.0035081547 3.269673e-03 3.191395e-03 1.349432e-05 2.289209e-02
#> G[C>G]A 0.0018290379 8.759125e-04 7.713371e-04 3.338594e-05 3.378832e-03
#> G[C>G]C 0.0075060518 8.999101e-04 7.763393e-04 1.929188e-04 2.139260e-02
#> G[C>G]G 0.0004567597 6.859315e-05 4.662037e-05 2.219066e-16 5.907958e-04
#> G[C>G]T 0.0033582336 2.279772e-04 9.314070e-04 2.688868e-05 8.736980e-03
#> G[C>T]A 0.0067964251 2.259774e-02 5.352339e-03 2.329019e-04 7.287481e-03
#> G[C>T]C 0.0113940068 3.789621e-02 5.142247e-03 2.219066e-16 1.779385e-02
#> G[C>T]G 0.0019689643 1.039896e-02 5.842553e-03 1.669297e-02 2.529126e-03
#> G[C>T]T 0.0056970034 5.319469e-02 3.931718e-03 5.167824e-04 6.027916e-03
#> G[T>A]A 0.0018990011 8.789122e-03 8.103541e-04 1.899200e-02 7.167522e-04
#> G[T>A]C 0.0029084701 8.219179e-03 3.621583e-04 2.418981e-03 5.558079e-03
#> G[T>A]G 0.0057669666 1.309869e-02 8.273616e-04 6.527252e-03 1.119613e-03
#> G[T>A]T 0.0007885852 6.159385e-03 1.760769e-03 7.476852e-03 2.859012e-03
#> G[T>C]A 0.0045276185 9.139087e-03 1.220533e-02 1.089541e-04 5.648047e-04
#> G[T>C]C 0.0065665460 7.669234e-03 7.943471e-03 6.457281e-04 2.029298e-03
#> G[T>C]G 0.0051273030 9.619039e-03 2.070905e-01 4.398148e-04 1.909340e-04
#> G[T>C]T 0.0046875344 1.289871e-02 9.714245e-03 2.219066e-16 4.208545e-04
#> G[T>G]A 0.0003038402 1.149885e-03 5.812540e-04 3.648464e-04 1.759392e-03
#> G[T>G]C 0.0008715416 7.399261e-04 6.372785e-04 2.219066e-16 5.068248e-03
#> G[T>G]G 0.0025486594 3.009699e-03 5.422370e-03 5.647622e-05 4.038604e-03
#> G[T>G]T 0.0028085227 7.849216e-04 4.511972e-04 4.168245e-04 3.348842e-03
#> T[C>A]A 0.0018590222 9.729028e-03 1.190520e-02 4.268203e-03 5.268179e-03
#> T[C>A]C 0.0093750687 9.289072e-03 5.112234e-03 1.219487e-03 2.309202e-02
#> T[C>A]G 0.0009544979 2.379762e-03 1.370599e-03 2.219066e-16 9.466727e-05
#> T[C>A]T 0.0044876395 9.639037e-03 1.280560e-02 3.198653e-05 1.529471e-02
#> T[C>G]A 0.0003957918 4.709530e-18 1.300568e-02 6.177399e-07 6.627709e-03
#> T[C>G]C 0.0029184649 1.099890e-03 2.511097e-03 1.399411e-04 5.628054e-03
#> T[C>G]G 0.0004157813 9.969004e-04 8.043515e-05 2.219066e-16 1.549464e-04
#> T[C>G]T 0.0042377709 6.919309e-04 2.010879e-02 2.149095e-03 2.119267e-02
#> T[C>T]A 0.0074760676 2.479752e-02 1.470643e-02 1.859217e-03 2.958977e-03
#> T[C>T]C 0.0245870672 3.869613e-02 3.171386e-03 2.888784e-04 1.259565e-02
#> T[C>T]G 0.0084055787 9.849016e-03 3.851683e-03 2.998737e-04 7.647356e-04
#> T[C>T]T 0.0194897484 6.699331e-02 9.043952e-03 8.076599e-04 8.037222e-03
#> T[T>A]A 0.0066964777 5.119489e-04 4.101792e-03 2.718855e-01 4.298514e-03
#> T[T>A]C 0.0037480285 2.449755e-03 2.170949e-04 2.219066e-16 5.298168e-03
#> T[T>A]G 0.0032682809 1.759824e-03 6.602885e-04 7.766730e-03 1.379523e-03
#> T[T>A]T 0.0088753316 7.109290e-04 2.721189e-03 4.598064e-02 5.408130e-03
#> T[T>C]A 0.0045875869 8.969104e-04 1.100481e-02 1.399411e-03 3.678728e-04
#> T[T>C]C 0.0102945850 1.219878e-03 1.250546e-02 6.237374e-03 8.217159e-04
#> T[T>C]G 0.0040078918 1.689831e-03 3.201399e-01 1.099537e-03 4.378486e-04
#> T[T>C]T 0.0120936387 6.839317e-04 9.123987e-03 7.077020e-03 1.059634e-03
#> T[T>G]A 0.0022488171 2.259774e-05 4.682046e-04 2.219066e-16 4.288517e-03
#> T[T>G]C 0.0023787488 2.239776e-04 1.640717e-04 2.219066e-16 1.939330e-03
#> T[T>G]G 0.0053471874 8.179183e-04 9.594193e-04 1.519360e-03 4.818334e-03
#> T[T>G]T 0.0072961622 6.349366e-04 2.250984e-03 2.319024e-04 3.618749e-03
#> SBS36 SBS37 SBS38 SBS39 SBS40
#> A[C>A]A 0.0251937771 0.0039508218 0.0127948693 0.011701521 2.820375e-02
#> A[C>A]C 0.0083179455 0.0014503017 0.0100959515 0.007150930 1.340178e-02
#> A[C>A]G 0.0022394469 0.0010602205 0.0018992384 0.002670347 2.920388e-03
#> A[C>A]T 0.0178955798 0.0018503849 0.0088464526 0.007400962 1.480197e-02
#> A[C>G]A 0.0018395456 0.0343071359 0.0026889217 0.047306150 1.220162e-02
#> A[C>G]C 0.0016695876 0.0112023301 0.0015793667 0.022502925 8.681155e-03
#> A[C>G]G 0.0004998765 0.0053511130 0.0006357451 0.013601768 2.250299e-03
#> A[C>G]T 0.0019095283 0.0188039112 0.0024390220 0.043405643 1.460194e-02
#> A[C>T]A 0.0059585282 0.0062412982 0.0034486171 0.009601248 1.970262e-02
#> A[C>T]C 0.0032791900 0.0030606366 0.0021491382 0.004040525 1.210161e-02
#> A[C>T]G 0.0070682541 0.0063313169 0.0051779237 0.006000780 2.670355e-04
#> A[C>T]T 0.0043089357 0.0056511754 0.0024390220 0.012801664 1.690225e-02
#> A[T>A]A 0.0024393975 0.0022504681 0.0019892023 0.005310690 6.100811e-03
#> A[T>A]C 0.0014296469 0.0016603454 0.0019392224 0.002880374 4.440591e-03
#> A[T>A]G 0.0025293752 0.0024905180 0.0010795671 0.006940902 6.930922e-03
#> A[T>A]T 0.0030692419 0.0027705763 0.0027189097 0.006120796 1.070142e-02
#> A[T>C]A 0.0052487036 0.0733152496 0.0027888817 0.011201456 1.870249e-02
#> A[T>C]C 0.0016895827 0.0384079889 0.0016393426 0.005640733 7.340976e-03
#> A[T>C]G 0.0038390518 0.0168034951 0.0021691302 0.009641253 1.550206e-02
#> A[T>C]T 0.0051187357 0.0480099861 0.0034886011 0.013601768 1.940258e-02
#> A[T>G]A 0.0010897308 0.0217045145 0.0011495390 0.003880504 7.230962e-03
#> A[T>G]C 0.0006228462 0.0106022053 0.0010695711 0.002970386 7.050938e-03
#> A[T>G]G 0.0009357689 0.0168034951 0.0020691703 0.007660996 8.061072e-03
#> A[T>G]T 0.0009837570 0.0247051387 0.0028588536 0.006420835 1.800239e-02
#> C[C>A]A 0.0557862208 0.0032206699 0.3808472802 0.010101313 2.080277e-02
#> C[C>A]C 0.0201950118 0.0008141693 0.0694721417 0.009061178 1.470196e-02
#> C[C>A]G 0.0070982467 0.0007471554 0.0509795572 0.005740746 2.540338e-03
#> C[C>A]T 0.0604850602 0.0017703682 0.1839262456 0.006030784 1.470196e-02
#> C[C>G]A 0.0012396938 0.0004420920 0.0016893226 0.028803744 7.561006e-03
#> C[C>G]C 0.0013696617 0.0003130651 0.0012594949 0.037704902 9.351244e-03
#> C[C>G]G 0.0004188965 0.0003210668 0.0009566164 0.012301599 1.680223e-03
#> C[C>G]T 0.0020894839 0.0005811209 0.0012694909 0.040205227 1.390185e-02
#> C[C>T]A 0.0067483332 0.0036107510 0.0042383004 0.009111184 1.960261e-02
#> C[C>T]C 0.0066783504 0.0021004369 0.0047281040 0.003860502 1.730230e-02
#> C[C>T]G 0.0053286838 0.0032706803 0.0034985971 0.007570984 2.360314e-03
#> C[C>T]T 0.0057485801 0.0060612607 0.0040983566 0.006990909 2.160287e-02
#> C[T>A]A 0.0012596889 0.0015703266 0.0008966404 0.004940642 1.090145e-03
#> C[T>A]C 0.0014596395 0.0011602413 0.0020191903 0.006440837 7.621014e-03
#> C[T>A]G 0.0021394716 0.0016003329 0.0017792865 0.006800884 3.460460e-03
#> C[T>A]T 0.0019595160 0.0020604286 0.0023590540 0.008271075 9.281234e-03
#> C[T>C]A 0.0014996296 0.0500104022 0.0019492184 0.007340954 1.090145e-02
#> C[T>C]C 0.0018795358 0.0218045353 0.0023190701 0.007911028 9.871313e-03
#> C[T>C]G 0.0018495432 0.0099520700 0.0025389819 0.007771010 1.050140e-02
#> C[T>C]T 0.0021594666 0.0504104854 0.0042682884 0.008591117 1.360181e-02
#> C[T>G]A 0.0004778820 0.0026005409 0.0009826060 0.005300689 3.350446e-03
#> C[T>G]C 0.0005658602 0.0023804951 0.0014094348 0.007390961 5.670754e-03
#> C[T>G]G 0.0008867810 0.0037707843 0.0015893627 0.009831278 5.590744e-03
#> C[T>G]T 0.0010697358 0.0041108551 0.0068772422 0.004940642 1.310174e-02
#> G[C>A]A 0.0676832822 0.0020404244 0.0119951899 0.006880895 1.420189e-02
#> G[C>A]C 0.0191952588 0.0006291309 0.0062774827 0.006950904 1.020136e-02
#> G[C>A]G 0.0048288073 0.0005061053 0.0013694509 0.004530589 2.550339e-03
#> G[C>A]T 0.0689829612 0.0012902684 0.0090863564 0.005890766 1.080144e-02
#> G[C>G]A 0.0008857812 0.0013202746 0.0011995190 0.024003120 5.060673e-03
#> G[C>G]C 0.0010797333 0.0009381951 0.0010795671 0.021302769 5.370714e-03
#> G[C>G]G 0.0001719575 0.0005771200 0.0010195911 0.009861282 1.190158e-03
#> G[C>G]T 0.0010497407 0.0012702642 0.0009166324 0.032404213 6.980928e-03
#> G[C>T]A 0.0037190814 0.0025505305 0.0023690500 0.008031044 1.430190e-02
#> G[C>T]C 0.0033991604 0.0023104806 0.0029588135 0.004500585 1.160154e-02
#> G[C>T]G 0.0056985924 0.0043208987 0.0044782042 0.005480712 3.930523e-18
#> G[C>T]T 0.0036291036 0.0023204827 0.0031987173 0.008611119 1.270169e-02
#> G[T>A]A 0.0008797827 0.0011502392 0.0008926421 0.004960645 2.650352e-03
#> G[T>A]C 0.0006308442 0.0007741610 0.0011195511 0.003520458 3.430456e-03
#> G[T>A]G 0.0011697111 0.0010802247 0.0012095150 0.006670867 4.410587e-03
#> G[T>A]T 0.0011197234 0.0016803495 0.0018392625 0.004090532 5.770768e-03
#> G[T>C]A 0.0023394222 0.0307063869 0.0016993186 0.007470971 6.010799e-03
#> G[T>C]C 0.0013996543 0.0182037864 0.0021591342 0.006890896 4.580609e-03
#> G[T>C]G 0.0018395456 0.0098320451 0.0018692504 0.005740746 5.650752e-03
#> G[T>C]T 0.0026493456 0.0400083217 0.0030487774 0.007510976 7.310972e-03
#> G[T>G]A 0.0001849543 0.0118024549 0.0005037980 0.003330433 2.490331e-03
#> G[T>G]C 0.0003129227 0.0068614272 0.0009386236 0.005800754 2.240298e-03
#> G[T>G]G 0.0015296222 0.0098320451 0.0021591342 0.007721004 4.450592e-03
#> G[T>G]T 0.0004888792 0.0171035575 0.0033386612 0.005940772 5.480729e-03
#> T[C>A]A 0.1409651816 0.0020004161 0.0176929051 0.005980778 2.600346e-02
#> T[C>A]C 0.0771809363 0.0015903308 0.0114953903 0.007861022 2.100279e-02
#> T[C>A]G 0.0146963700 0.0011202330 0.0023790460 0.003010391 3.170422e-03
#> T[C>A]T 0.2079486367 0.0024405076 0.0277888567 0.006550852 2.410321e-02
#> T[C>G]A 0.0039790172 0.0017903724 0.0026589338 0.034704512 1.250166e-02
#> T[C>G]C 0.0024094049 0.0011102309 0.0021791262 0.036704772 1.410188e-02
#> T[C>G]G 0.0003019254 0.0008601789 0.0010995591 0.009621251 1.740231e-03
#> T[C>G]T 0.0075881257 0.0025505305 0.0039484167 0.050706592 2.370315e-02
#> T[C>T]A 0.0106973578 0.0040208363 0.0064474146 0.003880504 3.000399e-02
#> T[C>T]C 0.0068583060 0.0025005201 0.0072271019 0.005280686 2.310307e-02
#> T[C>T]G 0.0038890394 0.0034307136 0.0034686091 0.004860632 2.120282e-03
#> T[C>T]T 0.0083279430 0.0058412150 0.0065773625 0.004230550 2.240298e-02
#> T[T>A]A 0.0024593925 0.0024505097 0.0024390220 0.006690870 7.130948e-03
#> T[T>A]C 0.0010197481 0.0011302351 0.0009276280 0.003690480 1.030137e-02
#> T[T>A]G 0.0008717847 0.0012802663 0.0008036777 0.005460710 5.020668e-03
#> T[T>A]T 0.0026993333 0.0019504057 0.0024989979 0.010701391 2.100279e-02
#> T[T>C]A 0.0029692666 0.0477099237 0.0021091542 0.005940772 1.020136e-02
#> T[T>C]C 0.0022794370 0.0451093828 0.0021891222 0.006440837 7.551004e-03
#> T[T>C]G 0.0013796592 0.0100020804 0.0019192304 0.004980647 6.010799e-03
#> T[T>C]T 0.0027993086 0.0614127739 0.0030587734 0.009481233 1.020136e-02
#> T[T>G]A 0.0007878054 0.0183038072 0.0011695310 0.008391091 8.461125e-03
#> T[T>G]C 0.0007438163 0.0195040568 0.0009026380 0.005080660 1.140152e-02
#> T[T>G]G 0.0009017773 0.0302062829 0.0018992384 0.007280947 8.661152e-03
#> T[T>G]T 0.0018095530 0.0291060541 0.0052878796 0.010901417 2.500333e-02
#> SBS41 SBS42 SBS43 SBS44 SBS45 SBS46
#> A[C>A]A 2.110193e-03 1.160252e-03 2.950629e-02 7.681946e-18 9.108136e-03 0.0044
#> A[C>A]C 1.220112e-03 2.060448e-02 5.901258e-03 1.500380e-04 2.849417e-03 0.0047
#> A[C>A]G 6.140562e-05 3.340726e-05 6.261335e-04 9.162321e-07 1.659660e-03 0.0003
#> A[C>A]T 1.330122e-03 7.971733e-03 2.070442e-03 5.781464e-03 9.638027e-03 0.0034
#> A[C>G]A 5.330488e-03 4.060883e-04 3.610770e-04 3.180806e-03 3.109364e-03 0.0012
#> A[C>G]C 3.160289e-03 5.061100e-04 3.130668e-05 2.330590e-04 1.929605e-03 0.0015
#> A[C>G]G 1.210111e-03 1.770385e-05 4.430945e-03 3.140795e-05 2.699447e-04 0.0000
#> A[C>G]T 8.270758e-03 4.310937e-04 3.540755e-04 3.290833e-03 1.429707e-03 0.0022
#> A[C>T]A 9.880905e-03 2.240487e-02 2.900619e-05 8.992278e-02 1.329728e-03 0.0152
#> A[C>T]C 3.360308e-03 3.980865e-02 1.280273e-04 1.690428e-02 6.008770e-04 0.0089
#> A[C>T]G 3.430314e-03 4.400957e-04 1.220260e-03 1.430362e-02 5.408893e-03 0.0046
#> A[C>T]T 6.350582e-03 3.520765e-02 9.101941e-04 3.030768e-02 1.219750e-03 0.0068
#> A[T>A]A 7.460683e-03 1.330289e-02 1.530326e-02 4.781211e-03 5.248926e-04 0.0027
#> A[T>A]C 4.300394e-03 4.010872e-03 3.780806e-03 2.600659e-03 4.968983e-04 0.0018
#> A[T>A]G 3.030278e-03 5.011089e-03 1.430305e-03 1.080274e-06 2.129564e-03 0.0005
#> A[T>A]T 6.960638e-02 6.851490e-03 4.280913e-03 3.080780e-02 6.048762e-04 0.0020
#> A[T>C]A 1.440132e-02 1.160252e-02 8.881894e-06 1.930489e-02 1.369720e-03 0.0185
#> A[T>C]C 5.790530e-03 3.510763e-03 3.130668e-02 3.240821e-03 4.179145e-04 0.0478
#> A[T>C]G 8.040737e-03 8.561861e-03 5.861250e-04 2.720689e-02 2.069576e-03 0.0329
#> A[T>C]T 1.770162e-02 2.700587e-03 8.801877e-03 2.670676e-04 1.459701e-03 0.0306
#> A[T>G]A 7.530690e-03 1.200261e-03 2.630561e-03 2.400608e-08 1.169761e-04 0.0001
#> A[T>G]C 1.640150e-03 4.050881e-04 4.070868e-03 3.260826e-05 5.838805e-04 0.0008
#> A[T>G]G 2.700247e-03 6.371385e-04 3.490744e-02 7.471892e-06 9.837986e-04 0.0016
#> A[T>G]T 7.610697e-03 9.111981e-04 5.641203e-03 1.420360e-03 1.659660e-04 0.0006
#> C[C>A]A 2.380218e-03 1.160252e-02 6.631414e-03 2.840719e-05 2.379513e-01 0.0156
#> C[C>A]C 9.190842e-04 3.280713e-02 8.201749e-05 3.030768e-02 1.509691e-01 0.0072
#> C[C>A]G 2.610239e-04 1.880409e-03 2.560546e-05 3.740947e-03 6.788610e-02 0.0045
#> C[C>A]T 2.650243e-03 2.110459e-02 5.221113e-18 8.672196e-02 1.939603e-01 0.0083
#> C[C>G]A 2.080191e-03 4.260926e-03 2.090446e-05 5.361358e-05 1.429707e-03 0.0005
#> C[C>G]C 1.200110e-03 6.621440e-03 2.120452e-04 2.490631e-05 7.998363e-04 0.0003
#> C[C>G]G 4.110377e-04 4.701022e-04 2.540542e-03 7.681946e-18 6.428684e-04 0.0001
#> C[C>G]T 5.030461e-03 6.841487e-03 8.531819e-04 8.642189e-05 1.909609e-03 0.0015
#> C[C>T]A 6.910633e-03 1.870407e-02 7.621625e-06 3.570904e-03 2.139562e-03 0.0284
#> C[C>T]C 1.850169e-03 4.811046e-02 4.350928e-18 2.860725e-03 5.068962e-05 0.0133
#> C[C>T]G 1.010093e-02 1.920417e-03 9.722073e-05 1.550393e-02 2.199550e-03 0.0083
#> C[C>T]T 7.730708e-03 3.290715e-02 7.441587e-04 5.041277e-03 2.729441e-03 0.0064
#> C[T>A]A 3.620332e-03 1.260274e-02 1.360290e-03 1.240314e-05 6.968574e-04 0.0042
#> C[T>A]C 3.190292e-03 1.720374e-03 1.210258e-05 3.250823e-03 1.039787e-03 0.0033
#> C[T>A]G 3.120286e-03 1.490324e-02 2.960631e-04 5.821474e-04 3.409302e-03 0.0043
#> C[T>A]T 9.010825e-03 7.571646e-03 2.030433e-04 1.380350e-05 1.339726e-03 0.0036
#> C[T>C]A 1.030094e-02 3.540770e-03 2.720580e-03 1.460370e-02 1.109773e-03 0.0223
#> C[T>C]C 5.250481e-03 3.130681e-03 1.050224e-01 3.200811e-03 2.869413e-03 0.0834
#> C[T>C]G 5.570510e-03 3.560774e-03 9.251973e-03 3.380856e-02 1.559681e-03 0.0504
#> C[T>C]T 7.870721e-03 3.240705e-03 9.452016e-03 7.711953e-03 6.018768e-04 0.0958
#> C[T>G]A 3.470318e-03 8.701892e-04 2.730582e-03 2.340593e-04 1.019791e-04 0.0000
#> C[T>G]C 2.410221e-03 7.531637e-04 7.261549e-03 2.530641e-03 2.809425e-04 0.0018
#> C[T>G]G 3.040278e-03 5.681235e-03 4.650992e-02 3.470879e-03 6.488672e-04 0.0016
#> C[T>G]T 1.050096e-02 3.480757e-03 6.261335e-18 3.840973e-04 7.278510e-04 0.0020
#> G[C>A]A 3.090283e-03 7.711677e-03 9.301984e-03 7.681946e-18 7.548455e-03 0.0072
#> G[C>A]C 7.230662e-04 2.680583e-02 1.690360e-03 4.671183e-03 5.728827e-03 0.0030
#> G[C>A]G 2.200202e-04 1.060230e-03 1.770378e-04 6.051533e-04 2.089572e-03 0.0004
#> G[C>A]T 1.950179e-03 1.810394e-02 1.390296e-03 1.130286e-02 6.988569e-03 0.0024
#> G[C>G]A 2.040187e-03 2.400522e-03 1.360290e-02 2.190555e-04 3.329318e-04 0.0001
#> G[C>G]C 2.690246e-03 1.420309e-03 1.520324e-02 1.190301e-03 1.009793e-03 0.0008
#> G[C>G]G 1.560143e-04 2.230485e-04 1.280273e-02 7.681946e-18 6.948578e-04 0.0000
#> G[C>G]T 3.560326e-03 2.770602e-03 1.800384e-02 1.850469e-03 9.318093e-04 0.0006
#> G[C>T]A 6.010551e-03 3.360731e-02 7.661634e-04 9.552419e-02 9.997953e-04 0.0126
#> G[C>T]C 8.640791e-03 1.520331e-01 4.100875e-18 8.142062e-02 9.328091e-04 0.0045
#> G[C>T]G 1.710157e-02 4.550989e-03 9.662060e-06 4.961257e-02 1.509691e-03 0.0015
#> G[C>T]T 8.410770e-03 8.651881e-02 1.860397e-03 6.661687e-02 1.989593e-03 0.0040
#> G[T>A]A 2.330213e-03 1.200261e-02 6.181318e-03 1.160294e-03 2.999386e-04 0.0061
#> G[T>A]C 2.290210e-03 1.840400e-03 1.330284e-03 2.360598e-03 6.378694e-04 0.0010
#> G[T>A]G 1.430131e-03 7.771690e-03 4.500960e-03 2.210560e-03 1.029789e-03 0.0024
#> G[T>A]T 4.520414e-03 3.250707e-03 1.310279e-03 3.180806e-03 5.098956e-04 0.0012
#> G[T>C]A 6.060555e-03 5.821266e-03 7.501600e-18 2.700684e-02 6.538662e-04 0.0221
#> G[T>C]C 3.740343e-03 3.310720e-03 2.190467e-02 1.160294e-03 5.698833e-04 0.0576
#> G[T>C]G 3.510322e-03 3.210698e-03 1.200256e-03 1.730438e-02 9.068144e-04 0.0353
#> G[T>C]T 3.890356e-03 2.390520e-03 5.181105e-04 1.110281e-02 1.389716e-03 0.0607
#> G[T>G]A 1.800165e-03 1.140248e-03 6.111303e-02 7.681946e-18 4.399100e-04 0.0000
#> G[T>G]C 9.500870e-04 7.051533e-05 7.561613e-02 1.830464e-05 5.198936e-04 0.0001
#> G[T>G]G 1.200110e-03 4.100892e-04 2.410514e-01 1.030261e-04 1.789634e-04 0.0012
#> G[T>G]T 3.470318e-03 9.202001e-04 7.461591e-02 2.800709e-03 4.958985e-04 0.0006
#> T[C>A]A 3.310303e-03 5.101109e-03 6.301344e-03 8.532161e-04 6.398690e-02 0.0123
#> T[C>A]C 1.720158e-03 5.401174e-02 5.371145e-06 2.220562e-03 6.418686e-02 0.0071
#> T[C>A]G 2.070190e-04 9.041966e-04 3.070655e-18 3.150798e-07 1.829625e-02 0.0025
#> T[C>A]T 5.900540e-03 2.730594e-02 6.521391e-18 1.660421e-02 6.198731e-02 0.0030
#> T[C>G]A 1.990182e-02 5.591216e-04 4.420943e-06 6.731705e-04 3.299325e-03 0.0028
#> T[C>G]C 1.420130e-02 1.870407e-03 1.030220e-03 9.402381e-06 2.009589e-03 0.0024
#> T[C>G]G 1.930177e-03 2.070450e-04 1.470314e-03 7.681946e-18 1.779636e-04 0.0001
#> T[C>G]T 4.460409e-02 3.810828e-04 2.510535e-04 2.590656e-03 3.289327e-03 0.0049
#> T[C>T]A 1.170107e-02 4.821048e-03 3.720793e-05 1.400355e-03 2.399509e-03 0.0185
#> T[C>T]C 6.470593e-03 3.270711e-02 5.061079e-18 2.250570e-03 2.019587e-03 0.0126
#> T[C>T]G 4.920451e-03 3.640792e-04 3.070655e-18 7.681946e-18 1.749642e-03 0.0037
#> T[C>T]T 1.150105e-02 1.510328e-02 8.361783e-04 3.020765e-03 2.949396e-03 0.0044
#> T[T>A]A 8.060738e-02 8.501848e-03 7.631627e-05 6.961763e-03 4.069167e-04 0.0045
#> T[T>A]C 1.430131e-02 2.260491e-03 9.382001e-04 2.070524e-05 2.619464e-04 0.0043
#> T[T>A]G 9.290851e-03 5.331159e-03 5.141096e-05 5.021272e-06 6.538662e-04 0.0005
#> T[T>A]T 5.350490e-02 3.520765e-03 8.771871e-18 1.390352e-02 1.389716e-03 0.0034
#> T[T>C]A 6.360583e-02 6.821483e-03 1.370292e-04 1.990504e-02 1.279738e-03 0.0093
#> T[T>C]C 2.680246e-02 3.030659e-03 3.590766e-02 1.050266e-02 1.099775e-03 0.0543
#> T[T>C]G 2.050188e-02 3.410741e-03 2.780593e-05 1.910484e-02 1.239746e-03 0.0237
#> T[T>C]T 4.610422e-02 2.360513e-03 1.840392e-03 3.710940e-02 5.448885e-04 0.0365
#> T[T>G]A 4.190384e-02 1.150250e-03 2.040435e-04 7.681946e-18 2.849417e-04 0.0007
#> T[T>G]C 1.550142e-02 2.740596e-04 8.251760e-03 7.681946e-18 1.349724e-04 0.0010
#> T[T>G]G 1.940178e-02 2.930637e-03 2.280486e-02 9.172323e-04 7.078551e-04 0.0009
#> T[T>G]T 8.790805e-02 1.740378e-03 1.320282e-03 9.002280e-03 7.238518e-04 0.0010
#> SBS47 SBS48 SBS49 SBS50 SBS51
#> A[C>A]A 6.778787e-02 8.554680e-04 2.511663e-02 1.190003e-01 0.1409639132
#> A[C>A]C 2.969469e-02 8.414603e-04 7.034657e-03 1.270003e-01 0.0016895675
#> A[C>A]G 1.379753e-03 2.581412e-04 7.114710e-03 5.770013e-03 0.0047987715
#> A[C>A]T 1.189787e-02 3.892129e-05 7.975280e-03 8.320019e-02 0.0211945742
#> A[C>G]A 1.029816e-03 1.981084e-04 2.881908e-04 3.850009e-03 0.0039589865
#> A[C>G]C 6.168897e-04 1.140624e-04 1.350894e-04 1.100003e-03 0.0045388381
#> A[C>G]G 3.279413e-04 8.034395e-05 2.041351e-04 8.270019e-04 0.0019694958
#> A[C>G]T 1.719692e-03 6.863755e-04 1.761166e-04 1.970005e-03 0.0008997697
#> A[C>T]A 4.269236e-03 2.871571e-04 5.753809e-04 3.520008e-03 0.0357908375
#> A[C>T]C 9.398319e-04 4.382397e-04 3.032007e-04 1.800004e-03 0.0056485540
#> A[C>T]G 3.049455e-03 1.210662e-03 2.011332e-03 1.390003e-02 0.0056485540
#> A[C>T]T 2.489555e-03 2.351286e-04 4.152749e-04 6.920016e-03 0.0031991810
#> A[T>A]A 1.379753e-01 6.603612e-04 1.290855e-04 5.360012e-03 0.1129710794
#> A[T>A]C 7.158719e-03 2.661456e-04 7.785154e-05 3.940009e-03 0.0013496545
#> A[T>A]G 7.448668e-03 4.652545e-04 2.411596e-04 5.730013e-04 0.0367905816
#> A[T>A]T 6.758791e-02 6.753695e-04 3.542345e-04 2.410006e-03 0.0294924499
#> A[T>C]A 2.829494e-03 1.100602e-03 6.134061e-04 2.630006e-03 0.0025893371
#> A[T>C]C 5.668986e-03 1.891034e-04 8.145392e-05 9.280021e-03 0.0192950605
#> A[T>C]G 2.089626e-03 2.851560e-04 2.001325e-04 1.130003e-03 0.0039489891
#> A[T>C]T 1.299767e-03 1.110608e-03 4.823193e-04 4.920011e-03 0.0018695214
#> A[T>G]A 1.709694e-04 5.172830e-04 1.961298e-04 7.430017e-04 0.0007228150
#> A[T>G]C 1.719692e-03 4.102244e-05 8.285485e-05 6.070014e-04 0.0040889532
#> A[T>G]G 3.679342e-03 3.511921e-04 1.260835e-04 3.940009e-03 0.0277928850
#> A[T>G]T 8.078555e-03 1.991089e-04 1.260835e-04 1.030002e-04 0.0021294549
#> C[C>A]A 2.459560e-02 1.180646e-03 2.291517e-01 2.250005e-02 0.0069782136
#> C[C>A]C 5.269057e-03 3.571954e-05 2.861895e-02 2.890007e-03 0.0031691887
#> C[C>A]G 2.709515e-04 1.370750e-01 5.153412e-01 5.180012e-18 0.0042988995
#> C[C>A]T 6.818780e-04 8.454625e-04 4.903246e-02 1.150003e-03 0.0050687024
#> C[C>G]A 9.558290e-04 9.935435e-05 2.161431e-04 6.560015e-05 0.0028492706
#> C[C>G]C 2.369576e-04 1.220668e-04 2.561696e-04 2.890007e-04 0.0001199693
#> C[C>G]G 6.698802e-04 3.631987e-05 2.381577e-04 1.420003e-03 0.0020294805
#> C[C>G]T 1.369755e-04 2.451341e-04 1.911265e-04 5.120012e-04 0.0026093320
#> C[C>T]A 8.638455e-04 1.820996e-05 4.703113e-04 3.840009e-03 0.0032291733
#> C[C>T]C 4.609176e-03 3.011647e-04 4.933266e-04 4.250010e-03 0.0046987971
#> C[C>T]G 1.519728e-03 1.871024e-05 1.380914e-03 1.080002e-03 0.0206947022
#> C[C>T]T 2.999463e-03 4.792622e-04 5.193438e-04 1.190003e-02 0.0040589609
#> C[T>A]A 1.399750e-02 8.624718e-05 7.414909e-05 1.930004e-04 0.0061084362
#> C[T>A]C 5.708979e-04 1.020558e-04 5.143405e-05 5.350012e-04 0.0014896187
#> C[T>A]G 5.818959e-05 3.101697e-04 2.321537e-04 5.160012e-04 0.0065183313
#> C[T>A]T 7.598641e-05 3.621981e-04 1.060702e-04 2.090005e-04 0.0036190735
#> C[T>C]A 1.909658e-03 1.450794e-04 1.210802e-04 8.390019e-04 0.0041789302
#> C[T>C]C 6.278877e-03 4.502463e-04 1.781179e-04 1.770004e-02 0.0710818031
#> C[T>C]G 3.099446e-03 3.211757e-05 1.080715e-04 2.420006e-03 0.0029292501
#> C[T>C]T 5.449025e-03 6.773705e-05 9.746452e-05 1.380003e-03 0.0066383006
#> C[T>G]A 1.369755e-04 1.340733e-04 1.060702e-04 8.940021e-04 0.0027792885
#> C[T>G]C 5.149079e-05 9.285079e-05 2.671769e-05 6.180014e-05 0.0025593448
#> C[T>G]G 3.669344e-03 1.040569e-04 1.120742e-04 3.660008e-03 0.0059284823
#> C[T>G]T 1.069809e-04 6.573596e-05 9.296154e-05 4.710011e-04 0.0022994114
#> G[C>A]A 1.109801e-02 7.524116e-04 7.885220e-03 1.420003e-02 0.0039389916
#> G[C>A]C 3.479378e-03 3.461894e-04 2.481643e-03 7.580017e-03 0.0032791605
#> G[C>A]G 7.828600e-04 7.394045e-04 6.834524e-03 2.440006e-04 0.0042789046
#> G[C>A]T 1.409748e-03 1.991089e-05 5.843869e-03 2.040005e-03 0.0034491170
#> G[C>G]A 1.679700e-03 7.844291e-05 1.521007e-04 2.670006e-02 0.0034091273
#> G[C>G]C 2.279592e-03 2.171188e-04 1.100729e-04 3.300008e-02 0.0011397082
#> G[C>G]G 4.649168e-04 4.312359e-05 3.672431e-05 2.800006e-03 0.0002669317
#> G[C>G]T 2.219603e-03 6.533574e-05 2.081378e-04 1.430003e-02 0.0028492706
#> G[C>T]A 1.059810e-03 3.451888e-04 1.841219e-04 2.420006e-03 0.0044688560
#> G[C>T]C 1.709694e-03 7.394045e-06 1.180782e-04 1.580004e-03 0.0030892092
#> G[C>T]G 1.719692e-03 3.031658e-04 1.040689e-03 5.500013e-03 0.0042789046
#> G[C>T]T 4.039277e-03 1.100602e-04 3.082040e-04 1.630004e-02 0.0059484772
#> G[T>A]A 1.599714e-02 1.300712e-04 5.043339e-05 7.320017e-04 0.0203947789
#> G[T>A]C 2.279592e-04 1.240679e-04 9.106028e-05 1.050002e-03 0.0038490147
#> G[T>A]G 1.309766e-05 1.430783e-04 1.100729e-04 1.990005e-04 0.0042889020
#> G[T>A]T 3.279413e-06 2.311264e-04 1.310868e-04 7.860018e-04 0.0001459626
#> G[T>C]A 4.169254e-04 1.570859e-04 6.594365e-05 1.380003e-03 0.0011796980
#> G[T>C]C 1.089805e-03 1.290706e-04 1.511000e-04 5.380012e-03 0.0022694190
#> G[T>C]G 3.099446e-03 4.672556e-05 6.534326e-05 3.710009e-03 0.0045588329
#> G[T>C]T 3.189429e-03 1.100602e-04 1.751159e-04 1.170003e-03 0.0040089737
#> G[T>G]A 2.199607e-02 7.644182e-06 6.614379e-05 8.670020e-03 0.0021894395
#> G[T>G]C 1.039814e-02 1.350739e-04 4.372895e-05 9.590022e-03 0.0052986435
#> G[T>G]G 2.719514e-02 6.633629e-05 1.470974e-04 3.510008e-02 0.0761804978
#> G[T>G]T 8.838419e-02 1.150629e-05 1.020676e-04 3.650008e-02 0.0020894651
#> T[C>A]A 1.689698e-02 1.240679e-01 3.292179e-02 1.900004e-02 0.0356908631
#> T[C>A]C 8.108550e-05 3.792074e-03 5.113385e-03 8.860020e-04 0.0028592680
#> T[C>A]G 2.389573e-05 7.093881e-01 4.052683e-02 4.190010e-05 0.0045388381
#> T[C>A]T 1.919657e-04 1.871024e-04 8.755796e-03 1.850004e-03 0.0003699053
#> T[C>G]A 1.379753e-04 1.370750e-04 4.803180e-05 9.320021e-04 0.0020494753
#> T[C>G]C 1.189787e-03 3.501916e-04 1.531014e-04 4.930011e-04 0.0036090761
#> T[C>G]G 0.000000e+00 2.821543e-05 6.334193e-05 1.030002e-04 0.0021594472
#> T[C>G]T 9.238347e-04 1.480810e-04 5.443604e-04 4.210010e-04 0.0033291477
#> T[C>T]A 7.238705e-03 2.141171e-04 1.871239e-04 1.940004e-02 0.0016995649
#> T[C>T]C 3.709336e-02 3.171735e-04 5.823855e-04 1.040002e-01 0.0017695470
#> T[C>T]G 1.939653e-03 4.022200e-04 9.346187e-04 3.970009e-03 0.0064883390
#> T[C>T]T 8.088553e-02 5.853202e-06 3.122067e-04 8.180019e-02 0.0423891484
#> T[T>A]A 1.559721e-01 2.351286e-05 4.202782e-04 1.690004e-03 0.0200948557
#> T[T>A]C 1.229780e-05 7.644182e-06 5.703776e-05 6.640015e-04 0.0025793397
#> T[T>A]G 4.519192e-04 8.324554e-06 7.534988e-05 7.540017e-05 0.0040289686
#> T[T>A]T 4.349222e-03 4.262332e-04 3.312193e-04 2.950007e-03 0.0063783671
#> T[T>C]A 1.369755e-03 6.053311e-04 1.731146e-04 1.090003e-03 0.0044588585
#> T[T>C]C 1.749687e-02 4.042211e-04 8.475611e-05 2.900007e-02 0.0039289942
#> T[T>C]G 1.579717e-03 2.971626e-04 6.314180e-05 1.020002e-03 0.0024693678
#> T[T>C]T 1.149794e-02 5.322912e-04 2.081378e-04 5.110012e-03 0.0212945486
#> T[T>G]A 2.409569e-03 2.501368e-04 1.500994e-04 3.270008e-04 0.0025493474
#> T[T>G]C 2.249598e-05 2.221215e-04 1.380914e-04 6.550015e-04 0.0034691119
#> T[T>G]G 1.539725e-03 3.501916e-04 1.120742e-04 8.720020e-03 0.0027592936
#> T[T>G]T 3.619353e-03 3.201751e-07 3.642411e-04 1.600004e-03 0.0029092552
#> SBS52 SBS53 SBS54 SBS55 SBS56
#> A[C>A]A 0.0151962769 5.383510e-03 2.160358e-03 5.881126e-03 1.259748e-02
#> A[C>A]C 0.0065383981 1.961279e-03 7.961318e-04 2.050393e-03 1.569686e-02
#> A[C>A]G 0.0041389859 3.812485e-02 1.640271e-03 4.490860e-05 2.059588e-04
#> A[C>A]T 0.0092377368 1.711115e-05 4.140685e-04 1.170224e-03 2.299540e-02
#> A[C>G]A 0.0017295763 7.034586e-03 1.550257e-03 2.850546e-03 4.179165e-04
#> A[C>G]C 0.0015196277 5.463562e-03 4.960821e-04 1.680322e-04 1.659668e-04
#> A[C>G]G 0.0008177996 2.511637e-03 1.700281e-03 5.100977e-04 4.279145e-04
#> A[C>G]T 0.0017095812 3.041983e-03 5.180857e-03 1.270243e-03 1.229754e-04
#> A[C>T]A 0.0026893411 7.224710e-03 1.480245e-03 5.110978e-03 7.398521e-03
#> A[C>T]C 0.0020994856 1.961279e-03 5.290876e-04 2.330446e-04 9.818037e-04
#> A[C>T]G 0.0040790006 6.954534e-03 3.430568e-04 5.321019e-03 1.519696e-03
#> A[C>T]T 0.0017595689 1.941266e-03 4.990826e-03 7.761486e-04 2.839432e-03
#> A[T>A]A 0.0017695665 5.893842e-03 9.561582e-04 4.260816e-03 5.048991e-06
#> A[T>A]C 0.0011797110 2.591690e-03 3.190528e-03 6.181183e-04 4.289143e-03
#> A[T>A]G 0.0011897085 2.871872e-03 4.230700e-03 8.101551e-03 5.128975e-04
#> A[T>A]T 0.0011897085 4.633020e-03 3.010498e-04 3.920751e-03 2.899420e-02
#> A[T>C]A 0.0037490815 1.130737e-02 2.920483e-02 4.350833e-03 1.249750e-02
#> A[T>C]C 0.0018795395 3.702414e-03 7.751283e-03 3.360643e-06 6.158769e-03
#> A[T>C]G 0.0026193583 8.255382e-03 2.020334e-01 4.020770e-03 9.548091e-03
#> A[T>C]T 0.0049187949 7.184684e-03 7.831296e-03 1.370262e-02 1.239752e-02
#> A[T>G]A 0.0017295763 4.592994e-03 3.870641e-05 2.620502e-04 1.209758e-04
#> A[T>G]C 0.0005288704 2.901892e-03 1.580262e-03 9.201762e-04 7.988403e-18
#> A[T>G]G 0.0011897085 5.063301e-03 1.150190e-03 1.450278e-01 1.269746e-05
#> A[T>G]T 0.0018595444 2.061344e-03 3.400563e-04 2.280437e-03 5.748851e-03
#> C[C>A]A 0.0573859404 3.342179e-01 6.321046e-05 6.251197e-03 2.479504e-03
#> C[C>A]C 0.0189953461 3.552316e-03 2.570425e-03 3.750718e-03 6.678665e-03
#> C[C>A]G 0.0135966688 6.774416e-02 5.930982e-03 6.411227e-04 6.718657e-18
#> C[C>A]T 0.0187953951 4.923209e-03 5.530915e-03 2.840544e-05 7.128575e-02
#> C[C>G]A 0.0011797110 2.721774e-03 1.130187e-03 2.940563e-03 2.039592e-04
#> C[C>G]C 0.0008347955 6.033934e-03 8.831462e-04 2.860548e-03 2.249550e-04
#> C[C>G]G 0.0005678609 1.621057e-03 4.340718e-04 2.640505e-04 6.658669e-05
#> C[C>G]T 0.0011997061 5.083314e-04 1.330220e-03 3.310634e-03 7.688463e-04
#> C[C>T]A 0.0032691990 1.460952e-02 3.370558e-03 7.251388e-03 2.979404e-04
#> C[C>T]C 0.0018195542 4.603001e-03 2.260374e-04 4.000766e-03 5.308939e-04
#> C[C>T]G 0.0023794170 1.370894e-02 2.830468e-02 6.591262e-05 7.948411e-03
#> C[C>T]T 0.0025693705 1.601044e-02 3.710614e-03 7.191377e-04 5.078985e-04
#> C[T>A]A 0.0012197012 3.692407e-03 7.451233e-18 7.391415e-05 1.189762e-03
#> C[T>A]C 0.0002309434 4.502935e-03 7.321212e-04 1.100211e-06 9.738053e-04
#> C[T>A]G 0.0012296987 3.302153e-03 1.920318e-03 1.600306e-02 1.589682e-03
#> C[T>A]T 0.0008557903 8.615617e-03 6.661102e-05 5.231001e-03 6.088783e-06
#> C[T>C]A 0.0023894146 1.010659e-02 1.140189e-02 4.180800e-03 3.369326e-03
#> C[T>C]C 0.0013096791 4.072655e-03 1.700281e-02 4.980954e-03 2.639472e-03
#> C[T>C]G 0.0012296987 8.495538e-03 1.930319e-01 9.491817e-04 4.809039e-04
#> C[T>C]T 0.0023394268 5.423536e-03 2.690445e-02 6.841310e-04 2.059588e-04
#> C[T>G]A 0.0008028033 1.490972e-03 4.360722e-03 1.650316e-03 5.818837e-03
#> C[T>G]C 0.0007748102 4.242766e-03 1.890313e-02 4.660892e-04 3.929215e-07
#> C[T>G]G 0.0007958050 2.981944e-03 2.210366e-02 1.130216e-01 4.449111e-03
#> C[T>G]T 0.0008627886 2.721774e-03 8.861467e-04 1.180226e-03 6.778645e-18
#> G[C>A]A 0.0082379817 4.322818e-04 5.190859e-03 8.551637e-04 2.169566e-04
#> G[C>A]C 0.0073182070 3.442244e-03 9.131511e-03 1.920368e-04 7.338533e-03
#> G[C>A]G 0.0040390104 5.083314e-02 5.640934e-03 7.721478e-05 9.788043e-06
#> G[C>A]T 0.0042089688 1.140744e-03 6.731114e-03 7.381413e-04 1.569686e-02
#> G[C>G]A 0.0013796620 1.380900e-03 2.190363e-03 8.511629e-04 1.869626e-04
#> G[C>G]C 0.0014496448 8.475525e-02 2.200364e-04 1.410270e-03 9.828035e-05
#> G[C>G]G 0.0010097526 3.001957e-03 1.590263e-03 5.721095e-03 5.618877e-06
#> G[C>G]T 0.0010197502 5.733738e-04 4.940818e-03 6.821306e-05 1.749650e-06
#> G[C>T]A 0.0017795640 9.185988e-03 2.220367e-04 6.501245e-03 9.488103e-06
#> G[C>T]C 0.0012197012 1.190776e-02 1.310217e-02 1.510289e-03 5.058989e-04
#> G[C>T]G 0.0028293068 5.993907e-03 1.910316e-02 1.190228e-02 2.059588e-03
#> G[C>T]T 0.0010197502 3.102022e-03 2.480411e-04 5.291013e-03 8.298341e-04
#> G[T>A]A 0.0005238717 4.452903e-03 2.330386e-03 2.430465e-03 4.199161e-04
#> G[T>A]C 0.0003989023 2.701761e-03 8.991488e-03 1.850354e-04 2.369526e-03
#> G[T>A]G 0.0012896840 3.962583e-03 2.640437e-03 1.250239e-02 4.359129e-04
#> G[T>A]T 0.0008108014 3.112029e-03 1.850306e-03 5.120980e-03 5.368927e-03
#> G[T>C]A 0.0024194072 5.613660e-03 1.140189e-02 2.610500e-03 7.298541e-04
#> G[T>C]C 0.0020494979 6.684358e-03 4.430733e-03 3.170607e-03 2.729454e-05
#> G[T>C]G 0.0009137761 2.561670e-03 1.210200e-01 6.011151e-03 1.649670e-03
#> G[T>C]T 0.0031092382 6.994560e-03 5.410896e-03 1.260241e-02 2.579484e-03
#> G[T>G]A 0.0011297232 4.382857e-03 1.700281e-04 5.671086e-03 6.718657e-18
#> G[T>G]C 0.0005608626 1.741135e-03 1.530253e-03 3.200613e-03 9.188163e-07
#> G[T>G]G 0.0013696644 4.733085e-03 7.451233e-18 2.990573e-01 6.718657e-18
#> G[T>G]T 0.0008637884 2.031324e-03 1.210200e-05 1.440276e-03 1.139772e-04
#> T[C>A]A 0.4638863478 2.671742e-03 6.691107e-04 1.740333e-03 2.189562e-01
#> T[C>A]C 0.0467885368 3.642374e-03 4.050670e-05 8.281585e-18 1.319736e-02
#> T[C>A]G 0.1339671780 4.472916e-04 8.281371e-04 9.911898e-05 5.458909e-03
#> T[C>A]T 0.0609850587 8.715682e-04 7.201192e-03 4.060777e-03 4.019197e-01
#> T[C>G]A 0.0019795150 3.742440e-03 4.690776e-03 7.061352e-03 1.129774e-03
#> T[C>G]C 0.0014396473 4.993255e-03 5.170856e-04 3.280628e-03 2.939412e-04
#> T[C>G]G 0.0005808577 1.871220e-03 1.230204e-03 2.290438e-04 8.388323e-05
#> T[C>G]T 0.0024194072 3.742440e-03 3.110515e-04 2.110404e-03 4.109179e-04
#> T[C>T]A 0.0014696399 5.733738e-03 7.451233e-18 5.821114e-11 1.999600e-04
#> T[C>T]C 0.0015296252 5.773764e-03 6.611094e-04 4.110787e-03 1.839632e-04
#> T[C>T]G 0.0021894636 1.020665e-02 1.190197e-13 4.810921e-03 1.539692e-04
#> T[C>T]T 0.0016495958 7.715029e-03 2.360391e-04 3.140601e-02 8.198361e-05
#> T[T>A]A 0.0010497428 3.102022e-03 1.550257e-03 3.610691e-03 9.418117e-03
#> T[T>A]C 0.0004688851 3.562322e-03 1.790296e-04 6.951331e-05 8.048391e-04
#> T[T>A]G 0.0007778094 1.601044e-03 3.290545e-04 9.481815e-03 6.358729e-03
#> T[T>A]T 0.0013396718 5.083314e-03 7.451233e-18 2.100402e-03 7.438513e-04
#> T[T>C]A 0.0027693215 7.114638e-03 4.730783e-03 4.880934e-03 5.678865e-04
#> T[T>C]C 0.0021794660 5.033281e-03 8.191356e-03 9.801876e-04 1.319736e-03
#> T[T>C]G 0.0010697379 4.723079e-03 8.841463e-02 4.160797e-03 1.849630e-03
#> T[T>C]T 0.0019995101 2.191429e-03 1.250207e-02 8.871698e-04 2.849430e-04
#> T[T>G]A 0.0014296497 1.300848e-03 3.240536e-05 6.061160e-03 9.458109e-03
#> T[T>G]C 0.0011197257 4.362844e-03 7.061169e-04 5.651082e-03 9.998001e-07
#> T[T>G]G 0.0014796375 6.154012e-03 7.691273e-03 7.951522e-02 1.009798e-04
#> T[T>G]T 0.0025293803 7.054599e-03 4.990826e-04 4.120789e-02 2.899420e-02
#> SBS57 SBS58 SBS59 SBS60 SBS84
#> A[C>A]A 1.230633e-02 5.887462e-02 3.588208e-03 6.152707e-03 3.471995e-03
#> A[C>A]C 1.430735e-03 6.747091e-03 2.368817e-03 7.793428e-04 5.007309e-03
#> A[C>A]G 3.331713e-03 8.246445e-04 1.419291e-04 2.230981e-16 4.526420e-04
#> A[C>A]T 8.644443e-03 5.577595e-03 1.449276e-02 4.441954e-04 9.295947e-03
#> A[C>G]A 1.540792e-02 2.059112e-02 2.938533e-03 3.771659e-04 6.758076e-03
#> A[C>G]C 3.131610e-03 1.739250e-03 2.438782e-03 5.882588e-04 1.081196e-02
#> A[C>G]G 2.771425e-03 1.689272e-03 8.295857e-04 2.761215e-04 4.600000e-05
#> A[C>G]T 5.072607e-03 2.029125e-03 3.828088e-03 2.501100e-04 2.959421e-02
#> A[C>T]A 3.261677e-02 8.046531e-02 3.918044e-03 2.761215e-03 5.388576e-02
#> A[C>T]C 1.290663e-02 6.757087e-03 2.858573e-03 1.340590e-03 4.210683e-02
#> A[C>T]G 1.760905e-02 8.626281e-03 2.558722e-03 4.211853e-03 2.540673e-03
#> A[C>T]T 1.540792e-02 7.306850e-03 3.388308e-03 2.981311e-04 5.434587e-02
#> A[T>A]A 3.281687e-03 2.448944e-02 1.999002e-03 3.971747e-03 1.562339e-03
#> A[T>A]C 6.433307e-03 1.459371e-03 2.498752e-03 2.230981e-04 3.974610e-04
#> A[T>A]G 5.802983e-03 4.687979e-03 2.188907e-03 3.521549e-04 7.079999e-05
#> A[T>A]T 6.313245e-03 8.766221e-03 2.798603e-03 7.283204e-04 1.065283e-02
#> A[T>C]A 2.661368e-02 8.046531e-02 9.945034e-03 1.290568e-03 0.000000e+00
#> A[T>C]C 9.664968e-03 4.927876e-03 2.608697e-03 2.771219e-04 3.231330e-04
#> A[T>C]G 1.030530e-02 6.747091e-03 3.518243e-03 3.521549e-06 1.150000e-05
#> A[T>C]T 1.790921e-02 8.156484e-03 1.079461e-02 3.631598e-05 9.382159e-03
#> A[T>G]A 7.063631e-03 1.349418e-02 1.789107e-03 2.501100e-02 1.271380e-04
#> A[T>G]C 7.894058e-04 7.876604e-04 1.559221e-03 1.050462e-02 1.270956e-03
#> A[T>G]G 1.230633e-03 2.708832e-03 1.699152e-03 2.611149e-02 9.526989e-04
#> A[T>G]T 5.973070e-03 2.079104e-03 3.438283e-03 1.640722e-02 1.764976e-03
#> C[C>A]A 8.704474e-03 6.177337e-03 2.228887e-03 1.180519e-03 0.000000e+00
#> C[C>A]C 3.942026e-03 1.829211e-03 5.927040e-03 2.531113e-04 5.218572e-03
#> C[C>A]G 1.070550e-03 1.459371e-03 8.145932e-04 3.791668e-04 6.919999e-05
#> C[C>A]T 8.214222e-03 1.959155e-03 2.018992e-03 5.412381e-05 5.640381e-03
#> C[C>G]A 8.884567e-04 7.936579e-04 2.078962e-03 4.712073e-05 7.119999e-06
#> C[C>G]C 2.871476e-03 1.279448e-03 1.729137e-03 1.420625e-04 3.440786e-03
#> C[C>G]G 7.633924e-04 5.107798e-05 6.896556e-04 3.371483e-04 2.200000e-06
#> C[C>G]T 2.871476e-03 1.249461e-03 3.458273e-03 1.460643e-04 1.330825e-02
#> C[C>T]A 1.490766e-02 8.086514e-03 2.868568e-03 1.520669e-03 1.802813e-02
#> C[C>T]C 1.210622e-02 9.915725e-03 4.087959e-04 1.880827e-03 4.062130e-02
#> C[C>T]G 6.403291e-03 7.986557e-03 1.099451e-03 4.061787e-03 0.000000e+00
#> C[C>T]T 3.201646e-02 2.768806e-02 2.418792e-03 2.511105e-03 4.223729e-02
#> C[T>A]A 6.393286e-03 2.478931e-03 7.026491e-05 6.642922e-05 1.365500e-04
#> C[T>A]C 6.593389e-03 2.229039e-02 1.639181e-03 5.142262e-04 0.000000e+00
#> C[T>A]G 1.290663e-03 8.576303e-04 1.389306e-04 3.811677e-07 1.251760e-04
#> C[T>A]T 1.070550e-02 1.299440e-03 3.708148e-03 1.320581e-04 0.000000e+00
#> C[T>C]A 1.200617e-02 3.918311e-03 2.198902e-03 8.793868e-04 2.269666e-03
#> C[T>C]C 4.562345e-03 9.495906e-03 5.727140e-03 2.791228e-03 3.250000e-06
#> C[T>C]G 8.304268e-03 5.927445e-03 1.639181e-03 5.802553e-04 3.628315e-03
#> C[T>C]T 2.431250e-02 2.818785e-02 1.219391e-02 2.100924e-03 9.185819e-04
#> C[T>G]A 1.400720e-04 5.027833e-04 1.009496e-03 3.231421e-03 8.971929e-04
#> C[T>G]C 8.474356e-04 1.039552e-03 2.618692e-03 4.161831e-03 2.148873e-03
#> C[T>G]G 2.191126e-03 6.986988e-04 2.018992e-03 7.113129e-03 7.886709e-04
#> C[T>G]T 5.162654e-03 4.727962e-04 2.118942e-02 1.800792e-05 0.000000e+00
#> G[C>A]A 1.890972e-03 2.738819e-03 1.029486e-01 5.172275e-04 2.703472e-03
#> G[C>A]C 7.523867e-04 1.079535e-03 1.289356e-01 8.663811e-04 1.022886e-02
#> G[C>A]G 6.573379e-18 2.728824e-03 1.209396e-02 3.901716e-04 7.636009e-04
#> G[C>A]T 1.951003e-03 3.498492e-04 4.987509e-01 1.330585e-04 1.017917e-02
#> G[C>G]A 3.791949e-03 2.119086e-03 1.439281e-03 1.630717e-04 1.115106e-02
#> G[C>G]C 2.571322e-03 1.489358e-03 1.719142e-03 1.350594e-04 1.575834e-02
#> G[C>G]G 1.860957e-03 1.709263e-03 3.588208e-04 2.020889e-04 1.697967e-03
#> G[C>G]T 4.362242e-04 1.079535e-03 2.258872e-03 6.432830e-05 7.605756e-02
#> G[C>T]A 5.142643e-03 6.777078e-03 2.438782e-03 1.240546e-03 8.917755e-02
#> G[C>T]C 6.933564e-03 3.148643e-03 2.348827e-03 1.440634e-03 1.116295e-01
#> G[C>T]G 8.444340e-03 7.356828e-03 3.238383e-18 3.361479e-03 9.223924e-03
#> G[C>T]T 6.183178e-03 5.027833e-03 2.958523e-03 8.943934e-04 1.804404e-01
#> G[T>A]A 3.331713e-03 2.069108e-03 2.548727e-04 1.090480e-04 1.098639e-03
#> G[T>A]C 5.973070e-04 6.257302e-04 1.979012e-03 1.100484e-04 6.560000e-05
#> G[T>A]G 2.461265e-03 2.039121e-02 5.047480e-04 3.601584e-04 3.373810e-04
#> G[T>A]T 7.934078e-03 2.768806e-03 1.509246e-03 6.372803e-04 1.357570e-04
#> G[T>C]A 3.861985e-03 2.179061e-03 7.096456e-04 7.613349e-04 0.000000e+00
#> G[T>C]C 2.291178e-03 7.796639e-04 3.178413e-03 6.352795e-04 8.659449e-04
#> G[T>C]G 4.722427e-03 1.109522e-02 9.855079e-04 5.002200e-04 1.979070e-04
#> G[T>C]T 5.362756e-03 2.019130e-03 1.189406e-03 6.963063e-04 3.662473e-03
#> G[T>G]A 1.400720e-03 8.066523e-03 1.229386e-03 2.821241e-02 1.890000e-05
#> G[T>G]C 1.710879e-04 2.688841e-03 1.649176e-03 2.881267e-02 1.229436e-03
#> G[T>G]G 8.614428e-04 2.338992e-02 2.288857e-03 6.622913e-01 2.127510e-04
#> G[T>G]T 2.831455e-03 1.689272e-02 7.446282e-03 4.742086e-02 1.340079e-03
#> T[C>A]A 1.430735e-02 7.366824e-03 2.368817e-05 2.020889e-03 2.083564e-03
#> T[C>A]C 7.093646e-04 4.288151e-04 2.018992e-02 1.630717e-04 9.059999e-06
#> T[C>A]G 2.231147e-04 2.728824e-03 6.336836e-04 2.050902e-04 0.000000e+00
#> T[C>A]T 6.193183e-03 1.469367e-02 3.828088e-03 4.061787e-04 1.203779e-03
#> T[C>G]A 2.281173e-03 2.129082e-03 2.348827e-06 5.292328e-04 0.000000e+00
#> T[C>G]C 2.801440e-03 1.799224e-03 2.088957e-03 3.481532e-04 1.139430e-04
#> T[C>G]G 1.330684e-03 6.297285e-04 4.047979e-04 6.592900e-05 7.209999e-07
#> T[C>G]T 1.290663e-02 1.809220e-02 1.519241e-03 7.613349e-04 4.953383e-03
#> T[C>T]A 8.144186e-03 4.288151e-03 1.609196e-04 4.071791e-05 7.079999e-05
#> T[C>T]C 1.730890e-02 1.529341e-02 2.798603e-04 9.584216e-04 2.690933e-02
#> T[C>T]G 4.602366e-03 3.338561e-03 4.537734e-18 1.730761e-03 6.919999e-06
#> T[C>T]T 3.721913e-02 1.789229e-01 2.088957e-03 3.911721e-03 1.683967e-02
#> T[T>A]A 3.021553e-03 1.189487e-02 2.088957e-03 1.130497e-03 6.569907e-03
#> T[T>A]C 9.234747e-03 8.976130e-04 1.859072e-03 2.230981e-16 8.645069e-04
#> T[T>A]G 4.402263e-03 8.286428e-04 4.527739e-04 4.241866e-05 7.840319e-04
#> T[T>A]T 2.891486e-02 1.459371e-02 2.988508e-03 5.302332e-04 7.059955e-03
#> T[T>C]A 4.902520e-03 3.308574e-03 2.048977e-03 2.401056e-04 4.329390e-04
#> T[T>C]C 2.671373e-02 1.959155e-02 2.238882e-03 1.090480e-03 5.384650e-04
#> T[T>C]G 2.961522e-03 2.159069e-03 1.349326e-03 1.090480e-04 2.240000e-05
#> T[T>C]T 1.951003e-01 3.198621e-02 2.608697e-03 1.320581e-03 9.820763e-03
#> T[T>G]A 3.221656e-03 7.976561e-04 1.599201e-03 1.610709e-03 1.875698e-03
#> T[T>G]C 3.962036e-03 1.589315e-03 2.328837e-03 1.060466e-02 7.379169e-04
#> T[T>G]G 5.402777e-03 6.737096e-03 1.959022e-03 2.391052e-02 0.000000e+00
#> T[T>G]T 1.190612e-01 2.169065e-02 1.299351e-17 3.181399e-02 6.603134e-03
#> SBS85 SBS86 SBS87 SBS88 SBS89
#> A[C>A]A 6.080257e-03 2.954301e-03 8.972551e-03 0.000000000 0.032168854
#> A[C>A]C 8.799370e-04 3.774501e-03 4.572575e-03 0.000000000 0.017693728
#> A[C>A]G 3.060110e-04 3.854901e-04 6.208566e-03 0.000000000 0.009670834
#> A[C>A]T 2.717279e-03 3.624001e-03 4.957473e-03 0.001731102 0.020743819
#> A[C>G]A 7.234927e-03 5.251601e-02 7.866457e-03 0.000000000 0.014817169
#> A[C>G]C 2.551355e-03 7.832102e-02 3.933979e-03 0.004039238 0.005883213
#> A[C>G]G 4.221970e-04 4.965301e-03 3.066183e-02 0.000000000 0.006050562
#> A[C>G]T 1.301976e-02 9.208202e-02 9.720347e-03 0.004039238 0.010900686
#> A[C>T]A 1.374781e-03 8.724302e-03 9.425049e-03 0.010386613 0.049898108
#> A[C>T]C 1.478442e-03 2.049500e-03 3.555581e-03 0.000000000 0.013521816
#> A[C>T]G 4.437760e-04 2.409101e-02 1.217193e-01 0.012694749 0.006105628
#> A[C>T]T 4.563583e-03 4.575101e-03 1.070194e-02 0.000000000 0.029636527
#> A[T>A]A 1.118587e-01 1.847700e-03 9.897046e-03 0.047893826 0.011516257
#> A[T>A]C 1.305125e-02 3.799901e-03 6.945262e-04 0.023658396 0.003067675
#> A[T>A]G 2.110726e-02 1.994100e-03 3.843379e-03 0.000577034 0.010670567
#> A[T>A]T 7.028841e-02 7.258402e-03 4.206177e-03 0.042700519 0.004448487
#> A[T>C]A 2.956702e-02 3.610801e-03 9.215050e-03 0.111367571 0.015782305
#> A[T>C]C 2.041049e-02 2.064400e-03 3.118983e-03 0.045585690 0.003453395
#> A[T>C]G 5.070940e-03 3.521801e-03 9.732147e-04 0.006347374 0.014690391
#> A[T>C]T 5.923408e-02 4.468701e-03 5.575570e-03 0.169648010 0.011812088
#> A[T>G]A 2.383822e-02 4.781101e-03 7.955057e-03 0.008078477 0.005237820
#> A[T>G]C 3.434920e-03 7.310002e-05 6.734163e-04 0.005193306 0.001300242
#> A[T>G]G 4.485501e-03 1.722000e-03 2.687785e-03 0.002308136 0.005110413
#> A[T>G]T 3.178596e-03 1.128500e-03 2.173988e-03 0.007501443 0.003994217
#> C[C>A]A 4.264235e-03 6.116101e-03 8.557454e-03 0.000000000 0.024671469
#> C[C>A]C 3.062350e-04 3.151701e-03 6.040367e-03 0.000000000 0.014514463
#> C[C>A]G 1.572570e-04 5.541201e-04 2.000689e-02 0.000000000 0.003289875
#> C[C>A]T 8.608510e-04 3.314601e-03 4.885573e-03 0.000000000 0.016733698
#> C[C>G]A 1.223945e-03 2.121801e-02 6.765663e-03 0.004616272 0.015425429
#> C[C>G]C 2.101790e-04 5.911701e-02 3.339182e-03 0.001154068 0.010618496
#> C[C>G]G 4.020000e-05 3.156001e-03 8.598453e-02 0.000000000 0.004169842
#> C[C>G]T 4.840840e-04 4.023301e-02 9.610648e-03 0.002885170 0.015833619
#> C[C>T]A 1.636999e-03 3.542601e-03 8.383154e-03 0.000000000 0.009444215
#> C[C>T]C 3.693730e-04 4.840501e-03 8.045256e-03 0.000000000 0.011558976
#> C[C>T]G 2.410000e-05 5.914801e-03 1.868990e-01 0.000000000 0.002333820
#> C[C>T]T 2.350306e-03 2.358401e-03 6.962062e-03 0.004039238 0.012886270
#> C[T>A]A 9.896320e-03 2.118001e-03 8.352155e-03 0.000000000 0.031552860
#> C[T>A]C 1.136017e-03 5.079901e-04 4.910873e-03 0.003462204 0.017709755
#> C[T>A]G 1.785830e-04 2.623201e-03 2.767285e-03 0.000000000 0.036874595
#> C[T>A]T 1.055116e-02 3.334101e-03 1.019194e-02 0.000000000 0.019947678
#> C[T>C]A 7.184034e-03 1.284000e-03 5.121972e-03 0.000000000 0.004889623
#> C[T>C]C 6.209066e-03 2.951901e-03 1.833990e-03 0.001731102 0.004215919
#> C[T>C]G 8.399520e-04 5.578101e-04 8.360955e-04 0.000000000 0.008097547
#> C[T>C]T 1.691314e-02 1.792600e-03 8.857152e-03 0.000000000 0.004313727
#> C[T>G]A 3.736475e-03 4.071701e-03 8.515354e-03 0.000000000 0.006903017
#> C[T>G]C 2.478170e-03 1.640900e-04 1.083894e-03 0.002308136 0.003219819
#> C[T>G]G 1.120299e-03 1.768900e-03 1.958989e-03 0.002308136 0.009030111
#> C[T>G]T 1.756870e-03 2.421301e-03 3.082183e-03 0.000000000 0.004179842
#> G[C>A]A 1.439703e-03 4.842501e-03 7.102761e-03 0.008655511 0.006781995
#> G[C>A]C 5.042680e-04 3.629101e-03 4.665975e-03 0.000000000 0.006025706
#> G[C>A]G 3.622830e-04 2.230401e-04 8.287855e-03 0.000577034 0.001679936
#> G[C>A]T 7.629470e-04 8.370602e-03 1.067494e-03 0.003462204 0.007237208
#> G[C>G]A 1.595924e-03 5.558801e-03 2.617586e-03 0.000000000 0.006521988
#> G[C>G]C 5.060362e-03 1.093400e-01 1.198293e-03 0.001731102 0.004590414
#> G[C>G]G 2.680000e-05 7.638002e-04 5.455470e-03 0.000577034 0.002079921
#> G[C>G]T 3.186104e-03 1.245400e-02 4.499176e-03 0.006924409 0.005716567
#> G[C>T]A 8.870330e-04 4.533601e-03 1.881690e-03 0.000577034 0.006853693
#> G[C>T]C 4.843660e-04 3.374301e-03 2.618086e-03 0.000000000 0.008529260
#> G[C>T]G 1.164240e-04 7.972002e-03 1.770890e-02 0.006347374 0.001879929
#> G[C>T]T 4.167105e-03 7.136002e-03 1.446392e-03 0.003462204 0.009225851
#> G[T>A]A 1.723923e-02 1.259200e-03 9.401649e-03 0.000000000 0.005810454
#> G[T>A]C 1.005109e-03 3.565001e-04 3.398982e-03 0.005193306 0.002521202
#> G[T>A]G 3.520166e-03 3.061901e-03 6.810563e-03 0.002885170 0.009132422
#> G[T>A]T 1.165850e-02 2.640301e-03 6.955462e-03 0.015002885 0.003874896
#> G[T>C]A 2.159071e-02 4.448301e-03 3.009584e-03 0.000000000 0.005049809
#> G[T>C]C 1.160614e-02 6.860402e-03 3.894779e-03 0.003462204 0.001644875
#> G[T>C]G 6.462688e-03 2.680701e-03 3.961778e-03 0.000577034 0.007259725
#> G[T>C]T 5.408900e-02 8.549902e-03 6.540964e-03 0.013271783 0.004059270
#> G[T>G]A 7.699624e-03 1.395400e-03 3.527981e-03 0.000000000 0.012761223
#> G[T>G]C 8.000680e-04 6.872402e-04 1.238693e-03 0.001731102 0.001270164
#> G[T>G]G 1.946514e-03 4.544801e-04 3.236482e-03 0.002885170 0.048482879
#> G[T>G]T 2.927906e-03 2.207901e-03 2.460587e-03 0.013271783 0.003769857
#> T[C>A]A 1.944387e-03 8.561702e-03 4.005478e-03 0.000000000 0.015740016
#> T[C>A]C 1.694280e-04 3.948601e-03 4.178977e-03 0.002308136 0.016784775
#> T[C>A]G 3.990000e-09 1.077500e-03 3.172283e-03 0.000577034 0.001949926
#> T[C>A]T 2.057492e-03 9.082702e-03 4.133778e-03 0.010386613 0.018713928
#> T[C>G]A 9.479950e-04 4.222501e-02 6.395365e-04 0.000000000 0.022471653
#> T[C>G]C 1.869405e-03 4.738701e-02 2.841185e-03 0.000000000 0.016591053
#> T[C>G]G 1.699970e-04 4.635901e-03 2.611686e-02 0.000577034 0.003639862
#> T[C>G]T 6.244143e-03 1.108400e-01 1.263093e-02 0.004039238 0.026080078
#> T[C>T]A 3.823611e-03 8.589702e-03 8.719953e-06 0.000000000 0.009469641
#> T[C>T]C 2.998121e-03 8.121902e-03 6.175266e-03 0.000000000 0.010544089
#> T[C>T]G 1.579590e-04 1.369100e-02 5.955568e-02 0.009232545 0.002440703
#> T[C>T]T 3.865089e-02 1.298500e-02 1.094794e-02 0.000000000 0.009482236
#> T[T>A]A 6.017990e-02 3.922301e-03 8.279655e-03 0.021350260 0.007089731
#> T[T>A]C 7.794895e-03 1.712300e-03 3.722580e-03 0.000000000 0.003164710
#> T[T>A]G 6.733400e-03 1.392500e-03 4.866274e-03 0.004039238 0.010062615
#> T[T>A]T 6.279828e-02 2.365301e-03 5.260771e-03 0.074437392 0.006350550
#> T[T>C]A 1.296355e-02 1.533900e-03 9.768947e-03 0.004039238 0.007517012
#> T[T>C]C 2.332445e-02 1.995000e-03 7.158861e-03 0.002308136 0.002556836
#> T[T>C]G 3.823535e-03 1.845900e-03 1.711291e-03 0.000000000 0.008690558
#> T[T>C]T 9.405438e-02 3.439301e-03 6.587764e-03 0.096364686 0.006789743
#> T[T>G]A 7.106411e-03 7.135502e-03 8.204455e-03 0.030582804 0.006865512
#> T[T>G]C 6.404454e-03 2.368501e-03 2.497286e-03 0.020773226 0.002929014
#> T[T>G]G 3.410000e-03 2.010700e-03 1.995989e-03 0.000000000 0.005037266
#> T[T>G]T 1.270876e-02 4.887201e-03 6.250766e-03 0.102135026 0.005689784
#> SBS90
#> A[C>A]A 2.201650e-03
#> A[C>A]C 7.082226e-04
#> A[C>A]G 1.385656e-04
#> A[C>A]T 1.755161e-03
#> A[C>G]A 5.080734e-04
#> A[C>G]C 2.771303e-04
#> A[C>G]G 4.620121e-05
#> A[C>G]T 9.237693e-04
#> A[C>T]A 7.080186e-04
#> A[C>T]C 2.925267e-04
#> A[C>T]G 9.240243e-05
#> A[C>T]T 6.466380e-04
#> A[T>A]A 6.135367e-02
#> A[T>A]C 3.541113e-04
#> A[T>A]G 3.541113e-04
#> A[T>A]T 2.346374e-02
#> A[T>C]A 5.711972e-03
#> A[T>C]C 1.847539e-04
#> A[T>C]G 1.077728e-04
#> A[T>C]T 2.863684e-03
#> A[T>G]A 5.434842e-03
#> A[T>G]C 4.620121e-05
#> A[T>G]G 2.309421e-04
#> A[T>G]T 2.047688e-03
#> C[C>A]A 1.185504e-03
#> C[C>A]C 4.464887e-04
#> C[C>A]G 2.160057e-04
#> C[C>A]T 1.016146e-03
#> C[C>G]A 3.387149e-04
#> C[C>G]C 7.700202e-05
#> C[C>G]G 1.540040e-05
#> C[C>G]T 2.925267e-04
#> C[C>T]A 6.158462e-04
#> C[C>T]C 3.079231e-04
#> C[C>T]G 2.001503e-04
#> C[C>T]T 3.695077e-04
#> C[T>A]A 1.020611e-01
#> C[T>A]C 3.541113e-04
#> C[T>A]G 3.695077e-04
#> C[T>A]T 1.005215e-01
#> C[T>C]A 4.772807e-03
#> C[T>C]C 2.155457e-04
#> C[T>C]G 2.001503e-04
#> C[T>C]T 6.358611e-03
#> C[T>G]A 8.945164e-03
#> C[T>G]C 4.620121e-05
#> C[T>G]G 1.231692e-04
#> C[T>G]T 9.700255e-03
#> G[C>A]A 9.699575e-04
#> G[C>A]C 4.156959e-04
#> G[C>A]G 1.230032e-04
#> G[C>A]T 4.002995e-04
#> G[C>G]A 4.310923e-04
#> G[C>G]C 2.925267e-04
#> G[C>G]G 4.620121e-05
#> G[C>G]T 2.617349e-04
#> G[C>T]A 4.464887e-04
#> G[C>T]C 3.233195e-04
#> G[C>T]G 1.690044e-04
#> G[C>T]T 5.080734e-04
#> G[T>A]A 3.896766e-02
#> G[T>A]C 1.693575e-04
#> G[T>A]G 1.539610e-04
#> G[T>A]T 1.662785e-02
#> G[T>C]A 3.280086e-03
#> G[T>C]C 9.240243e-05
#> G[T>C]G 7.700202e-05
#> G[T>C]T 1.324069e-03
#> G[T>G]A 6.358611e-03
#> G[T>G]C 4.620121e-05
#> G[T>G]G 2.309421e-04
#> G[T>G]T 2.880076e-03
#> T[C>A]A 2.016896e-03
#> T[C>A]C 7.852036e-04
#> T[C>A]G 7.700202e-05
#> T[C>A]T 1.447238e-03
#> T[C>G]A 6.466380e-04
#> T[C>G]C 3.233195e-04
#> T[C>G]G 6.160162e-05
#> T[C>G]T 1.431843e-03
#> T[C>T]A 2.110055e-03
#> T[C>T]C 9.853539e-04
#> T[C>T]G 2.925267e-04
#> T[C>T]T 2.771308e-03
#> T[T>A]A 3.570094e-01
#> T[T>A]C 8.775811e-04
#> T[T>A]G 6.004498e-04
#> T[T>A]T 1.626757e-01
#> T[T>C]A 1.011527e-02
#> T[T>C]C 4.464887e-04
#> T[T>C]G 1.385656e-04
#> T[T>C]T 4.000105e-03
#> T[T>G]A 1.858316e-02
#> T[T>G]C 1.847539e-04
#> T[T>G]G 2.925267e-04
#> T[T>G]T 8.330219e-03
#>
#> $aetiology
#> aetiology
#> SBS1 Spontaneous deamination of 5-methylcytosine (clock-like signature)
#> SBS2 Activity of APOBEC family of cytidine deaminases
#> SBS3 Defective homologous recombination DNA damage repair
#> SBS4 Tobacco smoking
#> SBS5 Unknown (clock-like signature)
#> SBS6 Defective DNA mismatch repair
#> SBS7a Ultraviolet light exposure
#> SBS7b Ultraviolet light exposure
#> SBS7c Ultraviolet light exposure
#> SBS7d Ultraviolet light exposure
#> SBS8 Unknown
#> SBS9 Polimerase eta somatic hypermutation activity
#> SBS10a Polymerase epsilon exonuclease domain mutations
#> SBS10b Polymerase epsilon exonuclease domain mutations
#> SBS11 Temozolomide treatment
#> SBS12 Unknown
#> SBS13 Activity of APOBEC family of cytidine deaminases
#> SBS14 Concurrent polymerase epsilon mutation and defective DNA mismatch repair
#> SBS15 Defective DNA mismatch repair
#> SBS16 Unknown
#> SBS17a Unknown
#> SBS17b Unknown
#> SBS18 Damage by reactive oxygen species
#> SBS19 Unknown
#> SBS20 Concurrent POLD1 mutations and defective DNA mismatch repair
#> SBS21 Defective DNA mismatch repair
#> SBS22 Aristolochic acid exposure
#> SBS23 Unknown
#> SBS24 Aflatoxin exposure
#> SBS25 Chemotherapy treatment
#> SBS26 Defective DNA mismatch repair
#> SBS27 Possible sequencing artefact
#> SBS28 Unknown
#> SBS29 Tobacco chewing
#> SBS30 Defective DNA base excision repair due to NTHL1 mutations
#> SBS31 Platinum chemotherapy treatment
#> SBS32 Azathioprine treatment
#> SBS33 Unknown
#> SBS34 Unknown
#> SBS35 Platinum chemotherapy treatment
#> SBS36 Defective DNA base excision repair due to MUTYH mutations
#> SBS37 Unknown
#> SBS38 Indirect effect of ultraviolet light
#> SBS39 Unknown
#> SBS40 Unknown
#> SBS41 Unknown
#> SBS42 Haloalkane exposure
#> SBS43 Possible sequencing artefact
#> SBS44 Defective DNA mismatch repair
#> SBS45 Possible sequencing artefact
#> SBS46 Possible sequencing artefact
#> SBS47 Possible sequencing artefact
#> SBS48 Possible sequencing artefact
#> SBS49 Possible sequencing artefact
#> SBS50 Possible sequencing artefact
#> SBS51 Possible sequencing artefact
#> SBS52 Possible sequencing artefact
#> SBS53 Possible sequencing artefact
#> SBS54 Possible sequencing artefact
#> SBS55 Possible sequencing artefact
#> SBS56 Possible sequencing artefact
#> SBS57 Possible sequencing artefact
#> SBS58 Possible sequencing artefact
#> SBS59 Possible sequencing artefact
#> SBS60 Possible sequencing artefact
#> SBS84 Activity of activation-induced cytidine deaminase (AID)
#> SBS85 Indirect effects of activation-induced cytidine deaminase (AID)
#> SBS86 Unknown chemotherapy treatment
#> SBS87 Thiopurine chemotherapy treatment
#> SBS88 Colibactin exposure (E.coli bacteria carrying pks pathogenicity island)
#> SBS89 Unknown
#> SBS90 Duocarmycin exposure
#>
#> $date
#> [1] "2020/09/29"
#>
s3
#> $db
#> DBS1 DBS2 DBS3 DBS4 DBS5
#> AC>CA 4.971263e-05 3.740792e-04 6.347323e-03 4.141857e-03 2.139822e-03
#> AC>CG 2.640671e-05 3.170671e-05 4.648040e-05 4.962225e-05 4.619616e-04
#> AC>CT 4.291091e-03 1.260267e-04 3.018727e-03 8.323733e-18 2.019832e-03
#> AC>GA 1.270323e-04 2.370502e-04 5.847534e-03 4.401974e-03 5.579536e-04
#> AC>GG 5.711452e-05 4.170883e-18 4.498103e-04 7.013145e-18 1.109908e-17
#> AC>GT 2.960753e-03 2.800593e-04 1.009574e-02 1.120503e-08 8.219316e-04
#> AC>TA 1.200305e-03 1.480313e-03 1.009574e-03 1.270570e-03 1.479877e-03
#> AC>TG 1.720437e-04 6.361346e-06 1.109532e-17 5.312382e-05 1.119907e-03
#> AC>TT 2.650674e-02 2.920618e-03 1.779250e-06 1.610722e-04 7.469379e-03
#> AT>CA 4.821225e-04 3.780800e-05 7.037032e-03 9.164110e-04 1.079910e-04
#> AT>CC 2.970755e-04 4.170883e-18 9.076172e-03 7.003141e-18 2.129823e-05
#> AT>CG 3.981012e-06 4.170883e-18 1.459385e-02 9.464244e-18 1.049913e-17
#> AT>GA 2.120539e-03 1.680356e-04 1.809237e-03 3.241454e-04 1.109908e-03
#> AT>GC 1.740442e-04 5.851238e-06 5.247787e-03 1.760790e-05 1.049913e-17
#> AT>TA 2.340595e-03 4.580969e-04 2.349009e-03 4.532032e-03 7.929340e-04
#> CC>AA 1.060269e-05 7.241532e-01 9.086168e-03 7.003141e-18 1.049913e-17
#> CC>AG 1.230313e-05 7.261537e-02 1.109532e-17 5.432436e-03 2.429798e-02
#> CC>AT 1.870475e-02 1.000212e-01 5.887517e-03 1.570704e-02 2.429798e-03
#> CC>GA 1.340341e-04 1.770375e-02 6.347323e-04 3.551593e-03 6.759438e-05
#> CC>GG 9.822496e-05 4.500952e-04 7.246944e-05 7.303275e-05 1.189901e-05
#> CC>GT 6.921759e-03 1.100233e-03 1.139519e-17 7.993585e-05 2.479794e-05
#> CC>TA 1.040264e-02 1.600339e-02 2.079123e-02 1.700763e-04 1.269894e-03
#> CC>TG 2.550648e-03 2.370502e-04 2.898778e-05 8.303724e-06 4.809600e-03
#> CC>TT 8.582181e-01 4.170883e-18 1.109532e-17 7.003141e-18 1.049913e-17
#> CG>AT 6.031533e-07 1.150243e-03 2.838803e-04 2.901301e-04 1.639864e-03
#> CG>GC 5.421378e-06 3.690781e-04 1.109532e-17 5.102288e-06 9.919175e-05
#> CG>GT 1.700432e-06 1.280271e-03 1.109532e-17 7.003141e-18 6.479461e-03
#> CG>TA 3.560905e-04 4.170883e-18 9.785873e-02 7.003141e-18 1.049913e-17
#> CG>TC 1.260320e-05 2.150455e-03 7.216956e-04 7.003141e-18 2.979752e-05
#> CG>TT 1.240315e-04 5.561177e-03 7.166978e-03 3.611620e-04 2.219815e-03
#> CT>AA 2.770704e-05 3.210679e-03 1.029566e-04 7.003141e-18 4.659612e-01
#> CT>AC 4.191065e-04 4.170883e-18 2.908773e-02 7.003141e-18 2.089826e-01
#> CT>AG 2.850725e-18 5.871242e-04 1.139519e-01 3.631629e-04 2.669778e-02
#> CT>GA 8.922268e-05 1.810383e-05 1.719275e-05 6.733020e-04 1.609866e-02
#> CT>GC 2.520641e-04 1.340284e-04 2.688866e-05 7.223239e-05 4.849597e-03
#> CT>GG 1.080275e-05 8.981901e-05 5.987475e-05 9.264155e-04 5.699526e-04
#> CT>TA 7.811985e-03 3.380715e-03 1.839224e-04 7.003141e-18 3.339722e-03
#> CT>TC 1.050267e-02 3.840813e-05 6.337327e-03 7.003141e-18 2.369803e-04
#> CT>TG 2.240569e-03 3.900825e-04 5.217800e-02 3.081382e-05 8.739273e-04
#> GC>AA 1.580402e-03 5.081075e-03 2.159089e-05 3.281472e-01 1.329889e-04
#> GC>AG 1.070272e-04 3.250688e-04 5.217800e-04 1.130507e-02 2.659779e-03
#> GC>AT 4.871238e-05 9.532017e-04 3.988318e-03 9.244146e-03 1.569869e-03
#> GC>CA 5.761464e-05 1.060224e-03 2.369001e-04 1.190534e-02 4.579619e-03
#> GC>CG 5.151309e-06 6.691416e-05 1.109532e-17 9.834410e-07 3.229731e-04
#> GC>TA 8.272102e-07 7.361558e-04 4.228217e-03 1.770794e-02 2.219815e-04
#> TA>AT 5.051284e-04 2.750582e-03 1.449389e-03 3.041364e-02 1.869844e-03
#> TA>CG 7.551919e-06 1.890400e-05 3.338592e-03 3.891745e-04 7.889344e-06
#> TA>CT 7.021785e-04 2.800593e-04 3.438550e-04 8.723912e-03 2.269811e-03
#> TA>GC 2.010511e-05 8.221740e-05 1.989161e-03 7.023150e-05 5.219566e-05
#> TA>GG 7.031787e-05 7.891670e-05 5.457698e-03 2.220996e-03 1.629864e-03
#> TA>GT 1.150292e-03 1.300275e-03 3.618474e-04 8.063616e-03 1.909841e-03
#> TC>AA 1.090277e-05 1.450307e-03 5.487686e-03 3.791700e-01 4.039664e-02
#> TC>AG 3.090786e-06 2.000423e-04 6.137412e-06 1.870839e-03 1.489876e-02
#> TC>AT 2.460625e-03 4.170883e-18 1.119528e-03 8.413773e-03 7.479378e-04
#> TC>CA 4.421124e-06 6.821443e-04 6.547239e-02 8.463796e-02 1.429881e-03
#> TC>CG 3.300839e-05 3.890823e-06 1.159511e-04 4.001795e-04 1.059912e-17
#> TC>CT 1.900483e-03 3.350709e-03 1.939182e-02 8.283715e-06 1.049913e-03
#> TC>GA 6.421632e-05 8.851873e-04 7.776720e-02 3.641633e-02 2.459795e-05
#> TC>GG 4.111045e-04 9.872089e-06 1.769254e-04 1.040467e-05 3.479711e-05
#> TC>GT 5.101297e-03 8.571814e-05 4.338171e-02 7.003141e-18 3.859679e-05
#> TG>AA 1.370348e-03 2.960626e-03 6.677184e-05 7.633423e-03 1.799850e-02
#> TG>AC 2.370603e-04 2.200466e-04 8.036611e-05 1.180529e-04 1.459879e-03
#> TG>AT 2.410613e-03 4.290908e-03 9.575962e-04 7.003141e-18 2.039830e-02
#> TG>CA 2.790709e-04 1.440305e-04 1.589330e-02 8.043607e-04 4.759604e-04
#> TG>CC 1.030262e-04 5.941257e-05 4.837960e-04 1.200538e-04 5.059579e-04
#> TG>CT 1.850470e-03 3.070650e-03 6.067441e-03 8.213684e-05 3.279727e-04
#> TG>GA 4.071035e-04 1.470311e-03 5.227795e-04 7.853522e-03 3.269728e-03
#> TG>GC 8.892260e-05 2.720576e-04 4.977901e-04 6.042710e-04 2.919757e-04
#> TG>GT 1.900483e-03 6.401355e-03 1.029566e-02 3.231449e-05 8.269312e-02
#> TT>AA 5.491396e-03 4.310912e-03 3.218643e-03 1.800808e-05 4.919591e-03
#> TT>AC 7.201830e-04 3.450730e-04 2.428976e-03 6.602961e-07 9.659196e-04
#> TT>AG 4.181063e-04 2.150455e-04 2.289035e-02 7.003141e-18 8.929257e-04
#> TT>CA 7.251843e-04 4.170883e-18 6.937074e-04 7.003141e-18 1.049913e-17
#> TT>CC 5.421378e-03 2.980631e-06 8.156560e-03 7.003141e-18 7.729357e-04
#> TT>CG 8.382130e-05 1.520322e-05 3.178659e-02 7.253253e-18 1.049913e-17
#> TT>GA 1.860473e-03 4.791014e-05 1.229482e-02 7.003141e-18 2.989751e-05
#> TT>GC 1.060269e-03 1.540326e-06 6.647197e-02 7.003141e-18 5.659529e-05
#> TT>GG 1.610409e-03 4.170883e-18 1.709279e-01 7.003141e-18 1.049913e-17
#> DBS6 DBS7 DBS8 DBS9 DBS10
#> AC>CA 2.660571e-03 4.588013e-02 2.149236e-01 2.459182e-02 9.630417e-03
#> AC>CG 1.460313e-04 6.247295e-03 9.726540e-04 2.069312e-03 1.770077e-05
#> AC>CT 2.400515e-04 1.359411e-02 3.178869e-01 2.849052e-02 1.350059e-02
#> AC>GA 8.581841e-03 9.725788e-03 1.159588e-03 2.529159e-02 5.350232e-03
#> AC>GG 1.040223e-04 2.538901e-03 8.097120e-04 7.127629e-03 5.900256e-04
#> AC>GT 1.320283e-04 4.498052e-03 1.509463e-04 1.209598e-02 2.870124e-02
#> AC>TA 1.010217e-02 5.417654e-03 1.239559e-02 4.118630e-02 1.050046e-04
#> AC>TG 4.490964e-04 9.975680e-04 2.569086e-03 1.789405e-02 7.660332e-06
#> AC>TT 3.180682e-03 1.179489e-03 2.679047e-04 4.438523e-02 7.100308e-04
#> AT>CA 1.140245e-04 1.109520e-02 2.779012e-05 1.269578e-02 3.530153e-03
#> AT>CC 6.391371e-05 6.257290e-03 1.429492e-04 1.779408e-03 1.160050e-03
#> AT>CG 1.820391e-06 1.109520e-03 2.659054e-04 9.216934e-18 2.590112e-03
#> AT>GA 1.620348e-03 1.439377e-02 1.619424e-04 6.367881e-03 8.060349e-05
#> AT>GC 1.720369e-05 9.285979e-03 2.259196e-04 1.809398e-03 4.080177e-03
#> AT>TA 2.200472e-03 3.398528e-02 3.148880e-04 9.196940e-03 2.930127e-03
#> CC>AA 8.301781e-18 9.036087e-18 3.808645e-02 9.017000e-18 1.370059e-02
#> CC>AG 6.161322e-02 8.296407e-05 1.549449e-02 2.639122e-02 7.130309e-05
#> CC>AT 4.380940e-04 8.516312e-04 2.878976e-02 1.949351e-02 1.050046e-02
#> CC>GA 3.550762e-02 3.018693e-04 8.087123e-04 1.099634e-02 3.390147e-03
#> CC>GG 1.810388e-02 2.049113e-03 5.598009e-05 3.058982e-03 7.410321e-18
#> CC>GT 3.440738e-03 1.629294e-04 2.289186e-04 1.789405e-02 1.080047e-03
#> CC>TA 2.220476e-03 9.036087e-18 7.157454e-04 6.867715e-04 2.390104e-02
#> CC>TG 6.871474e-03 2.358978e-04 4.208503e-03 1.549484e-02 7.410321e-18
#> CC>TT 8.301781e-18 9.036087e-18 4.378443e-03 9.017000e-18 2.060089e-02
#> CG>AT 7.541618e-03 6.207312e-05 3.218855e-04 2.189272e-04 7.410321e-18
#> CG>GC 5.901266e-04 1.869191e-04 1.129598e-17 1.199601e-05 1.900082e-05
#> CG>GT 3.220691e-03 2.069104e-05 1.209570e-03 9.936694e-05 1.020044e-05
#> CG>TA 8.301781e-18 9.036087e-18 5.058201e-04 9.017000e-18 3.580155e-01
#> CG>TC 8.911912e-03 4.867892e-05 9.046782e-04 1.329558e-04 2.650115e-03
#> CG>TT 1.870401e-02 3.128645e-05 3.288830e-04 8.287243e-05 7.770337e-03
#> CT>AA 4.480961e-03 9.036087e-18 2.059268e-02 9.017000e-18 3.930170e-03
#> CT>AC 1.950419e-03 1.009563e-17 1.399502e-02 9.017000e-18 1.300056e-02
#> CT>AG 3.950848e-02 1.259455e-03 2.039275e-02 5.818064e-04 2.650115e-02
#> CT>GA 7.341575e-03 1.869191e-03 5.568019e-03 2.839055e-03 7.410321e-18
#> CT>GC 1.790384e-03 1.559325e-02 2.369157e-04 3.108966e-03 7.410321e-18
#> CT>GG 6.811462e-03 3.998269e-03 3.058912e-04 1.039654e-02 7.410321e-18
#> CT>TA 8.841897e-05 9.036087e-18 1.089612e-02 9.017000e-18 4.030175e-03
#> CT>TC 8.301781e-18 6.317264e-02 1.779367e-02 2.999002e-05 2.750119e-03
#> CT>TG 1.120240e-02 9.036087e-18 9.656565e-04 9.456854e-18 4.570198e-02
#> GC>AA 8.301781e-18 9.036087e-18 1.289541e-02 9.017000e-18 4.080177e-03
#> GC>AG 3.660785e-03 7.296840e-05 8.516971e-03 1.239588e-01 7.410321e-18
#> GC>AT 1.880403e-03 3.498485e-04 5.508041e-03 1.259581e-01 7.750336e-03
#> GC>CA 8.691865e-03 6.697100e-04 4.828283e-03 2.739089e-02 1.050046e-04
#> GC>CG 9.041940e-18 2.648853e-03 2.419140e-04 2.499169e-03 7.410321e-18
#> GC>TA 8.291779e-04 6.237299e-06 8.556956e-03 1.399534e-02 2.810122e-03
#> TA>AT 8.571839e-03 5.577585e-02 9.696551e-03 1.549484e-02 1.040045e-02
#> TA>CG 2.590556e-04 3.048680e-03 2.089257e-05 1.349551e-03 4.110178e-03
#> TA>CT 2.610560e-02 2.908740e-02 4.098542e-03 1.419528e-02 1.620070e-03
#> TA>GC 2.640567e-04 1.509346e-03 7.887195e-04 5.788074e-04 7.410321e-18
#> TA>GG 2.180468e-04 4.308134e-03 2.169228e-04 3.248919e-03 8.590372e-03
#> TA>GT 6.251341e-05 2.628862e-02 1.529456e-04 7.777412e-03 3.610156e-03
#> TC>AA 4.580983e-02 1.959152e-02 3.878620e-02 3.688773e-03 7.560328e-03
#> TC>AG 8.281777e-03 3.998269e-06 1.159588e-02 4.668447e-02 2.710117e-04
#> TC>AT 5.941275e-04 2.289009e-03 1.849342e-02 5.178277e-02 3.090134e-03
#> TC>CA 1.180253e-02 2.708827e-03 1.759374e-02 4.878377e-02 2.520109e-02
#> TC>CG 8.621850e-04 1.629294e-03 1.089612e-02 7.787409e-03 8.420365e-04
#> TC>CT 9.392015e-03 9.186022e-03 8.756885e-03 5.138290e-02 2.620114e-02
#> TC>GA 7.341575e-03 9.036087e-18 9.606583e-03 1.729425e-02 4.380190e-02
#> TC>GG 1.510324e-03 7.056944e-04 1.909321e-03 3.728759e-03 7.410321e-18
#> TC>GT 8.301781e-18 9.036087e-18 2.759019e-04 9.146957e-18 4.590199e-02
#> TG>AA 2.550547e-02 2.259022e-02 8.646924e-03 1.579475e-02 1.420062e-03
#> TG>AC 1.010217e-02 2.618866e-03 3.848631e-03 7.267582e-03 2.070090e-04
#> TG>AT 2.210474e-01 1.289442e-03 8.217077e-03 7.457519e-04 2.500108e-03
#> TG>CA 1.140245e-02 2.388965e-02 5.058201e-03 2.279242e-02 2.920127e-02
#> TG>CC 7.891693e-03 1.049546e-03 1.249556e-03 1.179608e-02 1.900082e-04
#> TG>CT 2.750590e-01 9.036087e-18 1.949307e-02 9.676781e-04 4.330188e-03
#> TG>GA 7.441597e-03 8.246429e-03 2.709036e-04 6.177945e-03 2.020088e-05
#> TG>GC 5.601202e-03 3.878321e-03 3.538741e-03 3.908700e-03 7.410321e-18
#> TG>GT 2.740588e-02 8.706230e-03 7.857205e-03 3.338889e-03 2.170094e-03
#> TT>AA 1.930414e-04 2.348983e-01 3.578727e-03 3.408866e-04 1.450063e-02
#> TT>AC 1.280275e-04 3.998269e-02 1.129598e-17 6.657785e-03 7.410321e-18
#> TT>AG 2.120455e-03 5.387667e-02 1.459481e-02 9.176947e-04 6.960302e-03
#> TT>CA 8.301781e-18 9.765771e-02 6.287763e-03 9.026997e-18 1.290056e-03
#> TT>CC 8.301781e-18 3.538468e-02 2.938955e-04 5.158284e-03 2.880125e-03
#> TT>CG 1.120240e-05 2.668844e-03 1.159588e-04 1.979341e-05 8.580372e-03
#> TT>GA 8.301781e-18 4.358113e-02 3.628709e-03 9.166950e-18 8.690377e-03
#> TT>GC 4.090878e-07 3.668411e-03 2.858983e-04 3.558816e-05 2.580112e-02
#> TT>GG 8.301781e-18 9.036087e-18 5.378087e-04 9.017000e-18 8.470367e-02
#> DBS11
#> AC>CA 1.369907e-03
#> AC>CG 1.939868e-04
#> AC>CT 7.559485e-04
#> AC>GA 4.419699e-04
#> AC>GG 2.249847e-03
#> AC>GT 5.709611e-03
#> AC>TA 2.639820e-04
#> AC>TG 2.389837e-04
#> AC>TT 2.819808e-03
#> AT>CA 9.479354e-03
#> AT>CC 1.899870e-03
#> AT>CG 1.739881e-05
#> AT>GA 1.119924e-02
#> AT>GC 4.179715e-03
#> AT>TA 3.839738e-03
#> CC>AA 7.349499e-18
#> CC>AG 9.719337e-04
#> CC>AT 3.449765e-02
#> CC>GA 9.529350e-04
#> CC>GG 3.449765e-03
#> CC>GT 6.949526e-02
#> CC>TA 5.879599e-02
#> CC>TG 3.229780e-02
#> CC>TT 3.319774e-01
#> CG>AT 1.819876e-03
#> CG>GC 1.659887e-04
#> CG>GT 1.179920e-03
#> CG>TA 7.379497e-18
#> CG>TC 6.849533e-04
#> CG>TT 6.989523e-04
#> CT>AA 4.399700e-03
#> CT>AC 2.349840e-03
#> CT>AG 4.959662e-04
#> CT>GA 1.159921e-02
#> CT>GC 6.109583e-03
#> CT>GG 4.019726e-03
#> CT>TA 4.169716e-02
#> CT>TC 2.989796e-03
#> CT>TG 1.479899e-03
#> GC>AA 9.999318e-04
#> GC>AG 3.289776e-03
#> GC>AT 2.719815e-02
#> GC>CA 2.109856e-03
#> GC>CG 4.039725e-03
#> GC>TA 2.429834e-04
#> TA>AT 2.229848e-03
#> TA>CG 5.839602e-04
#> TA>CT 3.379770e-03
#> TA>GC 1.019930e-03
#> TA>GG 3.749744e-04
#> TA>GT 2.669818e-03
#> TC>AA 2.169852e-04
#> TC>AG 4.739677e-02
#> TC>AT 8.459423e-02
#> TC>CA 2.819808e-04
#> TC>CG 3.239779e-03
#> TC>CT 2.009863e-02
#> TC>GA 2.349840e-04
#> TC>GG 7.329500e-03
#> TC>GT 1.519896e-02
#> TG>AA 7.829466e-03
#> TG>AC 8.659410e-04
#> TG>AT 1.049928e-02
#> TG>CA 5.609618e-02
#> TG>CC 3.129787e-03
#> TG>CT 5.579620e-03
#> TG>GA 7.309502e-03
#> TG>GC 6.119583e-03
#> TG>GT 5.239643e-03
#> TT>AA 4.769675e-03
#> TT>AC 1.039929e-03
#> TT>AG 1.269913e-03
#> TT>CA 2.019862e-03
#> TT>CC 3.999727e-03
#> TT>CG 9.959321e-18
#> TT>GA 7.069518e-04
#> TT>GC 5.779606e-06
#> TT>GG 7.339500e-18
#>
#> $aetiology
#> aetiology
#> DBS1 Ultraviolet light exposure
#> DBS2 Tobacco smoking and other mutagens
#> DBS3 Polymerase epsilon exonuclease domain mutations
#> DBS4 Unknown
#> DBS5 Platinum chemotherapy treatment
#> DBS6 Unknown
#> DBS7 Defective DNA mismatch repair
#> DBS8 Unknown
#> DBS9 Unknown
#> DBS10 Defective DNA mismatch repair
#> DBS11 Unknown (possibly related to APOBEC mutagenesis)
#>
#> $date
#> [1] "2020/09/29"
#>
s4
#> $db
#> DBS1 DBS2 DBS3 DBS4 DBS5
#> AC>CA 4.723123e-05 3.542595e-04 5.860567e-03 3.934694e-03 2.103807e-03
#> AC>CG 2.508862e-05 3.002681e-05 4.291597e-05 4.714030e-05 4.541863e-04
#> AC>CT 4.076901e-03 1.193494e-04 2.787230e-03 7.907404e-18 1.985836e-03
#> AC>GA 1.206915e-04 2.244906e-04 5.399105e-03 4.181800e-03 5.485627e-04
#> AC>GG 5.426365e-05 3.949898e-18 4.153158e-04 6.662368e-18 1.091227e-17
#> AC>GT 2.812967e-03 2.652210e-04 9.321532e-03 1.064458e-08 8.080978e-04
#> AC>TA 1.140392e-03 1.401882e-03 9.321532e-04 1.207020e-03 1.454969e-03
#> AC>TG 1.634562e-04 6.024305e-06 1.024446e-17 5.046673e-05 1.101058e-03
#> AC>TT 2.518366e-02 2.765876e-03 1.642805e-06 1.530159e-04 7.343662e-03
#> AT>CA 5.070943e-04 3.963788e-05 7.192955e-03 9.637732e-04 1.175397e-04
#> AT>CC 3.124626e-04 4.372750e-18 9.277277e-03 7.365079e-18 2.318144e-05
#> AT>CG 4.187210e-06 4.372750e-18 1.491721e-02 9.953378e-18 1.142747e-17
#> AT>GA 2.230373e-03 1.761684e-04 1.849325e-03 3.408979e-04 1.208047e-03
#> AT>GC 1.830589e-04 6.134434e-06 5.364064e-03 1.851791e-05 1.142747e-17
#> AT>TA 2.461827e-03 4.802685e-04 2.401057e-03 4.766258e-03 8.630462e-04
#> CC>AA 1.061900e-05 7.229252e-01 8.843715e-03 7.013157e-18 1.088144e-17
#> CC>AG 1.232205e-05 7.249222e-02 1.079926e-17 5.440206e-03 2.518276e-02
#> CC>AT 1.873352e-02 9.985154e-02 5.730416e-03 1.572951e-02 2.518276e-03
#> CC>GA 1.342402e-04 1.767372e-02 6.177953e-04 3.556673e-03 7.005574e-05
#> CC>GG 9.837603e-05 4.493319e-04 7.053568e-05 7.313721e-05 1.233230e-05
#> CC>GT 6.932405e-03 1.098367e-03 1.109113e-17 8.005018e-05 2.570092e-05
#> CC>TA 1.041864e-02 1.597625e-02 2.023644e-02 1.703195e-04 1.316136e-03
#> CC>TG 2.554571e-03 2.366482e-04 2.821427e-05 8.315601e-06 4.984735e-03
#> CC>TT 8.595381e-01 4.163809e-18 1.079926e-17 7.013157e-18 1.088144e-17
#> CG>AT 7.223819e-07 1.373170e-03 3.304159e-04 3.474444e-04 2.032416e-03
#> CG>GC 6.493051e-06 4.406085e-04 1.291414e-17 6.110228e-06 1.229364e-04
#> CG>GT 2.036566e-06 1.528398e-03 1.291414e-17 8.386588e-18 8.030521e-03
#> CG>TA 4.264809e-04 4.979234e-18 1.139004e-01 8.386588e-18 1.301242e-17
#> CG>TC 1.509455e-05 2.567231e-03 8.400010e-04 8.386588e-18 3.693048e-05
#> CG>TT 1.485495e-04 6.638979e-03 8.341838e-03 4.325083e-04 2.751197e-03
#> CT>AA 2.651510e-05 3.062637e-03 9.575111e-05 6.701149e-18 4.614436e-01
#> CT>AC 4.010768e-04 3.978566e-18 2.705201e-02 6.701149e-18 2.069565e-01
#> CT>AG 2.728088e-18 5.600523e-04 1.059770e-01 3.475025e-04 2.643894e-02
#> CT>GA 8.538437e-05 1.726907e-05 1.598950e-05 6.442676e-04 1.594258e-02
#> CT>GC 2.412204e-04 1.278484e-04 2.500684e-05 6.911757e-05 4.802578e-03
#> CT>GG 1.033802e-05 8.567751e-05 5.568438e-05 8.864663e-04 5.644267e-04
#> CT>TA 7.475919e-03 3.224833e-03 1.710505e-04 6.701149e-18 3.307343e-03
#> CT>TC 1.005085e-02 3.663715e-05 5.893806e-03 6.701149e-18 2.346827e-04
#> CT>TG 2.144182e-03 3.720961e-04 4.852629e-02 2.948506e-05 8.654543e-04
#> GC>AA 1.665528e-03 5.337471e-03 2.211269e-05 3.457852e-01 1.450326e-04
#> GC>AG 1.127921e-04 3.414721e-04 5.343901e-04 1.191272e-02 2.900652e-03
#> GC>AT 5.133621e-05 1.001301e-03 4.084706e-03 9.741023e-03 1.712039e-03
#> GC>CA 6.071799e-05 1.113724e-03 2.426254e-04 1.254526e-02 4.994357e-03
#> GC>CG 5.428778e-06 7.029071e-05 1.136347e-17 1.036301e-06 3.522221e-04
#> GC>TA 8.717669e-07 7.733029e-04 4.330403e-03 1.865975e-02 2.420845e-04
#> TA>AT 5.224353e-04 2.835638e-03 1.456807e-03 3.145230e-02 2.001253e-03
#> TA>CG 7.810666e-06 1.948857e-05 3.355681e-03 4.024653e-04 8.443787e-06
#> TA>CT 7.262367e-04 2.887195e-04 3.456150e-04 9.021844e-03 2.429328e-03
#> TA>GC 2.079396e-05 8.475979e-05 1.999343e-03 7.262998e-05 5.586384e-05
#> TA>GG 7.272713e-05 8.135703e-05 5.485633e-03 2.296846e-03 1.744407e-03
#> TA>GT 1.189704e-03 1.340483e-03 3.636995e-04 8.338998e-03 2.044060e-03
#> TC>AA 1.044410e-05 1.384807e-03 5.108692e-03 3.631794e-01 4.004468e-02
#> TC>AG 2.960757e-06 1.910079e-04 5.713546e-06 1.791941e-03 1.476896e-02
#> TC>AT 2.357108e-03 3.982514e-18 1.042210e-03 8.058942e-03 7.414214e-04
#> TC>CA 4.235129e-06 6.513369e-04 6.095069e-02 8.106855e-02 1.417423e-03
#> TC>CG 3.161974e-05 3.715103e-06 1.079432e-04 3.833028e-04 1.050677e-17
#> TC>CT 1.820530e-03 3.199382e-03 1.805257e-02 7.934369e-06 1.040765e-03
#> TC>GA 6.151476e-05 8.452098e-04 7.239640e-02 3.488056e-02 2.438364e-05
#> TC>GG 3.938095e-04 9.426239e-06 1.647065e-04 9.965874e-06 3.449394e-05
#> TC>GT 4.886687e-03 8.184687e-05 4.038565e-02 6.707800e-18 3.826052e-05
#> TG>AA 1.341597e-03 2.889151e-03 6.352887e-05 7.472465e-03 1.823448e-02
#> TG>AC 2.320866e-04 2.147342e-04 7.646289e-05 1.155637e-04 1.479019e-03
#> TG>AT 2.360036e-03 4.187317e-03 9.110877e-04 6.855473e-18 2.066574e-02
#> TG>CA 2.732158e-04 1.405533e-04 1.512139e-02 7.874000e-04 4.822006e-04
#> TG>CC 1.008646e-04 5.797824e-05 4.602990e-04 1.175224e-04 5.125914e-04
#> TG>CT 1.811646e-03 2.996519e-03 5.772758e-03 8.040490e-05 3.322727e-04
#> TG>GA 3.985621e-04 1.434815e-03 4.973892e-04 7.687923e-03 3.312597e-03
#> TG>GC 8.705694e-05 2.654896e-04 4.736134e-04 5.915293e-04 2.958037e-04
#> TG>GT 1.860610e-03 6.246814e-03 9.795619e-03 3.163311e-05 8.377729e-02
#> TT>AA 5.916576e-03 4.629694e-03 3.370133e-03 1.940029e-05 5.485073e-03
#> TT>AC 7.759444e-04 3.705904e-04 2.543299e-03 7.113441e-07 1.076947e-03
#> TT>AG 4.504788e-04 2.309476e-04 2.396771e-02 7.544559e-18 9.955630e-04
#> TT>CA 7.813329e-04 4.479310e-18 7.263578e-04 7.544559e-18 1.170595e-17
#> TT>CC 5.841137e-03 3.201042e-06 8.540461e-03 7.544559e-18 8.617807e-04
#> TT>CG 9.031131e-05 1.632746e-05 3.328268e-02 7.814008e-18 1.170595e-17
#> TT>GA 2.004523e-03 5.145298e-05 1.287349e-02 7.544559e-18 3.333408e-05
#> TT>GC 1.142363e-03 1.654230e-06 6.960057e-02 7.544559e-18 6.310063e-05
#> TT>GG 1.735098e-03 4.479310e-18 1.789729e-01 7.544559e-18 1.170595e-17
#> DBS6 DBS7 DBS8 DBS9 DBS10
#> AC>CA 2.553587e-03 4.204587e-02 2.108978e-01 2.340914e-02 8.527124e-03
#> AC>CG 1.401593e-04 5.725201e-03 9.544353e-04 1.969793e-03 1.567291e-05
#> AC>CT 2.303988e-04 1.245804e-02 3.119326e-01 2.712034e-02 1.195391e-02
#> AC>GA 8.236757e-03 8.912993e-03 1.137867e-03 2.407525e-02 4.737291e-03
#> AC>GG 9.983948e-05 2.326722e-03 7.945453e-04 6.784843e-03 5.224302e-04
#> AC>GT 1.267193e-04 4.122145e-03 1.481189e-04 1.151425e-02 2.541313e-02
#> AC>TA 9.695949e-03 4.964894e-03 1.216341e-02 3.920554e-02 9.297487e-05
#> AC>TG 4.310377e-04 9.142001e-04 2.520965e-03 1.703348e-02 6.782738e-06
#> AC>TT 3.052784e-03 1.080918e-03 2.628866e-04 4.225063e-02 6.286872e-04
#> AT>CA 1.211553e-04 1.125648e-02 3.018889e-05 1.337897e-02 3.460348e-03
#> AT>CC 6.791075e-05 6.348247e-03 1.552882e-04 1.875163e-03 1.137111e-03
#> AT>CG 1.934234e-06 1.125648e-03 2.888578e-04 9.712923e-18 2.538895e-03
#> AT>GA 1.721681e-03 1.460300e-02 1.759209e-04 6.710555e-03 7.900964e-05
#> AT>GC 1.827958e-05 9.420960e-03 2.454205e-04 1.906767e-03 3.999495e-03
#> AT>TA 2.338085e-03 3.447929e-02 3.420684e-04 9.691854e-03 2.872186e-03
#> CC>AA 8.399471e-18 8.729393e-18 3.939704e-02 9.048190e-18 1.278797e-02
#> CC>AG 6.233825e-02 8.014819e-05 1.602767e-02 2.648251e-02 6.655347e-05
#> CC>AT 4.432492e-04 8.227260e-04 2.978044e-02 1.956094e-02 9.801002e-03
#> CC>GA 3.592545e-02 2.916235e-04 8.365408e-04 1.103438e-02 3.164324e-03
#> CC>GG 1.831692e-02 1.979564e-03 5.790641e-05 3.069563e-03 6.916707e-18
#> CC>GT 3.481227e-03 1.573995e-04 2.367958e-04 1.795594e-02 1.008103e-03
#> CC>TA 2.246606e-03 8.729393e-18 7.403748e-04 6.891471e-04 2.230895e-02
#> CC>TG 6.952334e-03 2.278912e-04 4.353321e-03 1.554844e-02 6.916707e-18
#> CC>TT 8.399471e-18 8.729393e-18 4.529108e-03 9.048190e-18 1.922863e-02
#> CG>AT 9.124665e-03 7.170987e-05 3.981678e-04 2.627066e-04 8.271249e-18
#> CG>GC 7.139990e-04 2.159379e-04 1.397297e-17 1.439488e-05 2.120833e-05
#> CG>GT 3.896740e-03 2.390329e-05 1.496221e-03 1.192376e-04 1.138553e-05
#> CG>TA 1.004439e-17 1.043893e-17 6.256923e-04 1.082015e-17 3.996096e-01
#> CG>TC 1.078260e-02 5.623624e-05 1.119074e-03 1.595433e-04 2.958004e-03
#> CG>TT 2.263014e-02 3.614362e-05 4.068237e-04 9.944465e-05 8.673092e-03
#> CT>AA 4.331991e-03 8.341032e-18 2.035361e-02 8.645646e-18 3.505173e-03
#> CT>AC 1.885577e-03 9.319073e-18 1.383255e-02 8.645646e-18 1.159472e-02
#> CT>AG 3.819501e-02 1.162577e-03 2.015601e-02 5.578454e-04 2.363539e-02
#> CT>GA 7.097504e-03 1.725413e-03 5.503380e-03 2.722132e-03 6.608990e-18
#> CT>GC 1.730863e-03 1.439382e-02 2.341654e-04 2.980927e-03 6.608990e-18
#> CT>GG 6.585014e-03 3.690722e-03 3.023401e-04 9.968372e-03 6.608990e-18
#> CT>TA 8.547948e-05 8.341032e-18 1.076963e-02 8.645646e-18 3.594363e-03
#> CT>TC 8.025788e-18 5.831341e-02 1.758710e-02 2.875492e-05 2.452729e-03
#> CT>TG 1.082998e-02 8.341032e-18 9.544461e-04 9.067385e-18 4.075990e-02
#> GC>AA 8.838306e-18 9.185464e-18 1.403606e-02 9.520917e-18 4.007360e-03
#> GC>AG 3.897373e-03 7.417466e-05 9.270331e-03 1.308862e-01 7.278074e-18
#> GC>AT 2.001929e-03 3.556319e-04 5.995249e-03 1.329973e-01 7.612020e-03
#> GC>CA 9.253600e-03 6.807811e-04 5.255364e-03 2.892163e-02 1.031306e-04
#> GC>CG 9.626299e-18 2.692642e-03 2.633122e-04 2.638835e-03 7.278074e-18
#> GC>TA 8.827657e-04 6.340409e-06 9.313854e-03 1.477748e-02 2.759971e-03
#> TA>AT 8.956080e-03 5.564333e-02 1.035795e-02 1.605647e-02 1.002485e-02
#> TA>CG 2.706680e-04 3.041436e-03 2.231763e-05 1.398467e-03 3.961743e-03
#> TA>CT 2.727581e-02 2.901830e-02 4.378100e-03 1.470980e-02 1.561563e-03
#> TA>GC 2.758933e-04 1.505760e-03 8.425174e-04 5.997870e-04 7.142704e-18
#> TA>GG 2.278209e-04 4.297899e-03 2.317190e-04 3.366680e-03 8.280139e-03
#> TA>GT 6.531564e-05 2.622616e-02 1.633779e-04 8.059314e-03 3.479779e-03
#> TC>AA 4.433083e-02 1.810248e-02 3.837398e-02 3.540365e-03 6.749467e-03
#> TC>AG 8.014394e-03 3.694385e-06 1.147263e-02 4.480625e-02 2.419452e-04
#> TC>AT 5.749457e-04 2.115035e-03 1.829687e-02 4.969943e-02 2.758711e-03
#> TC>CA 1.142148e-02 2.502946e-03 1.740675e-02 4.682109e-02 2.249822e-02
#> TC>CG 8.343488e-04 1.505462e-03 1.078032e-02 7.474104e-03 7.517264e-04
#> TC>CT 9.088788e-03 8.487849e-03 8.663815e-03 4.931565e-02 2.339101e-02
#> TC>GA 7.104548e-03 8.349309e-18 9.504482e-03 1.659846e-02 3.910405e-02
#> TC>GG 1.461562e-03 6.520589e-04 1.889028e-03 3.578743e-03 6.615549e-18
#> TC>GT 8.033753e-18 8.349309e-18 2.729695e-04 8.778954e-18 4.097891e-02
#> TG>AA 2.522539e-02 2.133280e-02 8.743363e-03 1.549302e-02 1.295667e-03
#> TG>AC 9.991232e-03 2.473095e-03 3.891555e-03 7.128750e-03 1.888754e-04
#> TG>AT 2.186200e-01 1.217669e-03 8.308722e-03 7.315059e-04 2.281104e-03
#> TG>CA 1.127723e-02 2.255991e-02 5.114615e-03 2.235702e-02 2.664329e-02
#> TG>CC 7.805032e-03 9.911257e-04 1.263492e-03 1.157074e-02 1.733639e-04
#> TG>CT 2.720385e-01 8.533120e-18 1.971047e-02 9.491926e-04 3.950871e-03
#> TG>GA 7.359878e-03 7.787416e-03 2.739250e-04 6.059928e-03 1.843132e-05
#> TG>GC 5.539693e-03 3.662445e-03 3.578209e-03 3.834032e-03 6.761191e-18
#> TG>GT 2.710493e-02 8.221624e-03 7.944836e-03 3.275107e-03 1.979998e-03
#> TT>AA 2.101123e-04 2.441202e-01 3.982373e-03 3.679848e-04 1.456027e-02
#> TT>AC 1.393491e-04 4.155238e-02 1.257006e-17 7.187034e-03 7.440801e-18
#> TT>AG 2.307969e-03 5.599183e-02 1.624096e-02 9.906452e-04 6.988930e-03
#> TT>CA 9.035917e-18 1.014917e-01 6.996962e-03 9.744582e-18 1.295362e-03
#> TT>CC 9.035917e-18 3.677386e-02 3.270440e-04 5.568333e-03 2.891971e-03
#> TT>CG 1.219304e-05 2.773621e-03 1.290378e-04 2.136686e-05 8.615664e-03
#> TT>GA 9.035917e-18 4.529209e-02 4.037992e-03 9.895661e-18 8.726121e-03
#> TT>GC 4.452639e-07 3.812431e-03 3.181448e-04 3.841718e-05 2.590724e-02
#> TT>GG 9.035917e-18 9.390838e-18 5.984683e-04 9.733791e-18 8.505207e-02
#> DBS11
#> AC>CA 1.310486e-03
#> AC>CG 1.855725e-04
#> AC>CT 7.231586e-04
#> AC>GA 4.227991e-04
#> AC>GG 2.152258e-03
#> AC>GT 5.461952e-03
#> AC>TA 2.525316e-04
#> AC>TG 2.286176e-04
#> AC>TT 2.697497e-03
#> AT>CA 1.003896e-02
#> AT>CC 2.012029e-03
#> AT>CG 1.842595e-05
#> AT>GA 1.186038e-02
#> AT>GC 4.426463e-03
#> AT>TA 4.066416e-03
#> CC>AA 7.411465e-18
#> CC>AG 9.801284e-04
#> CC>AT 3.478851e-02
#> CC>GA 9.609695e-04
#> CC>GG 3.478851e-03
#> CC>GT 7.008120e-02
#> CC>TA 5.929172e-02
#> CC>TG 3.257011e-02
#> CC>TT 3.347764e-01
#> CG>AT 2.194622e-03
#> CG>GC 2.001689e-04
#> CG>GT 1.422887e-03
#> CG>TA 8.899073e-18
#> CG>TC 8.259980e-04
#> CG>TT 8.428797e-04
#> CT>AA 4.239407e-03
#> CT>AC 2.264229e-03
#> CT>AG 4.778968e-04
#> CT>GA 1.117662e-02
#> CT>GC 5.886994e-03
#> CT>GG 3.873276e-03
#> CT>TA 4.017801e-02
#> CT>TC 2.880870e-03
#> CT>TG 1.425982e-03
#> GC>AA 1.061045e-03
#> GC>AG 3.490838e-03
#> GC>AT 2.886042e-02
#> GC>CA 2.238805e-03
#> GC>CG 4.286621e-03
#> GC>TA 2.578339e-04
#> TA>AT 2.322121e-03
#> TA>CG 6.081250e-04
#> TA>CT 3.519627e-03
#> TA>GC 1.062136e-03
#> TA>GG 3.904912e-04
#> TA>GT 2.780297e-03
#> TC>AA 2.092873e-04
#> TC>AG 4.571530e-02
#> TC>AT 8.159312e-02
#> TC>CA 2.719771e-04
#> TC>CG 3.124843e-03
#> TC>CT 1.938560e-02
#> TC>GA 2.266476e-04
#> TC>GG 7.069475e-03
#> TC>GT 1.465976e-02
#> TG>AA 7.717956e-03
#> TG>AC 8.536079e-04
#> TG>AT 1.034975e-02
#> TG>CA 5.529723e-02
#> TG>CC 3.085211e-03
#> TG>CT 5.500152e-03
#> TG>GA 7.205397e-03
#> TG>GC 6.032425e-03
#> TG>GT 5.165018e-03
#> TT>AA 5.174345e-03
#> TT>AC 1.128159e-03
#> TT>AG 1.377656e-03
#> TT>CA 2.191232e-03
#> TT>CC 4.339073e-03
#> TT>CG 1.080429e-17
#> TT>GA 7.669312e-04
#> TT>GC 6.269961e-06
#> TT>GG 7.962199e-18
#>
#> $aetiology
#> aetiology
#> DBS1 Ultraviolet light exposure
#> DBS2 Tobacco smoking and other mutagens
#> DBS3 Polymerase epsilon exonuclease domain mutations
#> DBS4 Unknown
#> DBS5 Platinum chemotherapy treatment
#> DBS6 Unknown
#> DBS7 Defective DNA mismatch repair
#> DBS8 Unknown
#> DBS9 Unknown
#> DBS10 Defective DNA mismatch repair
#> DBS11 Unknown (possibly related to APOBEC mutagenesis)
#>
#> $date
#> [1] "2020/09/29"
#>
s5
#> $db
#> Ref_Sig_1 Ref_Sig_18 Ref_Sig_17 Ref_Sig_MMR1 Ref_Sig_2
#> A[C>A]A 0.0144248973 0.0396635684 0.0063724598 0.0012848975 0.0060027728
#> A[C>A]C 0.0103603500 0.0185446099 0.0040759491 0.0021341853 0.0040709557
#> A[C>A]G 0.0017771932 0.0028085693 0.0007107410 0.0003912442 0.0010341738
#> A[C>A]T 0.0069194489 0.0214552439 0.0043368291 0.0036513535 0.0049137862
#> C[C>A]A 0.0078788413 0.0306763767 0.0068000312 0.0090416000 0.0054280572
#> C[C>A]C 0.0060930903 0.0094010660 0.0037283329 0.0161025253 0.0034207178
#> C[C>A]G 0.0014940013 0.0036710270 0.0008409968 0.0028696081 0.0009690241
#> C[C>A]T 0.0074901402 0.0210518525 0.0053463464 0.0493623377 0.0039061147
#> G[C>A]A 0.0100940963 0.0562791929 0.0046244215 0.0020164010 0.0040889081
#> G[C>A]C 0.0049726233 0.0133891798 0.0030510103 0.0039818282 0.0023790145
#> G[C>A]G 0.0018567843 0.0043325897 0.0004217728 0.0008716059 0.0007364173
#> G[C>A]T 0.0064399667 0.0328682036 0.0035492111 0.0102076459 0.0034198597
#> T[C>A]A 0.0095671195 0.0441889139 0.0068804668 0.0020309617 0.0205701829
#> T[C>A]C 0.0087605955 0.0267307634 0.0043538253 0.0040061453 0.0093815804
#> T[C>A]G 0.0019842241 0.0053216971 0.0008060915 0.0003698995 0.0014541802
#> T[C>A]T 0.0142382524 0.0756480165 0.0099547599 0.0117532321 0.0144151676
#> A[C>G]A 0.0036989767 0.0074231633 0.0033054608 0.0029155483 0.0025959311
#> A[C>G]C 0.0021232790 0.0041574290 0.0019839613 0.0013499357 0.0011420729
#> A[C>G]G 0.0009010241 0.0023376911 0.0006930929 0.0002998674 0.0005827186
#> A[C>G]T 0.0036788926 0.0060090176 0.0040139244 0.0027390251 0.0031837519
#> C[C>G]A 0.0015329148 0.0035601826 0.0024185979 0.0006183160 0.0024821224
#> C[C>G]C 0.0018428025 0.0033023130 0.0024343251 0.0005292283 0.0011608888
#> C[C>G]G 0.0010241532 0.0022738816 0.0008309908 0.0003223352 0.0004065433
#> C[C>G]T 0.0028662238 0.0048606464 0.0037690283 0.0010184699 0.0031643435
#> G[C>G]A 0.0016798845 0.0029841233 0.0014614937 0.0011869867 0.0012305772
#> G[C>G]C 0.0020601152 0.0018330485 0.0019833716 0.0021790070 0.0010977595
#> G[C>G]G 0.0003580831 0.0010455738 0.0002399197 0.0002509696 0.0003362056
#> G[C>G]T 0.0015763739 0.0033664151 0.0021933399 0.0015137469 0.0017399508
#> T[C>G]A 0.0019475848 0.0071332758 0.0047575058 0.0006949487 0.0695862724
#> T[C>G]C 0.0026509119 0.0050924553 0.0027438052 0.0010881830 0.0157032034
#> T[C>G]G 0.0006328590 0.0014129002 0.0006680160 0.0001483331 0.0023221183
#> T[C>G]T 0.0069511947 0.0116448642 0.0076193497 0.0017633772 0.0892006781
#> A[C>T]A 0.0239800353 0.0196393654 0.0080789889 0.0340308363 0.0107066847
#> A[C>T]C 0.0124778380 0.0097587364 0.0041464937 0.0156333767 0.0041160510
#> A[C>T]G 0.1486155843 0.0324356128 0.0088601305 0.0318078415 0.0141061307
#> A[C>T]T 0.0140133474 0.0159925361 0.0051325232 0.0140231842 0.0066856277
#> C[C>T]A 0.0156563672 0.0165347268 0.0072719114 0.0088487141 0.0169868704
#> C[C>T]C 0.0155139561 0.0116475140 0.0054555051 0.0124909935 0.0072714593
#> C[C>T]G 0.0856167478 0.0240098620 0.0069721993 0.0239186894 0.0108287743
#> C[C>T]T 0.0173628909 0.0151500114 0.0063862718 0.0118320821 0.0126846886
#> G[C>T]A 0.0173636052 0.0123264894 0.0053636321 0.0422570707 0.0084692649
#> G[C>T]C 0.0188875739 0.0118961962 0.0042055265 0.0535047340 0.0044394206
#> G[C>T]G 0.1080391716 0.0279209167 0.0082923209 0.0524535332 0.0093165753
#> G[C>T]T 0.0177160845 0.0131070663 0.0044123783 0.0388364819 0.0077604375
#> T[C>T]A 0.0155842135 0.0135682634 0.0117773149 0.0103658683 0.2641068396
#> T[C>T]C 0.0185350778 0.0187033257 0.0090633309 0.0136405553 0.0630302807
#> T[C>T]G 0.0608084337 0.0178468387 0.0049585919 0.0126366129 0.0324463844
#> T[C>T]T 0.0179997324 0.0184579583 0.0117001913 0.0133014683 0.1518939533
#> A[T>A]A 0.0062950689 0.0069501439 0.0029261397 0.0131565281 0.0029507404
#> A[T>A]C 0.0072568836 0.0044733816 0.0025023663 0.0133440903 0.0020263508
#> A[T>A]G 0.0056120011 0.0047923155 0.0018500065 0.0016051004 0.0023554699
#> A[T>A]T 0.0133347568 0.0194455854 0.0070030968 0.0197303058 0.0036847839
#> C[T>A]A 0.0016529912 0.0030632953 0.0022241582 0.0016759415 0.0015732212
#> C[T>A]C 0.0023579240 0.0035548511 0.0099472229 0.0039365838 0.0018641469
#> C[T>A]G 0.0021591576 0.0029329306 0.0045705480 0.0017665158 0.0022581190
#> C[T>A]T 0.0031061001 0.0071265478 0.0231478543 0.0018210733 0.0027470390
#> G[T>A]A 0.0016003611 0.0026483131 0.0014494088 0.0025956845 0.0010460918
#> G[T>A]C 0.0024336680 0.0021010479 0.0029390096 0.0066645462 0.0010445463
#> G[T>A]G 0.0019736067 0.0027826725 0.0018735924 0.0024804412 0.0012098518
#> G[T>A]T 0.0022933703 0.0049471892 0.0059958771 0.0034825204 0.0022062644
#> T[T>A]A 0.0098523312 0.0148783778 0.0049844703 0.0092528417 0.0025612849
#> T[T>A]C 0.0025687339 0.0049199986 0.0039284941 0.0033954442 0.0014643061
#> T[T>A]G 0.0015266174 0.0030063125 0.0023759351 0.0012787462 0.0014673469
#> T[T>A]T 0.0061465903 0.0139561837 0.0129169686 0.0058011522 0.0030834517
#> A[T>C]A 0.0172070317 0.0114112170 0.0087062606 0.0279563011 0.0055182011
#> A[T>C]C 0.0060095876 0.0047449472 0.0052745505 0.0105723186 0.0024211373
#> A[T>C]G 0.0092691856 0.0057567284 0.0051383009 0.0241874113 0.0037008849
#> A[T>C]T 0.0173831710 0.0126722552 0.0102467872 0.0126322894 0.0055199207
#> C[T>C]A 0.0044413086 0.0043562083 0.0093287341 0.0194732284 0.0009612171
#> C[T>C]C 0.0047711787 0.0052009834 0.0298520786 0.0102395453 0.0017084552
#> C[T>C]G 0.0047553895 0.0042605485 0.0213100016 0.0257985225 0.0018500957
#> C[T>C]T 0.0058213031 0.0071160308 0.0771759440 0.0149364105 0.0023570346
#> G[T>C]A 0.0087461940 0.0052547884 0.0044357806 0.0410768732 0.0014883726
#> G[T>C]C 0.0069522433 0.0032171982 0.0068202651 0.0147198590 0.0014081013
#> G[T>C]G 0.0057771414 0.0022385256 0.0059674629 0.0268918439 0.0016451559
#> G[T>C]T 0.0095132865 0.0064437798 0.0111695774 0.0250998210 0.0033112060
#> T[T>C]A 0.0073134861 0.0070466270 0.0088448440 0.0293500724 0.0029619682
#> T[T>C]C 0.0067563790 0.0085093729 0.0102243420 0.0162077228 0.0018310286
#> T[T>C]G 0.0044820341 0.0033372114 0.0070374647 0.0164299644 0.0011550885
#> T[T>C]T 0.0116128468 0.0107454617 0.0159383371 0.0264387951 0.0036406665
#> A[T>G]A 0.0024304679 0.0029431978 0.0046659093 0.0010856419 0.0012618442
#> A[T>G]C 0.0014410992 0.0015519064 0.0051784150 0.0014330734 0.0008010011
#> A[T>G]G 0.0023093020 0.0030247640 0.0031967141 0.0010602731 0.0011030619
#> A[T>G]T 0.0032452989 0.0040622216 0.0425079256 0.0026938377 0.0009612644
#> C[T>G]A 0.0013969769 0.0014802947 0.0041199189 0.0008504933 0.0004542188
#> C[T>G]C 0.0012771905 0.0010528259 0.0164170684 0.0039182317 0.0009413482
#> C[T>G]G 0.0023046486 0.0019283818 0.0095372470 0.0048145292 0.0013511967
#> C[T>G]T 0.0043838976 0.0032882632 0.1988482612 0.0044506776 0.0018881187
#> G[T>G]A 0.0011498276 0.0010611931 0.0015448603 0.0005701628 0.0002130068
#> G[T>G]C 0.0011213815 0.0007491129 0.0040555606 0.0013964708 0.0003767921
#> G[T>G]G 0.0024447975 0.0022130936 0.0034825380 0.0015155474 0.0008963881
#> G[T>G]T 0.0028458324 0.0019698071 0.0481748733 0.0058991290 0.0009474178
#> T[T>G]A 0.0023918103 0.0030510829 0.0074303449 0.0010863597 0.0015491857
#> T[T>G]C 0.0022233534 0.0017048092 0.0087031541 0.0011778256 0.0010164355
#> T[T>G]G 0.0024426361 0.0041031089 0.0064482909 0.0017777702 0.0011842357
#> T[T>G]T 0.0075619921 0.0084616356 0.0885362994 0.0039956900 0.0030574414
#> Ref_Sig_MMR2 Ref_Sig_5 Ref_Sig_8 Ref_Sig_13 Ref_Sig_3
#> A[C>A]A 0.0058829544 0.0197398923 0.0329213556 0.0033563920 0.015533816
#> A[C>A]C 0.0041577300 0.0130591283 0.0293565391 0.0016644925 0.012659870
#> A[C>A]G 0.0007208443 0.0040645944 0.0034381704 0.0004285476 0.002915952
#> A[C>A]T 0.0052773644 0.0113906558 0.0319103681 0.0022066033 0.014087260
#> C[C>A]A 0.0055325684 0.0161802260 0.0282741228 0.0029848549 0.017257815
#> C[C>A]C 0.0062794242 0.0097573727 0.0298276956 0.0020426386 0.015732682
#> C[C>A]G 0.0017788617 0.0029147272 0.0025293868 0.0004761911 0.002748845
#> C[C>A]T 0.0145502643 0.0075624513 0.0283008220 0.0022791569 0.011186180
#> G[C>A]A 0.0027431641 0.0100995909 0.0140675647 0.0018579778 0.005052994
#> G[C>A]C 0.0034857893 0.0115757166 0.0152022259 0.0013031618 0.008988306
#> G[C>A]G 0.0003981767 0.0050324138 0.0014464392 0.0003321086 0.001455741
#> G[C>A]T 0.0040387750 0.0074563324 0.0149018374 0.0016656365 0.007696574
#> T[C>A]A 0.0040257725 0.0126754540 0.0170110642 0.0316488014 0.006422586
#> T[C>A]C 0.0031357347 0.0150079542 0.0190164365 0.0146347333 0.014067473
#> T[C>A]G 0.0008358101 0.0021808944 0.0015505510 0.0025992305 0.001674777
#> T[C>A]T 0.0094711789 0.0096822633 0.0209778108 0.0159947997 0.006659819
#> A[C>G]A 0.0072388753 0.0073134376 0.0120015637 0.0050059481 0.028530484
#> A[C>G]C 0.0040235889 0.0046389308 0.0064688310 0.0017844228 0.014994354
#> A[C>G]G 0.0007101561 0.0013646425 0.0017620625 0.0005018768 0.008163439
#> A[C>G]T 0.0065800262 0.0064680570 0.0115239456 0.0051585251 0.025747320
#> C[C>G]A 0.0022100227 0.0055011798 0.0086715043 0.0049197225 0.018272362
#> C[C>G]C 0.0023824802 0.0059369747 0.0076090282 0.0018132815 0.015453531
#> C[C>G]G 0.0002721446 0.0023703893 0.0014377261 0.0004577198 0.006787774
#> C[C>G]T 0.0022139247 0.0088266170 0.0107854421 0.0067751540 0.023338604
#> G[C>G]A 0.0023486233 0.0034529075 0.0055149323 0.0020458827 0.012599040
#> G[C>G]C 0.0040554401 0.0039244105 0.0044352504 0.0018957084 0.011629594
#> G[C>G]G 0.0006669467 0.0008475774 0.0008551754 0.0004036772 0.003646145
#> G[C>G]T 0.0037073772 0.0033907473 0.0080969373 0.0035741543 0.016999564
#> T[C>G]A 0.0055841523 0.0068345469 0.0073408875 0.2023335312 0.016839462
#> T[C>G]C 0.0029153554 0.0069976720 0.0105566316 0.0449668689 0.022849099
#> T[C>G]G 0.0004839575 0.0014866200 0.0011710801 0.0089313066 0.004912099
#> T[C>G]T 0.0095233647 0.0084558437 0.0199399027 0.2326968051 0.034952540
#> A[C>T]A 0.0080215198 0.0200827850 0.0175786649 0.0045221234 0.018285631
#> A[C>T]C 0.0023403814 0.0122368689 0.0065498965 0.0018395299 0.007961498
#> A[C>T]G 0.0095096450 0.0114339165 0.0103785109 0.0063055284 0.007799384
#> A[C>T]T 0.0040735537 0.0125131792 0.0167756839 0.0027823257 0.016633134
#> C[C>T]A 0.0050208846 0.0201104692 0.0070917551 0.0065537075 0.014999271
#> C[C>T]C 0.0069049311 0.0199317838 0.0057368558 0.0025852529 0.009449450
#> C[C>T]G 0.0082301766 0.0088831647 0.0033597936 0.0057669097 0.008867696
#> C[C>T]T 0.0051444591 0.0269060486 0.0202279494 0.0048566459 0.016726793
#> G[C>T]A 0.0039616561 0.0173966955 0.0066353453 0.0044792348 0.011892319
#> G[C>T]C 0.0095848011 0.0151074978 0.0036639418 0.0038225435 0.006985395
#> G[C>T]G 0.0209053720 0.0073441720 0.0026609253 0.0068801310 0.006604093
#> G[C>T]T 0.0069097063 0.0155581388 0.0099326654 0.0033086714 0.009684597
#> T[C>T]A 0.0077797819 0.0137545568 0.0149707577 0.1550381105 0.002444905
#> T[C>T]C 0.0070129954 0.0181320133 0.0096696190 0.0276605688 0.010927382
#> T[C>T]G 0.0055716512 0.0052458752 0.0036477071 0.0173711348 0.005123944
#> T[C>T]T 0.0068173667 0.0178042603 0.0177454618 0.0644616855 0.009217919
#> A[T>A]A 0.0139282967 0.0143335843 0.0147350041 0.0021315124 0.004296507
#> A[T>A]C 0.0040866030 0.0079128890 0.0118218006 0.0013742545 0.003971768
#> A[T>A]G 0.0042738623 0.0131997204 0.0163347128 0.0015846705 0.007007613
#> A[T>A]T 0.0223897964 0.0111865784 0.0184538636 0.0031268521 0.004925229
#> C[T>A]A 0.0037991865 0.0065138742 0.0148876132 0.0009986252 0.009005533
#> C[T>A]C 0.0049827620 0.0063414702 0.0198362160 0.0010619865 0.009967070
#> C[T>A]G 0.0042495112 0.0109668141 0.0206368371 0.0011812085 0.011004722
#> C[T>A]T 0.0043549457 0.0081988247 0.0318751206 0.0017988194 0.015823027
#> G[T>A]A 0.0041414470 0.0062109714 0.0103145900 0.0006216012 0.005540095
#> G[T>A]C 0.0028749647 0.0038544381 0.0071130509 0.0006925184 0.004060391
#> G[T>A]G 0.0042973572 0.0066050075 0.0106183710 0.0008568579 0.007101097
#> G[T>A]T 0.0033518319 0.0050149020 0.0188512677 0.0009075688 0.009326385
#> T[T>A]A 0.0133364855 0.0102901289 0.0118852617 0.0029789730 0.011192703
#> T[T>A]C 0.0050648768 0.0068095874 0.0129345486 0.0008722701 0.007930602
#> T[T>A]G 0.0040196149 0.0071835435 0.0094658379 0.0010842359 0.006067169
#> T[T>A]T 0.0107291614 0.0129039997 0.0303664961 0.0021735772 0.014823849
#> A[T>C]A 0.0562682252 0.0570938173 0.0118614356 0.0037364165 0.011653682
#> A[T>C]C 0.0242191409 0.0113615912 0.0060815713 0.0013027761 0.010766206
#> A[T>C]G 0.0405759356 0.0341458070 0.0078492612 0.0025158635 0.010490210
#> A[T>C]T 0.0315767896 0.0367548664 0.0155786612 0.0046820148 0.019428699
#> C[T>C]A 0.0324813928 0.0161186509 0.0057683238 0.0015773137 0.010784781
#> C[T>C]C 0.0285162062 0.0084226526 0.0123517087 0.0019479164 0.014117644
#> C[T>C]G 0.0383582143 0.0130375452 0.0049080963 0.0009107902 0.009056752
#> C[T>C]T 0.0326703165 0.0112581838 0.0104699017 0.0025107598 0.013967344
#> G[T>C]A 0.0478019631 0.0216508369 0.0040102762 0.0023434609 0.004494982
#> G[T>C]C 0.0227522940 0.0093547305 0.0037303955 0.0020727638 0.006398800
#> G[T>C]G 0.0338812669 0.0112277261 0.0041982398 0.0013506880 0.004922759
#> G[T>C]T 0.0331798580 0.0193620989 0.0062898109 0.0026322555 0.009199060
#> T[T>C]A 0.0430849612 0.0260716856 0.0054333924 0.0024605244 0.013490508
#> T[T>C]C 0.0333550027 0.0106763452 0.0080029455 0.0017616174 0.014664892
#> T[T>C]G 0.0263159226 0.0116377830 0.0026456787 0.0008377048 0.004446722
#> T[T>C]T 0.0465701375 0.0197710464 0.0076393379 0.0017373290 0.013501815
#> A[T>G]A 0.0065536819 0.0048584738 0.0041876004 0.0010703439 0.006480227
#> A[T>G]C 0.0039917430 0.0023867951 0.0009228833 0.0002831768 0.002739373
#> A[T>G]G 0.0029805046 0.0040444850 0.0060448755 0.0009892435 0.009493459
#> A[T>G]T 0.0065491529 0.0049223199 0.0014738289 0.0011445732 0.006526130
#> C[T>G]A 0.0039292131 0.0032532923 0.0018255882 0.0006783039 0.006427911
#> C[T>G]C 0.0054196559 0.0031219169 0.0028155503 0.0005027870 0.005683314
#> C[T>G]G 0.0071703291 0.0046234553 0.0067444317 0.0006873203 0.010937667
#> C[T>G]T 0.0040002551 0.0036628325 0.0032252932 0.0008953926 0.007657011
#> G[T>G]A 0.0020408275 0.0016867855 0.0021916059 0.0002735480 0.005019035
#> G[T>G]C 0.0022881552 0.0016403400 0.0014822196 0.0003301441 0.002959193
#> G[T>G]G 0.0030281051 0.0029853904 0.0058841975 0.0010817002 0.008703466
#> G[T>G]T 0.0051674124 0.0030065008 0.0032048653 0.0011596449 0.006717240
#> T[T>G]A 0.0039624337 0.0046902138 0.0028028706 0.0017906130 0.011561751
#> T[T>G]C 0.0021110529 0.0044085265 0.0028204591 0.0009890862 0.006379557
#> T[T>G]G 0.0047789606 0.0052678580 0.0061318161 0.0010022639 0.012098625
#> T[T>G]T 0.0095204557 0.0113374664 0.0057634612 0.0023221170 0.013727913
#> Ref_Sig_30 Ref_Sig_MIXED1 Ref_Sig_4 Ref_Sig_N1 Ref_Sig_PLATINUM
#> A[C>A]A 0.0138309368 0.0156701154 0.0468292500 0.0128996611 1.144784e-02
#> A[C>A]C 0.0115395657 0.0130701260 0.0295427569 0.0115748079 2.769772e-02
#> A[C>A]G 0.0022800344 0.0022335575 0.0087738167 0.0015327212 8.015833e-04
#> A[C>A]T 0.0078322066 0.0112738801 0.0298010795 0.0109403259 1.456919e-02
#> C[C>A]A 0.0109749935 0.0169405820 0.0679069643 0.0094449978 2.225927e-02
#> C[C>A]C 0.0060662446 0.0157305528 0.0605678815 0.0074749641 2.009831e-02
#> C[C>A]G 0.0021845846 0.0014269275 0.0113748426 0.0010082887 2.222965e-03
#> C[C>A]T 0.0037495053 0.0107744536 0.0502455404 0.0077258356 4.115631e-02
#> G[C>A]A 0.0061498566 0.0057512139 0.0297726774 0.0032197924 1.363777e-02
#> G[C>A]C 0.0052514302 0.0047532743 0.0272212586 0.0041948672 3.248961e-02
#> G[C>A]G 0.0017162465 0.0005210835 0.0069313279 0.0009068156 1.331564e-03
#> G[C>A]T 0.0040564143 0.0078174547 0.0207831293 0.0047823662 1.308511e-02
#> T[C>A]A 0.0062383601 0.0132215967 0.0394104632 0.0074265512 1.586323e-02
#> T[C>A]C 0.0106085960 0.0137197786 0.0400547710 0.0047136309 1.774865e-02
#> T[C>A]G 0.0014921749 0.0008070802 0.0056666416 0.0008235142 1.420317e-03
#> T[C>A]T 0.0061261901 0.0174728084 0.0411438495 0.0152028899 1.998570e-02
#> A[C>G]A 0.0081800948 0.0210811865 0.0114230685 0.0069437192 5.150639e-03
#> A[C>G]C 0.0055748938 0.0119969580 0.0046727059 0.0044771671 3.282515e-03
#> A[C>G]G 0.0012622514 0.0030444725 0.0019015222 0.0006589576 7.800439e-04
#> A[C>G]T 0.0078098622 0.0259282639 0.0074821142 0.0110592066 7.229230e-03
#> C[C>G]A 0.0052975312 0.0146942023 0.0089158510 0.0026066479 3.656897e-03
#> C[C>G]C 0.0058039533 0.0098280407 0.0079767625 0.0020387266 4.893587e-03
#> C[C>G]G 0.0007250726 0.0024455393 0.0024115448 0.0009259727 1.145814e-03
#> C[C>G]T 0.0068225026 0.0218490983 0.0070391353 0.0045180996 1.133166e-02
#> G[C>G]A 0.0045471601 0.0086629831 0.0057833624 0.0026455636 2.776739e-03
#> G[C>G]C 0.0048320668 0.0097352446 0.0050211009 0.0034997762 1.435203e-02
#> G[C>G]G 0.0008051773 0.0016433389 0.0021036193 0.0005385771 6.919608e-05
#> G[C>G]T 0.0054841940 0.0164292841 0.0039178176 0.0023788781 9.536576e-03
#> T[C>G]A 0.0009934287 0.0523866718 0.0057098074 0.0014382465 2.193934e-03
#> T[C>G]C 0.0060181427 0.0295630154 0.0062437592 0.0036320527 2.790147e-03
#> T[C>G]G 0.0007619696 0.0035716643 0.0009957927 0.0007622827 1.981434e-04
#> T[C>G]T 0.0050186824 0.0909578602 0.0063103727 0.0067268458 1.932392e-02
#> A[C>T]A 0.0648583224 0.0114043153 0.0142358951 0.0140753894 1.101750e-02
#> A[C>T]C 0.0404750591 0.0061105927 0.0086615946 0.0066270957 1.016749e-02
#> A[C>T]G 0.0191925000 0.0113369911 0.0044066000 0.0149054864 4.726703e-03
#> A[C>T]T 0.0422082144 0.0125304774 0.0120121261 0.0160740286 8.246278e-03
#> C[C>T]A 0.0520078655 0.0113857610 0.0151715340 0.0119778815 2.043015e-02
#> C[C>T]C 0.0481173210 0.0031679484 0.0111864200 0.0058785063 8.430079e-02
#> C[C>T]G 0.0126387169 0.0073529409 0.0051489021 0.0090990838 6.719077e-03
#> C[C>T]T 0.0512285481 0.0108296946 0.0203236984 0.0176545122 7.080203e-02
#> G[C>T]A 0.0387864542 0.0100862330 0.0098061872 0.0068475874 1.665800e-02
#> G[C>T]C 0.0383213222 0.0057085691 0.0099173444 0.0040130459 1.690996e-02
#> G[C>T]G 0.0112389872 0.0078785262 0.0040952560 0.0115323515 6.763802e-03
#> G[C>T]T 0.0423091893 0.0092078440 0.0097817334 0.0091546913 1.371441e-02
#> T[C>T]A 0.0293992663 0.0339538672 0.0092330361 0.0080205792 1.389123e-02
#> T[C>T]C 0.0492691748 0.0130489673 0.0120152133 0.0099302852 2.844180e-02
#> T[C>T]G 0.0076420846 0.0058532594 0.0016652111 0.0070927045 6.978272e-03
#> T[C>T]T 0.0320327740 0.0290647283 0.0132427666 0.0213677657 1.687619e-02
#> A[T>A]A 0.0057838618 0.0066287710 0.0088854529 0.0408095333 4.301696e-03
#> A[T>A]C 0.0064481191 0.0045179820 0.0037174227 0.0132930753 6.242726e-03
#> A[T>A]G 0.0087150772 0.0076729868 0.0085211806 0.0199062558 3.519898e-03
#> A[T>A]T 0.0071287726 0.0083625308 0.0075344527 0.0445484141 4.857711e-03
#> C[T>A]A 0.0030769986 0.0056924425 0.0091324898 0.0136435518 2.650149e-02
#> C[T>A]C 0.0041492597 0.0075897356 0.0086475097 0.0122905200 2.064319e-02
#> C[T>A]G 0.0039264574 0.0079909074 0.0159758705 0.0089865736 2.721411e-02
#> C[T>A]T 0.0051083334 0.0122823448 0.0093171058 0.0212003010 3.737605e-02
#> G[T>A]A 0.0016701596 0.0030175394 0.0064237550 0.0132952962 2.476338e-03
#> G[T>A]C 0.0033920305 0.0019103004 0.0029982251 0.0085121628 4.843291e-03
#> G[T>A]G 0.0041089906 0.0049693532 0.0077691021 0.0069994345 3.846361e-03
#> G[T>A]T 0.0039496156 0.0073526016 0.0057717424 0.0110119648 2.588145e-03
#> T[T>A]A 0.0017835928 0.0078207327 0.0075468998 0.0400780605 4.294518e-03
#> T[T>A]C 0.0041303102 0.0038813344 0.0047175980 0.0119413204 5.018039e-03
#> T[T>A]G 0.0051426073 0.0041127092 0.0071552490 0.0094321870 2.845083e-03
#> T[T>A]T 0.0071479062 0.0113448748 0.0090681723 0.0326219735 6.795857e-03
#> A[T>C]A 0.0199694959 0.0185955723 0.0162947555 0.0339198025 1.239459e-02
#> A[T>C]C 0.0066307161 0.0074529998 0.0016386283 0.0099200817 3.512303e-03
#> A[T>C]G 0.0163563978 0.0138412716 0.0067584205 0.0123505857 7.045456e-03
#> A[T>C]T 0.0203675514 0.0173964063 0.0094525024 0.0337192849 1.088015e-02
#> C[T>C]A 0.0073340340 0.0056163073 0.0075006142 0.0082085515 8.333501e-03
#> C[T>C]C 0.0070934883 0.0102006878 0.0052286554 0.0072600222 7.219366e-03
#> C[T>C]G 0.0082732362 0.0056333436 0.0060015234 0.0018554519 9.196474e-03
#> C[T>C]T 0.0068292359 0.0114549452 0.0062427178 0.0140393074 1.704385e-02
#> G[T>C]A 0.0044301377 0.0056769876 0.0046936202 0.0147785456 3.237284e-03
#> G[T>C]C 0.0033021394 0.0057421645 0.0010045350 0.0122256772 8.072002e-03
#> G[T>C]G 0.0053937160 0.0069984667 0.0029452366 0.0061363112 1.997157e-03
#> G[T>C]T 0.0083838643 0.0076000099 0.0035628962 0.0256355021 4.522607e-03
#> T[T>C]A 0.0062501115 0.0073014532 0.0065783111 0.0193168046 2.358020e-03
#> T[T>C]C 0.0037138000 0.0084941967 0.0018855952 0.0218505261 2.248019e-03
#> T[T>C]G 0.0036811088 0.0051976007 0.0029200380 0.0037195054 3.309740e-03
#> T[T>C]T 0.0058553055 0.0099614212 0.0050988980 0.0340397591 5.209217e-03
#> A[T>G]A 0.0034599467 0.0067718865 0.0026248771 0.0188435784 2.694188e-03
#> A[T>G]C 0.0017708093 0.0021609030 0.0007225981 0.0043758008 1.859790e-03
#> A[T>G]G 0.0036081612 0.0063783552 0.0019091527 0.0041366920 3.757144e-03
#> A[T>G]T 0.0056016098 0.0039455509 0.0014110748 0.0044381281 3.284982e-03
#> C[T>G]A 0.0014398642 0.0049140122 0.0008263872 0.0055030931 2.381067e-03
#> C[T>G]C 0.0019093973 0.0035005404 0.0006345879 0.0029738418 1.670405e-03
#> C[T>G]G 0.0026517479 0.0073580234 0.0027181455 0.0033818020 3.618739e-03
#> C[T>G]T 0.0006966379 0.0013504053 0.0006967988 0.0008380963 2.454272e-03
#> G[T>G]A 0.0014474358 0.0028282026 0.0008449725 0.0053597646 1.430987e-03
#> G[T>G]C 0.0008892658 0.0016826936 0.0003789840 0.0020158500 4.169211e-03
#> G[T>G]G 0.0026588573 0.0070396333 0.0023593001 0.0008971177 4.679705e-03
#> G[T>G]T 0.0004024981 0.0030415265 0.0006399306 0.0033520127 2.048565e-03
#> T[T>G]A 0.0023414866 0.0090888640 0.0017865810 0.0153133540 2.439610e-03
#> T[T>G]C 0.0024681761 0.0055118161 0.0008432337 0.0069991642 2.456998e-03
#> T[T>G]G 0.0031119390 0.0091468160 0.0029921915 0.0078373874 3.761505e-03
#> T[T>G]T 0.0062556117 0.0090467651 0.0027839034 0.0132142285 6.178701e-03
#> Ref_Sig_MIXED2 Ref_Sig_33 Ref_Sig_22 Ref_Sig_10 Ref_Sig_36
#> A[C>A]A 6.738098e-03 0.0162819016 6.021869e-03 1.902081e-03 2.072396e-02
#> A[C>A]C 6.090299e-03 0.0091361140 3.532936e-03 2.917451e-03 9.412484e-03
#> A[C>A]G 2.878481e-04 0.0031735829 8.640196e-04 2.728535e-04 1.006201e-03
#> A[C>A]T 5.926141e-03 0.0087162888 4.065566e-03 1.351720e-02 1.814202e-02
#> C[C>A]A 5.075780e-03 0.0173408075 6.409783e-03 3.229600e-03 4.558057e-02
#> C[C>A]C 1.007986e-03 0.0104414014 5.720769e-03 1.174457e-03 1.576411e-02
#> C[C>A]G 1.893760e-03 0.0033583585 8.780096e-04 2.721001e-04 4.197190e-03
#> C[C>A]T 4.756729e-03 0.0100237692 4.902147e-03 1.497872e-02 6.714162e-02
#> G[C>A]A 1.821514e-03 0.0096068805 5.476800e-03 1.575751e-03 4.851741e-02
#> G[C>A]C 2.845256e-03 0.0068240201 6.306945e-03 1.814418e-03 1.707864e-02
#> G[C>A]G 2.106763e-03 0.0017112853 1.593502e-03 9.670732e-05 2.983557e-03
#> G[C>A]T 1.219633e-03 0.0056669584 4.788811e-03 8.939924e-03 5.179353e-02
#> T[C>A]A 1.196974e-02 0.0170114296 5.477944e-03 5.325962e-02 1.391986e-01
#> T[C>A]C 1.133886e-02 0.0163608789 5.776235e-03 6.464387e-03 5.309359e-02
#> T[C>A]G 1.596464e-03 0.0026665943 5.959579e-04 1.273530e-03 9.638718e-03
#> T[C>A]T 2.001435e-02 0.0163019181 7.415336e-03 3.624308e-01 2.133729e-01
#> A[C>G]A 1.798431e-03 0.0084585824 2.447632e-03 4.963770e-04 1.309437e-03
#> A[C>G]C 2.432736e-03 0.0041384200 9.279917e-04 2.402551e-04 6.707067e-04
#> A[C>G]G 5.569662e-04 0.0008768984 1.808570e-04 1.235765e-05 1.679685e-04
#> A[C>G]T 3.125379e-03 0.0060525995 1.636147e-03 3.084495e-04 6.140266e-04
#> C[C>G]A 2.256163e-03 0.0048224400 1.297611e-03 6.525949e-05 3.439105e-04
#> C[C>G]C 1.050768e-03 0.0045330472 1.167075e-03 6.426754e-05 3.270361e-04
#> C[C>G]G 1.243414e-03 0.0012647931 2.613964e-04 1.321157e-05 7.503129e-05
#> C[C>G]T 2.013404e-03 0.0036182964 1.139696e-03 9.798321e-05 5.376127e-04
#> G[C>G]A 1.208314e-03 0.0036239358 1.244820e-03 3.080054e-04 1.118406e-03
#> G[C>G]C 1.990828e-03 0.0029878610 1.292031e-03 2.083420e-04 1.172536e-03
#> G[C>G]G 2.292116e-04 0.0010102716 3.549211e-04 5.956401e-06 2.900320e-05
#> G[C>G]T 6.474419e-10 0.0017121945 9.174119e-04 2.997879e-04 2.848129e-04
#> T[C>G]A 1.858723e-02 0.0105109358 2.860091e-03 7.668083e-05 7.142618e-04
#> T[C>G]C 8.100722e-03 0.0069705591 2.074738e-03 8.226410e-05 2.182588e-03
#> T[C>G]G 1.523337e-03 0.0007429594 3.554474e-04 1.679499e-05 7.286133e-22
#> T[C>G]T 2.902834e-02 0.0166498370 3.397045e-03 2.411248e-04 2.135708e-03
#> A[C>T]A 2.889783e-02 0.0137360783 2.808344e-03 1.677194e-03 1.107685e-02
#> A[C>T]C 1.627424e-02 0.0072759065 2.777334e-03 3.718699e-03 6.016039e-03
#> A[C>T]G 2.021088e-02 0.0355831084 1.710398e-03 8.643056e-03 1.325701e-03
#> A[C>T]T 1.760335e-02 0.0094560320 2.014715e-03 6.101354e-03 4.569574e-03
#> C[C>T]A 3.385131e-02 0.0114735606 3.168360e-03 8.641858e-04 7.049243e-03
#> C[C>T]C 2.240211e-02 0.0088054484 6.563299e-03 1.485420e-03 3.748971e-03
#> C[C>T]G 1.692823e-02 0.0284312841 2.364071e-03 2.773792e-03 1.344959e-03
#> C[C>T]T 2.634396e-02 0.0121427248 3.471458e-03 2.423071e-03 3.130367e-03
#> G[C>T]A 1.689393e-02 0.0103505706 3.173286e-03 2.760905e-03 8.529864e-03
#> G[C>T]C 1.468047e-02 0.0102188689 4.355128e-03 1.186261e-02 6.827819e-03
#> G[C>T]G 1.973218e-02 0.0233290573 1.723662e-03 1.531471e-02 1.158693e-02
#> G[C>T]T 1.487834e-02 0.0095040822 3.146868e-03 1.445242e-02 3.984827e-03
#> T[C>T]A 1.522948e-01 0.0308843902 3.797367e-03 3.849956e-03 7.062614e-03
#> T[C>T]C 8.251034e-02 0.0161142814 3.393748e-03 1.171263e-02 6.783118e-03
#> T[C>T]G 2.143563e-02 0.0151962276 8.481872e-05 6.062920e-02 5.910037e-04
#> T[C>T]T 1.268166e-01 0.0255058040 2.269920e-03 3.148955e-02 1.108716e-02
#> A[T>A]A 6.005136e-03 0.0101374713 5.863706e-02 8.357861e-04 4.634586e-03
#> A[T>A]C 3.157888e-03 0.0024922473 9.213138e-03 3.879591e-04 3.052179e-03
#> A[T>A]G 5.197052e-03 0.0053031381 5.182048e-02 1.347076e-04 2.167248e-04
#> A[T>A]T 1.395514e-02 0.0071637855 1.714765e-02 5.779601e-03 2.213585e-02
#> C[T>A]A 2.086585e-03 0.0087570503 1.005324e-01 2.215250e-04 3.443211e-03
#> C[T>A]C 2.097755e-03 0.0058373217 4.731546e-02 4.475507e-04 1.608865e-03
#> C[T>A]G 2.692454e-03 0.0077850054 1.441800e-01 2.945155e-04 1.406623e-03
#> C[T>A]T 2.450747e-03 0.0070120942 4.404197e-02 1.152040e-03 3.001504e-04
#> G[T>A]A 2.547028e-03 0.0046916446 4.254719e-02 1.286935e-04 2.504597e-03
#> G[T>A]C 7.966960e-04 0.0012053026 9.867298e-03 2.484646e-04 1.705631e-04
#> G[T>A]G 2.068164e-03 0.0047100791 3.325710e-02 4.401467e-05 5.590746e-04
#> G[T>A]T 2.865211e-03 0.0041051978 9.418538e-03 7.341761e-04 2.863837e-03
#> T[T>A]A 1.238171e-02 0.0084349278 7.154662e-02 1.821045e-03 1.603150e-02
#> T[T>A]C 3.613336e-03 0.0042487047 1.830404e-02 7.777375e-04 2.700811e-03
#> T[T>A]G 1.507665e-03 0.0042390126 5.542338e-02 8.612468e-04 2.624436e-03
#> T[T>A]T 7.849123e-03 0.0071318511 2.780281e-02 6.870365e-03 7.298750e-03
#> A[T>C]A 6.402149e-03 0.0212501641 2.474426e-02 7.381218e-03 9.027932e-03
#> A[T>C]C 3.462807e-03 0.0038971864 8.087460e-04 4.368952e-03 2.764092e-03
#> A[T>C]G 3.479623e-03 0.0389565940 7.658194e-03 3.316882e-03 5.854062e-03
#> A[T>C]T 9.611592e-03 0.0103232769 3.411320e-03 6.964821e-03 7.061764e-03
#> C[T>C]A 5.605645e-03 0.0127414272 6.715777e-03 1.105538e-03 2.545483e-03
#> C[T>C]C 5.488621e-03 0.0163151615 3.016349e-03 1.712992e-03 1.186213e-03
#> C[T>C]G 3.081284e-03 0.0188036687 3.048093e-03 1.284193e-03 4.632997e-04
#> C[T>C]T 5.588564e-03 0.0059509030 1.231299e-03 2.397377e-03 1.493926e-03
#> G[T>C]A 2.525543e-03 0.0120643564 4.189789e-03 9.113948e-03 5.674277e-03
#> G[T>C]C 3.819882e-03 0.0034908731 2.072784e-03 8.492324e-03 3.991801e-03
#> G[T>C]G 1.144261e-03 0.0709256811 2.141554e-03 3.664624e-03 2.096211e-03
#> G[T>C]T 3.824269e-03 0.0066562445 1.222052e-03 1.417974e-02 6.237627e-03
#> T[T>C]A 5.277042e-03 0.0114066063 8.579286e-03 7.322665e-03 4.729805e-03
#> T[T>C]C 5.974466e-03 0.0062695804 8.256104e-04 7.809353e-03 7.846305e-03
#> T[T>C]G 1.747679e-03 0.1116413189 4.830910e-03 4.506953e-03 3.504190e-03
#> T[T>C]T 8.466753e-03 0.0089206102 9.393090e-04 1.193732e-02 8.204968e-03
#> A[T>G]A 3.234399e-03 0.0023901620 4.840594e-03 4.363255e-03 3.201915e-03
#> A[T>G]C 4.317101e-04 0.0013341280 2.799946e-04 3.567186e-03 1.272421e-03
#> A[T>G]G 2.126851e-03 0.0028007256 3.571832e-03 1.779813e-03 3.833788e-05
#> A[T>G]T 1.005571e-02 0.0030138417 1.759853e-03 2.946588e-02 2.541823e-03
#> C[T>G]A 3.653476e-04 0.0049961508 3.996126e-03 3.457548e-03 3.594858e-04
#> C[T>G]C 1.682097e-03 0.0020219861 1.089491e-03 1.294430e-03 7.405876e-04
#> C[T>G]G 2.547938e-03 0.0022143452 1.018425e-02 2.278568e-03 1.023763e-03
#> C[T>G]T 2.936089e-03 0.0025468239 1.182024e-03 1.667526e-02 5.616144e-04
#> G[T>G]A 2.373197e-03 0.0016514200 1.858737e-03 1.027115e-03 2.080978e-04
#> G[T>G]C 7.806653e-05 0.0011681734 5.293214e-04 1.648929e-03 2.731612e-05
#> G[T>G]G 3.009247e-03 0.0097613944 2.622231e-03 8.582988e-04 1.029345e-04
#> G[T>G]T 1.086734e-02 0.0015424004 7.598906e-04 4.724404e-03 4.097811e-13
#> T[T>G]A 2.516271e-03 0.0026105689 4.062553e-03 1.567577e-02 6.605101e-03
#> T[T>G]C 1.904097e-03 0.0023479870 6.934360e-04 6.562187e-03 3.523870e-05
#> T[T>G]G 1.120290e-03 0.0022488800 5.799660e-03 2.760308e-03 1.329298e-03
#> T[T>G]T 1.639080e-02 0.0038792806 2.075235e-03 1.311473e-01 1.367519e-02
#> Ref_Sig_7 Ref_Sig_MIXED3 Ref_Sig_16 Ref_Sig_19 Ref_Sig_N2
#> A[C>A]A 0.0062625340 1.777128e-02 2.186668e-02 9.241122e-03 0.0147922339
#> A[C>A]C 0.0029223781 9.488339e-03 9.292729e-03 8.472831e-03 0.0097500205
#> A[C>A]G 0.0004262525 1.441559e-03 1.861149e-03 1.292161e-03 0.0018437059
#> A[C>A]T 0.0044302705 8.285931e-03 1.314783e-02 2.591406e-03 0.0094847384
#> C[C>A]A 0.0042736998 1.408774e-02 1.555677e-02 1.137185e-02 0.0058119611
#> C[C>A]C 0.0042456665 7.421407e-03 1.004139e-02 6.636580e-03 0.0021033972
#> C[C>A]G 0.0002447005 1.305572e-03 2.151493e-03 8.263072e-04 0.0005326510
#> C[C>A]T 0.0059414479 1.449261e-02 1.128062e-02 2.924944e-03 0.0060611186
#> G[C>A]A 0.0031442832 2.741271e-02 1.259733e-02 4.050276e-03 0.0018264751
#> G[C>A]C 0.0022699929 5.869447e-03 9.126254e-03 4.219213e-03 0.0026259463
#> G[C>A]G 0.0003349953 2.223743e-03 1.314621e-03 2.453378e-04 0.0003469625
#> G[C>A]T 0.0032467890 1.265668e-02 1.067321e-02 4.018857e-03 0.0033257993
#> T[C>A]A 0.0054416810 1.316882e-02 1.911271e-02 3.555030e-03 0.0161158704
#> T[C>A]C 0.0031765172 6.981944e-03 1.387657e-02 5.733912e-03 0.0060132120
#> T[C>A]G 0.0005374713 1.601191e-03 1.383588e-03 8.086907e-04 0.0006720419
#> T[C>A]T 0.0030534338 2.890110e-02 2.245120e-02 4.043258e-03 0.0210400094
#> A[C>G]A 0.0042318201 3.786447e-03 7.924006e-03 3.586213e-03 0.0108527571
#> A[C>G]C 0.0024475544 3.079539e-03 4.026307e-03 2.063119e-03 0.0062129257
#> A[C>G]G 0.0001913231 7.474250e-04 6.445651e-04 1.337193e-04 0.0021469418
#> A[C>G]T 0.0023037379 2.890423e-03 1.878590e-02 3.110770e-03 0.0198934161
#> C[C>G]A 0.0019784724 1.569700e-03 4.917995e-03 2.367132e-03 0.0042802901
#> C[C>G]C 0.0017271823 2.574356e-03 3.714140e-03 1.716665e-03 0.0029922173
#> C[C>G]G 0.0005489962 5.025655e-04 1.416947e-03 5.729955e-05 0.0007284548
#> C[C>G]T 0.0017554673 2.438933e-03 1.387284e-02 1.723265e-03 0.0066759452
#> G[C>G]A 0.0020205294 1.147270e-03 2.347425e-03 8.688507e-04 0.0029990809
#> G[C>G]C 0.0015677732 1.400061e-03 5.052593e-03 1.110133e-03 0.0063199853
#> G[C>G]G 0.0002018979 3.467414e-04 1.042947e-06 2.922457e-04 0.0004510886
#> G[C>G]T 0.0010369506 1.342629e-03 8.050446e-03 1.730353e-03 0.0080262436
#> T[C>G]A 0.0029534053 1.635252e-02 4.550722e-03 1.355362e-03 0.0161605984
#> T[C>G]C 0.0007297788 3.228498e-03 4.475031e-03 1.101967e-03 0.0079571334
#> T[C>G]G 0.0001728866 1.704663e-04 1.184321e-03 1.027172e-03 0.0011619573
#> T[C>G]T 0.0010033388 1.925879e-09 4.013521e-02 4.352446e-03 0.0391099435
#> A[C>T]A 0.0091135365 2.596304e-02 6.259306e-03 2.706568e-02 0.0082396913
#> A[C>T]C 0.0168892934 1.438129e-02 8.289530e-03 4.754914e-03 0.0043323676
#> A[C>T]G 0.0087007224 5.110941e-02 3.062621e-03 1.978214e-02 0.0138128397
#> A[C>T]T 0.0158801944 2.023051e-02 1.329230e-02 2.403357e-02 0.0076892819
#> C[C>T]A 0.0522859269 2.147390e-02 8.206305e-03 8.230355e-02 0.0078001383
#> C[C>T]C 0.0630864381 1.969882e-02 5.855139e-03 7.540640e-02 0.0023368965
#> C[C>T]G 0.0104347506 3.527687e-02 4.208335e-08 2.273337e-02 0.0092497572
#> C[C>T]T 0.0646572443 2.212803e-02 1.978168e-02 1.612368e-01 0.0044354133
#> G[C>T]A 0.0083236775 1.730387e-02 1.027755e-02 4.254755e-02 0.0045184087
#> G[C>T]C 0.0128694741 1.437205e-02 7.910156e-03 4.711081e-02 0.0012982362
#> G[C>T]G 0.0027748895 4.155848e-02 1.575342e-03 1.700263e-02 0.0111421183
#> G[C>T]T 0.0181466488 1.459897e-02 1.449862e-02 8.087916e-02 0.0030001478
#> T[C>T]A 0.1370704231 7.790358e-02 1.771208e-03 2.672446e-02 0.0174051041
#> T[C>T]C 0.2052989197 3.931348e-02 1.047823e-02 1.158911e-02 0.0086654886
#> T[C>T]G 0.0480301051 2.161711e-02 4.177706e-04 6.015343e-03 0.0094555927
#> T[C>T]T 0.1048629797 5.726415e-02 1.758232e-02 3.055299e-02 0.0123616312
#> A[T>A]A 0.0041720971 3.312082e-03 1.352659e-02 4.017045e-03 0.0121138759
#> A[T>A]C 0.0043211849 4.620743e-03 6.591070e-03 3.630395e-03 0.0076431990
#> A[T>A]G 0.0028456580 4.069997e-03 8.707277e-03 4.580079e-03 0.0078406871
#> A[T>A]T 0.0096831276 1.170370e-02 1.047373e-02 1.544571e-03 0.0174975424
#> C[T>A]A 0.0030284849 2.300604e-03 4.612238e-03 3.783720e-03 0.0128773679
#> C[T>A]C 0.0039929621 5.176709e-03 5.718535e-03 4.453738e-03 0.0068666343
#> C[T>A]G 0.0024294301 4.897857e-03 2.622090e-03 1.309721e-03 0.0060610037
#> C[T>A]T 0.0031730710 9.186524e-03 6.235792e-03 4.802689e-03 0.0227674226
#> G[T>A]A 0.0004901613 1.424150e-03 1.535845e-03 1.923164e-03 0.0059008494
#> G[T>A]C 0.0021531762 1.553822e-03 2.501681e-03 2.417032e-04 0.0051039911
#> G[T>A]G 0.0017972492 2.479711e-03 3.372809e-03 1.944146e-03 0.0049315516
#> G[T>A]T 0.0025501818 4.744687e-03 1.562590e-03 1.783973e-03 0.0064076205
#> T[T>A]A 0.0066283312 1.417074e-02 9.587050e-03 5.505737e-03 0.0291000095
#> T[T>A]C 0.0031273155 1.366202e-03 4.763894e-03 2.879685e-03 0.0093486063
#> T[T>A]G 0.0021717494 2.884225e-03 4.225489e-03 3.514994e-03 0.0097148952
#> T[T>A]T 0.0073567287 9.692143e-03 2.607042e-03 6.110771e-03 0.0318362060
#> A[T>C]A 0.0033667105 5.270146e-03 1.479547e-01 2.654435e-02 0.0306631119
#> A[T>C]C 0.0015808843 4.625795e-03 1.140683e-02 3.863254e-03 0.0037585125
#> A[T>C]G 0.0015143808 3.993892e-03 4.302692e-02 1.907968e-02 0.0052791893
#> A[T>C]T 0.0032916365 6.665949e-03 7.970203e-02 1.507985e-02 0.0100263317
#> C[T>C]A 0.0030051280 3.297436e-03 1.837957e-02 3.230178e-03 0.0285396385
#> C[T>C]C 0.0012080416 6.857633e-03 6.557230e-03 2.256805e-03 0.0063890145
#> C[T>C]G 0.0025005802 4.532953e-03 9.795367e-03 5.863175e-03 0.0007220899
#> C[T>C]T 0.0078496146 1.753676e-02 1.982753e-02 6.479023e-03 0.0084586557
#> G[T>C]A 0.0019025708 6.537351e-03 1.022392e-02 6.560457e-03 0.0147211319
#> G[T>C]C 0.0002638991 4.970378e-03 2.786386e-03 1.859144e-03 0.0037677245
#> G[T>C]G 0.0005070216 2.703300e-03 6.487338e-03 4.768703e-03 0.0006337506
#> G[T>C]T 0.0142129600 4.024542e-03 6.683249e-03 1.432347e-02 0.0050079360
#> T[T>C]A 0.0066948156 2.426061e-03 2.542253e-02 8.145851e-03 0.0764211285
#> T[T>C]C 0.0014537500 6.426401e-03 3.999903e-03 1.934110e-03 0.0106517714
#> T[T>C]G 0.0036343870 9.571295e-04 7.910726e-03 6.552553e-03 0.0126118394
#> T[T>C]T 0.0064784119 1.224349e-02 1.102690e-02 1.248336e-02 0.0170484402
#> A[T>G]A 0.0006072287 1.442547e-03 1.029267e-02 5.894703e-03 0.0228935953
#> A[T>G]C 0.0003516313 8.255130e-04 2.469382e-03 2.185383e-03 0.0018633089
#> A[T>G]G 0.0033566337 2.163454e-03 3.907399e-03 4.180482e-03 0.0053628897
#> A[T>G]T 0.0014317084 1.056302e-02 7.224253e-03 1.174679e-03 0.0072874686
#> C[T>G]A 0.0007017290 2.588233e-03 2.249997e-03 9.520922e-04 0.0114320183
#> C[T>G]C 0.0004767440 2.397165e-03 3.250404e-03 1.381794e-03 0.0035284442
#> C[T>G]G 0.0027976226 2.962802e-03 4.561633e-03 1.448624e-03 0.0036731541
#> C[T>G]T 0.0012046336 4.585877e-02 1.237274e-03 8.700625e-04 0.0218562323
#> G[T>G]A 0.0006199208 1.222586e-03 2.073996e-03 3.567300e-04 0.0045185313
#> G[T>G]C 0.0001990250 8.073584e-04 1.114265e-03 7.626512e-04 0.0019689223
#> G[T>G]G 0.0036185384 3.341189e-03 2.309676e-03 1.617791e-03 0.0023467852
#> G[T>G]T 0.0022460080 1.261177e-02 2.389192e-03 1.538689e-03 0.0017012612
#> T[T>G]A 0.0013000616 1.328988e-03 8.771188e-03 3.688132e-03 0.0456804255
#> T[T>G]C 0.0006781141 1.620311e-03 4.788011e-03 2.914429e-03 0.0111152395
#> T[T>G]G 0.0032707444 2.896028e-03 4.085563e-03 1.117469e-03 0.0106048649
#> T[T>G]T 0.0045055031 2.183592e-02 1.334848e-02 2.499274e-03 0.0493968938
#> Ref_Sig_9 Ref_Sig_N3 Ref_Sig_52 Ref_Sig_11 Ref_Sig_38
#> A[C>A]A 1.002162e-02 3.152716e-05 8.820322e-03 4.693774e-04 5.780576e-03
#> A[C>A]C 1.068685e-02 1.582543e-04 2.813218e-03 4.123511e-04 9.140234e-03
#> A[C>A]G 4.231560e-04 5.786899e-07 3.517274e-03 8.382244e-23 6.446316e-04
#> A[C>A]T 4.407820e-03 3.334786e-03 6.190007e-03 7.138749e-04 6.674443e-03
#> C[C>A]A 8.261511e-04 3.172242e-03 3.398055e-02 1.390993e-04 2.620366e-01
#> C[C>A]C 3.535716e-03 2.720618e-03 6.701617e-03 7.250643e-04 3.025916e-02
#> C[C>A]G 5.108685e-04 4.148314e-14 5.327423e-03 3.604907e-05 3.828995e-02
#> C[C>A]T 7.453978e-06 7.115757e-03 6.538190e-03 7.581352e-04 1.010792e-01
#> G[C>A]A 6.079736e-03 6.882160e-14 1.529957e-03 7.357702e-05 1.270875e-02
#> G[C>A]C 1.013194e-02 2.092066e-05 2.683186e-03 2.167596e-04 6.681934e-03
#> G[C>A]G 1.979445e-05 3.035633e-04 3.495802e-03 7.823781e-22 2.366225e-03
#> G[C>A]T 2.074459e-03 7.871241e-03 3.543528e-03 3.357635e-04 7.552678e-03
#> T[C>A]A 3.916724e-02 1.595973e-02 2.708758e-01 4.642611e-04 1.800591e-02
#> T[C>A]C 5.870822e-03 7.231133e-14 3.450285e-02 9.481212e-04 1.226775e-02
#> T[C>A]G 1.029088e-03 1.152280e-03 6.954683e-02 4.049306e-05 3.416924e-03
#> T[C>A]T 2.501119e-02 2.623196e-02 3.424604e-02 7.963710e-04 3.961501e-02
#> A[C>G]A 5.103167e-03 6.447031e-04 8.187227e-03 4.140144e-04 7.055168e-03
#> A[C>G]C 1.035345e-03 1.433934e-03 6.321527e-03 2.422272e-04 7.475977e-03
#> A[C>G]G 2.130935e-04 1.352811e-03 1.897005e-03 5.679953e-05 1.584859e-21
#> A[C>G]T 2.523450e-03 4.455168e-04 1.109163e-02 2.716612e-04 1.040659e-03
#> C[C>G]A 5.348477e-13 2.273532e-14 4.298491e-03 1.998515e-04 1.595647e-03
#> C[C>G]C 6.809062e-05 1.525927e-03 3.375379e-03 9.471534e-05 1.941037e-03
#> C[C>G]G 1.100416e-04 6.012442e-04 6.607369e-21 3.437885e-05 1.776115e-03
#> C[C>G]T 1.622191e-03 1.053984e-03 3.496536e-03 2.582445e-04 4.554128e-03
#> G[C>G]A 2.835297e-03 3.853897e-03 5.739738e-03 9.235068e-05 3.608472e-03
#> G[C>G]C 3.329156e-05 4.526850e-03 4.830605e-03 1.635328e-04 8.906892e-04
#> G[C>G]G 3.020235e-04 3.642823e-04 1.420659e-03 2.278999e-05 1.546024e-03
#> G[C>G]T 8.100601e-05 5.884888e-03 2.726067e-03 1.637761e-04 3.703191e-03
#> T[C>G]A 3.710979e-22 7.327269e-03 8.723225e-03 6.397843e-04 1.143687e-02
#> T[C>G]C 2.481216e-19 4.500686e-03 3.642079e-03 4.475508e-04 8.441500e-03
#> T[C>G]G 3.710979e-22 8.394742e-05 1.179481e-03 8.382244e-23 7.270908e-04
#> T[C>G]T 1.032601e-03 8.362785e-03 9.006897e-03 7.501421e-04 2.032770e-02
#> A[C>T]A 7.884710e-03 2.459934e-05 1.377043e-02 2.742586e-02 1.090876e-02
#> A[C>T]C 4.944064e-03 3.744538e-06 4.779717e-03 1.190992e-01 4.396973e-03
#> A[C>T]G 6.453290e-03 4.057134e-03 1.604480e-02 5.925908e-03 2.495032e-02
#> A[C>T]T 3.960646e-03 8.787616e-04 8.378278e-03 9.149425e-02 6.133622e-03
#> C[C>T]A 6.188850e-03 8.860357e-06 1.759810e-02 2.247821e-02 1.213824e-02
#> C[C>T]C 3.619831e-03 8.293301e-11 7.824089e-03 1.236273e-01 1.510794e-02
#> C[C>T]G 3.023183e-03 7.544535e-04 1.091773e-02 3.349626e-03 1.294433e-02
#> C[C>T]T 7.254987e-03 3.421228e-03 1.375328e-02 8.457230e-02 4.767611e-03
#> G[C>T]A 3.343477e-03 4.900444e-04 7.428775e-03 2.420417e-02 1.225856e-02
#> G[C>T]C 8.482966e-16 1.165013e-02 3.564320e-03 9.522914e-02 9.597189e-03
#> G[C>T]G 3.710979e-22 1.635953e-02 1.424613e-02 4.546578e-03 2.445011e-02
#> G[C>T]T 1.181358e-21 1.584868e-02 4.439998e-03 6.374606e-02 6.764105e-03
#> T[C>T]A 1.803007e-05 2.120611e-02 8.571158e-03 2.900507e-02 1.992738e-02
#> T[C>T]C 3.622582e-03 9.080928e-03 7.407166e-03 1.535366e-01 1.764115e-02
#> T[C>T]G 3.067831e-07 2.122507e-04 1.138182e-02 3.557157e-03 1.610977e-02
#> T[C>T]T 3.116652e-03 1.178263e-02 4.495017e-03 1.222195e-01 2.053256e-02
#> A[T>A]A 1.283529e-02 1.353210e-04 8.170139e-03 5.348127e-04 4.878709e-03
#> A[T>A]C 3.048439e-03 1.660054e-02 2.213742e-03 1.225748e-04 2.478055e-03
#> A[T>A]G 8.983090e-03 1.834888e-03 4.161089e-03 1.844559e-04 5.925110e-03
#> A[T>A]T 1.526562e-02 6.006649e-03 6.459031e-03 6.217478e-04 5.152244e-03
#> C[T>A]A 5.926536e-03 9.012991e-04 1.666254e-03 3.798462e-04 8.543937e-05
#> C[T>A]C 2.019530e-21 3.771981e-03 1.036497e-03 1.921053e-04 9.993828e-04
#> C[T>A]G 8.418769e-03 1.200744e-04 3.905898e-03 2.156935e-04 3.112059e-03
#> C[T>A]T 9.634233e-18 5.003305e-04 2.411952e-03 5.178254e-04 1.836258e-03
#> G[T>A]A 2.866724e-03 4.022617e-05 1.244175e-03 4.060880e-05 6.895182e-04
#> G[T>A]C 3.710979e-22 8.719633e-03 7.404778e-04 2.898646e-04 1.584859e-21
#> G[T>A]G 4.967448e-04 2.650756e-07 7.174714e-03 2.055859e-04 2.318738e-03
#> G[T>A]T 3.277680e-03 1.712084e-03 1.268192e-03 3.417977e-04 2.090514e-03
#> T[T>A]A 2.739364e-02 8.632413e-03 1.730520e-03 3.088370e-04 2.468455e-03
#> T[T>A]C 2.651795e-03 2.641501e-03 4.647327e-04 1.597185e-04 3.688985e-03
#> T[T>A]G 3.552048e-02 7.325859e-20 2.329475e-03 2.700001e-04 1.584859e-21
#> T[T>A]T 1.678685e-02 1.124572e-03 5.142671e-03 8.304268e-04 1.104125e-03
#> A[T>C]A 2.906722e-02 1.419983e-02 1.942338e-02 2.203938e-04 8.248369e-03
#> A[T>C]C 9.620965e-03 1.557269e-02 8.872757e-03 7.338689e-04 3.383218e-03
#> A[T>C]G 1.976492e-02 1.471890e-02 1.042285e-02 7.525878e-17 7.210535e-03
#> A[T>C]T 2.415652e-02 1.550258e-02 2.185915e-02 9.984905e-04 7.462647e-03
#> C[T>C]A 1.412956e-02 5.114681e-03 1.293576e-02 3.719245e-04 2.276444e-03
#> C[T>C]C 6.971506e-03 1.123252e-02 6.335165e-03 6.681155e-04 1.037295e-03
#> C[T>C]G 1.473538e-02 9.438554e-03 4.222313e-03 2.511127e-20 6.334921e-03
#> C[T>C]T 1.258250e-02 3.400585e-03 1.186982e-02 3.654305e-04 4.344236e-03
#> G[T>C]A 5.613136e-03 1.209222e-02 1.094664e-02 1.485760e-03 4.573637e-03
#> G[T>C]C 2.498742e-03 3.976495e-02 8.047779e-03 8.674427e-04 2.397292e-04
#> G[T>C]G 6.370348e-03 1.947625e-02 2.667887e-03 4.469732e-04 4.030319e-03
#> G[T>C]T 1.993636e-04 1.678780e-02 1.270072e-02 9.614703e-04 1.114286e-02
#> T[T>C]A 1.666622e-02 3.475991e-03 1.328865e-02 3.602707e-04 7.808456e-03
#> T[T>C]C 8.032387e-03 4.226013e-02 6.596448e-03 5.443207e-04 2.907550e-03
#> T[T>C]G 1.017474e-02 8.002148e-03 9.896877e-05 3.286256e-04 6.127183e-03
#> T[T>C]T 2.916707e-02 7.341303e-03 7.490042e-03 6.128840e-04 5.121164e-03
#> A[T>G]A 7.804695e-02 9.937283e-03 5.620233e-03 1.637078e-04 1.671692e-04
#> A[T>G]C 6.986099e-03 4.364052e-03 2.160859e-03 8.382244e-23 7.435833e-04
#> A[T>G]G 8.323091e-03 6.444136e-03 3.127531e-03 4.594876e-05 6.077762e-03
#> A[T>G]T 2.148243e-02 2.804901e-02 8.291184e-03 2.308216e-04 2.582344e-03
#> C[T>G]A 4.101923e-02 2.499614e-02 4.311956e-03 8.382244e-23 1.584859e-21
#> C[T>G]C 8.380482e-05 1.162888e-02 1.579439e-03 4.714890e-22 1.244376e-03
#> C[T>G]G 1.658099e-02 2.416487e-02 1.853986e-03 8.382244e-23 2.687250e-03
#> C[T>G]T 1.787585e-02 1.002523e-01 2.864760e-04 1.979287e-04 3.440313e-03
#> G[T>G]A 9.472196e-03 7.879153e-03 3.351742e-03 4.840987e-05 9.202269e-04
#> G[T>G]C 6.854575e-03 1.204160e-02 2.703945e-03 6.580383e-05 1.082063e-03
#> G[T>G]G 4.267795e-03 1.639338e-02 4.500177e-03 8.622360e-05 3.951768e-03
#> G[T>G]T 8.420657e-03 1.227435e-01 3.224711e-03 1.671378e-04 1.145190e-03
#> T[T>G]A 1.348045e-01 3.203787e-02 2.634151e-03 5.206521e-05 2.194610e-04
#> T[T>G]C 1.001065e-02 3.265051e-03 4.259419e-03 2.526429e-04 8.279893e-04
#> T[T>G]G 1.815816e-02 8.153031e-03 6.813083e-03 2.649521e-04 1.168136e-03
#> T[T>G]T 7.619665e-02 9.071155e-02 1.253325e-02 2.444986e-04 3.397369e-03
#> Ref_Sig_51 Ref_Sig_N4 Ref_Sig_N5 Ref_Sig_N6 Ref_Sig_N7
#> A[C>A]A 1.072440e-01 6.371023e-03 1.139358e-02 1.438278e-02 1.783563e-02
#> A[C>A]C 1.563811e-02 1.216170e-02 1.715944e-02 2.444077e-02 1.428945e-05
#> A[C>A]G 5.014373e-03 9.497014e-04 1.104750e-03 4.101380e-03 9.829294e-04
#> A[C>A]T 2.676498e-02 8.824336e-03 8.269632e-03 1.218547e-02 8.979608e-03
#> C[C>A]A 2.234187e-02 7.263846e-03 3.054332e-02 3.943616e-03 2.343996e-02
#> C[C>A]C 3.422638e-03 1.192607e-02 5.520484e-03 1.833758e-22 7.541543e-03
#> C[C>A]G 1.137755e-03 3.055901e-03 1.260751e-03 1.524283e-03 1.465988e-17
#> C[C>A]T 8.649499e-03 8.200949e-20 1.409857e-02 5.382011e-03 4.610496e-03
#> G[C>A]A 4.754455e-02 7.146837e-03 7.657532e-03 1.265577e-06 1.214469e-02
#> G[C>A]C 8.376135e-03 6.383735e-03 6.949757e-03 1.394786e-02 9.372574e-04
#> G[C>A]G 3.325722e-03 1.168077e-20 5.143226e-04 2.802367e-03 2.090781e-03
#> G[C>A]T 4.844796e-06 6.931016e-03 7.635675e-03 1.833758e-22 1.303200e-20
#> T[C>A]A 1.367453e-02 1.211365e-02 6.619023e-03 1.194331e-02 1.169356e-02
#> T[C>A]C 4.440197e-04 8.022938e-03 9.870985e-03 1.476160e-02 4.723298e-03
#> T[C>A]G 4.710281e-03 1.168077e-20 4.721077e-04 9.657393e-04 2.441556e-03
#> T[C>A]T 3.959744e-07 9.369219e-03 1.165610e-02 6.740501e-03 8.429627e-08
#> A[C>G]A 1.624110e-02 8.364264e-03 1.249227e-15 6.887280e-03 9.658342e-03
#> A[C>G]C 4.757316e-03 8.290288e-03 3.281954e-03 7.032534e-03 7.196893e-03
#> A[C>G]G 1.485542e-12 1.168077e-20 1.466388e-15 4.190541e-03 1.139974e-03
#> A[C>G]T 5.438412e-03 1.032957e-02 6.754402e-03 6.030614e-03 6.473930e-03
#> C[C>G]A 4.308009e-03 3.425462e-04 1.133682e-03 5.945622e-03 3.135638e-03
#> C[C>G]C 7.546557e-03 4.703007e-03 1.843669e-21 1.190877e-03 7.986950e-04
#> C[C>G]G 9.748595e-08 4.487039e-03 1.843669e-21 3.385101e-03 9.888615e-04
#> C[C>G]T 3.109410e-03 5.494326e-03 3.106931e-03 2.178172e-03 5.098626e-04
#> G[C>G]A 9.034117e-04 2.287456e-03 2.238753e-03 6.034466e-03 5.435692e-03
#> G[C>G]C 9.924524e-04 4.128901e-03 3.082270e-03 5.059567e-03 1.303200e-20
#> G[C>G]G 5.992481e-05 1.650716e-03 1.843669e-21 5.016713e-03 4.393517e-03
#> G[C>G]T 1.951616e-20 2.903132e-03 5.191689e-14 3.538010e-03 2.284064e-11
#> T[C>G]A 9.667160e-08 1.016677e-02 4.398972e-03 1.833758e-22 2.470883e-03
#> T[C>G]C 1.242145e-02 4.206606e-03 4.958528e-03 4.590008e-03 5.147201e-03
#> T[C>G]G 1.542524e-21 4.151645e-04 1.783590e-03 2.798960e-03 1.303200e-20
#> T[C>G]T 2.879656e-07 1.507567e-02 1.300063e-02 1.833758e-22 2.399067e-03
#> A[C>T]A 2.554667e-02 2.950599e-02 6.826793e-03 5.038946e-02 4.621345e-02
#> A[C>T]C 1.069197e-02 1.642946e-02 6.861046e-03 3.108239e-09 2.749647e-02
#> A[C>T]G 5.137535e-03 7.332013e-02 3.109523e-02 2.674634e-02 5.539176e-02
#> A[C>T]T 3.559711e-03 1.766099e-02 1.132469e-02 2.158144e-02 2.193957e-02
#> C[C>T]A 8.863647e-03 1.063267e-02 1.666304e-02 3.017323e-02 3.464181e-02
#> C[C>T]C 1.466706e-02 2.484710e-02 1.440466e-02 7.376624e-03 9.648857e-03
#> C[C>T]G 5.671859e-03 3.011759e-02 2.636795e-02 4.724155e-02 2.518991e-02
#> C[C>T]T 6.022584e-03 3.643503e-02 2.273178e-02 2.159679e-14 4.207880e-02
#> G[C>T]A 9.874831e-09 1.664826e-02 4.862342e-03 1.974591e-02 1.558212e-02
#> G[C>T]C 8.709558e-03 1.910759e-02 8.738150e-03 3.745322e-05 1.133829e-02
#> G[C>T]G 2.412098e-06 3.731549e-02 2.411354e-02 3.106503e-02 3.988928e-02
#> G[C>T]T 1.518720e-02 2.437727e-02 1.097168e-02 1.010150e-03 1.127469e-02
#> T[C>T]A 1.182724e-09 1.903987e-02 4.020141e-02 2.909513e-02 1.591418e-02
#> T[C>T]C 1.396317e-02 1.356902e-02 5.309419e-02 1.221532e-02 5.068013e-03
#> T[C>T]G 6.984742e-03 2.157745e-02 3.681165e-02 3.231575e-02 1.600867e-02
#> T[C>T]T 4.552169e-02 2.074738e-02 2.403044e-02 1.856460e-02 4.598887e-02
#> A[T>A]A 5.142960e-02 1.418412e-02 1.636641e-02 2.652046e-02 3.008616e-02
#> A[T>A]C 1.014977e-02 8.291575e-03 5.684718e-03 1.374537e-02 2.767971e-17
#> A[T>A]G 4.166323e-02 9.244255e-03 3.060989e-03 9.907299e-03 1.260279e-02
#> A[T>A]T 1.430532e-02 1.331292e-02 7.355349e-03 2.634595e-02 3.790146e-03
#> C[T>A]A 6.769085e-03 5.664413e-03 3.785244e-03 2.807838e-03 8.656202e-05
#> C[T>A]C 2.676285e-03 5.802348e-03 2.681127e-03 4.761481e-03 3.021073e-03
#> C[T>A]G 5.536417e-03 1.406908e-11 6.730528e-03 4.272644e-03 6.141851e-03
#> C[T>A]T 5.816076e-03 3.935151e-03 8.060830e-03 4.732045e-03 1.303200e-20
#> G[T>A]A 8.089701e-03 2.534935e-03 3.650451e-03 8.335287e-03 5.663613e-03
#> G[T>A]C 1.172000e-03 2.999449e-03 4.898315e-03 6.346532e-03 8.729544e-03
#> G[T>A]G 6.016376e-03 2.896677e-03 2.197536e-03 4.356503e-03 1.154493e-02
#> G[T>A]T 1.205165e-02 4.796394e-03 4.788683e-03 1.893302e-03 7.527255e-05
#> T[T>A]A 8.744865e-03 2.250908e-02 5.675370e-12 2.069884e-02 3.375948e-03
#> T[T>A]C 2.523944e-03 8.955258e-03 4.552634e-03 6.292650e-03 2.742601e-03
#> T[T>A]G 4.713139e-03 9.959261e-03 6.748833e-03 4.363179e-03 1.303200e-20
#> T[T>A]T 2.923266e-03 2.258610e-02 1.220616e-02 1.534998e-02 1.001388e-02
#> A[T>C]A 1.769123e-02 1.868632e-02 1.526994e-02 3.654149e-02 4.325552e-02
#> A[T>C]C 6.751311e-03 6.884018e-03 6.686812e-03 7.740685e-03 8.053371e-03
#> A[T>C]G 5.691014e-03 1.433573e-02 1.184690e-02 3.991604e-03 1.696257e-02
#> A[T>C]T 7.237515e-03 1.507900e-02 1.849319e-02 1.912343e-02 2.856964e-02
#> C[T>C]A 2.980607e-13 5.319541e-03 7.903751e-03 6.487968e-03 9.821269e-03
#> C[T>C]C 3.329900e-02 6.226556e-03 8.215002e-03 1.122864e-02 2.157342e-02
#> C[T>C]G 1.097173e-03 8.224605e-03 6.275010e-03 8.543183e-03 1.173205e-02
#> C[T>C]T 4.272235e-03 1.013759e-02 1.633755e-02 9.241237e-03 1.285769e-02
#> G[T>C]A 2.238682e-10 8.221669e-03 1.714262e-02 1.961262e-02 4.545322e-04
#> G[T>C]C 1.582149e-03 3.371032e-03 8.616908e-03 1.318962e-02 5.219218e-04
#> G[T>C]G 3.912683e-03 2.337616e-03 5.466655e-03 1.227614e-02 5.450413e-03
#> G[T>C]T 5.242399e-03 4.276367e-03 6.959107e-02 1.782078e-02 1.122534e-02
#> T[T>C]A 3.390222e-13 7.846705e-03 1.288424e-02 2.164981e-02 1.035413e-02
#> T[T>C]C 4.896462e-03 2.442467e-03 9.930895e-03 2.174010e-02 8.601752e-03
#> T[T>C]G 2.340685e-03 6.077192e-03 3.300683e-03 8.722209e-03 2.551076e-03
#> T[T>C]T 1.502935e-02 7.900708e-03 1.943064e-02 2.215552e-02 2.067632e-02
#> A[T>G]A 1.093990e-02 1.547774e-02 7.394074e-03 4.533140e-03 1.994252e-14
#> A[T>G]C 4.733245e-03 5.722054e-03 3.119223e-03 1.269098e-03 1.303200e-20
#> A[T>G]G 1.748530e-02 5.567853e-03 3.284531e-02 1.091182e-02 1.094597e-02
#> A[T>G]T 7.541867e-03 1.994674e-03 4.353115e-03 5.540942e-03 3.307739e-03
#> C[T>G]A 5.042838e-03 1.071781e-02 3.768128e-03 2.169107e-03 2.821424e-05
#> C[T>G]C 1.163587e-12 3.993562e-03 2.527353e-03 1.746258e-03 1.303200e-20
#> C[T>G]G 1.204372e-02 1.909152e-03 1.296436e-02 7.102152e-03 4.905159e-03
#> C[T>G]T 3.480696e-17 2.155318e-03 2.626793e-04 3.820199e-03 2.722667e-03
#> G[T>G]A 5.943646e-03 2.245941e-03 5.830996e-03 1.994028e-03 6.875248e-03
#> G[T>G]C 5.074652e-03 2.999382e-03 1.293882e-03 5.619259e-04 3.202083e-03
#> G[T>G]G 1.077895e-01 8.752956e-03 3.920895e-02 1.783573e-02 7.674207e-02
#> G[T>G]T 6.188140e-03 1.298025e-03 6.374164e-03 4.635479e-03 1.303200e-20
#> T[T>G]A 2.701545e-03 5.199140e-02 6.038695e-03 5.561127e-03 1.303200e-20
#> T[T>G]C 6.789231e-03 2.108212e-03 1.048865e-03 4.492620e-03 7.864139e-04
#> T[T>G]G 6.602352e-03 6.079483e-03 1.097314e-02 9.287899e-03 5.486325e-03
#> T[T>G]T 1.289806e-02 1.725065e-02 8.273057e-03 9.184654e-03 3.613755e-03
#> Ref_Sig_N8 Ref_Sig_N9 Ref_Sig_N10 Ref_Sig_N11 Ref_Sig_24
#> A[C>A]A 2.171063e-02 2.448627e-02 1.806309e-02 1.234235e-02 3.643496e-02
#> A[C>A]C 1.817394e-02 6.366784e-03 4.850377e-03 8.840874e-03 2.501352e-02
#> A[C>A]G 6.046024e-03 6.363805e-04 3.283158e-03 3.049168e-03 2.060985e-02
#> A[C>A]T 6.306418e-03 8.538074e-03 7.919809e-03 5.989167e-03 2.285712e-02
#> C[C>A]A 3.327384e-02 8.523135e-03 1.165837e-02 8.491870e-03 4.287272e-02
#> C[C>A]C 3.208276e-02 1.185277e-02 5.443276e-06 8.969500e-03 3.459202e-02
#> C[C>A]G 8.022419e-03 2.179883e-03 1.490101e-03 2.043693e-03 1.642758e-02
#> C[C>A]T 8.660270e-03 3.991204e-03 9.910799e-03 6.706090e-03 2.325295e-02
#> G[C>A]A 6.875714e-03 4.370204e-21 8.589611e-03 2.719381e-03 4.904387e-02
#> G[C>A]C 1.169638e-03 6.479739e-04 3.252063e-03 7.481193e-07 9.771313e-02
#> G[C>A]G 6.098864e-04 1.915360e-03 1.758849e-03 2.153242e-03 4.304386e-02
#> G[C>A]T 1.602108e-08 1.468616e-04 4.897882e-03 3.290096e-11 4.361206e-02
#> T[C>A]A 1.021486e-02 9.779780e-04 8.745406e-04 2.074714e-02 2.833443e-02
#> T[C>A]C 2.979406e-02 4.163331e-03 1.677774e-14 2.437367e-02 5.113067e-02
#> T[C>A]G 6.126283e-03 2.191075e-03 4.070355e-04 3.070800e-03 1.426318e-02
#> T[C>A]T 1.138278e-07 1.892915e-03 6.467775e-03 1.469638e-02 1.904359e-02
#> A[C>G]A 5.834666e-03 2.246988e-02 8.094471e-03 1.569620e-03 7.042825e-03
#> A[C>G]C 6.836836e-03 4.963063e-03 4.692597e-03 1.949691e-03 6.581974e-03
#> A[C>G]G 2.237263e-03 1.126088e-03 4.623480e-03 1.178452e-21 2.128557e-03
#> A[C>G]T 7.286242e-03 1.610458e-02 6.542659e-03 1.453826e-06 3.441948e-03
#> C[C>G]A 1.324914e-02 1.271824e-03 3.793785e-04 3.075359e-03 5.225027e-03
#> C[C>G]C 1.070424e-02 4.212421e-04 1.258043e-03 4.427945e-03 6.591635e-03
#> C[C>G]G 4.112525e-03 2.830408e-04 4.804362e-04 8.308121e-04 9.421020e-04
#> C[C>G]T 1.494866e-02 5.547659e-10 1.299820e-03 2.200447e-03 1.353668e-03
#> G[C>G]A 5.054486e-03 4.699341e-03 5.781340e-03 1.528565e-15 7.059031e-03
#> G[C>G]C 1.771751e-03 2.603700e-03 4.981787e-03 1.849649e-03 1.016121e-02
#> G[C>G]G 1.845787e-08 2.245330e-03 1.179328e-03 1.611076e-16 5.677607e-03
#> G[C>G]T 4.315183e-03 8.964963e-03 4.067761e-03 2.317376e-12 3.844010e-03
#> T[C>G]A 1.261530e-07 4.757333e-03 8.512093e-03 7.238749e-03 8.760986e-03
#> T[C>G]C 9.952440e-03 3.888041e-03 4.856593e-03 3.553616e-03 8.145893e-03
#> T[C>G]G 2.163575e-03 3.781687e-03 3.118139e-03 9.519187e-04 2.094695e-03
#> T[C>G]T 3.874122e-03 1.798817e-02 5.328726e-03 6.597311e-03 9.119868e-03
#> A[C>T]A 1.653433e-02 1.857350e-02 3.180000e-02 3.959258e-02 9.501902e-03
#> A[C>T]C 1.638629e-02 6.926562e-03 1.473151e-02 2.436362e-02 5.145336e-03
#> A[C>T]G 2.028967e-02 1.693409e-03 6.858262e-03 2.524538e-07 1.684202e-03
#> A[C>T]T 1.397077e-02 2.315109e-02 3.733630e-02 1.648341e-02 5.686694e-03
#> C[C>T]A 2.552563e-02 3.920543e-02 1.439726e-02 3.756963e-02 9.818210e-03
#> C[C>T]C 1.960531e-02 1.002260e-02 1.026934e-02 2.262406e-02 8.808008e-03
#> C[C>T]G 1.261587e-02 5.696030e-03 3.753576e-03 4.615749e-04 3.090521e-03
#> C[C>T]T 1.686489e-03 3.430674e-03 3.019374e-02 4.276822e-03 9.379419e-03
#> G[C>T]A 5.527362e-03 1.669644e-02 1.320840e-02 4.020466e-02 1.499729e-02
#> G[C>T]C 7.190596e-03 9.053904e-03 6.629223e-03 2.743460e-02 2.493943e-02
#> G[C>T]G 8.249258e-03 3.647054e-03 9.628029e-07 2.005288e-04 3.557817e-03
#> G[C>T]T 1.636116e-05 1.587834e-02 1.263111e-02 6.770847e-03 1.539705e-02
#> T[C>T]A 1.810146e-02 2.865876e-02 1.176426e-02 5.157009e-02 9.960500e-03
#> T[C>T]C 2.005023e-02 6.746972e-03 1.479184e-02 4.005688e-02 1.317453e-02
#> T[C>T]G 1.080462e-02 6.097300e-03 8.264450e-03 7.026832e-04 5.008822e-03
#> T[C>T]T 6.178766e-03 3.412892e-02 2.053109e-02 3.444546e-02 6.217691e-03
#> A[T>A]A 3.172284e-07 3.184656e-02 2.914715e-03 1.910902e-02 3.343442e-03
#> A[T>A]C 3.963409e-03 7.927449e-03 9.230457e-03 4.857320e-03 4.171334e-03
#> A[T>A]G 2.117217e-02 4.422431e-03 1.449142e-02 1.713764e-03 2.479077e-03
#> A[T>A]T 1.055304e-04 1.087534e-02 2.093730e-02 8.447590e-03 2.669816e-03
#> C[T>A]A 7.992966e-08 1.579457e-02 7.713244e-03 6.116170e-03 4.575398e-03
#> C[T>A]C 5.819967e-03 1.351744e-02 3.976554e-05 7.742478e-04 3.293974e-03
#> C[T>A]G 1.729156e-02 1.063847e-02 9.445038e-03 7.533884e-06 1.204904e-02
#> C[T>A]T 1.677738e-03 5.623991e-03 1.449745e-02 1.928910e-03 9.419636e-03
#> G[T>A]A 5.383193e-03 3.441011e-03 1.111333e-02 3.921989e-03 2.203361e-03
#> G[T>A]C 2.722953e-03 4.837637e-03 5.862337e-03 3.552347e-03 9.534716e-04
#> G[T>A]G 1.447593e-02 1.132322e-02 8.330692e-03 3.381651e-03 4.121310e-03
#> G[T>A]T 5.674451e-03 3.181392e-03 1.397845e-02 2.186828e-03 1.206452e-04
#> T[T>A]A 1.970773e-03 8.048038e-03 7.629771e-03 1.550772e-02 5.095692e-03
#> T[T>A]C 2.469889e-03 7.535332e-03 2.854790e-03 5.046747e-03 5.591524e-03
#> T[T>A]G 1.534831e-02 2.602525e-02 1.926538e-03 5.025222e-03 3.856381e-03
#> T[T>A]T 9.168233e-03 9.598982e-03 7.467698e-03 6.444441e-03 2.113742e-03
#> A[T>C]A 4.301969e-02 4.463272e-02 3.396161e-02 5.252937e-02 1.510428e-02
#> A[T>C]C 1.291698e-02 2.461605e-02 3.061124e-02 4.768878e-03 1.496206e-03
#> A[T>C]G 8.833789e-02 1.908186e-02 2.548916e-03 1.285703e-02 2.099746e-04
#> A[T>C]T 4.021392e-02 3.968413e-02 2.225544e-02 1.324205e-02 5.990846e-03
#> C[T>C]A 1.361004e-02 3.513844e-02 2.621196e-02 1.892369e-02 6.482117e-03
#> C[T>C]C 7.723547e-03 3.670479e-02 8.408738e-03 1.990940e-03 2.769596e-03
#> C[T>C]G 3.511159e-02 2.881184e-03 2.192786e-03 9.725938e-03 1.756561e-03
#> C[T>C]T 4.498537e-03 1.283187e-02 4.003186e-02 6.653047e-03 7.804099e-03
#> G[T>C]A 7.576036e-03 6.267319e-03 2.495188e-02 6.136967e-02 4.837588e-03
#> G[T>C]C 2.697334e-03 1.515308e-02 1.300858e-02 8.145064e-03 5.576407e-03
#> G[T>C]G 2.754822e-02 4.007961e-03 1.182077e-03 1.051194e-02 6.390976e-09
#> G[T>C]T 1.246823e-02 2.032176e-02 2.656997e-02 3.381085e-02 5.287934e-03
#> T[T>C]A 1.516634e-02 1.274992e-02 3.659141e-02 6.777927e-02 2.999209e-05
#> T[T>C]C 1.849301e-06 1.291959e-02 2.745974e-02 7.782498e-03 5.013589e-03
#> T[T>C]G 2.771681e-02 6.851364e-13 1.222398e-03 1.557379e-02 4.012597e-04
#> T[T>C]T 2.264769e-04 3.723542e-02 3.055767e-02 2.991762e-02 5.271780e-03
#> A[T>G]A 1.457508e-04 1.200708e-02 1.780310e-02 1.034572e-02 4.578426e-03
#> A[T>G]C 2.412082e-03 6.122372e-03 5.742369e-03 1.659780e-03 2.374874e-03
#> A[T>G]G 4.963552e-03 5.782197e-03 9.456357e-03 1.153786e-05 5.206118e-03
#> A[T>G]T 2.859273e-03 1.828635e-02 1.076559e-02 7.571300e-03 6.530288e-03
#> C[T>G]A 4.669804e-03 6.218040e-04 5.671215e-04 1.309253e-03 9.615687e-04
#> C[T>G]C 1.039348e-02 3.396614e-03 1.026628e-03 3.204753e-03 7.142533e-04
#> C[T>G]G 1.089312e-02 1.485368e-03 1.161769e-03 4.983243e-12 1.660659e-03
#> C[T>G]T 1.584661e-08 2.124443e-03 2.030295e-08 3.065803e-03 1.191070e-02
#> G[T>G]A 3.773270e-03 1.931141e-03 1.039879e-02 2.216189e-03 6.416481e-04
#> G[T>G]C 2.666745e-03 1.414742e-03 6.225456e-03 6.883590e-04 8.525061e-04
#> G[T>G]G 6.944593e-03 9.343030e-03 4.713191e-03 1.178452e-21 1.919132e-03
#> G[T>G]T 1.456413e-03 4.320452e-03 9.184222e-03 1.759850e-03 3.604916e-03
#> T[T>G]A 3.670827e-03 5.288607e-03 1.382451e-02 5.667107e-03 2.891373e-03
#> T[T>G]C 5.141735e-03 6.099980e-03 1.542530e-02 2.593839e-03 4.942231e-03
#> T[T>G]G 7.066619e-03 6.753840e-03 1.945793e-02 1.916031e-03 4.465908e-03
#> T[T>G]T 2.723556e-03 1.247348e-02 2.226149e-02 9.188995e-03 9.871340e-03
#> Ref_Sig_N12
#> A[C>A]A 1.089199e-02
#> A[C>A]C 3.039543e-03
#> A[C>A]G 1.953962e-04
#> A[C>A]T 2.121350e-03
#> C[C>A]A 5.199849e-03
#> C[C>A]C 2.715682e-03
#> C[C>A]G 1.250833e-03
#> C[C>A]T 5.973029e-03
#> G[C>A]A 1.742992e-03
#> G[C>A]C 5.261922e-03
#> G[C>A]G 8.079789e-04
#> G[C>A]T 4.949691e-03
#> T[C>A]A 2.297333e-02
#> T[C>A]C 1.173976e-02
#> T[C>A]G 1.875735e-03
#> T[C>A]T 1.189424e-02
#> A[C>G]A 7.276488e-03
#> A[C>G]C 1.248577e-02
#> A[C>G]G 3.379215e-04
#> A[C>G]T 2.150010e-02
#> C[C>G]A 5.447108e-03
#> C[C>G]C 1.511497e-02
#> C[C>G]G 1.807398e-03
#> C[C>G]T 2.744684e-02
#> G[C>G]A 3.619820e-03
#> G[C>G]C 4.488002e-03
#> G[C>G]G 7.969712e-04
#> G[C>G]T 8.570043e-03
#> T[C>G]A 1.529767e-04
#> T[C>G]C 1.474693e-02
#> T[C>G]G 2.317261e-03
#> T[C>G]T 2.188993e-02
#> A[C>T]A 1.526425e-02
#> A[C>T]C 3.848324e-03
#> A[C>T]G 2.527893e-03
#> A[C>T]T 1.139896e-02
#> C[C>T]A 1.245212e-02
#> C[C>T]C 1.511858e-02
#> C[C>T]G 1.061980e-03
#> C[C>T]T 1.286550e-02
#> G[C>T]A 1.359376e-02
#> G[C>T]C 5.192008e-03
#> G[C>T]G 5.288679e-04
#> G[C>T]T 8.816487e-03
#> T[C>T]A 2.584714e-02
#> T[C>T]C 7.954059e-03
#> T[C>T]G 1.170634e-04
#> T[C>T]T 8.875282e-03
#> A[T>A]A 1.023592e-02
#> A[T>A]C 6.600991e-03
#> A[T>A]G 1.039272e-02
#> A[T>A]T 1.421256e-02
#> C[T>A]A 2.293204e-06
#> C[T>A]C 8.772097e-03
#> C[T>A]G 5.878893e-03
#> C[T>A]T 5.452961e-03
#> G[T>A]A 4.241938e-03
#> G[T>A]C 5.225458e-03
#> G[T>A]G 5.339447e-03
#> G[T>A]T 5.118103e-03
#> T[T>A]A 1.611623e-02
#> T[T>A]C 2.331084e-02
#> T[T>A]G 1.006200e-02
#> T[T>A]T 4.809865e-02
#> A[T>C]A 2.332010e-02
#> A[T>C]C 5.467650e-03
#> A[T>C]G 1.596325e-02
#> A[T>C]T 2.465520e-02
#> C[T>C]A 1.727486e-02
#> C[T>C]C 4.375421e-03
#> C[T>C]G 8.571151e-03
#> C[T>C]T 3.769336e-03
#> G[T>C]A 1.202916e-02
#> G[T>C]C 3.255491e-03
#> G[T>C]G 8.374378e-03
#> G[T>C]T 6.113288e-03
#> T[T>C]A 1.741117e-02
#> T[T>C]C 6.904935e-03
#> T[T>C]G 8.626702e-03
#> T[T>C]T 1.210608e-02
#> A[T>G]A 1.478133e-02
#> A[T>G]C 1.870208e-02
#> A[T>G]G 1.573056e-02
#> A[T>G]T 4.362632e-02
#> C[T>G]A 7.214138e-03
#> C[T>G]C 1.231865e-02
#> C[T>G]G 8.575638e-03
#> C[T>G]T 6.353531e-06
#> G[T>G]A 3.091745e-03
#> G[T>G]C 3.726348e-03
#> G[T>G]G 5.999090e-03
#> G[T>G]T 3.253674e-03
#> T[T>G]A 1.855844e-02
#> T[T>G]C 2.972485e-02
#> T[T>G]G 1.815250e-02
#> T[T>G]T 5.316491e-02
#>
#> $aetiology
#> aetiology
#> Ref_Sig_1 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_18 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_17 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_MMR1 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_2 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_MMR2 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_5 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_8 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_13 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_3 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_30 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_MIXED1 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_4 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_N1 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_PLATINUM See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_MIXED2 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_33 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_22 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_10 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_36 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_7 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_MIXED3 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_16 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_19 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_N2 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_9 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_N3 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_52 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_11 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_38 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_51 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_N4 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_N5 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_N6 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_N7 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_N8 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_N9 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_N10 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_N11 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_24 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_N12 See COSMIC signatures with same ID or https://doi.org/10.1038/s43018-020-0027-5
#>
#> $date
#> [1] "2020/10/20"
#>
s6
#> $db
#> ID1 ID2 ID3 ID4 ID5
#> 1:Del:C:0 1.598890e-04 4.824116e-03 1.247271e-01 7.249717e-03 0.022202108
#> 1:Del:C:1 7.735230e-04 2.210000e-05 2.088762e-01 2.734869e-03 0.028547215
#> 1:Del:C:2 3.310000e-18 3.110000e-06 1.763242e-01 2.041063e-03 0.026596927
#> 1:Del:C:3 1.907613e-03 2.472076e-03 6.404276e-02 1.112283e-03 0.014159122
#> 1:Del:C:4 7.059900e-04 3.856976e-03 4.398981e-02 1.075684e-03 0.002873422
#> 1:Del:C:5 3.370115e-03 1.461542e-02 2.241749e-02 2.246178e-03 0.002602449
#> 1:Del:T:0 1.311605e-03 7.905966e-03 3.759923e-02 6.635052e-03 0.101481148
#> 1:Del:T:1 3.310000e-18 3.950000e-18 1.330982e-02 1.622466e-03 0.106099610
#> 1:Del:T:2 9.364530e-04 7.036418e-03 1.650185e-02 2.633405e-03 0.114128463
#> 1:Del:T:3 2.295855e-03 2.023474e-02 2.014148e-02 3.060380e-04 0.088962207
#> 1:Del:T:4 4.291422e-03 4.711993e-02 1.581436e-02 1.023202e-03 0.052259532
#> 1:Del:T:5 3.310000e-18 8.146972e-01 8.066314e-03 1.544420e-04 0.030610523
#> 1:Ins:C:0 3.310000e-18 3.950000e-18 2.083092e-03 6.620000e-18 0.000542252
#> 1:Ins:C:1 3.310000e-18 2.270260e-04 1.578887e-03 2.723990e-04 0.001242898
#> 1:Ins:C:2 3.310000e-18 2.620000e-05 1.747946e-03 6.880000e-05 0.003151667
#> 1:Ins:C:3 8.459860e-04 4.300500e-04 6.177647e-03 5.124810e-04 0.000602848
#> 1:Ins:C:4 1.785525e-03 2.911846e-03 7.104447e-03 6.620000e-18 0.000197582
#> 1:Ins:C:5 2.429654e-02 9.017536e-03 7.351101e-03 2.491430e-04 0.000433544
#> 1:Ins:T:0 2.283824e-03 1.328556e-03 1.872237e-02 3.336650e-04 0.006361965
#> 1:Ins:T:1 4.030000e-05 3.950000e-18 4.311903e-02 1.010044e-03 0.013462697
#> 1:Ins:T:2 1.928650e-04 6.470330e-04 4.015704e-02 1.060000e-05 0.029721144
#> 1:Ins:T:3 4.243267e-03 1.082879e-03 2.512543e-02 1.739350e-04 0.018840250
#> 1:Ins:T:4 1.664913e-02 3.487461e-03 6.563305e-03 1.600000e-05 0.011268752
#> 1:Ins:T:5 8.909065e-01 3.132585e-03 2.618124e-02 8.329260e-04 0.001439215
#> 2:Del:R:0 6.860460e-04 1.638090e-04 6.897553e-03 7.172421e-02 0.028054407
#> 2:Del:R:1 1.219969e-03 3.568885e-03 8.474654e-03 2.305129e-01 0.024562729
#> 2:Del:R:2 4.727490e-04 1.849574e-03 1.180064e-02 5.505940e-02 0.004562618
#> 2:Del:R:3 4.267200e-04 7.390440e-04 6.671125e-03 1.281101e-02 0.000395919
#> 2:Del:R:4 5.460000e-05 8.819320e-04 2.822525e-03 3.219218e-03 0.000867563
#> 2:Del:R:5 3.310000e-18 4.670000e-18 1.012390e-04 2.382721e-03 0.021426780
#> 3:Del:R:0 1.280450e-04 1.250000e-05 5.891240e-04 5.068954e-03 0.017136370
#> 3:Del:R:1 5.011085e-03 5.003258e-03 3.723860e-04 9.711447e-02 0.005909794
#> 3:Del:R:2 7.693830e-04 2.289891e-03 9.630000e-05 2.148428e-02 0.000842710
#> 3:Del:R:3 3.712560e-04 4.025870e-04 2.450000e-05 3.837627e-03 0.000621155
#> 3:Del:R:4 3.310000e-18 3.970000e-18 3.820000e-06 7.862950e-04 0.005867075
#> 3:Del:R:5 3.310000e-18 3.950000e-18 3.830000e-07 1.138609e-03 0.008378911
#> 4:Del:R:0 9.970000e-05 1.210000e-05 1.776450e-04 7.252429e-03 0.010791265
#> 4:Del:R:1 9.005030e-04 2.115787e-03 6.345730e-04 6.352373e-02 0.002843569
#> 4:Del:R:2 3.230000e-06 5.432920e-04 1.167990e-04 1.454892e-02 0.000164644
#> 4:Del:R:3 3.310000e-18 7.270000e-06 4.120000e-18 4.554752e-03 0.003877814
#> 4:Del:R:4 3.310000e-18 3.950000e-18 4.120000e-18 8.496790e-04 0.004557254
#> 4:Del:R:5 2.890000e-05 2.104130e-04 2.830000e-06 6.107800e-04 0.001584436
#> 5:Del:R:0 8.350000e-06 3.850000e-05 1.776785e-03 4.132826e-03 0.018447949
#> 5:Del:R:1 1.906760e-04 2.977512e-03 7.410000e-05 1.571853e-02 0.000410335
#> 5:Del:R:2 1.263550e-04 3.975250e-04 2.780000e-06 2.343845e-03 0.000470925
#> 5:Del:R:3 1.890000e-05 1.581510e-04 4.120000e-18 1.182480e-03 0.000257167
#> 5:Del:R:4 3.110000e-06 8.470000e-05 4.370000e-05 1.469230e-04 0.000097300
#> 5:Del:R:5 3.130000e-05 2.120000e-05 3.820000e-06 1.061740e-04 0.000585018
#> 2:Ins:R:0 4.020360e-04 3.318530e-04 2.635950e-03 4.929220e-04 0.006349454
#> 2:Ins:R:1 7.880000e-06 2.716650e-04 2.242683e-03 5.533020e-04 0.018387642
#> 2:Ins:R:2 2.213470e-04 1.035341e-03 9.556040e-04 2.663350e-04 0.007207952
#> 2:Ins:R:3 5.142680e-04 3.813260e-04 8.972380e-04 1.377940e-04 0.001172292
#> 2:Ins:R:4 2.913100e-03 1.977423e-03 2.530850e-04 7.190000e-05 0.000068800
#> 2:Ins:R:5 1.812158e-02 1.363338e-02 6.670000e-06 1.036890e-04 0.000994122
#> 3:Ins:R:0 3.060000e-07 5.780000e-05 9.600000e-05 2.630000e-05 0.003792478
#> 3:Ins:R:1 2.546950e-04 1.227050e-03 2.861440e-04 4.509830e-04 0.006122761
#> 3:Ins:R:2 4.410000e-05 2.100750e-04 9.750000e-05 6.003350e-04 0.001143468
#> 3:Ins:R:3 1.667020e-04 3.020000e-06 1.360000e-05 7.420000e-05 0.000010200
#> 3:Ins:R:4 8.890000e-05 1.418070e-04 1.560000e-06 7.400000e-05 0.000011800
#> 3:Ins:R:5 1.248696e-03 1.864707e-03 4.120000e-18 3.960000e-05 0.000102574
#> 4:Ins:R:0 3.310000e-18 1.680000e-05 4.120000e-18 1.666450e-04 0.002439186
#> 4:Ins:R:1 7.443810e-04 1.203728e-03 1.759820e-04 1.266435e-03 0.003612298
#> 4:Ins:R:2 7.550000e-05 1.220000e-05 2.740000e-05 9.840000e-05 0.000376459
#> 4:Ins:R:3 1.575440e-04 1.341690e-04 4.770000e-05 5.250000e-05 0.000001870
#> 4:Ins:R:4 3.196530e-04 2.493850e-04 4.180000e-06 1.469110e-04 0.000006410
#> 4:Ins:R:5 1.001320e-03 2.193545e-03 3.290000e-05 1.352050e-04 0.000635977
#> 5:Ins:R:0 3.310000e-18 3.950000e-18 8.830000e-05 8.580000e-05 0.004750071
#> 5:Ins:R:1 1.443126e-03 1.356580e-04 6.562200e-04 2.135852e-03 0.004793431
#> 5:Ins:R:2 2.548320e-04 5.530000e-06 5.510000e-06 2.220270e-04 0.000298796
#> 5:Ins:R:3 2.370870e-04 9.770000e-05 3.320000e-05 7.590000e-06 0.000165546
#> 5:Ins:R:4 2.618650e-04 2.150000e-06 7.870000e-06 2.530000e-05 0.000126707
#> 5:Ins:R:5 1.198340e-04 1.156290e-04 3.480000e-06 1.602290e-04 0.000626342
#> 2:Del:M:1 1.197815e-03 1.755530e-04 6.930764e-03 1.889975e-01 0.028687946
#> 3:Del:M:1 8.190000e-05 5.460000e-07 3.446120e-04 7.034156e-03 0.013157147
#> 3:Del:M:2 1.479593e-03 2.944063e-03 3.028500e-04 4.941660e-02 0.009004210
#> 4:Del:M:1 8.380000e-05 1.470050e-04 7.350000e-05 1.098172e-02 0.008732202
#> 4:Del:M:2 1.454790e-04 5.506140e-04 3.402160e-04 2.948388e-02 0.006047187
#> 4:Del:M:3 1.606840e-04 6.935660e-04 1.304630e-04 4.886664e-02 0.003442442
#> 5:Del:M:1 8.160000e-07 6.249630e-04 1.369634e-03 4.531210e-04 0.008617073
#> 5:Del:M:2 2.380000e-10 1.177080e-04 1.751272e-03 1.362320e-04 0.007851021
#> 5:Del:M:3 2.330000e-12 5.670000e-05 7.749580e-04 1.112236e-03 0.007157975
#> 5:Del:M:4 3.880000e-05 4.628420e-04 6.405550e-04 3.652946e-03 0.002492549
#> 5:Del:M:5 6.651160e-04 2.367319e-03 3.629700e-04 4.560000e-05 0.001112367
#> ID6 ID7 ID8 ID9 ID10
#> 1:Del:C:0 0.030506799 0.000466561 0.039827558 3.349399e-01 2.510541e-02
#> 1:Del:C:1 0.005491903 0.000000000 0.023915938 9.999423e-02 2.930632e-02
#> 1:Del:C:2 0.008033994 0.008561945 0.003330554 2.690655e-03 1.880406e-02
#> 1:Del:C:3 0.001102379 0.042360147 0.005403153 1.062542e-02 1.650356e-02
#> 1:Del:C:4 0.002478170 0.114891908 0.001275709 1.249690e-02 2.930632e-03
#> 1:Del:C:5 0.001322073 0.251763140 0.000933729 4.480000e-05 8.420000e-18
#> 1:Del:T:0 0.004284162 0.002667490 0.034243687 1.051054e-01 2.830611e-02
#> 1:Del:T:1 0.000677688 0.007732725 0.010452076 4.429364e-02 8.420000e-18
#> 1:Del:T:2 0.011659665 0.000254760 0.008992030 8.586196e-02 1.510326e-03
#> 1:Del:T:3 0.022242391 0.028972742 0.009825045 1.132507e-01 1.420306e-03
#> 1:Del:T:4 0.017697141 0.158850552 0.001273780 9.441274e-02 2.410520e-03
#> 1:Del:T:5 0.007954345 0.000000192 0.010620342 9.298350e-04 1.270000e-17
#> 1:Ins:C:0 0.002086887 0.000672367 0.002764271 5.410000e-18 8.420000e-18
#> 1:Ins:C:1 0.001773433 0.000026200 0.002169119 1.930000e-06 3.450740e-04
#> 1:Ins:C:2 0.000246169 0.000025800 0.001527000 3.526230e-04 2.720590e-04
#> 1:Ins:C:3 0.000232169 0.002407735 0.000116524 5.410000e-18 2.580556e-03
#> 1:Ins:C:4 0.000376592 0.015485431 0.000554177 2.160000e-06 4.110890e-04
#> 1:Ins:C:5 0.000247997 0.060343229 0.000489489 7.370000e-05 8.511840e-04
#> 1:Ins:T:0 0.006396251 0.000001360 0.004507979 1.261448e-02 1.700367e-02
#> 1:Ins:T:1 0.001041187 0.000373648 0.004868696 1.038527e-02 4.380945e-02
#> 1:Ins:T:2 0.000738848 0.018382706 0.001429636 2.314663e-03 3.650787e-03
#> 1:Ins:T:3 0.000930638 0.008891635 0.001087286 1.600885e-03 3.750809e-03
#> 1:Ins:T:4 0.001349852 0.012787969 0.000822618 1.585355e-03 9.660000e-06
#> 1:Ins:T:5 0.014390041 0.010789849 0.020161248 5.772480e-03 1.110000e-08
#> 2:Del:R:0 0.001783647 0.000023300 0.008769219 1.317475e-02 8.391810e-04
#> 2:Del:R:1 0.002454347 0.008182302 0.010307145 3.198541e-03 9.472042e-03
#> 2:Del:R:2 0.002088600 0.008991541 0.000532026 1.189697e-03 6.541411e-03
#> 2:Del:R:3 0.000525746 0.072132138 0.000027100 9.590000e-05 1.850400e-04
#> 2:Del:R:4 0.000232527 0.052250842 0.000274027 5.410000e-18 8.420000e-18
#> 2:Del:R:5 0.000215685 0.057046331 0.000833079 5.410000e-18 8.420000e-18
#> 3:Del:R:0 0.001051047 0.000625412 0.010964101 2.858095e-03 1.200259e-03
#> 3:Del:R:1 0.005413653 0.011689003 0.001348867 4.301910e-03 4.270921e-02
#> 3:Del:R:2 0.000536054 0.005474849 0.000376571 1.275717e-03 5.061091e-03
#> 3:Del:R:3 0.000047000 0.003456748 0.000253509 3.021100e-04 2.730589e-03
#> 3:Del:R:4 0.000073100 0.000492537 0.000002680 5.410000e-18 8.420000e-18
#> 3:Del:R:5 0.000150616 0.000436589 0.000091000 5.410000e-18 8.420000e-18
#> 4:Del:R:0 0.002315098 0.000130877 0.006691309 1.432774e-03 1.470317e-03
#> 4:Del:R:1 0.002806729 0.003396804 0.001622955 4.594217e-03 5.211120e-04
#> 4:Del:R:2 0.000474490 0.002777387 0.000272623 8.960240e-04 7.500000e-05
#> 4:Del:R:3 0.000291345 0.000439586 0.000028800 2.380000e-05 1.320280e-04
#> 4:Del:R:4 0.000110576 0.000201810 0.000097300 5.410000e-18 8.420000e-18
#> 4:Del:R:5 0.000056800 0.000250764 0.000006340 1.370000e-05 2.090450e-04
#> 5:Del:R:0 0.019333291 0.000085500 0.237978862 7.720520e-04 1.390300e-03
#> 5:Del:R:1 0.007501825 0.003476729 0.000572257 4.795510e-04 2.620565e-02
#> 5:Del:R:2 0.000370524 0.001168900 0.000516838 2.649690e-04 1.770382e-03
#> 5:Del:R:3 0.000168175 0.000406617 0.000008160 6.120000e-06 1.370300e-04
#> 5:Del:R:4 0.000053200 0.000125882 0.000112898 7.250000e-06 1.250270e-04
#> 5:Del:R:5 0.000011500 0.000020800 0.000044300 2.990000e-05 1.120242e-03
#> 2:Ins:R:0 0.001998387 0.000030400 0.001916710 1.162339e-03 2.530546e-02
#> 2:Ins:R:1 0.000208533 0.000397626 0.001661816 2.100192e-03 3.890839e-02
#> 2:Ins:R:2 0.000790414 0.000070100 0.000304586 7.609410e-04 2.620565e-02
#> 2:Ins:R:3 0.000499074 0.003147039 0.000177583 3.516350e-04 2.800600e-04
#> 2:Ins:R:4 0.000189469 0.001828280 0.000016600 3.070000e-05 8.420000e-18
#> 2:Ins:R:5 0.000748642 0.000244770 0.001764384 5.410000e-18 8.420000e-18
#> 3:Ins:R:0 0.001219185 0.000000000 0.000667863 2.545730e-04 1.810391e-02
#> 3:Ins:R:1 0.000288615 0.000005510 0.000671723 8.233550e-04 5.521191e-02
#> 3:Ins:R:2 0.000746533 0.000054700 0.000135768 1.182610e-04 9.432034e-03
#> 3:Ins:R:3 0.000249737 0.000177833 0.000037900 5.180000e-06 4.610990e-04
#> 3:Ins:R:4 0.000155952 0.000415609 0.000122041 1.610000e-05 1.870400e-04
#> 3:Ins:R:5 0.000019800 0.000769276 0.000036600 5.410000e-18 1.850400e-04
#> 4:Ins:R:0 0.001467917 0.000000000 0.000777758 1.643870e-04 1.600345e-02
#> 4:Ins:R:1 0.000476283 0.000026100 0.001103901 7.155650e-04 7.461609e-02
#> 4:Ins:R:2 0.000528663 0.000194817 0.000079900 4.240000e-05 4.090882e-03
#> 4:Ins:R:3 0.000334824 0.000273742 0.000008580 2.150000e-05 2.390520e-04
#> 4:Ins:R:4 0.000056000 0.000258757 0.000205515 5.410000e-18 2.280492e-03
#> 4:Ins:R:5 0.000106861 0.000008740 0.000885225 2.180000e-06 1.380298e-02
#> 5:Ins:R:0 0.008716781 0.000000000 0.000318329 1.658460e-04 4.921061e-02
#> 5:Ins:R:1 0.005405643 0.000000000 0.009761114 1.253996e-03 2.780600e-01
#> 5:Ins:R:2 0.001321843 0.000008840 0.000101153 1.028490e-04 9.221989e-03
#> 5:Ins:R:3 0.000028800 0.000004460 0.000070900 8.020000e-05 3.660789e-03
#> 5:Ins:R:4 0.000048300 0.000010600 0.000006740 5.050000e-05 3.340720e-03
#> 5:Ins:R:5 0.000061700 0.000004280 0.000190551 9.890000e-06 2.740591e-03
#> 2:Del:M:1 0.000632866 0.003127058 0.004913672 3.900972e-03 6.381380e-04
#> 3:Del:M:1 0.000990097 0.000254760 0.009290337 3.011328e-03 3.960854e-03
#> 3:Del:M:2 0.004433630 0.004635639 0.004302693 1.543302e-03 1.930416e-02
#> 4:Del:M:1 0.002745395 0.000183827 0.005809551 1.927721e-03 1.790390e-04
#> 4:Del:M:2 0.008682710 0.001019041 0.001591587 3.297448e-03 3.870830e-04
#> 4:Del:M:3 0.004773094 0.000717325 0.001098342 2.544079e-03 8.220000e-05
#> 5:Del:M:1 0.071066579 0.000023600 0.280724260 3.540000e-05 1.330287e-03
#> 5:Del:M:2 0.253108348 0.000245769 0.123610163 2.212360e-04 1.240270e-04
#> 5:Del:M:3 0.216806033 0.000061600 0.046130408 5.709070e-04 5.650000e-05
#> 5:Del:M:4 0.120483943 0.000068200 0.016367256 4.483080e-04 1.040220e-04
#> 5:Del:M:5 0.099282999 0.001738365 0.012814882 5.410000e-18 4.140893e-02
#> ID11 ID12 ID13 ID14 ID15
#> 1:Del:C:0 1.576565e-03 5.278774e-02 0.065548371 1.201601e-02 2.652737e-02
#> 1:Del:C:1 5.503180e-04 1.467466e-02 0.017536463 1.946232e-03 1.210098e-01
#> 1:Del:C:2 3.573380e-04 5.619320e-04 0.005120219 6.836960e-04 1.478289e-01
#> 1:Del:C:3 9.080000e-18 9.955770e-04 0.005350516 4.874680e-04 1.360061e-01
#> 1:Del:C:4 9.080000e-18 2.240050e-03 0.004346005 2.071921e-03 8.419770e-02
#> 1:Del:C:5 1.564650e-04 2.941081e-02 0.000843056 2.370276e-03 1.845829e-02
#> 1:Del:T:0 9.442060e-04 4.513512e-02 0.053698762 1.830980e-02 2.395164e-02
#> 1:Del:T:1 2.585050e-04 1.420000e-17 0.498224165 8.525590e-04 7.996011e-02
#> 1:Del:T:2 5.165190e-04 1.096920e-02 0.023777805 1.085642e-02 1.204105e-01
#> 1:Del:T:3 4.256800e-04 2.210937e-02 0.062780952 1.718395e-02 1.134312e-01
#> 1:Del:T:4 1.932451e-03 4.407796e-02 0.023004382 1.334790e-02 7.917883e-02
#> 1:Del:T:5 6.539395e-03 3.485120e-04 0.006079575 3.861700e-02 4.690321e-02
#> 1:Ins:C:0 1.862380e-04 1.420000e-17 0.002850428 4.543870e-01 6.580046e-18
#> 1:Ins:C:1 1.634829e-01 1.676970e-04 0.001652256 1.277743e-02 6.580046e-18
#> 1:Ins:C:2 9.373884e-02 1.596586e-03 0.000821250 6.588500e-04 6.580046e-18
#> 1:Ins:C:3 3.617564e-02 4.503190e-04 0.000375555 1.564403e-03 6.580046e-18
#> 1:Ins:C:4 1.118979e-02 4.393930e-03 0.000148578 1.539502e-03 6.580046e-18
#> 1:Ins:C:5 3.412242e-03 1.705149e-02 0.000706981 2.292999e-03 6.580046e-18
#> 1:Ins:T:0 4.069450e-04 4.265301e-03 0.041137013 3.261201e-02 6.580046e-18
#> 1:Ins:T:1 3.142773e-01 2.496518e-03 0.004748853 3.165883e-03 6.580046e-18
#> 1:Ins:T:2 1.618078e-01 1.420000e-17 0.003054171 1.774606e-03 6.580046e-18
#> 1:Ins:T:3 1.077253e-01 1.056740e-04 0.009271857 1.173836e-03 6.580046e-18
#> 1:Ins:T:4 4.903068e-02 3.364800e-04 0.012098641 4.784999e-03 6.580046e-18
#> 1:Ins:T:5 2.362904e-02 1.665500e-04 0.011099794 2.327476e-01 6.580046e-18
#> 2:Del:R:0 9.080000e-18 6.268105e-03 0.022184399 6.619960e-04 6.580046e-18
#> 2:Del:R:1 1.363099e-03 2.784250e-04 0.004333215 6.600036e-03 6.580046e-18
#> 2:Del:R:2 1.507290e-04 1.398167e-03 0.003108924 2.701930e-03 6.580046e-18
#> 2:Del:R:3 9.080000e-18 6.733100e-04 0.000105566 3.927990e-04 6.580046e-18
#> 2:Del:R:4 9.130000e-06 1.198074e-02 0.000006130 1.410000e-06 6.580046e-18
#> 2:Del:R:5 4.527713e-03 2.515198e-01 0.000066300 4.370000e-05 6.580046e-18
#> 3:Del:R:0 1.894420e-04 7.599859e-03 0.003039667 1.146659e-03 6.580046e-18
#> 3:Del:R:1 3.908630e-04 5.694290e-04 0.001186963 4.840165e-03 6.580046e-18
#> 3:Del:R:2 1.704220e-04 2.680339e-03 0.000384379 1.053481e-03 9.352326e-05
#> 3:Del:R:3 1.275760e-04 5.920051e-03 0.000069000 2.496050e-04 6.580046e-18
#> 3:Del:R:4 1.202108e-03 6.862214e-02 0.000003090 9.190000e-18 6.580046e-18
#> 3:Del:R:5 1.742363e-03 9.748094e-02 0.000099600 9.190000e-18 6.580046e-18
#> 4:Del:R:0 9.080000e-18 1.734516e-03 0.002155349 1.936870e-04 6.580046e-18
#> 4:Del:R:1 3.555040e-04 2.302595e-03 0.000023000 6.173370e-04 6.580046e-18
#> 4:Del:R:2 9.080000e-18 6.116790e-04 0.000079200 5.242950e-04 6.580046e-18
#> 4:Del:R:3 3.121370e-04 3.925906e-02 0.000039200 5.030000e-05 1.394472e-06
#> 4:Del:R:4 6.873660e-04 5.328787e-02 0.000009470 7.730000e-06 6.580046e-18
#> 4:Del:R:5 1.576030e-04 1.864445e-02 0.000063000 9.190000e-18 1.759437e-06
#> 5:Del:R:0 1.281454e-03 3.382885e-03 0.020097536 6.086814e-03 2.840180e-04
#> 5:Del:R:1 4.746340e-04 2.797035e-03 0.002980534 3.144620e-04 6.580046e-18
#> 5:Del:R:2 9.080000e-18 5.103842e-03 0.000069900 2.130000e-05 6.580046e-18
#> 5:Del:R:3 9.080000e-18 2.200952e-03 0.000006400 2.850000e-05 1.245787e-06
#> 5:Del:R:4 9.080000e-18 1.256186e-03 0.000001460 1.500000e-05 6.580046e-18
#> 5:Del:R:5 8.180000e-08 6.181260e-03 0.000002350 9.080000e-05 1.736492e-06
#> 2:Ins:R:0 1.904670e-04 7.440331e-03 0.010618411 2.394226e-02 6.580046e-18
#> 2:Ins:R:1 9.080000e-18 1.062301e-03 0.001801368 1.237730e-04 6.580046e-18
#> 2:Ins:R:2 2.478850e-04 5.502380e-04 0.000688524 1.114199e-03 6.580046e-18
#> 2:Ins:R:3 3.723560e-04 1.655250e-04 0.000743544 8.714830e-04 6.580046e-18
#> 2:Ins:R:4 4.423840e-04 1.018206e-03 0.000213354 2.973978e-03 6.580046e-18
#> 2:Ins:R:5 2.888010e-04 3.800520e-02 0.000846575 5.442750e-04 6.580046e-18
#> 3:Ins:R:0 9.080000e-18 1.515014e-02 0.000082100 6.623497e-03 6.580046e-18
#> 3:Ins:R:1 2.070830e-04 8.695730e-04 0.003688328 2.523200e-03 6.580046e-18
#> 3:Ins:R:2 2.215260e-04 1.838910e-04 0.000202511 2.045010e-04 6.580046e-18
#> 3:Ins:R:3 2.180000e-05 8.700000e-05 0.000023700 3.274930e-04 6.580046e-18
#> 3:Ins:R:4 9.080000e-18 3.407880e-04 0.000003490 6.018600e-04 6.580046e-18
#> 3:Ins:R:5 9.010000e-05 2.840312e-03 0.000035400 2.205997e-03 6.580046e-18
#> 4:Ins:R:0 1.596210e-04 5.701178e-03 0.001118797 5.946930e-03 6.580046e-18
#> 4:Ins:R:1 3.776360e-04 1.908886e-03 0.002691635 1.326926e-03 6.580046e-18
#> 4:Ins:R:2 9.080000e-18 2.184900e-04 0.000069300 8.450000e-05 6.580046e-18
#> 4:Ins:R:3 9.080000e-18 1.765690e-04 0.000000639 7.138520e-04 1.360924e-06
#> 4:Ins:R:4 9.080000e-18 6.360530e-04 0.000012100 1.665010e-03 1.445999e-06
#> 4:Ins:R:5 9.080000e-18 1.167054e-02 0.000000314 2.744490e-04 6.580046e-18
#> 5:Ins:R:0 6.660600e-04 1.379064e-02 0.002590231 2.712141e-03 6.580046e-18
#> 5:Ins:R:1 1.151910e-03 3.834265e-03 0.013501952 2.645553e-02 6.580046e-18
#> 5:Ins:R:2 3.660070e-04 2.130016e-03 0.000045900 4.883130e-04 1.181990e-06
#> 5:Ins:R:3 8.340000e-07 2.660489e-03 0.000046100 1.038310e-04 1.621273e-06
#> 5:Ins:R:4 2.250000e-06 1.592407e-03 0.000002430 1.575930e-04 6.580046e-18
#> 5:Ins:R:5 1.840000e-06 6.136070e-03 0.000043300 2.150000e-05 6.580046e-18
#> 2:Del:M:1 3.820640e-04 2.653503e-03 0.008872408 2.640925e-03 6.580046e-18
#> 3:Del:M:1 2.004430e-04 1.032835e-02 0.001140083 1.575173e-03 6.580046e-18
#> 3:Del:M:2 3.017440e-04 6.061158e-03 0.000450306 3.236935e-03 6.580046e-18
#> 4:Del:M:1 9.080000e-18 3.771718e-03 0.001270798 8.200000e-06 6.580046e-18
#> 4:Del:M:2 9.080000e-18 4.573153e-03 0.000159723 9.504930e-04 6.580046e-18
#> 4:Del:M:3 7.898680e-04 5.252630e-04 0.000270578 2.230434e-03 6.580046e-18
#> 5:Del:M:1 2.827940e-04 5.633780e-04 0.011740777 6.551706e-03 6.608771e-04
#> 5:Del:M:2 3.727710e-04 1.420000e-17 0.007055421 4.498634e-03 4.324095e-04
#> 5:Del:M:3 7.501270e-04 3.235680e-04 0.002165984 1.404487e-03 2.661261e-04
#> 5:Del:M:4 1.302780e-04 2.776630e-04 0.000281736 1.001430e-04 2.479281e-04
#> 5:Del:M:5 5.189550e-04 6.657973e-03 0.013131907 9.315120e-04 1.398288e-04
#> ID16 ID17 ID18
#> 1:Del:C:0 9.527689e-04 6.117599e-03 0.006012048
#> 1:Del:C:1 2.639156e-18 3.667555e-03 0.002004016
#> 1:Del:C:2 8.154166e-05 1.220327e-03 0.002004016
#> 1:Del:C:3 1.624914e-03 2.259268e-08 0.004008032
#> 1:Del:C:4 3.378643e-03 1.940944e-08 0.000000000
#> 1:Del:C:5 2.650638e-18 1.220933e-03 0.002004016
#> 1:Del:T:0 6.286495e-04 6.088347e-03 0.086172690
#> 1:Del:T:1 1.570401e-04 4.903196e-03 0.172345380
#> 1:Del:T:2 2.658064e-18 1.225482e-03 0.118236947
#> 1:Del:T:3 2.660794e-18 1.223810e-03 0.238477910
#> 1:Del:T:4 1.001651e-03 1.341503e-09 0.090180723
#> 1:Del:T:5 2.790977e-18 4.626775e-08 0.070140562
#> 1:Ins:C:0 6.027134e-02 4.878118e-03 0.000000000
#> 1:Ins:C:1 1.364841e-01 1.476720e-02 0.002004016
#> 1:Ins:C:2 1.246836e-01 2.926040e-02 0.000000000
#> 1:Ins:C:3 9.888312e-02 4.925452e-02 0.000000000
#> 1:Ins:C:4 6.209438e-02 2.453841e-02 0.000000000
#> 1:Ins:C:5 3.103460e-02 9.790503e-03 0.000000000
#> 1:Ins:T:0 3.019429e-02 4.892794e-03 0.000000000
#> 1:Ins:T:1 1.031602e-01 3.889364e-02 0.002004016
#> 1:Ins:T:2 1.087385e-01 4.392461e-02 0.000000000
#> 1:Ins:T:3 1.009394e-01 4.872091e-03 0.002000008
#> 1:Ins:T:4 5.196238e-02 4.903486e-03 0.008016064
#> 1:Ins:T:5 3.500769e-02 4.873830e-03 0.004008032
#> 2:Del:R:0 1.922942e-03 1.468205e-02 0.000000000
#> 2:Del:R:1 2.014646e-03 8.535951e-03 0.036072289
#> 2:Del:R:2 1.116794e-03 1.460023e-08 0.002004016
#> 2:Del:R:3 4.722571e-04 3.495832e-08 0.000000000
#> 2:Del:R:4 3.882612e-05 4.344539e-08 0.002004016
#> 2:Del:R:5 2.640646e-18 3.886952e-08 0.000000000
#> 3:Del:R:0 1.060141e-03 8.558573e-03 0.004008032
#> 3:Del:R:1 2.325923e-03 2.445446e-03 0.006012048
#> 3:Del:R:2 1.150375e-03 3.411578e-08 0.000000000
#> 3:Del:R:3 1.205531e-04 1.985371e-08 0.000000000
#> 3:Del:R:4 1.607024e-05 2.130652e-08 0.000000000
#> 3:Del:R:5 9.580848e-06 4.514807e-08 0.000000000
#> 4:Del:R:0 6.989125e-04 6.109585e-03 0.004008032
#> 4:Del:R:1 4.262960e-04 1.553509e-08 0.002004016
#> 4:Del:R:2 7.834975e-05 3.826494e-08 0.000000000
#> 4:Del:R:3 2.636511e-18 1.460641e-08 0.000000000
#> 4:Del:R:4 2.630987e-06 3.193723e-09 0.000000000
#> 4:Del:R:5 2.637974e-18 4.438089e-09 0.000000000
#> 5:Del:R:0 5.568790e-03 2.339638e-02 0.024048192
#> 5:Del:R:1 1.102408e-04 1.915842e-08 0.000000000
#> 5:Del:R:2 1.543386e-05 4.858202e-08 0.000000000
#> 5:Del:R:3 6.725311e-06 3.434359e-08 0.000000000
#> 5:Del:R:4 2.671935e-07 9.206612e-09 0.000000000
#> 5:Del:R:5 2.629570e-18 3.335357e-08 0.000000000
#> 2:Ins:R:0 2.191793e-03 3.437941e-02 0.000000000
#> 2:Ins:R:1 1.087848e-03 5.850865e-02 0.000000000
#> 2:Ins:R:2 7.299316e-04 6.369419e-02 0.000000000
#> 2:Ins:R:3 9.481124e-05 9.762713e-03 0.002004016
#> 2:Ins:R:4 1.316643e-04 3.843714e-09 0.000000000
#> 2:Ins:R:5 1.183233e-06 4.644066e-08 0.002004016
#> 3:Ins:R:0 5.705892e-04 1.958314e-02 0.004008032
#> 3:Ins:R:1 1.092184e-03 1.122733e-01 0.000000000
#> 3:Ins:R:2 2.812705e-04 3.887448e-02 0.000000000
#> 3:Ins:R:3 3.180388e-05 1.391695e-08 0.000000000
#> 3:Ins:R:4 7.557336e-05 2.835100e-08 0.000000000
#> 3:Ins:R:5 2.289875e-05 2.780749e-08 0.000000000
#> 4:Ins:R:0 3.275599e-04 1.469245e-02 0.000000000
#> 4:Ins:R:1 1.506978e-03 2.102451e-01 0.002004016
#> 4:Ins:R:2 4.499627e-05 9.749097e-03 0.000000000
#> 4:Ins:R:3 3.016467e-07 1.860943e-08 0.000000000
#> 4:Ins:R:4 9.395155e-06 9.677650e-09 0.000000000
#> 4:Ins:R:5 2.656344e-18 1.165487e-08 0.000000000
#> 5:Ins:R:0 1.172587e-03 1.467388e-02 0.012024096
#> 5:Ins:R:1 1.101192e-03 4.919532e-03 0.002004016
#> 5:Ins:R:2 8.282668e-07 4.644581e-08 0.000000000
#> 5:Ins:R:3 2.657573e-18 4.755658e-08 0.000000000
#> 5:Ins:R:4 2.655640e-18 3.955673e-08 0.000000000
#> 5:Ins:R:5 2.650695e-18 4.482839e-08 0.000000000
#> 2:Del:M:1 1.374201e-03 3.668966e-03 0.018036144
#> 3:Del:M:1 7.644703e-04 4.887304e-03 0.000000000
#> 3:Del:M:2 9.803640e-04 3.681076e-03 0.000000000
#> 4:Del:M:1 5.047179e-04 1.097973e-02 0.006012048
#> 4:Del:M:2 4.097995e-04 4.890442e-03 0.000000000
#> 4:Del:M:3 4.023676e-04 3.659617e-03 0.000000000
#> 5:Del:M:1 5.362049e-03 2.077133e-02 0.030060241
#> 5:Del:M:2 5.021715e-03 1.229006e-02 0.022044176
#> 5:Del:M:3 3.338840e-03 8.596258e-03 0.006012048
#> 5:Del:M:4 1.329897e-03 4.897913e-03 0.004008032
#> 5:Del:M:5 1.601629e-03 6.075636e-03 0.000000000
#>
#> $aetiology
#> aetiology
#> ID1 Slippage during DNA replication of the replicated DNA strand
#> ID2 Slippage during DNA replication of the template DNA strand
#> ID3 Tobacco smoking
#> ID4 Unknown
#> ID5 Unknown
#> ID6 Defective homologous recombination DNA damage repair
#> ID7 Defective DNA mismatch repair
#> ID8 Repair of DNA double strand breaks by NHEJ mechanisms or mutations in topoisomerase TOP2A
#> ID9 Unknown
#> ID10 Unknown
#> ID11 Unknown
#> ID12 Unknown
#> ID13 Ultraviolet light exposure
#> ID14 Unknown
#> ID15 Unknown
#> ID16 Unknown
#> ID17 Mutations in topoisomerase TOP2A
#> ID18 Colibactin exposure (E.coli bacteria carrying pks pathogenicity island)
#>
#> $date
#> [1] "2020/09/29"
#>
s7
#> $db
#> BRCA_RS1 BRCA_RS2 BRCA_RS3 BRCA_RS4
#> clustered:del:1-10Kb 0.00000000 0.00060006 0.00030006 9.797061e-03
#> clustered:del:10-100Kb 0.00000000 0.00010001 0.00060012 9.697091e-03
#> clustered:del:100Kb-1Mb 0.00000000 0.00000000 0.00100020 2.059382e-02
#> clustered:del:1Mb-10Mb 0.00000000 0.00000000 0.00200040 3.069079e-02
#> clustered:del:>10Mb 0.00000000 0.00000000 0.00000000 8.397481e-03
#> clustered:tds:1-10Kb 0.00080008 0.00000000 0.00180036 2.199340e-03
#> clustered:tds:10-100Kb 0.00140014 0.00000000 0.00190038 5.898231e-03
#> clustered:tds:100Kb-1Mb 0.00570057 0.00000000 0.00080016 1.279616e-02
#> clustered:tds:1Mb-10Mb 0.00100010 0.00000000 0.00190038 2.909127e-02
#> clustered:tds:>10Mb 0.00000000 0.00000000 0.00000000 8.197541e-03
#> clustered:inv:1-10Kb 0.00010001 0.00040004 0.00090018 2.709187e-02
#> clustered:inv:10-100Kb 0.00000000 0.00010001 0.00070014 2.119364e-02
#> clustered:inv:100Kb-1Mb 0.00000000 0.00000000 0.00190038 3.279016e-02
#> clustered:inv:1Mb-10Mb 0.00000000 0.00000000 0.00400080 6.438069e-02
#> clustered:inv:>10Mb 0.00000000 0.00000000 0.00000000 1.499550e-02
#> clustered:trans 0.00000000 0.00000000 0.00000000 5.597321e-01
#> non-clustered:del:1-10Kb 0.00100010 0.01660166 0.01860372 0.000000e+00
#> non-clustered:del:10-100Kb 0.00980098 0.01260126 0.00130026 2.899130e-03
#> non-clustered:del:100Kb-1Mb 0.03850385 0.05040504 0.00180036 2.599220e-03
#> non-clustered:del:1Mb-10Mb 0.00770077 0.06030603 0.00160032 9.697091e-03
#> non-clustered:del:>10Mb 0.00020002 0.06450645 0.00620124 1.699490e-03
#> non-clustered:tds:1-10Kb 0.00000000 0.00000000 0.52550510 0.000000e+00
#> non-clustered:tds:10-100Kb 0.15661566 0.00000000 0.22264453 0.000000e+00
#> non-clustered:tds:100Kb-1Mb 0.53785379 0.00000000 0.00610122 9.997001e-05
#> non-clustered:tds:1Mb-10Mb 0.16831683 0.02110211 0.00100020 1.409577e-02
#> non-clustered:tds:>10Mb 0.00070007 0.04920492 0.00630126 3.099070e-03
#> non-clustered:inv:1-10Kb 0.00990099 0.04570457 0.01070214 1.109667e-02
#> non-clustered:inv:10-100Kb 0.02110211 0.02400240 0.00320064 4.698590e-03
#> non-clustered:inv:100Kb-1Mb 0.02250225 0.04450445 0.00090018 3.598920e-03
#> non-clustered:inv:1Mb-10Mb 0.00340034 0.10121012 0.00280056 1.289613e-02
#> non-clustered:inv:>10Mb 0.00790079 0.11671167 0.01020204 4.898530e-03
#> non-clustered:trans 0.00550055 0.39193919 0.16333267 7.107868e-02
#> BRCA_RS5 BRCA_RS6
#> clustered:del:1-10Kb 0.0019 0.00809919
#> clustered:del:10-100Kb 0.0012 0.01049895
#> clustered:del:100Kb-1Mb 0.0004 0.03319668
#> clustered:del:1Mb-10Mb 0.0000 0.07469253
#> clustered:del:>10Mb 0.0000 0.07129287
#> clustered:tds:1-10Kb 0.0002 0.00339966
#> clustered:tds:10-100Kb 0.0007 0.00829917
#> clustered:tds:100Kb-1Mb 0.0000 0.02649735
#> clustered:tds:1Mb-10Mb 0.0000 0.07279272
#> clustered:tds:>10Mb 0.0000 0.06989301
#> clustered:inv:1-10Kb 0.0005 0.01759824
#> clustered:inv:10-100Kb 0.0015 0.01509849
#> clustered:inv:100Kb-1Mb 0.0000 0.04619538
#> clustered:inv:1Mb-10Mb 0.0000 0.14978502
#> clustered:inv:>10Mb 0.0000 0.13798620
#> clustered:trans 0.0000 0.00000000
#> non-clustered:del:1-10Kb 0.3195 0.02689731
#> non-clustered:del:10-100Kb 0.2182 0.02199780
#> non-clustered:del:100Kb-1Mb 0.0546 0.01709829
#> non-clustered:del:1Mb-10Mb 0.0061 0.02419758
#> non-clustered:del:>10Mb 0.0106 0.01749825
#> non-clustered:tds:1-10Kb 0.0113 0.00000000
#> non-clustered:tds:10-100Kb 0.1150 0.00000000
#> non-clustered:tds:100Kb-1Mb 0.0093 0.00049995
#> non-clustered:tds:1Mb-10Mb 0.0013 0.01259874
#> non-clustered:tds:>10Mb 0.0080 0.01259874
#> non-clustered:inv:1-10Kb 0.0546 0.01349865
#> non-clustered:inv:10-100Kb 0.0330 0.01319868
#> non-clustered:inv:100Kb-1Mb 0.0028 0.01329867
#> non-clustered:inv:1Mb-10Mb 0.0001 0.03919608
#> non-clustered:inv:>10Mb 0.0197 0.03089691
#> non-clustered:trans 0.1295 0.01119888
#>
#> $aetiology
#> aetiology
#> BRCA_RS1 See https://doi.org/10.1038/nature17676
#> BRCA_RS2 See https://doi.org/10.1038/nature17676
#> BRCA_RS3 See https://doi.org/10.1038/nature17676
#> BRCA_RS4 See https://doi.org/10.1038/nature17676
#> BRCA_RS5 See https://doi.org/10.1038/nature17676
#> BRCA_RS6 See https://doi.org/10.1038/nature17676
#>
#> $date
#> [1] "2021/01/15"
#>
s8
#> $db
#> USARC_RS1 USARC_RS2 USARC_RS3 USARC_RS4
#> clustered:del:1-10Kb 6.834884e-03 6.303495e-03 6.407684e-03 9.230378e-03
#> clustered:del:10-100Kb 4.270060e-03 5.641905e-03 1.241242e-02 7.867927e-03
#> clustered:del:100Kb-1Mb 7.687676e-03 1.110580e-03 1.511366e-02 2.276247e-02
#> clustered:del:1Mb-10Mb 2.017710e-02 1.074960e-19 1.537279e-04 8.807448e-02
#> clustered:del:>10Mb 2.458750e-03 1.022069e-05 3.674769e-05 7.747770e-02
#> clustered:inv:1-10Kb 1.394281e-03 2.582252e-05 7.076408e-03 1.196188e-02
#> clustered:inv:10-100Kb 2.957325e-03 1.074960e-19 4.422139e-03 1.400617e-02
#> clustered:inv:100Kb-1Mb 4.604242e-03 2.678928e-05 6.188232e-03 4.551902e-02
#> clustered:inv:1Mb-10Mb 1.154309e-06 1.074960e-19 4.682783e-03 1.966010e-01
#> clustered:inv:>10Mb 4.217556e-08 9.973345e-04 7.614874e-05 1.617201e-01
#> clustered:tds:1-10Kb 2.246868e-03 1.022874e-02 1.391611e-03 2.169201e-03
#> clustered:tds:10-100Kb 6.942607e-03 3.008850e-02 4.413594e-03 5.107370e-03
#> clustered:tds:100Kb-1Mb 3.710163e-03 5.896155e-04 1.163424e-02 1.551601e-02
#> clustered:tds:1Mb-10Mb 2.199998e-02 1.074960e-19 1.166070e-03 8.075208e-02
#> clustered:tds:>10Mb 7.878537e-03 1.074960e-19 2.905490e-04 8.842995e-02
#> clustered:trans 7.292845e-01 1.074960e-19 3.885840e-08 3.703848e-03
#> non-clustered:del:1-10Kb 2.470374e-03 9.521139e-02 1.648661e-02 1.063134e-02
#> non-clustered:del:10-100Kb 8.392111e-03 9.003557e-02 4.729829e-02 1.751525e-02
#> non-clustered:del:100Kb-1Mb 1.639782e-02 4.782250e-02 7.786521e-02 8.005716e-03
#> non-clustered:del:1Mb-10Mb 1.432097e-02 1.577827e-06 9.197157e-02 1.303726e-02
#> non-clustered:del:>10Mb 2.683083e-03 1.547815e-02 5.703203e-02 9.765517e-03
#> non-clustered:inv:1-10Kb 7.833948e-20 6.300174e-02 7.622642e-02 1.173190e-02
#> non-clustered:inv:10-100Kb 2.524234e-03 3.620390e-02 3.439264e-02 4.281051e-03
#> non-clustered:inv:100Kb-1Mb 1.734318e-03 2.023886e-02 5.244040e-02 1.689450e-02
#> non-clustered:inv:1Mb-10Mb 3.984866e-12 4.383551e-03 1.794423e-01 2.895853e-02
#> non-clustered:inv:>10Mb 8.480314e-04 3.014562e-02 1.386317e-01 2.620483e-02
#> non-clustered:tds:1-10Kb 2.947409e-04 5.913130e-02 6.518139e-03 2.004883e-03
#> non-clustered:tds:10-100Kb 6.808324e-03 3.503722e-01 1.933668e-10 3.086576e-05
#> non-clustered:tds:100Kb-1Mb 2.329894e-04 9.111675e-02 3.058558e-02 6.296708e-03
#> non-clustered:tds:1Mb-10Mb 3.337900e-03 1.869247e-02 5.947671e-02 6.907679e-03
#> non-clustered:tds:>10Mb 1.589342e-02 9.422320e-03 5.499027e-02 6.831157e-03
#> non-clustered:trans 1.016135e-01 1.371905e-02 1.176107e-03 3.217896e-06
#> USARC_RS5
#> clustered:del:1-10Kb 1.691945e-03
#> clustered:del:10-100Kb 5.125897e-04
#> clustered:del:100Kb-1Mb 2.527845e-03
#> clustered:del:1Mb-10Mb 2.019511e-07
#> clustered:del:>10Mb 7.341289e-20
#> clustered:inv:1-10Kb 7.958734e-04
#> clustered:inv:10-100Kb 6.522976e-04
#> clustered:inv:100Kb-1Mb 8.441701e-04
#> clustered:inv:1Mb-10Mb 1.214824e-05
#> clustered:inv:>10Mb 1.162990e-08
#> clustered:tds:1-10Kb 2.642799e-05
#> clustered:tds:10-100Kb 1.623973e-03
#> clustered:tds:100Kb-1Mb 4.941240e-03
#> clustered:tds:1Mb-10Mb 1.638187e-05
#> clustered:tds:>10Mb 8.001834e-05
#> clustered:trans 1.546201e-06
#> non-clustered:del:1-10Kb 1.868152e-02
#> non-clustered:del:10-100Kb 1.493504e-02
#> non-clustered:del:100Kb-1Mb 1.052680e-02
#> non-clustered:del:1Mb-10Mb 2.378175e-02
#> non-clustered:del:>10Mb 2.080472e-02
#> non-clustered:inv:1-10Kb 1.364876e-02
#> non-clustered:inv:10-100Kb 8.742159e-03
#> non-clustered:inv:100Kb-1Mb 1.281543e-02
#> non-clustered:inv:1Mb-10Mb 1.487855e-02
#> non-clustered:inv:>10Mb 8.603248e-03
#> non-clustered:tds:1-10Kb 4.841486e-04
#> non-clustered:tds:10-100Kb 1.761335e-03
#> non-clustered:tds:100Kb-1Mb 2.585580e-02
#> non-clustered:tds:1Mb-10Mb 2.961122e-02
#> non-clustered:tds:>10Mb 2.263581e-02
#> non-clustered:trans 7.585070e-01
#>
#> $aetiology
#> aetiology
#> USARC_RS1 See https://doi.org/10.1016/j.ccell.2019.02.002
#> USARC_RS2 See https://doi.org/10.1016/j.ccell.2019.02.002
#> USARC_RS3 See https://doi.org/10.1016/j.ccell.2019.02.002
#> USARC_RS4 See https://doi.org/10.1016/j.ccell.2019.02.002
#> USARC_RS5 See https://doi.org/10.1016/j.ccell.2019.02.002
#>
#> $date
#> [1] "2021/01/15"
#>
s9
#> $db
#> Ref_Sig_R2 Ref_Sig_R4 Ref_Sig_R6a Ref_Sig_R1
#> clustered:del:1-10Kb 1.567159e-03 0.007628322 0.004381155 1.223105e-03
#> clustered:del:10-100Kb 1.471896e-03 0.004711254 0.005842322 2.266545e-03
#> clustered:del:100Kb-1Mb 2.083010e-03 0.008922722 0.012343086 3.002204e-03
#> clustered:del:1Mb-10Mb 3.677654e-04 0.022058664 0.042638521 4.588832e-04
#> clustered:del:>10Mb 6.437584e-04 0.009323692 0.145218560 5.591982e-05
#> clustered:tds:1-10Kb 3.752478e-05 0.003136015 0.002430200 2.208152e-03
#> clustered:tds:10-100Kb 7.105964e-04 0.006880208 0.002914075 6.289380e-03
#> clustered:tds:100Kb-1Mb 8.302720e-04 0.010882614 0.006877399 1.217804e-02
#> clustered:tds:1Mb-10Mb 6.216691e-04 0.020019357 0.043490224 6.341885e-04
#> clustered:tds:>10Mb 5.828615e-20 0.007735317 0.149748951 1.567466e-04
#> clustered:inv:1-10Kb 3.359224e-03 0.013653318 0.011227758 3.033044e-03
#> clustered:inv:10-100Kb 1.889627e-03 0.014271561 0.005301825 2.763701e-03
#> clustered:inv:100Kb-1Mb 5.001086e-04 0.018001317 0.014929333 1.991098e-03
#> clustered:inv:1Mb-10Mb 1.078703e-03 0.039613402 0.079424379 4.631841e-20
#> clustered:inv:>10Mb 1.087986e-03 0.017726522 0.293316071 3.395110e-04
#> clustered:trans 1.425173e-03 0.602520197 0.001599834 2.144462e-16
#> non-clustered:del:1-10Kb 2.463566e-02 0.002304270 0.012914656 1.611709e-02
#> non-clustered:del:10-100Kb 6.976516e-03 0.007288048 0.006962496 2.077641e-02
#> non-clustered:del:100Kb-1Mb 4.145224e-02 0.007261394 0.011918882 2.491302e-02
#> non-clustered:del:1Mb-10Mb 4.748532e-02 0.009922924 0.014222503 3.973143e-03
#> non-clustered:del:>10Mb 4.434001e-02 0.010893135 0.021585867 5.238734e-03
#> non-clustered:tds:1-10Kb 1.032493e-02 0.004264439 0.001915442 3.236104e-02
#> non-clustered:tds:10-100Kb 1.314464e-02 0.007444080 0.003176208 1.917076e-01
#> non-clustered:tds:100Kb-1Mb 2.024243e-02 0.001757187 0.004241789 4.565517e-01
#> non-clustered:tds:1Mb-10Mb 1.957862e-02 0.006837159 0.008383241 7.093931e-02
#> non-clustered:tds:>10Mb 3.428747e-02 0.006064474 0.017486335 5.379584e-03
#> non-clustered:inv:1-10Kb 6.119126e-02 0.005022447 0.005614620 7.468987e-03
#> non-clustered:inv:10-100Kb 2.507619e-02 0.003508302 0.001351172 2.566760e-02
#> non-clustered:inv:100Kb-1Mb 2.961631e-02 0.004680941 0.004440492 2.497468e-02
#> non-clustered:inv:1Mb-10Mb 5.468148e-02 0.008241426 0.017372184 3.550415e-03
#> non-clustered:inv:>10Mb 7.546806e-02 0.015751741 0.039551436 1.424898e-02
#> non-clustered:trans 4.738244e-01 0.091673551 0.007178986 5.953120e-02
#> Ref_Sig_R7 Ref_Sig_R5 Ref_Sig_R6b Ref_Sig_R8
#> clustered:del:1-10Kb 3.694462e-03 6.879448e-03 1.142501e-02 2.888008e-04
#> clustered:del:10-100Kb 1.510923e-02 4.758640e-03 1.944332e-02 4.317593e-04
#> clustered:del:100Kb-1Mb 3.117728e-02 1.184960e-03 4.790208e-02 4.518481e-04
#> clustered:del:1Mb-10Mb 6.747269e-20 3.945072e-04 1.181623e-01 8.763251e-13
#> clustered:del:>10Mb 6.892943e-04 6.680637e-04 5.835798e-03 4.154253e-04
#> clustered:tds:1-10Kb 1.208774e-03 5.264591e-04 7.398411e-03 7.783581e-04
#> clustered:tds:10-100Kb 2.903183e-03 4.054854e-03 7.536560e-03 5.375335e-04
#> clustered:tds:100Kb-1Mb 1.979580e-03 1.119317e-03 3.716081e-02 1.091260e-03
#> clustered:tds:1Mb-10Mb 9.683644e-04 7.005780e-20 1.265566e-01 5.784393e-20
#> clustered:tds:>10Mb 6.747269e-20 7.005780e-20 6.851506e-03 5.784393e-20
#> clustered:inv:1-10Kb 4.254240e-03 8.727811e-03 4.086175e-02 7.800608e-03
#> clustered:inv:10-100Kb 2.271653e-03 6.089805e-04 2.658468e-02 4.952682e-04
#> clustered:inv:100Kb-1Mb 3.304986e-03 1.620386e-04 8.004888e-02 7.944402e-04
#> clustered:inv:1Mb-10Mb 6.747269e-20 1.006563e-03 2.490400e-01 5.784393e-20
#> clustered:inv:>10Mb 4.623234e-03 1.758729e-04 1.352527e-02 5.784393e-20
#> clustered:trans 6.747269e-20 1.360090e-03 3.717530e-15 6.448176e-04
#> non-clustered:del:1-10Kb 9.233000e-02 3.133244e-01 3.390027e-03 7.930462e-03
#> non-clustered:del:10-100Kb 2.582196e-01 1.990759e-01 9.811587e-03 3.448516e-03
#> non-clustered:del:100Kb-1Mb 3.165124e-01 1.197823e-01 2.283594e-02 6.277033e-03
#> non-clustered:del:1Mb-10Mb 3.425977e-02 1.409803e-02 1.793806e-02 5.066261e-03
#> non-clustered:del:>10Mb 1.435968e-02 1.698575e-02 9.202892e-03 5.196884e-03
#> non-clustered:tds:1-10Kb 2.145203e-02 2.502670e-02 5.293003e-03 9.141358e-04
#> non-clustered:tds:10-100Kb 1.763870e-02 3.319246e-02 7.730273e-03 2.270871e-03
#> non-clustered:tds:100Kb-1Mb 4.579915e-03 7.961236e-03 5.265743e-03 2.252603e-02
#> non-clustered:tds:1Mb-10Mb 4.075974e-03 2.438118e-03 1.051386e-02 3.126904e-03
#> non-clustered:tds:>10Mb 7.405011e-03 9.430680e-03 5.745133e-03 8.618603e-03
#> non-clustered:inv:1-10Kb 2.231210e-02 4.296381e-02 1.246487e-02 7.884750e-01
#> non-clustered:inv:10-100Kb 2.563061e-02 3.334342e-02 1.440214e-02 6.844035e-02
#> non-clustered:inv:100Kb-1Mb 3.284889e-02 1.693914e-02 1.525691e-02 7.505938e-03
#> non-clustered:inv:1Mb-10Mb 2.298952e-02 6.786365e-03 4.293955e-02 6.524713e-03
#> non-clustered:inv:>10Mb 1.779009e-02 2.221669e-02 6.608978e-03 2.475892e-03
#> non-clustered:trans 3.541141e-02 1.048074e-01 1.226804e-02 4.747228e-02
#> Ref_Sig_R3 Ref_Sig_R9 Ref_Sig_R10 Ref_Sig_R11
#> clustered:del:1-10Kb 1.747958e-04 4.578525e-03 0.001568886 3.002798e-20
#> clustered:del:10-100Kb 2.658309e-03 1.397877e-03 0.003764180 3.002798e-20
#> clustered:del:100Kb-1Mb 2.689439e-03 5.707227e-20 0.005433341 3.002798e-20
#> clustered:del:1Mb-10Mb 4.849496e-20 5.707227e-20 0.007315930 9.899429e-03
#> clustered:del:>10Mb 4.849496e-20 5.707227e-20 0.002926372 3.260640e-03
#> clustered:tds:1-10Kb 8.089492e-04 2.428934e-05 0.004901891 3.281168e-03
#> clustered:tds:10-100Kb 5.887643e-03 5.707227e-20 0.004187741 4.935395e-13
#> clustered:tds:100Kb-1Mb 4.851449e-04 2.649546e-04 0.001908603 4.160710e-14
#> clustered:tds:1Mb-10Mb 3.701375e-04 1.533737e-03 0.009266845 7.949062e-03
#> clustered:tds:>10Mb 4.849496e-20 5.707227e-20 0.002926372 3.002798e-20
#> clustered:inv:1-10Kb 4.849496e-20 2.096731e-03 0.002367858 7.623122e-03
#> clustered:inv:10-100Kb 2.920005e-04 1.024877e-03 0.002178143 3.002798e-20
#> clustered:inv:100Kb-1Mb 4.849496e-20 5.707227e-20 0.005990998 2.165802e-03
#> clustered:inv:1Mb-10Mb 4.849496e-20 4.559049e-04 0.015607317 1.017268e-02
#> clustered:inv:>10Mb 4.849496e-20 5.707227e-20 0.002438643 2.716306e-13
#> clustered:trans 4.849496e-20 5.707227e-20 0.008880482 6.315756e-15
#> non-clustered:del:1-10Kb 4.416577e-02 6.767956e-01 0.066757214 6.116676e-03
#> non-clustered:del:10-100Kb 2.156268e-02 8.262766e-02 0.094730346 1.803897e-02
#> non-clustered:del:100Kb-1Mb 9.988890e-03 1.153834e-02 0.120208498 2.195164e-02
#> non-clustered:del:1Mb-10Mb 1.315914e-03 1.180865e-02 0.043144691 1.082218e-01
#> non-clustered:del:>10Mb 4.083190e-03 3.683978e-03 0.022242247 8.718493e-02
#> non-clustered:tds:1-10Kb 3.093494e-01 4.992907e-03 0.045066599 5.667611e-03
#> non-clustered:tds:10-100Kb 3.663985e-01 6.152731e-02 0.161192728 3.002798e-20
#> non-clustered:tds:100Kb-1Mb 1.970344e-02 4.061174e-18 0.062054949 3.665310e-05
#> non-clustered:tds:1Mb-10Mb 9.609342e-04 2.913765e-03 0.013651884 7.163814e-02
#> non-clustered:tds:>10Mb 5.874025e-03 3.239969e-03 0.005189954 9.214935e-02
#> non-clustered:inv:1-10Kb 1.769235e-02 4.800413e-02 0.039870430 4.001429e-02
#> non-clustered:inv:10-100Kb 1.395990e-02 1.573345e-02 0.025785885 2.258781e-02
#> non-clustered:inv:100Kb-1Mb 3.257709e-03 3.659538e-03 0.024398589 3.401032e-02
#> non-clustered:inv:1Mb-10Mb 3.674957e-03 4.443362e-03 0.030422068 1.994008e-01
#> non-clustered:inv:>10Mb 1.428912e-02 1.170508e-02 0.060828088 1.892005e-01
#> non-clustered:trans 1.503567e-01 4.594940e-02 0.102792228 5.942857e-02
#> Ref_Sig_R12 Ref_Sig_R13 Ref_Sig_R14 Ref_Sig_R15
#> clustered:del:1-10Kb 2.637234e-02 3.648546e-02 6.966639e-20 2.328901e-16
#> clustered:del:10-100Kb 1.402898e-02 1.637696e-02 2.690050e-03 3.570212e-03
#> clustered:del:100Kb-1Mb 5.862472e-02 6.512912e-02 8.691184e-04 3.859875e-20
#> clustered:del:1Mb-10Mb 6.614287e-02 2.070216e-02 2.332023e-03 3.859875e-20
#> clustered:del:>10Mb 8.651652e-20 1.293921e-05 6.966639e-20 3.859875e-20
#> clustered:tds:1-10Kb 2.064280e-03 4.437263e-20 6.966639e-20 3.859875e-20
#> clustered:tds:10-100Kb 1.424396e-02 4.437263e-20 2.235943e-03 2.641809e-03
#> clustered:tds:100Kb-1Mb 6.447736e-02 7.502147e-03 3.073972e-03 3.859875e-20
#> clustered:tds:1Mb-10Mb 5.500733e-02 4.437263e-20 1.037148e-03 3.859875e-20
#> clustered:tds:>10Mb 8.651652e-20 4.437263e-20 6.966639e-20 3.859875e-20
#> clustered:inv:1-10Kb 9.750561e-02 1.973988e-01 6.966639e-20 5.524662e-03
#> clustered:inv:10-100Kb 5.038460e-02 7.409019e-02 6.966639e-20 3.886918e-03
#> clustered:inv:100Kb-1Mb 1.149912e-01 5.363620e-02 6.966639e-20 3.859875e-20
#> clustered:inv:1Mb-10Mb 1.248706e-01 4.437263e-20 1.072656e-03 3.859875e-20
#> clustered:inv:>10Mb 8.651652e-20 4.437263e-20 6.966639e-20 3.859875e-20
#> clustered:trans 8.651652e-20 4.437263e-20 4.223818e-03 3.859875e-20
#> non-clustered:del:1-10Kb 2.370538e-02 1.951757e-07 2.691732e-03 3.859875e-20
#> non-clustered:del:10-100Kb 1.312107e-02 4.437263e-20 9.858685e-05 1.736966e-01
#> non-clustered:del:100Kb-1Mb 1.134590e-19 8.708858e-02 6.966639e-20 1.002027e-01
#> non-clustered:del:1Mb-10Mb 1.703491e-02 5.982474e-11 1.389408e-02 1.118480e-01
#> non-clustered:del:>10Mb 6.489648e-12 4.418352e-02 1.286831e-02 1.052713e-01
#> non-clustered:tds:1-10Kb 8.651652e-20 4.437263e-20 8.820014e-18 3.859875e-20
#> non-clustered:tds:10-100Kb 1.264793e-03 4.437263e-20 6.966639e-20 3.859875e-20
#> non-clustered:tds:100Kb-1Mb 6.996080e-07 4.437263e-20 3.716683e-01 3.859875e-20
#> non-clustered:tds:1Mb-10Mb 2.019205e-02 4.437263e-20 3.827861e-01 1.050773e-02
#> non-clustered:tds:>10Mb 3.184393e-03 4.505147e-14 1.708062e-02 5.307273e-02
#> non-clustered:inv:1-10Kb 1.219492e-01 2.984689e-01 1.057704e-02 3.859875e-20
#> non-clustered:inv:10-100Kb 2.812034e-02 5.889617e-02 1.008224e-02 2.487705e-02
#> non-clustered:inv:100Kb-1Mb 4.702233e-02 2.917688e-02 2.131323e-02 1.230172e-01
#> non-clustered:inv:1Mb-10Mb 3.537272e-02 1.085181e-02 2.595458e-02 1.262866e-01
#> non-clustered:inv:>10Mb 1.155047e-11 4.437263e-20 1.172959e-02 1.555965e-01
#> non-clustered:trans 3.182750e-04 4.437263e-20 1.017208e-01 3.859875e-20
#> Ref_Sig_R16 Ref_Sig_R17 Ref_Sig_R18 Ref_Sig_R19
#> clustered:del:1-10Kb 1.546305e-02 1.634480e-03 1.933307e-02 8.886469e-03
#> clustered:del:10-100Kb 6.810828e-03 1.873313e-19 2.012641e-02 1.431786e-02
#> clustered:del:100Kb-1Mb 2.563362e-02 2.900284e-02 2.936994e-02 2.373617e-02
#> clustered:del:1Mb-10Mb 4.975067e-02 1.873313e-19 8.917663e-03 1.006271e-02
#> clustered:del:>10Mb 3.025379e-02 3.048844e-02 2.900056e-03 1.238272e-02
#> clustered:tds:1-10Kb 3.514961e-15 7.301037e-03 6.820658e-20 1.107688e-02
#> clustered:tds:10-100Kb 1.680766e-02 1.873313e-19 8.518834e-03 1.531701e-02
#> clustered:tds:100Kb-1Mb 2.420303e-02 2.283240e-03 3.392704e-02 4.506443e-02
#> clustered:tds:1Mb-10Mb 3.630454e-02 4.252683e-02 2.090335e-02 1.160435e-02
#> clustered:tds:>10Mb 2.084150e-02 1.873313e-19 6.820658e-20 1.732333e-02
#> clustered:inv:1-10Kb 7.502304e-02 4.073154e-02 7.688871e-02 4.223506e-02
#> clustered:inv:10-100Kb 3.025379e-02 1.293120e-02 2.740837e-02 3.534051e-02
#> clustered:inv:100Kb-1Mb 5.042298e-02 2.015267e-02 3.535372e-02 6.066714e-02
#> clustered:inv:1Mb-10Mb 7.193678e-02 2.812846e-02 1.613920e-02 3.385344e-02
#> clustered:inv:>10Mb 4.571683e-02 1.873313e-19 6.820658e-20 2.250229e-02
#> clustered:trans 9.076136e-02 4.014376e-02 2.245019e-01 1.200058e-01
#> non-clustered:del:1-10Kb 6.446439e-15 7.291692e-02 3.427148e-18 2.997769e-20
#> non-clustered:del:10-100Kb 7.671467e-02 1.219449e-14 6.894267e-08 1.241546e-07
#> non-clustered:del:100Kb-1Mb 7.112502e-02 1.873313e-19 2.695761e-03 3.480136e-02
#> non-clustered:del:1Mb-10Mb 1.431733e-03 1.922425e-02 1.753847e-02 1.287266e-02
#> non-clustered:del:>10Mb 3.466221e-03 2.221899e-02 9.015202e-03 2.264110e-03
#> non-clustered:tds:1-10Kb 1.931725e-02 1.873313e-19 6.820658e-20 5.874657e-10
#> non-clustered:tds:10-100Kb 1.478331e-02 3.138036e-02 6.820658e-20 7.238901e-07
#> non-clustered:tds:100Kb-1Mb 2.346379e-02 1.297030e-01 4.959291e-08 1.584978e-01
#> non-clustered:tds:1Mb-10Mb 3.929908e-03 2.687962e-02 6.820658e-20 5.741713e-02
#> non-clustered:tds:>10Mb 8.317606e-03 1.873313e-19 5.068581e-03 6.760365e-03
#> non-clustered:inv:1-10Kb 5.368646e-02 1.776091e-01 9.706200e-02 2.370738e-03
#> non-clustered:inv:10-100Kb 3.222730e-02 7.236061e-02 5.212603e-02 3.289633e-02
#> non-clustered:inv:100Kb-1Mb 7.754328e-03 9.785024e-03 1.835253e-02 4.522800e-02
#> non-clustered:inv:1Mb-10Mb 2.099863e-02 8.210125e-10 1.249983e-02 7.558932e-03
#> non-clustered:inv:>10Mb 1.634265e-19 1.873313e-19 3.303224e-03 2.792412e-02
#> non-clustered:trans 7.260033e-02 1.825976e-01 2.580500e-01 1.270315e-01
#> Ref_Sig_R20
#> clustered:del:1-10Kb 1.939619e-02
#> clustered:del:10-100Kb 4.997337e-02
#> clustered:del:100Kb-1Mb 1.269926e-01
#> clustered:del:1Mb-10Mb 2.408314e-02
#> clustered:del:>10Mb 1.541967e-19
#> clustered:tds:1-10Kb 1.829925e-02
#> clustered:tds:10-100Kb 1.749794e-02
#> clustered:tds:100Kb-1Mb 1.244064e-01
#> clustered:tds:1Mb-10Mb 2.873669e-02
#> clustered:tds:>10Mb 1.541967e-19
#> clustered:inv:1-10Kb 3.738250e-02
#> clustered:inv:10-100Kb 5.402858e-02
#> clustered:inv:100Kb-1Mb 2.204243e-01
#> clustered:inv:1Mb-10Mb 3.080089e-02
#> clustered:inv:>10Mb 1.541967e-19
#> clustered:trans 1.541967e-19
#> non-clustered:del:1-10Kb 3.590464e-02
#> non-clustered:del:10-100Kb 2.952375e-02
#> non-clustered:del:100Kb-1Mb 4.576690e-02
#> non-clustered:del:1Mb-10Mb 2.611601e-02
#> non-clustered:del:>10Mb 1.541967e-19
#> non-clustered:tds:1-10Kb 1.035538e-03
#> non-clustered:tds:10-100Kb 1.541967e-19
#> non-clustered:tds:100Kb-1Mb 8.033007e-03
#> non-clustered:tds:1Mb-10Mb 1.218020e-02
#> non-clustered:tds:>10Mb 1.541967e-19
#> non-clustered:inv:1-10Kb 4.116713e-03
#> non-clustered:inv:10-100Kb 4.187950e-03
#> non-clustered:inv:100Kb-1Mb 5.301169e-02
#> non-clustered:inv:1Mb-10Mb 2.232215e-02
#> non-clustered:inv:>10Mb 5.779666e-03
#> non-clustered:trans 1.541967e-19
#>
#> $aetiology
#> aetiology
#> Ref_Sig_R2 See https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_R4 See https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_R6a See https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_R1 See https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_R7 See https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_R5 See https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_R6b See https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_R8 See https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_R3 See https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_R9 See https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_R10 See https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_R11 See https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_R12 See https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_R13 See https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_R14 See https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_R15 See https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_R16 See https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_R17 See https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_R18 See https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_R19 See https://doi.org/10.1038/s43018-020-0027-5
#> Ref_Sig_R20 See https://doi.org/10.1038/s43018-020-0027-5
#>
#> $date
#> [1] "2021/01/15"
#>
s10
#> $db
#> USARC_CNS1 USARC_CNS2 USARC_CNS3 USARC_CNS4
#> 5+:het:0-10Kb 5.274497e-03 1.593587e-03 9.397894e-04 3.228938e-03
#> 5+:het:10Kb-100Kb 4.863780e-02 8.764740e-20 7.759632e-20 8.372139e-20
#> 5+:het:100Kb-1Mb 1.229463e-01 3.696390e-02 7.759632e-20 8.372139e-20
#> 5+:het:1Mb-10Mb 1.531798e-01 1.956715e-03 7.759632e-20 8.372139e-20
#> 5+:het:>10Mb 7.062742e-02 8.764740e-20 7.759632e-20 8.372139e-20
#> 5+:LOH:0-10Kb 1.961968e-02 2.686555e-02 7.759632e-20 8.860806e-03
#> 5+:LOH:10Kb-100Kb 4.948102e-02 1.273464e-02 2.788866e-03 1.524402e-02
#> 5+:LOH:100Kb-1Mb 5.148843e-02 3.296569e-02 2.960668e-13 8.372139e-20
#> 5+:LOH:1Mb-10Mb 5.884358e-02 2.217591e-02 7.759632e-20 8.372139e-20
#> 5+:LOH:>10Mb 1.550456e-02 8.764740e-20 7.759632e-20 8.372139e-20
#> 0-1:homdel:0-10Kb 8.435095e-03 4.279845e-03 2.716091e-03 8.847770e-03
#> 0-1:homdel:10Kb-100Kb 2.076796e-02 7.826196e-03 1.342032e-02 5.188978e-02
#> 0-1:homdel:100Kb-1Mb 1.141792e-02 3.512656e-03 1.831468e-02 5.136559e-02
#> 0-1:homdel:1Mb-10Mb 5.977538e-03 1.675601e-03 8.403604e-03 4.121933e-03
#> 0-1:LOH:10Kb-100Kb 1.069575e-02 9.996772e-03 2.495192e-02 6.693989e-02
#> 0-1:LOH:100Kb-1Mb 4.690414e-03 2.873800e-03 7.869251e-02 1.033684e-01
#> 0-1:LOH:1Mb-10Mb 1.791622e-03 8.727480e-04 1.282256e-01 3.565910e-02
#> 0-1:LOH:>10Mb 6.537326e-20 8.764740e-20 1.073453e-01 4.654088e-14
#> 3-4:het:10Kb-100Kb 1.395288e-02 1.410292e-02 3.314799e-02 1.087583e-04
#> 3-4:het:100Kb-1Mb 3.080201e-19 1.784433e-01 8.537421e-02 3.768087e-05
#> 3-4:het:1Mb-10Mb 6.537326e-20 1.083397e-01 5.285143e-02 8.372139e-20
#> 3-4:het:>10Mb 1.207830e-02 8.764740e-20 8.361399e-03 1.825474e-02
#> 3-4:LOH:0-10Kb 1.447601e-02 1.136173e-02 6.339878e-03 1.585258e-02
#> 3-4:LOH:10Kb-100Kb 2.824487e-02 2.647171e-02 3.913762e-03 5.131968e-02
#> 3-4:LOH:100Kb-1Mb 5.228094e-02 1.844997e-01 4.824391e-03 2.565020e-02
#> 3-4:LOH:1Mb-10Mb 7.772041e-02 1.864758e-01 7.759632e-20 8.372139e-20
#> 3-4:LOH:>10Mb 8.776371e-02 2.321991e-02 7.759632e-20 7.090787e-03
#> 2:het:10Kb-100Kb 1.287775e-03 8.764740e-20 5.574207e-03 8.372139e-20
#> 2:het:100Kb-1Mb 6.537326e-20 4.876532e-03 5.394076e-02 7.444040e-03
#> 2:het:1Mb-10Mb 6.537326e-20 4.788785e-14 1.334470e-01 5.296963e-04
#> 2:LOH:0-10Kb 6.177925e-03 5.260825e-03 2.522409e-03 8.545624e-03
#> 2:LOH:10Kb-100Kb 1.342788e-02 1.265345e-02 2.069331e-02 3.904540e-02
#> 2:LOH:100Kb-1Mb 2.425268e-02 2.400273e-03 3.013930e-02 1.053687e-01
#> 2:LOH:1Mb-10Mb 1.309646e-09 3.098649e-02 2.907286e-03 1.513234e-01
#> 2:LOH:>10Mb 6.537326e-20 3.419327e-02 7.759632e-20 1.957647e-01
#> 0-1:LOH:0-10Kb 7.597433e-03 8.091020e-03 4.929189e-03 2.318312e-02
#> 3-4:het:0-10Kb 6.706152e-04 7.911334e-04 3.292362e-03 8.372139e-20
#> 2:het:>10Mb 6.537326e-20 8.764740e-20 1.608283e-01 8.372139e-20
#> 2:het:0-10Kb 9.423487e-05 1.538662e-03 1.114222e-03 2.168858e-07
#> 0-1:homdel:>10Mb 5.949244e-04 8.764740e-20 7.759632e-20 9.544556e-04
#> USARC_CNS5 USARC_CNS6 USARC_CNS7
#> 5+:het:0-10Kb 3.625428e-03 6.763016e-03 4.960484e-04
#> 5+:het:10Kb-100Kb 1.246612e-01 5.887014e-02 1.499437e-07
#> 5+:het:100Kb-1Mb 2.821866e-01 1.006715e-10 3.136746e-02
#> 5+:het:1Mb-10Mb 8.995008e-02 2.748799e-15 1.493354e-01
#> 5+:het:>10Mb 5.978670e-16 4.621804e-03 2.816981e-02
#> 5+:LOH:0-10Kb 7.855001e-05 1.070641e-02 2.411472e-02
#> 5+:LOH:10Kb-100Kb 1.189917e-02 2.374562e-02 5.790417e-03
#> 5+:LOH:100Kb-1Mb 7.421417e-03 8.422503e-20 1.164417e-03
#> 5+:LOH:1Mb-10Mb 2.432626e-04 8.422503e-20 5.671105e-20
#> 5+:LOH:>10Mb 6.339807e-20 8.422503e-20 5.671105e-20
#> 0-1:homdel:0-10Kb 6.339807e-20 1.104579e-02 5.926512e-04
#> 0-1:homdel:10Kb-100Kb 6.339807e-20 6.299922e-03 5.671105e-20
#> 0-1:homdel:100Kb-1Mb 9.565687e-04 1.057325e-10 1.188603e-19
#> 0-1:homdel:1Mb-10Mb 6.339807e-20 3.643841e-03 5.671105e-20
#> 0-1:LOH:10Kb-100Kb 6.339807e-20 5.939530e-02 5.671105e-20
#> 0-1:LOH:100Kb-1Mb 3.791177e-08 8.228020e-02 5.671105e-20
#> 0-1:LOH:1Mb-10Mb 2.580460e-14 2.172322e-02 5.184317e-03
#> 0-1:LOH:>10Mb 6.339807e-20 8.213112e-15 5.671105e-20
#> 3-4:het:10Kb-100Kb 2.455825e-02 1.178730e-01 6.280078e-03
#> 3-4:het:100Kb-1Mb 1.353052e-01 9.089293e-02 9.741581e-02
#> 3-4:het:1Mb-10Mb 1.099580e-01 1.169311e-01 3.193144e-01
#> 3-4:het:>10Mb 5.383941e-02 1.417908e-02 2.391260e-01
#> 3-4:LOH:0-10Kb 6.021248e-04 2.541427e-02 6.761658e-03
#> 3-4:LOH:10Kb-100Kb 2.760318e-03 3.837643e-02 5.530548e-03
#> 3-4:LOH:100Kb-1Mb 1.256322e-03 1.293233e-02 7.265273e-10
#> 3-4:LOH:1Mb-10Mb 6.339807e-20 1.731009e-14 5.671105e-20
#> 3-4:LOH:>10Mb 6.339807e-20 8.422503e-20 5.671105e-20
#> 2:het:10Kb-100Kb 2.838906e-03 5.919499e-02 5.140683e-04
#> 2:het:100Kb-1Mb 7.455267e-03 9.131630e-02 1.316008e-02
#> 2:het:1Mb-10Mb 2.803118e-03 2.948838e-02 3.262415e-02
#> 2:LOH:0-10Kb 1.372718e-03 1.992817e-02 2.324400e-03
#> 2:LOH:10Kb-100Kb 3.674605e-03 4.000238e-02 3.688148e-05
#> 2:LOH:100Kb-1Mb 5.794475e-02 1.069995e-02 3.573889e-08
#> 2:LOH:1Mb-10Mb 6.376390e-02 3.092485e-02 4.329769e-03
#> 2:LOH:>10Mb 8.107825e-03 1.401324e-11 2.235870e-02
#> 0-1:LOH:0-10Kb 6.339807e-20 7.535108e-03 3.418975e-18
#> 3-4:het:0-10Kb 2.737002e-03 1.810799e-03 3.760385e-03
#> 2:het:>10Mb 6.339807e-20 8.422503e-20 5.671105e-20
#> 2:het:0-10Kb 6.339807e-20 3.404721e-03 5.671105e-20
#> 0-1:homdel:>10Mb 6.339807e-20 8.422503e-20 2.476800e-04
#>
#> $aetiology
#> aetiology
#> USARC_CNS1 See https://doi.org/10.1016/j.ccell.2019.02.002
#> USARC_CNS2 See https://doi.org/10.1016/j.ccell.2019.02.002
#> USARC_CNS3 See https://doi.org/10.1016/j.ccell.2019.02.002
#> USARC_CNS4 See https://doi.org/10.1016/j.ccell.2019.02.002
#> USARC_CNS5 See https://doi.org/10.1016/j.ccell.2019.02.002
#> USARC_CNS6 See https://doi.org/10.1016/j.ccell.2019.02.002
#> USARC_CNS7 See https://doi.org/10.1016/j.ccell.2019.02.002
#>
#> $date
#> [1] "2021/01/15"
#>
s11
#> $db
#> CN1 CN2 CN3 CN4 CN5
#> 0:homdel:0-100Kb 1.795054e-03 2.237674e-03 0.06404424 0.00096628 0.025822490
#> 0:homdel:100Kb-1Mb 3.807104e-03 7.195788e-03 0.00640384 0.00021955 0.024993570
#> 0:homdel:>1Mb 2.436746e-03 3.837108e-03 0.01303343 0.00006124 0.003888700
#> 1:LOH:0-100Kb 2.840449e-03 2.826536e-03 0.06221358 0.05615077 0.015829115
#> 1:LOH:100Kb-1Mb 1.226306e-02 6.323915e-03 0.01261482 0.24779892 0.026544940
#> 1:LOH:1Mb-10Mb 1.916342e-02 1.023764e-03 0.01928346 0.08336934 0.001358030
#> 1:LOH:10Mb-40Mb 4.729776e-02 4.833643e-04 0.00871990 0.00010096 0.000573685
#> 1:LOH:>40Mb 7.364600e-02 1.243217e-04 0.00409212 0.00230378 0.000080995
#> 2:LOH:0-100Kb 1.187984e-03 2.488917e-03 0.00138849 0.01414630 0.013351500
#> 2:LOH:100Kb-1Mb 4.303102e-03 1.946487e-02 0.03383514 0.04008938 0.255496412
#> 2:LOH:1Mb-10Mb 4.438013e-03 3.355154e-02 0.01899058 0.00618009 0.264575824
#> 2:LOH:10Mb-40Mb 4.318590e-03 5.229117e-02 0.00267497 0.00024516 0.067065891
#> 2:LOH:>40Mb 1.221565e-02 6.737476e-02 0.00008237 0.00241502 0.019616490
#> 3-4:LOH:0-100Kb 1.379947e-03 2.717402e-03 0.00271910 0.01402566 0.005480255
#> 3-4:LOH:100Kb-1Mb 1.667853e-03 1.381945e-02 0.02381122 0.01144021 0.026855770
#> 3-4:LOH:1Mb-10Mb 1.514284e-03 1.247139e-02 0.03436767 0.00010785 0.029519046
#> 3-4:LOH:10Mb-40Mb 1.022026e-04 1.063124e-02 0.02189155 0.00000010 0.004552090
#> 3-4:LOH:>40Mb 7.367609e-03 1.742692e-02 0.02529479 0.00000013 0.000735890
#> 5-8:LOH:0-100Kb 3.512978e-04 1.689411e-03 0.00000053 0.02552717 0.000664530
#> 5-8:LOH:100Kb-1Mb 2.121070e-04 3.416253e-03 0.00256956 0.00169273 0.000652505
#> 5-8:LOH:1Mb-10Mb 2.077835e-04 4.495306e-03 0.00554920 0.00000019 0.000278185
#> 5-8:LOH:10Mb-40Mb 9.971522e-05 2.756042e-03 0.00000071 0.00001314 0.000125705
#> 5-8:LOH:>40Mb 3.319383e-04 1.008962e-02 0.00535955 0.00000014 0.000098750
#> 9+:LOH:0-100Kb 1.339948e-04 5.201960e-04 0.00000071 0.00001056 0.001312595
#> 9+:LOH:100Kb-1Mb 4.119878e-04 6.686430e-04 0.00216196 0.00000028 0.003306250
#> 9+:LOH:1Mb-10Mb 2.007700e-04 8.289973e-04 0.00220660 0.00000028 0.000649225
#> 9+:LOH:10Mb-40Mb 6.514783e-06 3.509030e-04 0.00211290 0.00000028 0.000015135
#> 9+:LOH:>40Mb 2.757826e-06 7.127680e-04 0.00092755 0.00000028 0.000012310
#> 2:het:0-100Kb 1.268552e-04 1.077283e-03 0.02085150 0.00018321 0.001733870
#> 2:het:100Kb-1Mb 2.392692e-03 1.448575e-03 0.01137198 0.00093060 0.008359660
#> 2:het:1Mb-10Mb 1.722643e-02 5.714677e-04 0.02363235 0.00124271 0.047988820
#> 2:het:10Mb-40Mb 1.120439e-01 4.012700e-04 0.02432782 0.00653021 0.040189910
#> 2:het:>40Mb 6.475482e-01 1.616667e-06 0.02278876 0.04721082 0.000000615
#> 3-4:het:0-100Kb 9.864370e-04 1.301613e-03 0.01675940 0.02839772 0.004295095
#> 3-4:het:100Kb-1Mb 3.623147e-03 1.521748e-02 0.04264799 0.20328865 0.027386325
#> 3-4:het:1Mb-10Mb 1.734587e-03 5.815643e-02 0.02762061 0.05567599 0.015401125
#> 3-4:het:10Mb-40Mb 3.009542e-03 1.352009e-01 0.01850544 0.00340995 0.020384580
#> 3-4:het:>40Mb 5.373925e-03 3.902848e-01 0.00000018 0.00472731 0.002974155
#> 5-8:het:0-100Kb 7.412117e-04 1.717201e-03 0.00551728 0.06860624 0.003368305
#> 5-8:het:100Kb-1Mb 1.163800e-04 1.163041e-02 0.03952374 0.05686576 0.007209015
#> 5-8:het:1Mb-10Mb 2.040022e-04 1.933555e-02 0.16260339 0.01134511 0.008309545
#> 5-8:het:10Mb-40Mb 1.934870e-05 2.564167e-02 0.12226601 0.00463152 0.000973130
#> 5-8:het:>40Mb 5.256617e-04 4.417481e-02 0.07693656 0.00000001 0.001276840
#> 9+:het:0-100Kb 1.052583e-04 9.914510e-04 0.00254618 0.00005163 0.003029025
#> 9+:het:100Kb-1Mb 3.181774e-04 3.241010e-03 0.00174383 0.00002151 0.007385620
#> 9+:het:1Mb-10Mb 1.870352e-04 3.779865e-03 0.00000071 0.00000026 0.006117540
#> 9+:het:10Mb-40Mb 1.743043e-06 1.908404e-03 0.00197462 0.00000024 0.000067940
#> 9+:het:>40Mb 1.175522e-05 2.099960e-03 0.00203108 0.00001474 0.000093000
#> CN6 CN7 CN8 CN9 CN10
#> 0:homdel:0-100Kb 0.0034924998 0.00000000 0.000216260 8.181842e-03 0.00779524
#> 0:homdel:100Kb-1Mb 0.0075503095 0.00000000 0.000720975 2.099919e-02 0.03122532
#> 0:homdel:>1Mb 0.0013361699 0.00000000 0.000269340 9.009219e-03 0.00455881
#> 1:LOH:0-100Kb 0.0059558296 0.00011082 0.000950405 1.858365e-02 0.00879753
#> 1:LOH:100Kb-1Mb 0.0105207593 0.00504080 0.007283630 1.308079e-01 0.03974523
#> 1:LOH:1Mb-10Mb 0.0009915099 0.00007442 0.002204905 1.599492e-01 0.01091525
#> 1:LOH:10Mb-40Mb 0.0004099400 0.00000002 0.003664150 7.622936e-02 0.00290428
#> 1:LOH:>40Mb 0.0001791700 0.00000000 0.006089315 2.700069e-02 0.00148398
#> 2:LOH:0-100Kb 0.0192514487 0.00277607 0.011115840 4.119057e-03 0.00635726
#> 2:LOH:100Kb-1Mb 0.1772921576 0.00454340 0.022282900 1.377423e-02 0.08782354
#> 2:LOH:1Mb-10Mb 0.1163828519 0.00457336 0.008298320 1.159439e-02 0.13191050
#> 2:LOH:10Mb-40Mb 0.0063248096 0.00004105 0.001159380 4.945152e-03 0.08706983
#> 2:LOH:>40Mb 0.0002609300 0.00000000 0.000131970 2.407305e-03 0.01593395
#> 3-4:LOH:0-100Kb 0.0050518296 0.00420447 0.009564720 1.833529e-03 0.00743812
#> 3-4:LOH:100Kb-1Mb 0.0135102791 0.00232790 0.004662895 2.848605e-03 0.06845530
#> 3-4:LOH:1Mb-10Mb 0.0040970397 0.00021573 0.003492150 3.443510e-03 0.09646664
#> 3-4:LOH:10Mb-40Mb 0.0000560700 0.00000079 0.002194095 1.390007e-03 0.04754809
#> 3-4:LOH:>40Mb 0.0003285500 0.00000674 0.003399115 1.198601e-03 0.01319828
#> 5-8:LOH:0-100Kb 0.0004894900 0.00552275 0.010770475 3.759373e-04 0.00260391
#> 5-8:LOH:100Kb-1Mb 0.0003104600 0.00682636 0.009675285 8.361655e-04 0.02207809
#> 5-8:LOH:1Mb-10Mb 0.0002143500 0.00006776 0.002155840 6.616173e-04 0.02022345
#> 5-8:LOH:10Mb-40Mb 0.0001177100 0.00000000 0.001022835 3.764864e-04 0.00679665
#> 5-8:LOH:>40Mb 0.0003040600 0.00004933 0.001459620 3.826345e-04 0.00017289
#> 9+:LOH:0-100Kb 0.0049314197 0.00632901 0.022043315 7.594236e-04 0.00018531
#> 9+:LOH:100Kb-1Mb 0.0054595396 0.02139771 0.028381515 1.234374e-03 0.00299660
#> 9+:LOH:1Mb-10Mb 0.0008671599 0.01464548 0.008094730 5.745618e-04 0.00365022
#> 9+:LOH:10Mb-40Mb 0.0000126800 0.00000061 0.000025265 1.019000e-05 0.00044558
#> 9+:LOH:>40Mb 0.0000340000 0.00000002 0.000111790 4.554545e-06 0.00000009
#> 2:het:0-100Kb 0.0035613998 0.00021658 0.001038500 2.813763e-03 0.00213926
#> 2:het:100Kb-1Mb 0.0018074599 0.00209292 0.000889200 5.745673e-02 0.00460283
#> 2:het:1Mb-10Mb 0.0086287494 0.00016457 0.002329035 1.599203e-01 0.00069290
#> 2:het:10Mb-40Mb 0.0089315194 0.00000000 0.002674940 1.295436e-01 0.00078362
#> 2:het:>40Mb 0.0020075299 0.00000031 0.002161405 6.767871e-03 0.00000006
#> 3-4:het:0-100Kb 0.0094994693 0.00362014 0.013551545 6.686778e-03 0.00557084
#> 3-4:het:100Kb-1Mb 0.2055037256 0.06003456 0.041391180 6.747132e-02 0.04177622
#> 3-4:het:1Mb-10Mb 0.2333349037 0.12143735 0.026193135 4.351086e-02 0.08695636
#> 3-4:het:10Mb-40Mb 0.0629906556 0.00493032 0.004956070 7.530375e-03 0.06757995
#> 3-4:het:>40Mb 0.0024052698 0.00022509 0.024168520 2.876185e-03 0.00000001
#> 5-8:het:0-100Kb 0.0036253197 0.01467759 0.032617975 1.719672e-03 0.00596208
#> 5-8:het:100Kb-1Mb 0.0045492397 0.16196039 0.127337371 1.350210e-03 0.04005666
#> 5-8:het:1Mb-10Mb 0.0020514199 0.21136197 0.061241481 1.136105e-03 0.01210908
#> 5-8:het:10Mb-40Mb 0.0002642700 0.00484320 0.008361195 4.680918e-04 0.00183866
#> 5-8:het:>40Mb 0.0000219000 0.00032996 0.004528565 4.135518e-04 0.00000000
#> 9+:het:0-100Kb 0.0167008988 0.02554054 0.094947456 1.681830e-03 0.00047103
#> 9+:het:100Kb-1Mb 0.0434289570 0.16018674 0.266746762 4.252061e-03 0.00025120
#> 9+:het:1Mb-10Mb 0.0048971397 0.14906452 0.110528846 8.088173e-04 0.00000001
#> 9+:het:10Mb-40Mb 0.0000335800 0.00053612 0.001809925 3.116636e-05 0.00012153
#> 9+:het:>40Mb 0.0000235700 0.00002253 0.001085855 2.928636e-05 0.00030777
#> CN11 CN12 CN13 CN14 CN15
#> 0:homdel:0-100Kb 0.00161374 0.02309338 0.008542550 0.00366730 0.00136668
#> 0:homdel:100Kb-1Mb 0.00590270 0.05272477 0.018208835 0.00109281 0.00143123
#> 0:homdel:>1Mb 0.00313081 0.00686610 0.000509140 0.04053983 0.00145330
#> 1:LOH:0-100Kb 0.00275430 0.02182354 0.003672495 0.00142666 0.00211427
#> 1:LOH:100Kb-1Mb 0.00623170 0.06597701 0.014565860 0.00580905 0.00507205
#> 1:LOH:1Mb-10Mb 0.01775071 0.00423455 0.006219620 0.00343106 0.01868840
#> 1:LOH:10Mb-40Mb 0.00184154 0.00004033 0.001830770 0.00204512 0.00550295
#> 1:LOH:>40Mb 0.00005754 0.00000464 0.001703205 0.00064424 0.00000134
#> 2:LOH:0-100Kb 0.00148901 0.00590696 0.000472365 0.00067984 0.00055893
#> 2:LOH:100Kb-1Mb 0.01694496 0.08093648 0.013083940 0.01758306 0.00062269
#> 2:LOH:1Mb-10Mb 0.04392020 0.13267104 0.027714505 0.01162738 0.08444233
#> 2:LOH:10Mb-40Mb 0.02467614 0.17672789 0.061904045 0.00291477 0.08848328
#> 2:LOH:>40Mb 0.01121149 0.13622451 0.283071266 0.00170498 0.00750380
#> 3-4:LOH:0-100Kb 0.00158209 0.00930253 0.004443780 0.00093853 0.00267395
#> 3-4:LOH:100Kb-1Mb 0.04824190 0.03071852 0.021381520 0.02159759 0.02375527
#> 3-4:LOH:1Mb-10Mb 0.15626472 0.04005227 0.009517420 0.04370100 0.09462731
#> 3-4:LOH:10Mb-40Mb 0.05527416 0.02606018 0.001045855 0.03291840 0.05183615
#> 3-4:LOH:>40Mb 0.03509218 0.01659015 0.003249145 0.19071235 0.00224311
#> 5-8:LOH:0-100Kb 0.00501223 0.00578286 0.001066340 0.00347840 0.00128554
#> 5-8:LOH:100Kb-1Mb 0.04217432 0.00208666 0.000563220 0.00980644 0.00726579
#> 5-8:LOH:1Mb-10Mb 0.07357179 0.00322838 0.001505195 0.01073875 0.01836005
#> 5-8:LOH:10Mb-40Mb 0.01532663 0.00163617 0.000402270 0.00622641 0.00502947
#> 5-8:LOH:>40Mb 0.00347323 0.00110016 0.011616100 0.01067078 0.00000129
#> 9+:LOH:0-100Kb 0.00062013 0.00048688 0.000026095 0.00384194 0.00012468
#> 9+:LOH:100Kb-1Mb 0.01160088 0.00011188 0.000117410 0.00471630 0.00005302
#> 9+:LOH:1Mb-10Mb 0.02224864 0.00012019 0.000009970 0.00000235 0.00001369
#> 9+:LOH:10Mb-40Mb 0.00252885 0.00006139 0.000002465 0.00000235 0.00005292
#> 9+:LOH:>40Mb 0.00148788 0.00001647 0.000018935 0.00333085 0.00000029
#> 2:het:0-100Kb 0.00000000 0.00068448 0.002632120 0.00266672 0.00038608
#> 2:het:100Kb-1Mb 0.00000001 0.00313133 0.000689820 0.00197375 0.00018880
#> 2:het:1Mb-10Mb 0.00000000 0.00410482 0.000855655 0.00185384 0.00087384
#> 2:het:10Mb-40Mb 0.00000393 0.00107820 0.000937360 0.00136271 0.00061789
#> 2:het:>40Mb 0.00000008 0.00000043 0.004108450 0.00000075 0.00000000
#> 3-4:het:0-100Kb 0.00042229 0.00495000 0.001197990 0.00179605 0.00015917
#> 3-4:het:100Kb-1Mb 0.00000650 0.00936991 0.007901100 0.02323495 0.00188043
#> 3-4:het:1Mb-10Mb 0.01763335 0.01812126 0.057236571 0.01723295 0.18503820
#> 3-4:het:10Mb-40Mb 0.00761337 0.10067989 0.071385861 0.00618312 0.18827023
#> 3-4:het:>40Mb 0.00006203 0.00090365 0.352795454 0.00048235 0.00053600
#> 5-8:het:0-100Kb 0.00002945 0.00044794 0.000553290 0.01032126 0.00049621
#> 5-8:het:100Kb-1Mb 0.04380270 0.00783497 0.000657615 0.04438502 0.01240360
#> 5-8:het:1Mb-10Mb 0.18536884 0.00156351 0.000140470 0.08961901 0.12902796
#> 5-8:het:10Mb-40Mb 0.05728550 0.00131279 0.000333540 0.08336645 0.05516663
#> 5-8:het:>40Mb 0.01649539 0.00069671 0.002045620 0.25307107 0.00000001
#> 9+:het:0-100Kb 0.00000001 0.00002484 0.000001280 0.00338768 0.00005391
#> 9+:het:100Kb-1Mb 0.00000813 0.00018166 0.000000860 0.00331660 0.00007486
#> 9+:het:1Mb-10Mb 0.05279432 0.00016027 0.000000905 0.00998959 0.00013899
#> 9+:het:10Mb-40Mb 0.00605752 0.00013193 0.000020315 0.00316669 0.00012341
#> 9+:het:>40Mb 0.00039210 0.00003551 0.000041410 0.00674090 0.00000001
#> CN16 CN17 CN18 CN19
#> 0:homdel:0-100Kb 1.108940e-03 0.00591472 0.00004078 0.00000055
#> 0:homdel:100Kb-1Mb 3.030450e-03 0.00677398 0.00017845 0.00022928
#> 0:homdel:>1Mb 7.584001e-04 0.00411050 0.00011722 0.00135207
#> 1:LOH:0-100Kb 1.555600e-03 0.01041569 0.00050182 0.00024820
#> 1:LOH:100Kb-1Mb 1.418760e-03 0.06429375 0.00081924 0.01235880
#> 1:LOH:1Mb-10Mb 2.810300e-04 0.03777062 0.00624116 0.05642821
#> 1:LOH:10Mb-40Mb 8.000001e-08 0.02105378 0.00283775 0.04607252
#> 1:LOH:>40Mb 1.650000e-06 0.00174097 0.00001202 0.01887089
#> 2:LOH:0-100Kb 2.736320e-03 0.00566334 0.00060974 0.00070358
#> 2:LOH:100Kb-1Mb 6.551800e-03 0.05489644 0.00134094 0.06234918
#> 2:LOH:1Mb-10Mb 1.851700e-04 0.11706714 0.01443458 0.03913487
#> 2:LOH:10Mb-40Mb 1.569500e-04 0.04188772 0.00966270 0.00129894
#> 2:LOH:>40Mb 7.257001e-05 0.03389879 0.00049936 0.00195567
#> 3-4:LOH:0-100Kb 2.264060e-03 0.01388264 0.00256100 0.00053506
#> 3-4:LOH:100Kb-1Mb 1.402709e-02 0.01258572 0.02182453 0.00002091
#> 3-4:LOH:1Mb-10Mb 5.963823e-02 0.00110793 0.02055562 0.00277049
#> 3-4:LOH:10Mb-40Mb 7.185142e-02 0.00278047 0.00224340 0.00027444
#> 3-4:LOH:>40Mb 5.059881e-02 0.00421117 0.00094554 0.00172068
#> 5-8:LOH:0-100Kb 4.821290e-03 0.00002587 0.00091844 0.00000025
#> 5-8:LOH:100Kb-1Mb 2.136849e-02 0.00000814 0.00241053 0.00005463
#> 5-8:LOH:1Mb-10Mb 4.681185e-02 0.00001578 0.00524955 0.00001666
#> 5-8:LOH:10Mb-40Mb 2.208834e-02 0.00068876 0.00029923 0.00000036
#> 5-8:LOH:>40Mb 5.369940e-03 0.00012041 0.00012116 0.00003896
#> 9+:LOH:0-100Kb 2.414730e-03 0.00107168 0.00014531 0.00000036
#> 9+:LOH:100Kb-1Mb 1.211638e-02 0.00117826 0.00085741 0.00000397
#> 9+:LOH:1Mb-10Mb 1.534961e-02 0.00000016 0.00046208 0.00008476
#> 9+:LOH:10Mb-40Mb 9.794001e-04 0.00000016 0.00010940 0.00001589
#> 9+:LOH:>40Mb 7.700001e-07 0.00004662 0.00001071 0.00005384
#> 2:het:0-100Kb 2.975900e-04 0.00311810 0.00053199 0.00030646
#> 2:het:100Kb-1Mb 3.020000e-05 0.03122830 0.00464189 0.01868806
#> 2:het:1Mb-10Mb 1.100000e-07 0.01642660 0.00278654 0.12630566
#> 2:het:10Mb-40Mb 3.400000e-07 0.00452687 0.00139670 0.20984674
#> 2:het:>40Mb 3.200000e-07 0.00000046 0.00000815 0.07227018
#> 3-4:het:0-100Kb 1.170860e-03 0.01701046 0.00077956 0.00800623
#> 3-4:het:100Kb-1Mb 1.200890e-02 0.20570138 0.08651517 0.27819347
#> 3-4:het:1Mb-10Mb 0.000000e+00 0.12230612 0.33498797 0.03014244
#> 3-4:het:10Mb-40Mb 2.278490e-03 0.07593595 0.16201175 0.00614880
#> 3-4:het:>40Mb 2.652536e-02 0.00256084 0.00119273 0.00000028
#> 5-8:het:0-100Kb 2.308180e-03 0.00185133 0.01515300 0.00031093
#> 5-8:het:100Kb-1Mb 2.222437e-02 0.02780896 0.14454268 0.00022234
#> 5-8:het:1Mb-10Mb 1.440961e-01 0.02161426 0.10976846 0.00000972
#> 5-8:het:10Mb-40Mb 1.813603e-01 0.00344696 0.01800115 0.00012714
#> 5-8:het:>40Mb 9.531376e-02 0.00000023 0.00182344 0.00247148
#> 9+:het:0-100Kb 9.341201e-03 0.00503956 0.00357070 0.00005991
#> 9+:het:100Kb-1Mb 5.049958e-02 0.00484797 0.00971177 0.00011614
#> 9+:het:1Mb-10Mb 8.409050e-02 0.01332158 0.00568101 0.00000036
#> 9+:het:10Mb-40Mb 1.848061e-02 0.00001563 0.00085042 0.00015659
#> 9+:het:>40Mb 2.415120e-03 0.00002722 0.00003526 0.00002306
#>
#> $aetiology
#> aetiology
#> CN1 See https://cancer.sanger.ac.uk/signatures/cn/
#> CN2 See https://cancer.sanger.ac.uk/signatures/cn/
#> CN3 See https://cancer.sanger.ac.uk/signatures/cn/
#> CN4 See https://cancer.sanger.ac.uk/signatures/cn/
#> CN5 See https://cancer.sanger.ac.uk/signatures/cn/
#> CN6 See https://cancer.sanger.ac.uk/signatures/cn/
#> CN7 See https://cancer.sanger.ac.uk/signatures/cn/
#> CN8 See https://cancer.sanger.ac.uk/signatures/cn/
#> CN9 See https://cancer.sanger.ac.uk/signatures/cn/
#> CN10 See https://cancer.sanger.ac.uk/signatures/cn/
#> CN11 See https://cancer.sanger.ac.uk/signatures/cn/
#> CN12 See https://cancer.sanger.ac.uk/signatures/cn/
#> CN13 See https://cancer.sanger.ac.uk/signatures/cn/
#> CN14 See https://cancer.sanger.ac.uk/signatures/cn/
#> CN15 See https://cancer.sanger.ac.uk/signatures/cn/
#> CN16 See https://cancer.sanger.ac.uk/signatures/cn/
#> CN17 See https://cancer.sanger.ac.uk/signatures/cn/
#> CN18 See https://cancer.sanger.ac.uk/signatures/cn/
#> CN19 See https://cancer.sanger.ac.uk/signatures/cn/
#>
#> $date
#> [1] "2021/07/23"
#>
s12
#> $db
#> TCGA_CNS1 TCGA_CNS2 TCGA_CNS3 TCGA_CNS4 TCGA_CNS5
#> E:HH:0:AA 3.136216e-04 4.988040e-07 6.815695e-06 8.021438e-09 3.327538e-04
#> E:HH:0:BB 3.691456e-05 4.638372e-07 1.642536e-06 1.118458e-06 6.452815e-05
#> E:HH:1:AA 6.162166e-05 1.019485e-06 7.185481e-08 1.535494e-06 1.441825e-04
#> E:HH:1:BB 1.130346e-03 5.637708e-08 8.611531e-09 1.152187e-06 3.160044e-03
#> E:HH:2:AA 2.418135e-02 5.828878e-01 3.977355e-08 2.915167e-07 6.581839e-03
#> E:HH:2:BB 9.869729e-03 5.774190e-04 3.230786e-08 3.446467e-08 5.609463e-07
#> E:HH:2LOH:AA 2.446604e-07 4.747765e-07 6.621146e-03 4.326621e-03 1.791218e-04
#> E:HH:2LOH:BB 6.913226e-08 4.394443e-08 1.406042e-03 1.359514e-06 4.777816e-04
#> E:HH:3:AA 5.407846e-07 1.046331e-06 1.305388e-02 8.005557e-02 3.507171e-07
#> E:HH:3:BB 1.566407e-08 6.037377e-07 6.073675e-03 1.865751e-02 2.849052e-06
#> E:HH:3+LOH:AA 8.642484e-07 9.944414e-07 2.530974e-04 3.999090e-07 3.474007e-07
#> E:HH:3+LOH:BB 6.823173e-07 7.543759e-07 1.053852e-05 7.006492e-47 6.932187e-04
#> E:HH:4:AA 9.016682e-07 1.032041e-06 6.784210e-02 6.849484e-06 4.706435e-04
#> E:HH:4:BB 2.971945e-07 6.432792e-07 3.488889e-02 1.401298e-47 1.247770e-03
#> E:HH:5-8:AA 8.313214e-07 1.211908e-06 1.215289e-02 7.311463e-10 5.291195e-07
#> E:HH:5-8:BB 6.667707e-07 9.803865e-07 5.032131e-03 0.000000e+00 1.744373e-05
#> E:HH:9+:AA 9.359344e-07 1.374270e-06 4.763274e-06 0.000000e+00 2.152008e-06
#> E:HH:9+:BB 1.165594e-06 1.413440e-06 9.448219e-09 0.000000e+00 8.022677e-07
#> E:LD:1:AA 1.093060e-02 2.195432e-07 3.254865e-08 4.081449e-06 1.476140e-02
#> E:LD:2:AA 3.994242e-01 2.131949e-01 8.291435e-10 9.154083e-09 2.591952e-01
#> E:LD:2LOH:AA 1.681646e-06 5.241753e-07 4.685688e-06 1.323441e-06 6.831337e-07
#> E:LD:3:AA 2.857135e-08 2.292778e-07 6.254004e-03 1.207591e-01 4.495713e-04
#> E:LD:3:BB 5.735267e-08 3.524492e-07 1.266729e-04 2.810419e-03 4.240707e-07
#> E:LD:3+LOH:AA 5.999853e-07 2.967804e-07 9.449313e-05 3.034869e-06 4.745932e-06
#> E:LD:3+LOH:BB 7.042510e-07 4.827244e-07 4.005902e-09 4.654752e-09 1.315923e-03
#> E:LD:4:AA 6.056264e-08 3.717440e-07 9.927629e-02 9.978955e-06 1.831529e-03
#> E:LD:4:BB 9.569109e-08 1.533668e-07 1.356720e-02 8.947114e-11 1.572294e-03
#> E:LD:5-8:AA 7.111602e-07 6.307467e-07 3.078102e-02 5.381211e-08 5.458645e-07
#> E:LD:5-8:BB 2.880770e-07 3.930045e-07 5.483363e-03 2.156430e-08 1.266190e-05
#> E:LD:9+:AA 1.118646e-06 1.288332e-06 2.208493e-05 0.000000e+00 7.741705e-07
#> E:LD:9+:BB 1.228278e-06 1.168313e-06 1.401298e-47 0.000000e+00 7.527807e-07
#> E:LL:1:AA 1.662829e-03 3.231155e-07 6.347543e-08 9.293528e-11 2.044278e-03
#> E:LL:2:AA 1.566834e-01 2.682867e-03 5.091799e-09 2.834810e-10 6.607214e-02
#> E:LL:2LOH:AA 7.605320e-05 4.344870e-07 1.390566e-08 1.195283e-08 4.125781e-06
#> E:LL:3:AA 1.653672e-04 4.836429e-07 2.049738e-08 3.249813e-04 9.450851e-05
#> E:LL:3:BB 5.087294e-05 9.695269e-07 2.454541e-09 2.592289e-06 5.282608e-07
#> E:LL:3+LOH:AA 3.470560e-08 4.084283e-09 1.064261e-05 1.945475e-09 7.423419e-07
#> E:LL:3+LOH:BB 9.507174e-07 4.812423e-07 0.000000e+00 2.802597e-47 9.339879e-04
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#> M:HH:3:AA 2.357358e-07 7.002752e-07 8.856009e-03 9.163325e-03 2.671292e-04
#> M:HH:3:BB 1.454212e-08 7.192823e-07 7.963546e-04 1.989418e-03 3.680371e-05
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#> M:LD:2LOH:AA 0.000000e+00 2.331391e-06 2.768343e-06 1.896718e-03 1.821965e-05
#> M:LD:3:AA 6.820802e-09 6.089048e-05 2.141734e-04 1.379394e-02 2.344883e-04
#> M:LD:3:BB 4.359637e-11 2.652726e-07 3.002719e-06 1.456189e-03 9.710038e-05
#> M:LD:3+LOH:AA 3.076434e-08 1.675734e-07 1.870408e-03 1.994764e-03 4.088551e-05
#> M:LD:3+LOH:BB 9.018167e-08 5.257483e-07 3.665030e-05 1.020792e-07 5.414520e-04
#> M:LD:4:AA 1.522834e-08 9.166791e-07 2.659258e-03 1.034710e-02 2.157906e-05
#> M:LD:4:BB 2.365157e-08 8.293725e-07 5.154806e-04 1.350375e-03 5.501316e-05
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#> M:LD:5-8:BB 6.373377e-08 3.542290e-07 3.504314e-03 1.017911e-03 8.820335e-06
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#> M:LD:9+:BB 1.003213e-06 1.306787e-06 9.400762e-10 2.302391e-33 7.963661e-07
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#> M:LL:3:BB 4.166343e-04 1.855994e-06 4.164733e-06 2.214125e-05 1.267050e-05
#> M:LL:3+LOH:AA 1.242386e-08 2.361237e-03 4.999164e-03 4.091913e-03 4.271569e-03
#> M:LL:3+LOH:BB 5.862669e-03 4.348248e-03 1.306072e-03 6.547280e-05 4.686269e-03
#> M:LL:4:AA 6.468571e-03 5.451023e-04 3.493609e-04 6.456370e-02 3.909852e-04
#> M:LL:4:BB 3.288955e-06 6.754183e-07 1.724660e-09 1.038774e-05 1.001190e-04
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#> S:HH:1:AA 1.559389e-06 2.135159e-02 8.934534e-04 2.127076e-04 4.356299e-01
#> S:HH:1:BB 1.224130e-08 5.783094e-08 1.451429e-04 1.738124e-06 1.914420e-04
#> S:HH:2:AA 2.147846e-08 1.198060e-06 1.237854e-03 1.586136e-04 2.515943e-03
#> S:HH:2:BB 1.333365e-09 5.459012e-07 9.830957e-04 1.706119e-04 4.363844e-05
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#> S:HH:2LOH:BB 1.577105e-08 3.569742e-07 3.383344e-05 1.592265e-06 6.299035e-05
#> S:HH:3:AA 6.044770e-07 1.325953e-06 4.842707e-03 2.647004e-05 8.075196e-04
#> S:HH:3:BB 1.077785e-07 1.086223e-06 7.959453e-04 7.712661e-05 3.829643e-05
#> S:HH:3+LOH:AA 6.664936e-07 1.362450e-06 2.979301e-04 7.417612e-09 2.085694e-05
#> S:HH:3+LOH:BB 8.665493e-08 9.872697e-07 5.312149e-07 4.576363e-06 5.415922e-05
#> S:HH:4:AA 8.844660e-08 1.056265e-06 1.137111e-03 1.966640e-05 5.216878e-05
#> S:HH:4:BB 7.307129e-07 1.076301e-06 4.290145e-04 9.205530e-08 1.494612e-06
#> S:HH:5-8:AA 2.488823e-07 1.016301e-06 5.739516e-04 1.417424e-05 2.344222e-05
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#> S:HH:9+:AA 1.049753e-06 1.399692e-06 5.951304e-06 4.472377e-07 1.354106e-06
#> S:HH:9+:BB 5.320250e-07 1.235972e-06 4.203895e-47 2.496509e-07 2.386383e-06
#> S:LD:1:AA 3.749160e-04 4.641677e-05 1.183924e-05 6.887502e-05 1.293966e-03
#> S:LD:2:AA 5.605194e-47 7.835313e-06 8.220636e-06 1.136637e-04 1.613058e-04
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#> S:LD:3:AA 3.493071e-09 1.674181e-04 6.210686e-05 1.523856e-03 4.218629e-04
#> S:LD:3:BB 1.494385e-08 3.196161e-06 2.787474e-05 6.281381e-07 4.683576e-05
#> S:LD:3+LOH:AA 3.805022e-08 9.445303e-07 1.348534e-03 2.118008e-03 5.660216e-05
#> S:LD:3+LOH:BB 2.461449e-08 4.396668e-07 4.076273e-07 4.657627e-06 7.191519e-05
#> S:LD:4:AA 4.398913e-06 1.892010e-06 2.878564e-04 8.185491e-04 9.421360e-05
#> S:LD:4:BB 7.710793e-08 5.857122e-07 1.348491e-05 5.338451e-05 1.862570e-05
#> S:LD:5-8:AA 1.691120e-08 6.254168e-07 1.116221e-03 6.121401e-04 3.146257e-05
#> S:LD:5-8:BB 4.219137e-06 3.750931e-07 4.118519e-04 3.168350e-05 9.806588e-05
#> S:LD:9+:AA 1.527159e-07 9.850973e-07 6.622443e-06 4.255823e-06 8.566585e-07
#> S:LD:9+:BB 3.848470e-08 6.517868e-07 6.720511e-10 6.664919e-09 4.845105e-05
#> S:LL:1:AA 1.718290e-04 1.312209e-06 2.172017e-08 7.240911e-06 1.665879e-04
#> S:LL:2:AA 1.121998e-07 8.891526e-06 1.571059e-07 3.498594e-08 7.167600e-04
#> S:LL:2LOH:AA 1.319423e-07 1.198600e-06 1.015376e-06 8.596303e-06 5.049805e-06
#> S:LL:3:AA 3.642248e-09 5.148601e-02 1.506940e-06 9.496748e-07 3.379141e-02
#> S:LL:3:BB 4.516607e-04 6.580093e-06 3.093923e-06 8.555383e-06 3.494393e-05
#> S:LL:3+LOH:AA 1.301837e-08 1.306007e-04 6.357462e-04 1.685198e-04 4.733218e-03
#> S:LL:3+LOH:BB 1.737741e-07 2.168579e-07 5.150486e-06 6.355108e-10 2.497407e-03
#> S:LL:4:AA 4.562302e-04 3.484881e-02 2.655708e-05 8.598824e-04 3.672220e-02
#> S:LL:4:BB 1.077988e-03 2.219652e-08 1.918403e-08 1.268781e-06 6.405493e-04
#> S:LL:5-8:AA 9.209290e-08 5.266579e-06 7.022167e-03 3.337592e-03 1.550919e-03
#> S:LL:5-8:BB 5.637255e-03 7.532803e-08 1.124614e-02 2.126259e-04 2.407299e-03
#> S:LL:9+:AA 1.107665e-06 1.359977e-06 1.330198e-04 2.095192e-07 3.515378e-06
#> S:LL:9+:BB 2.098664e-07 1.824320e-08 1.124773e-04 5.284209e-10 2.258481e-03
#> TCGA_CNS6 TCGA_CNS7 TCGA_CNS8 TCGA_CNS9 TCGA_CNS10
#> E:HH:0:AA 1.006882e-06 9.895064e-05 1.188928e-07 1.021690e-03 1.689613e-04
#> E:HH:0:BB 1.489879e-05 1.871470e-06 1.200687e-04 3.120903e-04 3.884562e-05
#> E:HH:1:AA 1.827702e-07 3.651685e-07 3.526177e-07 1.227794e-03 7.102482e-04
#> E:HH:1:BB 2.001008e-06 1.468635e-07 1.384094e-07 9.445005e-03 1.992347e-08
#> E:HH:2:AA 1.243413e-08 3.297222e-07 2.596247e-07 3.829667e-07 1.122662e-05
#> E:HH:2:BB 8.912584e-08 5.289493e-07 3.917317e-07 4.133418e-07 4.286630e-08
#> E:HH:2LOH:AA 1.131332e-07 1.183370e-02 1.525424e-07 1.838265e-04 2.353081e-08
#> E:HH:2LOH:BB 1.406728e-02 3.092616e-04 1.247773e-02 8.674816e-03 6.715909e-07
#> E:HH:3:AA 7.847271e-46 1.452435e-03 9.268894e-04 2.358616e-08 3.880175e-09
#> E:HH:3:BB 8.633513e-03 4.131584e-04 7.082763e-04 1.489928e-04 2.541453e-10
#> E:HH:3+LOH:AA 3.578146e-08 3.775115e-07 6.960403e-04 1.155915e-04 9.305143e-08
#> E:HH:3+LOH:BB 1.599771e-04 1.840867e-08 9.712890e-03 1.327464e-03 8.677465e-09
#> E:HH:4:AA 2.802597e-47 2.099455e-03 1.293122e-04 2.377248e-07 1.008670e-08
#> E:HH:4:BB 3.006156e-03 1.013950e-02 1.731038e-03 3.112385e-02 8.770572e-10
#> E:HH:5-8:AA 4.901735e-09 3.714148e-08 1.946229e-02 4.289007e-06 1.285707e-08
#> E:HH:5-8:BB 3.751862e-03 5.947414e-09 3.522837e-02 1.552398e-04 1.428187e-09
#> E:HH:9+:AA 4.095390e-04 1.329410e-06 1.238397e-03 1.105116e-05 5.818439e-09
#> E:HH:9+:BB 1.079814e-03 6.529052e-07 2.118962e-03 2.026270e-05 6.976296e-09
#> E:LD:1:AA 2.552194e-08 6.604594e-07 4.463839e-07 3.999750e-02 2.585478e-05
#> E:LD:2:AA 6.657815e-10 2.520404e-08 3.447767e-08 1.396901e-07 4.362848e-02
#> E:LD:2LOH:AA 3.500315e-08 5.782737e-06 3.928406e-07 2.839190e-06 9.686240e-07
#> E:LD:3:AA 3.366001e-08 3.107367e-03 5.477024e-03 1.344617e-07 3.225817e-06
#> E:LD:3:BB 1.984857e-03 5.287255e-05 6.191809e-04 2.496236e-04 1.212924e-05
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#> M:LL:4:BB 2.245364e-06 3.932892e-04 1.802737e-08 6.118903e-04 9.482709e-06
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#> S:HH:1:AA 2.372164e-06 1.765897e-04 2.281024e-04 1.938587e-07 1.638574e-03
#> S:HH:1:BB 2.105964e-04 8.436259e-03 1.457856e-02 7.082311e-02 1.727006e-04
#> S:HH:2:AA 4.203895e-46 7.580941e-02 1.059569e-07 8.446301e-04 9.171928e-10
#> S:HH:2:BB 3.993380e-04 2.149582e-03 1.911878e-02 1.936683e-03 2.503660e-05
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#> S:HH:2LOH:BB 2.311888e-03 4.013232e-05 5.485943e-03 3.154950e-04 6.742513e-05
#> S:HH:3:AA 1.150596e-06 2.757008e-02 1.190343e-04 2.616625e-04 1.178785e-07
#> S:HH:3:BB 1.243046e-03 1.171368e-03 1.293523e-02 1.818311e-04 4.042409e-07
#> S:HH:3+LOH:AA 1.401298e-47 4.289905e-04 1.910377e-04 3.133743e-05 2.805913e-08
#> S:HH:3+LOH:BB 4.373531e-03 1.647571e-06 1.828701e-03 1.410502e-04 5.874846e-06
#> S:HH:4:AA 3.349660e-07 6.766183e-04 3.436929e-03 2.557031e-06 9.126087e-07
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#> S:HH:5-8:AA 2.224986e-05 1.658033e-04 1.402464e-03 8.697210e-06 2.692533e-07
#> S:HH:5-8:BB 4.066804e-03 1.237389e-05 2.493394e-03 1.887582e-05 1.767411e-07
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#> S:HH:9+:BB 2.877848e-03 1.223183e-06 3.959600e-07 1.049441e-05 7.140174e-07
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#> S:LD:3+LOH:BB 6.596911e-03 1.119847e-05 7.103236e-08 1.941324e-04 7.130383e-05
#> S:LD:4:AA 8.281638e-05 1.191884e-05 6.517459e-05 6.552723e-05 4.806262e-05
#> S:LD:4:BB 7.310456e-04 5.385226e-07 2.319340e-06 3.337168e-05 2.893260e-05
#> S:LD:5-8:AA 2.315748e-04 5.969894e-05 8.165975e-06 4.445984e-05 7.201383e-06
#> S:LD:5-8:BB 3.786312e-03 1.141629e-05 5.851428e-05 4.990254e-04 1.400558e-04
#> S:LD:9+:AA 1.700559e-04 2.934992e-07 7.827501e-06 1.238194e-05 1.941689e-06
#> S:LD:9+:BB 7.824838e-03 6.866266e-07 1.271075e-08 1.085828e-04 7.298520e-05
#> S:LL:1:AA 0.000000e+00 3.809194e-05 4.441646e-07 3.805134e-04 4.447020e-04
#> S:LL:2:AA 3.937690e-06 2.262793e-06 2.237387e-06 2.889361e-05 2.253473e-03
#> S:LL:2LOH:AA 3.347436e-07 1.674404e-06 6.679356e-07 6.837368e-05 1.452200e-07
#> S:LL:3:AA 1.124533e-08 2.969936e-05 2.286279e-07 4.041652e-07 1.836436e-03
#> S:LL:3:BB 1.685690e-06 1.059852e-07 3.640228e-07 1.106447e-04 1.424726e-04
#> S:LL:3+LOH:AA 5.605194e-47 1.270320e-03 1.306092e-04 2.200267e-04 7.147181e-05
#> S:LL:3+LOH:BB 3.284564e-03 6.422554e-04 3.061499e-03 1.055690e-02 2.275149e-03
#> S:LL:4:AA 5.423794e-10 1.158977e-03 5.007764e-08 3.754196e-05 1.916400e-03
#> S:LL:4:BB 1.739142e-07 1.812078e-05 1.917484e-07 2.102217e-03 6.340501e-04
#> S:LL:5-8:AA 4.203895e-47 2.573219e-02 5.193867e-04 1.913560e-04 2.336210e-08
#> S:LL:5-8:BB 1.755850e-10 4.794573e-02 2.286691e-03 9.404614e-03 5.500277e-05
#> S:LL:9+:AA 1.550313e-04 2.575113e-06 1.081406e-04 4.484565e-06 2.085257e-08
#> S:LL:9+:BB 1.326754e-02 4.139345e-03 4.725589e-02 6.481360e-02 3.166975e-03
#> TCGA_CNS11 TCGA_CNS12 TCGA_CNS13 TCGA_CNS14 TCGA_CNS15
#> E:HH:0:AA 1.476498e-09 2.081814e-04 1.931265e-03 6.070207e-04 3.283831e-04
#> E:HH:0:BB 8.407791e-47 4.515397e-04 8.145589e-05 1.458491e-04 3.812556e-06
#> E:HH:1:AA 2.789663e-04 9.794645e-05 4.813831e-01 1.698739e-03 2.531193e-07
#> E:HH:1:BB 1.440964e-06 1.775633e-03 2.764099e-02 3.188293e-03 6.126490e-08
#> E:HH:2:AA 8.300620e-02 1.447400e-07 6.146648e-06 2.559522e-03 1.664174e-07
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#> TCGA_CNS16 TCGA_CNS17 TCGA_CNS18 TCGA_CNS19 TCGA_CNS20
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#> S:LD:1:AA 4.149249e-03 6.945985e-04 9.072108e-04 5.474907e-04 5.750433e-04
#> S:LD:2:AA 9.253238e-04 8.126600e-04 1.590403e-05 1.417223e-03 1.017459e-04
#> S:LD:2LOH:AA 2.044938e-04 9.839807e-04 3.637822e-05 2.791043e-03 6.150653e-05
#> S:LD:3:AA 1.399536e-03 7.006492e-47 1.313181e-04 2.145662e-03 2.411388e-04
#> S:LD:3:BB 2.483570e-04 1.728861e-05 3.521479e-04 2.055702e-03 1.116199e-04
#> S:LD:3+LOH:AA 1.046703e-03 1.404028e-07 3.066509e-05 2.392524e-03 1.592676e-04
#> S:LD:3+LOH:BB 2.142074e-04 1.015028e-08 5.786837e-04 3.826874e-03 8.165711e-05
#> S:LD:4:AA 6.544796e-04 6.488458e-05 1.755137e-04 1.906644e-03 1.141788e-04
#> S:LD:4:BB 9.532886e-05 6.542687e-06 1.268633e-04 3.310940e-03 3.646419e-05
#> S:LD:5-8:AA 2.408933e-04 1.584137e-05 2.200504e-05 5.534507e-04 1.343803e-04
#> S:LD:5-8:BB 6.534649e-04 2.035535e-05 9.479076e-04 4.853300e-03 5.721643e-04
#> S:LD:9+:AA 6.021901e-06 1.117762e-06 1.038672e-05 1.780392e-05 3.052020e-05
#> S:LD:9+:BB 4.532062e-05 1.215275e-07 5.552389e-04 8.976794e-04 3.226009e-05
#> S:LL:1:AA 1.072039e-03 2.848698e-05 3.291666e-05 3.503530e-04 8.349398e-05
#> S:LL:2:AA 1.803504e-03 2.171365e-05 1.841677e-07 7.386283e-05 3.488953e-05
#> S:LL:2LOH:AA 5.603994e-05 2.934913e-07 5.742528e-07 6.197834e-06 1.965383e-06
#> S:LL:3:AA 8.830046e-02 4.772024e-06 1.121039e-46 1.001059e-08 1.755268e-07
#> S:LL:3:BB 2.643578e-04 1.386918e-05 5.043868e-04 3.486241e-04 9.857895e-04
#> S:LL:3+LOH:AA 2.647839e-03 1.667215e-03 6.854525e-04 3.235482e-04 4.814210e-04
#> S:LL:3+LOH:BB 2.849989e-03 1.810432e-04 3.706069e-02 2.516905e-02 8.303834e-03
#> S:LL:4:AA 8.845261e-02 4.424943e-03 1.513502e-02 1.322962e-09 2.257487e-03
#> S:LL:4:BB 5.818801e-04 4.574066e-06 3.856638e-03 1.366126e-02 4.250974e-04
#> S:LL:5-8:AA 7.600007e-03 2.020529e-02 9.712005e-08 2.382207e-46 1.773282e-03
#> S:LL:5-8:BB 3.256620e-02 9.701770e-03 2.014210e-01 7.205277e-04 9.966950e-02
#> S:LL:9+:AA 1.917222e-05 6.147158e-07 2.881439e-06 4.988759e-06 5.720619e-06
#> S:LL:9+:BB 2.333754e-03 2.919062e-08 4.654406e-02 1.097702e-02 2.183184e-02
#>
#> $aetiology
#> aetiology
#> TCGA_CNS1 See https://doi.org/10.1093/bib/bbad053
#> TCGA_CNS2 See https://doi.org/10.1093/bib/bbad053
#> TCGA_CNS3 See https://doi.org/10.1093/bib/bbad053
#> TCGA_CNS4 See https://doi.org/10.1093/bib/bbad053
#> TCGA_CNS5 See https://doi.org/10.1093/bib/bbad053
#> TCGA_CNS6 See https://doi.org/10.1093/bib/bbad053
#> TCGA_CNS7 See https://doi.org/10.1093/bib/bbad053
#> TCGA_CNS8 See https://doi.org/10.1093/bib/bbad053
#> TCGA_CNS9 See https://doi.org/10.1093/bib/bbad053
#> TCGA_CNS10 See https://doi.org/10.1093/bib/bbad053
#> TCGA_CNS11 See https://doi.org/10.1093/bib/bbad053
#> TCGA_CNS12 See https://doi.org/10.1093/bib/bbad053
#> TCGA_CNS13 See https://doi.org/10.1093/bib/bbad053
#> TCGA_CNS14 See https://doi.org/10.1093/bib/bbad053
#> TCGA_CNS15 See https://doi.org/10.1093/bib/bbad053
#> TCGA_CNS16 See https://doi.org/10.1093/bib/bbad053
#> TCGA_CNS17 See https://doi.org/10.1093/bib/bbad053
#> TCGA_CNS18 See https://doi.org/10.1093/bib/bbad053
#> TCGA_CNS19 See https://doi.org/10.1093/bib/bbad053
#> TCGA_CNS20 See https://doi.org/10.1093/bib/bbad053
#>
#> $date
#> [1] "2023/03/17"
#>
s13
#> $db
#> PCAWG_CNS1 PCAWG_CNS2 PCAWG_CNS3 PCAWG_CNS4 PCAWG_CNS5
#> E:HH:0:AA 3.243998e-06 1.320014e-05 1.648288e-06 4.586754e-06 5.283389e-05
#> E:HH:0:BB 2.751601e-05 2.259891e-08 3.094850e-06 4.095607e-05 1.185009e-04
#> E:HH:1:AA 1.059197e-06 6.484162e-07 3.157658e-06 3.966876e-09 4.207511e-06
#> E:HH:1:BB 4.245759e-06 6.888785e-04 1.059734e-06 1.954016e-05 2.188011e-04
#> E:HH:2:AA 2.741700e-08 2.053069e-08 9.873434e-01 3.410758e-08 2.645018e-07
#> E:HH:2:BB 6.457549e-04 2.209116e-06 9.926329e-04 1.276455e-03 3.047955e-06
#> E:HH:2LOH:AA 1.168539e-02 8.335892e-03 7.661501e-03 0.000000e+00 1.305919e-02
#> E:HH:2LOH:BB 2.154588e-03 1.486494e-04 9.691761e-07 2.622258e-03 1.536599e-02
#> E:HH:3:AA 2.009348e-02 6.244500e-02 1.413300e-06 7.323027e-10 4.329455e-03
#> E:HH:3:BB 2.678136e-03 3.517546e-03 2.998815e-06 1.009852e-03 6.293253e-03
#> E:HH:3+LOH:AA 4.625108e-04 5.605194e-47 2.463414e-06 2.484206e-10 9.834544e-03
#> E:HH:3+LOH:BB 5.155285e-04 4.658817e-09 2.830072e-06 2.219296e-07 8.782265e-03
#> E:HH:4:AA 3.230150e-02 4.224280e-03 2.408951e-06 1.627580e-09 1.144407e-02
#> E:HH:4:BB 3.595770e-03 2.168152e-04 2.546849e-06 7.036097e-04 9.531727e-03
#> E:HH:5-8:AA 5.273976e-03 3.100727e-05 2.606587e-06 1.085520e-08 1.739954e-02
#> E:HH:5-8:BB 1.030014e-03 1.157471e-06 3.089467e-06 1.043337e-04 1.009449e-02
#> E:HH:9+:AA 2.688579e-05 5.194780e-09 3.770219e-06 2.160140e-06 4.632889e-04
#> E:HH:9+:BB 4.800561e-05 8.661942e-09 3.950845e-06 1.252077e-08 6.699412e-04
#> E:LD:1:AA 1.060369e-09 9.335200e-04 5.903399e-07 1.660765e-09 1.101744e-03
#> E:LD:2:AA 3.866350e-09 1.491881e-08 2.801160e-03 5.718702e-09 7.008077e-08
#> E:LD:2LOH:AA 1.221895e-04 4.791550e-03 2.616563e-07 1.505120e-06 7.483975e-03
#> E:LD:3:AA 5.971281e-03 7.505124e-02 1.401298e-47 0.000000e+00 1.398238e-02
#> E:LD:3:BB 7.696644e-04 1.432755e-04 2.499449e-06 1.393910e-03 8.007470e-03
#> E:LD:3+LOH:AA 7.292565e-04 2.249922e-04 6.288827e-07 1.184316e-08 1.786329e-02
#> E:LD:3+LOH:BB 3.272998e-04 5.327606e-06 1.862954e-06 2.229354e-09 9.599525e-03
#> E:LD:4:AA 3.451240e-02 5.338861e-03 4.989498e-07 7.568174e-08 2.990509e-02
#> E:LD:4:BB 1.322693e-03 1.738127e-04 2.199976e-06 6.985661e-04 1.157769e-02
#> E:LD:5-8:AA 9.987201e-03 1.234990e-04 9.445482e-07 6.910901e-11 3.957644e-02
#> E:LD:5-8:BB 2.834998e-03 2.156121e-08 1.355697e-06 4.768737e-09 3.695284e-02
#> E:LD:9+:AA 6.659823e-05 2.201566e-09 3.467550e-06 7.759827e-06 1.037691e-03
#> E:LD:9+:BB 2.143592e-04 6.337752e-09 3.456573e-06 3.344219e-05 3.745462e-03
#> E:LL:1:AA 1.539075e-08 1.141161e-04 1.574008e-06 8.331993e-09 1.297646e-04
#> E:LL:2:AA 6.272726e-10 2.597887e-04 2.822569e-07 2.272042e-08 7.449445e-04
#> E:LL:2LOH:AA 2.037628e-06 1.160238e-03 6.206767e-07 5.418300e-09 1.487198e-03
#> E:LL:3:AA 4.147910e-08 5.811890e-06 8.289389e-04 8.374357e-04 2.565327e-08
#> E:LL:3:BB 5.882508e-09 9.204075e-05 3.817455e-06 9.675784e-10 7.369617e-05
#> E:LL:3+LOH:AA 3.736461e-04 1.114680e-03 3.400787e-07 2.802597e-47 1.340831e-02
#> E:LL:3+LOH:BB 1.164143e-04 1.158704e-04 1.828703e-06 0.000000e+00 3.795348e-03
#> E:LL:4:AA 3.096104e-04 1.092436e-03 1.625552e-06 1.287006e-04 2.925478e-03
#> E:LL:4:BB 5.761418e-06 4.034632e-04 2.604031e-06 0.000000e+00 8.278276e-05
#> E:LL:5-8:AA 6.072356e-03 2.162099e-04 6.873642e-07 1.239526e-08 3.403813e-02
#> E:LL:5-8:BB 1.787568e-03 1.399021e-08 1.705468e-06 0.000000e+00 3.451324e-02
#> E:LL:9+:AA 7.510388e-05 3.973248e-06 3.903915e-06 1.956557e-06 1.360988e-03
#> E:LL:9+:BB 3.497420e-04 2.504611e-06 3.646931e-06 1.039771e-04 5.858872e-03
#> L:HH:0:AA 2.780933e-07 1.365095e-03 1.202083e-06 3.518502e-09 1.360005e-03
#> L:HH:0:BB 2.281877e-05 1.259495e-04 2.511543e-06 1.301149e-06 7.204393e-04
#> L:HH:1:AA 1.599308e-04 5.789376e-03 0.000000e+00 4.203896e-47 1.073076e-03
#> L:HH:1:BB 6.574504e-05 9.437288e-04 8.395644e-07 7.004475e-05 1.940501e-08
#> L:HH:2:AA 1.505421e-04 6.247712e-03 2.205720e-06 7.722259e-05 3.374702e-05
#> L:HH:2:BB 7.020860e-04 2.643791e-06 2.444013e-06 4.298483e-03 1.136547e-05
#> L:HH:2LOH:AA 5.746286e-03 3.267714e-02 6.766222e-09 1.412678e-09 3.408016e-03
#> L:HH:2LOH:BB 3.960591e-03 8.400932e-04 9.601360e-07 5.919017e-03 5.708922e-03
#> L:HH:3:AA 1.542342e-02 9.027689e-02 1.969005e-06 1.492180e-04 1.289173e-04
#> L:HH:3:BB 6.128820e-03 9.029265e-04 2.055378e-06 8.001924e-03 3.144867e-03
#> L:HH:3+LOH:AA 6.539003e-04 1.940349e-04 1.728506e-06 3.526222e-07 8.192308e-03
#> L:HH:3+LOH:BB 1.297800e-03 2.740232e-09 2.095492e-06 2.621868e-04 1.158602e-02
#> L:HH:4:AA 4.144656e-02 8.844724e-03 2.597005e-06 3.983059e-07 6.901617e-03
#> L:HH:4:BB 6.217902e-03 2.419450e-04 2.192467e-06 7.052224e-03 1.169670e-02
#> L:HH:5-8:AA 1.979771e-02 6.922449e-04 1.777426e-06 8.898940e-04 2.527369e-02
#> L:HH:5-8:BB 2.903116e-03 1.623274e-05 1.857321e-06 7.932691e-03 2.231029e-02
#> L:HH:9+:AA 1.570154e-04 6.565867e-10 3.703080e-06 9.587577e-04 2.562792e-03
#> L:HH:9+:BB 1.419274e-04 2.139085e-08 3.556668e-06 5.194252e-03 4.340610e-03
#> L:LD:1:AA 5.607950e-09 7.174980e-04 1.011510e-06 2.270593e-06 7.006804e-04
#> L:LD:2:AA 7.457203e-07 1.103288e-04 1.135061e-07 1.277326e-09 2.079142e-04
#> L:LD:2LOH:AA 1.053453e-04 5.054446e-03 2.140539e-08 1.926961e-04 2.027989e-03
#> L:LD:3:AA 4.464275e-03 6.085790e-02 0.000000e+00 9.660474e-06 8.177010e-04
#> L:LD:3:BB 1.175719e-03 9.507624e-04 2.550392e-06 1.829818e-03 1.121506e-03
#> L:LD:3+LOH:AA 7.107905e-04 2.004532e-04 6.422374e-07 4.421616e-09 5.000083e-03
#> L:LD:3+LOH:BB 8.578533e-04 4.467740e-09 2.533855e-06 3.073915e-04 5.636630e-03
#> L:LD:4:AA 3.155602e-02 4.003493e-02 2.694343e-07 1.619683e-04 5.513843e-03
#> L:LD:4:BB 4.191832e-03 1.589084e-03 2.320946e-06 2.760705e-03 3.775866e-03
#> L:LD:5-8:AA 4.608208e-02 4.842468e-03 4.226296e-07 6.811379e-04 3.465385e-02
#> L:LD:5-8:BB 1.239476e-02 6.498376e-04 5.026171e-08 6.238527e-03 4.564335e-02
#> L:LD:9+:AA 4.410759e-04 1.370412e-07 3.704583e-06 1.777794e-03 6.525208e-03
#> L:LD:9+:BB 8.529334e-04 2.090971e-05 1.805813e-06 1.434523e-02 2.026489e-02
#> L:LL:1:AA 2.267020e-06 1.814819e-04 1.810772e-06 5.805334e-06 9.063215e-05
#> L:LL:2:AA 1.448222e-08 2.021226e-05 2.515843e-06 1.587532e-08 3.180607e-07
#> L:LL:2LOH:AA 1.330557e-07 7.061147e-04 2.161312e-07 5.297568e-09 7.274833e-04
#> L:LL:3:AA 4.757889e-04 4.424148e-03 7.062747e-05 1.000071e-05 7.534416e-04
#> L:LL:3:BB 5.394488e-06 2.693066e-05 3.735846e-06 6.558224e-07 9.028722e-05
#> L:LL:3+LOH:AA 1.670842e-03 8.462876e-04 1.838502e-07 1.586785e-07 3.150573e-03
#> L:LL:3+LOH:BB 4.599119e-04 1.923376e-06 2.666024e-06 7.969503e-05 3.506993e-03
#> L:LL:4:AA 3.382045e-03 1.049695e-01 4.183347e-07 7.422258e-05 2.323053e-03
#> L:LL:4:BB 5.010095e-10 5.653422e-04 1.483231e-06 9.137122e-12 2.789343e-05
#> L:LL:5-8:AA 6.495646e-02 2.769069e-02 1.401298e-47 1.321955e-03 4.693180e-02
#> L:LL:5-8:BB 1.145084e-02 4.689691e-03 0.000000e+00 4.633246e-04 3.823963e-02
#> L:LL:9+:AA 7.069962e-04 4.608661e-08 3.237862e-06 8.955535e-04 8.012585e-03
#> L:LL:9+:BB 1.739175e-03 1.432200e-05 1.691183e-06 1.265240e-02 3.602051e-02
#> M:HH:0:AA 3.025572e-06 3.470092e-03 5.860133e-07 3.589986e-08 3.509420e-03
#> M:HH:0:BB 7.322076e-05 3.449059e-04 1.735967e-06 3.511679e-04 1.942113e-03
#> M:HH:1:AA 3.304248e-04 3.918892e-03 8.407791e-47 5.617628e-05 2.914652e-03
#> M:HH:1:BB 1.111330e-04 7.980309e-04 1.308424e-06 5.808551e-05 1.755269e-05
#> M:HH:2:AA 1.207140e-03 1.307690e-02 3.351747e-07 1.694538e-03 3.702201e-04
#> M:HH:2:BB 3.406048e-04 1.231295e-05 3.093647e-06 4.515615e-03 1.383120e-08
#> M:HH:2LOH:AA 2.951702e-03 1.636084e-02 1.137079e-08 7.722499e-05 1.716319e-03
#> M:HH:2LOH:BB 2.977733e-03 5.003792e-04 1.572539e-06 4.932937e-03 2.537430e-03
#> M:HH:3:AA 1.105392e-02 4.238839e-02 1.534625e-06 3.575563e-03 3.302997e-04
#> M:HH:3:BB 2.219600e-03 9.288025e-05 2.646006e-06 1.253793e-02 3.646358e-04
#> M:HH:3+LOH:AA 1.339486e-03 6.629771e-04 2.915443e-07 2.887730e-04 8.273149e-03
#> M:HH:3+LOH:BB 2.080993e-03 1.174074e-09 2.345882e-06 8.169082e-03 3.541439e-03
#> M:HH:4:AA 2.538909e-02 4.628619e-03 2.137982e-06 2.956234e-03 3.942578e-03
#> M:HH:4:BB 3.915970e-03 6.100092e-05 2.435895e-06 1.533748e-02 3.110582e-03
#> M:HH:5-8:AA 2.227665e-02 1.077899e-03 1.660075e-06 3.592166e-03 1.332869e-02
#> M:HH:5-8:BB 4.742396e-03 7.863962e-06 1.942727e-06 2.074967e-02 1.186057e-02
#> M:HH:9+:AA 4.691585e-05 9.629140e-09 3.859655e-06 1.032259e-02 5.007891e-04
#> M:HH:9+:BB 1.039749e-05 8.407791e-47 2.814870e-06 3.880992e-02 3.591934e-04
#> M:LD:1:AA 1.154583e-05 9.767635e-04 1.512388e-06 9.126167e-05 9.009023e-04
#> M:LD:2:AA 1.404134e-04 4.825923e-04 4.134874e-07 2.472258e-05 2.553770e-05
#> M:LD:2LOH:AA 9.459523e-05 1.396691e-03 2.417850e-07 9.875328e-10 5.771974e-04
#> M:LD:3:AA 1.455327e-03 1.936247e-02 1.120471e-06 6.923478e-05 9.444325e-06
#> M:LD:3:BB 3.391402e-04 7.078166e-06 3.667390e-06 2.895494e-03 5.440429e-06
#> M:LD:3+LOH:AA 1.557679e-03 2.092387e-04 6.774634e-07 6.270658e-04 8.498758e-04
#> M:LD:3+LOH:BB 2.597134e-03 1.490837e-07 2.461038e-06 1.272484e-02 1.015464e-03
#> M:LD:4:AA 1.432642e-02 2.282109e-02 1.039626e-06 2.961596e-03 3.651870e-04
#> M:LD:4:BB 2.175228e-03 2.981842e-04 2.151010e-06 4.983621e-03 4.376780e-04
#> M:LD:5-8:AA 4.302667e-02 5.585756e-03 1.003152e-06 7.211529e-03 7.538688e-03
#> M:LD:5-8:BB 1.535399e-02 4.319995e-04 6.811715e-07 2.525725e-02 1.036317e-02
#> M:LD:9+:AA 5.188335e-04 1.556904e-06 3.269118e-06 1.839089e-02 3.207055e-03
#> M:LD:9+:BB 1.937157e-04 1.001107e-07 1.566717e-06 9.717679e-02 3.664195e-03
#> M:LL:1:AA 1.184254e-08 1.863896e-04 2.377839e-06 6.090864e-06 1.665430e-04
#> M:LL:2:AA 2.957913e-08 2.899877e-08 3.586643e-06 2.115541e-07 1.897992e-07
#> M:LL:2LOH:AA 1.885317e-05 4.191818e-04 3.447700e-07 0.000000e+00 4.622595e-04
#> M:LL:3:AA 4.283071e-07 7.143649e-08 3.898388e-06 6.802275e-05 1.994044e-07
#> M:LL:3:BB 2.520959e-06 1.049630e-04 8.683232e-06 0.000000e+00 7.859568e-05
#> M:LL:3+LOH:AA 8.094891e-03 6.597617e-03 3.404314e-08 5.571610e-09 1.962575e-03
#> M:LL:3+LOH:BB 2.638683e-03 9.345906e-08 2.268441e-06 8.289531e-03 2.903518e-03
#> M:LL:4:AA 4.970999e-03 1.213189e-01 8.845741e-07 2.437992e-03 9.292709e-04
#> M:LL:4:BB 3.318723e-06 4.299059e-04 3.567447e-06 1.009792e-05 4.192929e-06
#> M:LL:5-8:AA 1.260239e-01 3.931684e-02 3.575264e-10 4.356981e-03 2.134506e-02
#> M:LL:5-8:BB 2.317805e-02 3.396269e-03 4.671468e-09 6.494310e-03 1.538285e-02
#> M:LL:9+:AA 1.588659e-03 3.926576e-06 2.935484e-06 1.487099e-02 7.394025e-03
#> M:LL:9+:BB 3.053468e-03 4.041831e-08 7.417255e-10 1.134617e-01 2.694231e-02
#> S:HH:0:AA 2.618270e-06 1.944535e-03 1.046456e-06 1.012099e-05 1.732356e-03
#> S:HH:0:BB 2.869030e-04 3.395081e-04 1.553152e-06 1.360869e-03 1.012340e-03
#> S:HH:1:AA 4.213305e-04 3.054838e-03 3.026232e-08 1.603120e-05 2.073205e-03
#> S:HH:1:BB 4.288936e-03 1.481691e-03 2.320886e-07 6.558818e-05 6.776437e-04
#> S:HH:2:AA 2.278476e-03 1.062357e-02 0.000000e+00 1.664733e-03 9.042747e-04
#> S:HH:2:BB 1.901121e-03 1.872448e-04 2.203329e-06 4.167584e-03 3.642928e-04
#> S:HH:2LOH:AA 1.160473e-03 4.114063e-03 2.146509e-07 2.610183e-05 4.707401e-04
#> S:HH:2LOH:BB 1.215787e-03 2.409871e-04 2.311723e-06 2.281723e-03 3.049572e-04
#> S:HH:3:AA 8.765265e-03 1.595911e-02 4.247712e-07 1.507422e-03 1.911304e-03
#> S:HH:3:BB 2.857735e-03 5.276215e-06 2.488909e-06 9.263086e-03 5.826036e-04
#> S:HH:3+LOH:AA 5.741109e-04 3.901638e-04 1.538731e-06 9.554122e-04 1.465350e-03
#> S:HH:3+LOH:BB 1.206528e-03 9.754999e-06 3.345109e-06 8.346635e-03 3.956161e-04
#> S:HH:4:AA 1.812564e-02 2.697362e-03 1.930897e-06 1.508095e-03 3.746636e-03
#> S:HH:4:BB 3.734047e-03 3.545329e-05 2.752003e-06 8.099924e-03 1.845574e-03
#> S:HH:5-8:AA 1.665477e-02 6.556924e-04 2.080076e-06 4.159190e-03 1.241654e-02
#> S:HH:5-8:BB 4.757003e-03 2.911532e-06 2.481946e-06 1.917516e-02 2.328422e-03
#> S:HH:9+:AA 1.058343e-04 1.478202e-06 3.531219e-06 1.025886e-02 2.092127e-04
#> S:HH:9+:BB 2.111840e-08 8.912637e-11 2.670213e-06 5.008638e-02 4.654115e-08
#> S:LD:1:AA 2.709910e-06 5.049313e-04 1.622941e-06 8.517855e-06 3.416706e-04
#> S:LD:2:AA 2.363534e-04 4.050676e-04 1.137108e-06 7.075450e-09 5.871803e-05
#> S:LD:2LOH:AA 1.622129e-04 2.656208e-04 1.591469e-06 9.542407e-05 1.493238e-04
#> S:LD:3:AA 1.244759e-03 7.578466e-03 8.938114e-07 1.067812e-04 3.663659e-04
#> S:LD:3:BB 5.644240e-04 5.433932e-05 3.527123e-06 1.075168e-03 7.912291e-05
#> S:LD:3+LOH:AA 4.362504e-04 2.814224e-05 2.518862e-06 8.198749e-04 2.292932e-04
#> S:LD:3+LOH:BB 1.794695e-03 8.725150e-10 3.131598e-06 1.435477e-02 7.309086e-04
#> S:LD:4:AA 5.959910e-03 8.171785e-03 1.876341e-06 4.641896e-04 2.636279e-04
#> S:LD:4:BB 1.590363e-03 5.395704e-05 3.248845e-06 1.616313e-03 3.325598e-04
#> S:LD:5-8:AA 2.353905e-02 1.860496e-03 1.924286e-06 2.751753e-03 6.111234e-03
#> S:LD:5-8:BB 8.855748e-03 1.405049e-04 1.399083e-06 1.719272e-02 2.516088e-03
#> S:LD:9+:AA 1.394611e-04 2.015412e-08 3.638374e-06 1.664874e-02 4.194167e-04
#> S:LD:9+:BB 3.394968e-04 7.579543e-09 1.718988e-06 9.727600e-02 3.171799e-04
#> S:LL:1:AA 5.892636e-06 1.775889e-04 2.026599e-06 7.627230e-06 1.481907e-04
#> S:LL:2:AA 1.431469e-08 2.044430e-07 2.427753e-06 6.208369e-09 9.455165e-08
#> S:LL:2LOH:AA 7.786966e-06 9.181879e-05 1.460600e-06 1.417455e-07 3.588729e-05
#> S:LL:3:AA 3.566042e-04 5.753181e-05 9.669003e-07 7.256527e-05 3.054792e-06
#> S:LL:3:BB 2.010359e-05 7.834442e-05 1.964726e-06 6.628387e-05 6.449033e-05
#> S:LL:3+LOH:AA 1.694107e-03 3.783302e-04 1.048044e-06 1.889193e-04 7.437766e-04
#> S:LL:3+LOH:BB 1.927327e-03 1.324213e-06 3.510576e-06 1.174206e-02 6.840758e-04
#> S:LL:4:AA 4.808767e-03 3.546749e-02 1.617110e-07 1.926165e-03 5.962142e-04
#> S:LL:4:BB 2.625097e-04 3.988770e-04 1.759234e-06 1.378904e-05 4.361139e-05
#> S:LL:5-8:AA 7.378951e-02 1.195776e-02 1.044884e-07 3.075657e-03 1.017328e-02
#> S:LL:5-8:BB 1.671421e-02 4.990041e-04 2.228604e-07 8.402282e-03 3.545245e-03
#> S:LL:9+:AA 3.025212e-03 1.136354e-05 2.783539e-06 1.685082e-02 1.992284e-03
#> S:LL:9+:BB 1.259336e-02 4.585426e-06 7.920983e-11 1.382447e-01 5.326158e-03
#> PCAWG_CNS6 PCAWG_CNS7 PCAWG_CNS8 PCAWG_CNS9 PCAWG_CNS10
#> E:HH:0:AA 1.524146e-04 2.761240e-06 6.209019e-06 2.381678e-04 3.726017e-04
#> E:HH:0:BB 3.730051e-04 0.000000e+00 6.939968e-08 2.761184e-05 2.793372e-05
#> E:HH:1:AA 1.771532e-04 9.857869e-04 1.151427e-03 8.200988e-07 3.301664e-04
#> E:HH:1:BB 1.596036e-04 2.922431e-07 2.129739e-03 1.426216e-04 1.799000e-05
#> E:HH:2:AA 4.824014e-08 7.444015e-04 1.268768e-03 8.863803e-07 4.517340e-03
#> E:HH:2:BB 8.416874e-10 5.379592e-04 5.761895e-10 6.483173e-08 2.073523e-05
#> E:HH:2LOH:AA 7.024111e-02 6.073705e-08 5.558601e-10 7.942168e-02 6.513510e-03
#> E:HH:2LOH:BB 1.095919e-02 0.000000e+00 1.650599e-08 2.126577e-02 9.400398e-04
#> E:HH:3:AA 2.288782e-03 6.965655e-04 1.621660e-09 4.064788e-03 2.299804e-05
#> E:HH:3:BB 4.319671e-05 2.565539e-05 9.296757e-09 3.527820e-04 1.888847e-04
#> E:HH:3+LOH:AA 1.107225e-02 0.000000e+00 3.099185e-08 8.090691e-05 1.978366e-05
#> E:HH:3+LOH:BB 2.906019e-03 0.000000e+00 9.199710e-08 2.462588e-07 5.592870e-05
#> E:HH:4:AA 4.354159e-06 0.000000e+00 5.553010e-08 1.955719e-04 4.538516e-07
#> E:HH:4:BB 1.021171e-04 0.000000e+00 3.554709e-08 6.646161e-04 1.687073e-04
#> E:HH:5-8:AA 2.966157e-05 0.000000e+00 5.816323e-08 1.593775e-04 1.262606e-06
#> E:HH:5-8:BB 2.385806e-05 0.000000e+00 6.867128e-08 4.401733e-05 6.284014e-05
#> E:HH:9+:AA 5.439698e-09 0.000000e+00 4.346525e-07 6.397347e-06 3.798289e-06
#> E:HH:9+:BB 1.401299e-47 0.000000e+00 1.386094e-07 4.892775e-07 7.150385e-07
#> E:LD:1:AA 2.435929e-04 5.115726e-05 1.910315e-03 5.578120e-07 3.479915e-02
#> E:LD:2:AA 4.443248e-10 1.565529e-07 4.553557e-02 2.009464e-07 3.727968e-01
#> E:LD:2LOH:AA 3.779172e-02 1.401298e-47 7.433865e-08 5.844377e-03 6.332592e-03
#> E:LD:3:AA 7.609308e-03 8.316082e-04 4.081595e-09 5.336358e-02 1.084978e-03
#> E:LD:3:BB 8.215436e-05 6.042465e-05 0.000000e+00 3.423450e-03 2.076075e-04
#> E:LD:3+LOH:AA 3.549274e-02 1.798261e-09 1.038863e-07 2.098053e-03 1.039311e-04
#> E:LD:3+LOH:BB 8.799007e-03 0.000000e+00 7.535360e-08 1.373456e-03 5.748386e-05
#> E:LD:4:AA 2.514377e-05 6.186520e-10 2.227558e-08 9.099000e-02 1.130190e-06
#> E:LD:4:BB 7.031237e-04 0.000000e+00 3.802136e-05 1.314921e-02 2.349185e-04
#> E:LD:5-8:AA 3.662085e-05 0.000000e+00 7.838773e-08 2.013414e-03 2.337250e-07
#> E:LD:5-8:BB 1.879989e-06 4.414919e-09 2.370379e-08 9.494214e-03 2.797331e-05
#> E:LD:9+:AA 6.605367e-11 0.000000e+00 1.240143e-07 5.900262e-05 4.318709e-06
#> E:LD:9+:BB 2.606718e-08 1.401298e-47 2.694731e-08 1.150822e-05 2.371813e-05
#> E:LL:1:AA 2.250105e-05 0.000000e+00 3.595632e-04 1.854733e-06 3.872335e-03
#> E:LL:2:AA 6.483546e-11 4.194209e-10 1.000557e-01 2.588062e-07 1.005865e-01
#> E:LL:2LOH:AA 6.552465e-03 2.176896e-04 2.305300e-05 1.091328e-04 2.080471e-03
#> E:LL:3:AA 1.966582e-04 1.664509e-04 1.469336e-04 3.410043e-02 2.214764e-05
#> E:LL:3:BB 3.510865e-05 0.000000e+00 5.035131e-05 4.491446e-05 4.267974e-04
#> E:LL:3+LOH:AA 2.813940e-02 3.198640e-10 2.506541e-08 1.051906e-02 9.511891e-04
#> E:LL:3+LOH:BB 6.186309e-03 0.000000e+00 3.469184e-06 3.399446e-03 1.394510e-05
#> E:LL:4:AA 8.300475e-08 2.162889e-06 1.166757e-07 2.970561e-01 1.415770e-05
#> E:LL:4:BB 6.508717e-10 1.346195e-06 7.439195e-04 7.572182e-03 1.170536e-04
#> E:LL:5-8:AA 2.171840e-04 1.227898e-11 2.796764e-07 2.859040e-02 2.396233e-07
#> E:LL:5-8:BB 2.518615e-06 4.438545e-09 4.190841e-07 6.581783e-02 2.679789e-07
#> E:LL:9+:AA 5.690360e-06 0.000000e+00 5.607053e-07 5.151023e-05 1.359682e-05
#> E:LL:9+:BB 3.212787e-05 0.000000e+00 1.009299e-05 1.041911e-04 3.953594e-05
#> L:HH:0:AA 1.535916e-03 4.622965e-07 1.124856e-03 2.811974e-03 2.502008e-02
#> L:HH:0:BB 2.087317e-03 0.000000e+00 1.239953e-04 8.446335e-04 1.369236e-03
#> L:HH:1:AA 7.773049e-03 1.683725e-02 1.803102e-01 1.867866e-04 3.567637e-02
#> L:HH:1:BB 1.226092e-04 3.499937e-04 2.871817e-03 9.535942e-07 1.375448e-05
#> L:HH:2:AA 2.127461e-04 1.754285e-01 3.420039e-10 1.249735e-08 2.495900e-07
#> L:HH:2:BB 4.379380e-05 3.381119e-04 1.471340e-07 1.029063e-08 4.442708e-06
#> L:HH:2LOH:AA 4.931185e-02 3.642695e-07 4.991356e-06 3.803111e-02 2.306549e-03
#> L:HH:2LOH:BB 8.932203e-03 0.000000e+00 1.414944e-05 1.270778e-02 1.507034e-03
#> L:HH:3:AA 1.533938e-05 2.437078e-03 3.234436e-08 4.928943e-04 2.099569e-06
#> L:HH:3:BB 1.169728e-04 2.453871e-05 1.696278e-08 4.203895e-47 6.780481e-04
#> L:HH:3+LOH:AA 2.629866e-02 0.000000e+00 1.614282e-06 5.001987e-05 1.532680e-04
#> L:HH:3+LOH:BB 8.966955e-03 0.000000e+00 3.016809e-07 7.692185e-08 5.974003e-04
#> L:HH:4:AA 3.647719e-08 2.802597e-47 3.556831e-08 3.530616e-06 2.495466e-05
#> L:HH:4:BB 2.065417e-05 3.146315e-08 1.046721e-07 6.183096e-06 5.291536e-04
#> L:HH:5-8:AA 3.602167e-06 1.113027e-06 5.534199e-08 5.328190e-08 2.526572e-04
#> L:HH:5-8:BB 2.229239e-04 0.000000e+00 8.308778e-08 4.388753e-08 5.534060e-04
#> L:HH:9+:AA 2.889806e-06 0.000000e+00 4.414087e-08 4.006284e-07 5.035116e-05
#> L:HH:9+:BB 7.395180e-06 1.401298e-47 1.918908e-08 5.858215e-07 1.308845e-04
#> L:LD:1:AA 1.139094e-03 1.107740e-03 1.816363e-03 8.745603e-06 2.140511e-02
#> L:LD:2:AA 4.414204e-04 2.778182e-02 2.237435e-02 2.802597e-47 1.612832e-02
#> L:LD:2LOH:AA 2.349163e-02 3.110429e-03 1.850504e-05 4.819639e-04 1.646197e-03
#> L:LD:3:AA 1.016964e-02 4.108057e-02 5.339561e-04 3.655962e-03 5.385262e-04
#> L:LD:3:BB 6.579403e-04 1.551569e-04 6.241537e-05 0.000000e+00 2.237489e-04
#> L:LD:3+LOH:AA 4.678008e-02 1.555273e-04 4.056418e-09 1.744200e-08 2.257892e-04
#> L:LD:3+LOH:BB 1.753003e-02 0.000000e+00 1.083968e-06 2.326637e-07 5.798581e-04
#> L:LD:4:AA 5.752125e-03 5.601903e-04 3.887217e-05 2.786070e-03 3.877275e-04
#> L:LD:4:BB 2.384239e-03 2.361426e-07 1.084725e-04 6.244253e-05 3.506488e-04
#> L:LD:5-8:AA 8.177917e-04 5.979131e-05 1.983122e-08 2.141230e-07 3.590397e-04
#> L:LD:5-8:BB 1.527384e-03 1.278739e-04 5.024898e-05 2.276601e-04 1.027596e-03
#> L:LD:9+:AA 2.677511e-05 1.401298e-47 1.647358e-07 1.041479e-06 1.138730e-04
#> L:LD:9+:BB 1.195203e-04 6.393901e-09 5.197594e-05 1.329002e-05 4.859508e-04
#> L:LL:1:AA 7.378827e-05 3.737283e-05 1.189956e-03 1.049720e-05 2.712858e-03
#> L:LL:2:AA 1.046811e-08 1.401298e-47 1.355337e-01 8.092319e-07 2.717108e-03
#> L:LL:2LOH:AA 6.983168e-03 1.206572e-02 3.638372e-05 1.430768e-07 7.571445e-04
#> L:LL:3:AA 2.106197e-03 1.723455e-01 1.708528e-03 5.016066e-04 6.133497e-04
#> L:LL:3:BB 3.703436e-06 0.000000e+00 1.960104e-04 5.598912e-05 1.941644e-04
#> L:LL:3+LOH:AA 6.882602e-02 7.382182e-04 2.392708e-09 6.006248e-09 5.266915e-04
#> L:LL:3+LOH:BB 2.030930e-02 1.952350e-08 8.837780e-08 1.043799e-06 4.056526e-04
#> L:LL:4:AA 8.906022e-04 9.644207e-03 4.227743e-04 3.231789e-02 7.389548e-04
#> L:LL:4:BB 3.724258e-05 2.059532e-05 9.590093e-04 1.574747e-04 1.119343e-04
#> L:LL:5-8:AA 1.422704e-04 3.003135e-05 9.592506e-08 5.562560e-03 2.549057e-04
#> L:LL:5-8:BB 2.690412e-03 9.709719e-07 4.866741e-04 2.011082e-02 8.519145e-04
#> L:LL:9+:AA 1.539940e-05 0.000000e+00 5.861867e-08 1.310965e-06 9.035697e-05
#> L:LL:9+:BB 1.230024e-05 6.528658e-06 5.732426e-05 5.858079e-05 6.579120e-04
#> M:HH:0:AA 6.393699e-03 8.714648e-05 4.696241e-03 1.470652e-03 7.457043e-02
#> M:HH:0:BB 5.268768e-03 1.401298e-47 2.980388e-04 8.741685e-04 3.438385e-03
#> M:HH:1:AA 2.099342e-02 1.033992e-02 1.574155e-01 5.204769e-04 1.090971e-01
#> M:HH:1:BB 3.793139e-04 0.000000e+00 2.394803e-03 8.002218e-05 5.201663e-05
#> M:HH:2:AA 4.060652e-04 4.925950e-02 1.304556e-04 7.588918e-04 2.086832e-04
#> M:HH:2:BB 5.916720e-06 2.129869e-05 2.414730e-05 2.671328e-07 1.736089e-07
#> M:HH:2LOH:AA 2.983168e-02 3.138685e-05 1.205117e-04 5.253639e-02 2.213784e-03
#> M:HH:2LOH:BB 4.651472e-03 0.000000e+00 2.884529e-08 6.540899e-03 1.165151e-03
#> M:HH:3:AA 3.583476e-06 5.574010e-04 1.298120e-07 1.329138e-02 8.488404e-05
#> M:HH:3:BB 3.059915e-05 7.006492e-47 3.685431e-08 4.170609e-08 5.333278e-04
#> M:HH:3+LOH:AA 2.456615e-02 7.859940e-10 3.435445e-04 2.323092e-03 2.948978e-04
#> M:HH:3+LOH:BB 7.086215e-03 0.000000e+00 1.563444e-07 1.162616e-04 1.371950e-03
#> M:HH:4:AA 4.798163e-05 8.867039e-07 1.111815e-07 1.622860e-03 1.433670e-04
#> M:HH:4:BB 1.107433e-05 0.000000e+00 2.418916e-07 3.148815e-07 4.276688e-04
#> M:HH:5-8:AA 1.835564e-05 7.105624e-07 2.926761e-08 3.285813e-07 3.219229e-04
#> M:HH:5-8:BB 1.992433e-06 1.401298e-47 1.597780e-07 6.377137e-08 1.119302e-03
#> M:HH:9+:AA 2.111161e-08 0.000000e+00 4.428152e-08 5.942734e-07 8.684392e-05
#> M:HH:9+:BB 3.866947e-09 0.000000e+00 3.221135e-07 1.148534e-06 1.395615e-04
#> M:LD:1:AA 2.251299e-03 5.589012e-05 8.584575e-04 5.865098e-06 1.927215e-02
#> M:LD:2:AA 3.817181e-04 1.164735e-02 1.748459e-02 7.581456e-08 1.012653e-03
#> M:LD:2LOH:AA 9.658765e-03 4.076379e-03 1.168040e-04 1.526606e-03 9.357759e-04
#> M:LD:3:AA 9.872692e-04 4.333158e-02 4.384180e-04 1.360803e-03 3.901216e-05
#> M:LD:3:BB 1.401299e-47 3.777009e-05 5.288351e-05 3.857341e-07 5.238162e-05
#> M:LD:3+LOH:AA 3.248071e-02 6.174350e-04 2.074794e-07 2.420992e-08 5.801968e-04
#> M:LD:3+LOH:BB 1.638034e-02 8.771552e-06 4.388606e-07 6.870915e-08 1.949209e-03
#> M:LD:4:AA 5.320293e-05 6.406587e-03 2.200592e-07 1.008015e-04 5.209551e-05
#> M:LD:4:BB 1.836676e-06 3.302601e-04 1.567597e-04 4.023779e-07 2.027247e-04
#> M:LD:5-8:AA 6.732778e-06 1.964695e-04 1.053916e-08 7.282599e-10 5.670766e-04
#> M:LD:5-8:BB 1.169496e-04 2.064510e-06 1.256947e-08 1.401298e-47 1.732542e-03
#> M:LD:9+:AA 1.604586e-06 1.239163e-07 9.672852e-08 2.261572e-07 2.105654e-04
#> M:LD:9+:BB 9.423510e-07 4.032904e-07 1.124791e-07 4.031481e-07 6.243464e-04
#> M:LL:1:AA 6.615522e-05 5.087798e-06 5.154282e-04 5.708355e-05 5.015991e-03
#> M:LL:2:AA 1.240678e-08 3.023774e-05 1.045486e-01 9.872510e-07 1.627961e-03
#> M:LL:2LOH:AA 6.158868e-03 1.889792e-02 2.023316e-09 3.026742e-06 8.254788e-04
#> M:LL:3:AA 2.042180e-09 2.654355e-01 8.291020e-04 1.063109e-06 4.408140e-06
#> M:LL:3:BB 3.305474e-04 1.170894e-04 2.132302e-05 2.676524e-05 3.858421e-04
#> M:LL:3+LOH:AA 8.852972e-02 1.995195e-03 2.302772e-09 4.168556e-09 9.462784e-04
#> M:LL:3+LOH:BB 3.079018e-02 1.551963e-05 3.135323e-07 1.765663e-07 2.117004e-03
#> M:LL:4:AA 4.392897e-04 4.945260e-02 2.485452e-04 3.851455e-03 1.054420e-02
#> M:LL:4:BB 6.536699e-10 1.326993e-05 2.656916e-03 7.988555e-06 2.249119e-04
#> M:LL:5-8:AA 1.202059e-04 3.196711e-03 2.802597e-47 1.095763e-04 3.061536e-04
#> M:LL:5-8:BB 3.626150e-06 4.060476e-05 4.920007e-07 9.650680e-04 1.545819e-03
#> M:LL:9+:AA 1.658822e-08 9.091916e-06 4.391468e-08 1.839602e-08 2.878060e-04
#> M:LL:9+:BB 1.138152e-09 4.250804e-07 2.213763e-08 2.446214e-09 1.740544e-03
#> S:HH:0:AA 2.935397e-03 8.886401e-06 4.995051e-03 5.754076e-04 4.616839e-02
#> S:HH:0:BB 7.406478e-04 7.579505e-07 2.573895e-04 1.233829e-03 1.453652e-03
#> S:HH:1:AA 1.097761e-02 1.258677e-03 1.351057e-01 1.412742e-04 4.269126e-03
#> S:HH:1:BB 1.313954e-03 6.453256e-10 2.876050e-03 1.919591e-03 7.279278e-04
#> S:HH:2:AA 1.015287e-02 5.340158e-03 3.971706e-04 2.688260e-03 3.547860e-04
#> S:HH:2:BB 1.340586e-03 3.424532e-06 8.727121e-09 4.004212e-04 5.537237e-04
#> S:HH:2LOH:AA 1.061196e-02 1.291655e-06 8.762662e-04 2.147108e-02 5.656119e-04
#> S:HH:2LOH:BB 1.433710e-03 7.475656e-09 1.388589e-06 1.575346e-03 4.715998e-04
#> S:HH:3:AA 9.679941e-03 2.762073e-05 4.147036e-05 1.746727e-02 3.405373e-04
#> S:HH:3:BB 6.028360e-04 1.169382e-07 5.639194e-08 2.236052e-07 7.539538e-04
#> S:HH:3+LOH:AA 9.034444e-03 3.754560e-05 1.298539e-04 2.136039e-03 2.630001e-04
#> S:HH:3+LOH:BB 1.285801e-03 1.841773e-06 1.089410e-07 3.246942e-06 7.877888e-04
#> S:HH:4:AA 1.115764e-03 2.174595e-06 4.710701e-05 1.249224e-03 1.548441e-04
#> S:HH:4:BB 9.644381e-06 0.000000e+00 9.192355e-08 2.836282e-06 4.772485e-04
#> S:HH:5-8:AA 2.432048e-04 0.000000e+00 1.002984e-07 6.276940e-05 3.690867e-04
#> S:HH:5-8:BB 1.608116e-04 6.689611e-08 4.743224e-08 1.554447e-07 1.276533e-03
#> S:HH:9+:AA 9.539032e-08 0.000000e+00 4.262190e-07 6.093893e-06 4.373101e-05
#> S:HH:9+:BB 1.011951e-09 0.000000e+00 9.206240e-08 9.900614e-07 5.017642e-07
#> S:LD:1:AA 1.824059e-03 9.973594e-06 7.240863e-04 1.197464e-06 8.521660e-03
#> S:LD:2:AA 7.553444e-04 7.965375e-04 5.640341e-03 1.029514e-07 1.962967e-04
#> S:LD:2LOH:AA 1.718613e-03 2.674275e-04 6.308211e-05 2.749305e-04 1.296102e-04
#> S:LD:3:AA 1.416714e-03 7.133091e-03 3.915456e-04 1.392466e-03 2.333022e-04
#> S:LD:3:BB 8.972936e-06 2.157207e-05 8.015567e-05 6.428361e-06 1.141148e-04
#> S:LD:3+LOH:AA 1.009118e-02 2.187297e-05 1.600119e-05 1.139645e-05 2.320249e-04
#> S:LD:3+LOH:BB 3.039475e-03 1.347726e-09 1.501382e-07 3.726618e-07 1.428161e-03
#> S:LD:4:AA 2.354013e-03 1.015387e-03 3.034361e-09 3.165726e-04 1.949348e-04
#> S:LD:4:BB 3.134626e-04 1.288745e-07 6.719185e-05 1.919929e-04 2.554880e-04
#> S:LD:5-8:AA 1.580714e-03 1.488306e-08 2.690297e-05 6.356995e-09 5.585510e-04
#> S:LD:5-8:BB 1.100729e-03 1.244797e-06 4.779614e-05 5.725596e-07 1.720967e-03
#> S:LD:9+:AA 1.552798e-06 4.827704e-08 3.789969e-08 7.945350e-07 6.106316e-05
#> S:LD:9+:BB 1.559526e-08 5.605194e-47 1.905484e-07 6.969425e-07 3.275871e-04
#> S:LL:1:AA 3.102219e-04 1.721398e-06 2.858464e-04 1.878946e-05 3.486255e-03
#> S:LL:2:AA 1.743872e-04 1.248220e-03 4.639778e-02 6.389038e-07 5.672584e-04
#> S:LL:2LOH:AA 6.128628e-04 2.653609e-03 6.677764e-06 5.507196e-06 3.039405e-04
#> S:LL:3:AA 2.162734e-03 3.760963e-02 3.006720e-04 1.269645e-06 1.637228e-05
#> S:LL:3:BB 2.377672e-04 6.225486e-07 1.343322e-04 1.451420e-04 5.486924e-04
#> S:LL:3+LOH:AA 3.623151e-02 4.400351e-04 3.635032e-09 4.016431e-09 3.542227e-04
#> S:LL:3+LOH:BB 9.345426e-03 4.339733e-08 1.736124e-08 1.798038e-07 1.485881e-03
#> S:LL:4:AA 9.285658e-03 6.268757e-03 1.281445e-03 1.079529e-03 4.581635e-03
#> S:LL:4:BB 3.250976e-06 0.000000e+00 2.915303e-03 7.470322e-06 3.084158e-04
#> S:LL:5-8:AA 9.312158e-03 8.299631e-04 0.000000e+00 4.134752e-04 3.646752e-04
#> S:LL:5-8:BB 6.682373e-03 8.369588e-06 3.417971e-07 3.106001e-05 2.053270e-03
#> S:LL:9+:AA 1.214633e-04 0.000000e+00 9.859530e-08 3.165031e-08 3.821983e-04
#> S:LL:9+:BB 1.908665e-03 7.453242e-08 1.608668e-06 5.896504e-09 4.414848e-03
#> PCAWG_CNS11 PCAWG_CNS12 PCAWG_CNS13 PCAWG_CNS14
#> E:HH:0:AA 1.341873e-03 1.259408e-03 7.198090e-04 1.208583e-04
#> E:HH:0:BB 2.275423e-06 3.323935e-05 3.000871e-04 2.972876e-05
#> E:HH:1:AA 4.865140e-01 5.825866e-07 1.703588e-05 7.106797e-03
#> E:HH:1:BB 1.112301e-02 3.204197e-04 4.885804e-02 8.422440e-04
#> E:HH:2:AA 5.949835e-03 4.516494e-07 1.741379e-06 1.767608e-05
#> E:HH:2:BB 3.702623e-04 1.262879e-05 5.888824e-02 4.109108e-07
#> E:HH:2LOH:AA 1.183920e-08 5.444536e-02 0.000000e+00 1.045759e-02
#> E:HH:2LOH:BB 8.590293e-10 8.052903e-04 4.536768e-05 2.183354e-03
#> E:HH:3:AA 2.867735e-09 8.682028e-04 0.000000e+00 5.369212e-03
#> E:HH:3:BB 1.173543e-07 2.409601e-04 4.959992e-03 7.223598e-04
#> E:HH:3+LOH:AA 3.701627e-07 5.749388e-05 1.401298e-47 3.307049e-07
#> E:HH:3+LOH:BB 8.832551e-08 5.731472e-05 3.619180e-09 7.986282e-05
#> E:HH:4:AA 6.002483e-07 7.784569e-04 0.000000e+00 7.607444e-04
#> E:HH:4:BB 1.372106e-08 1.828693e-04 3.697302e-06 3.200746e-04
#> E:HH:5-8:AA 1.499576e-07 9.705425e-05 0.000000e+00 1.211179e-04
#> E:HH:5-8:BB 3.770095e-08 3.860968e-05 1.146097e-07 5.216067e-05
#> E:HH:9+:AA 6.684829e-07 7.916831e-08 8.916677e-10 4.754302e-06
#> E:HH:9+:BB 2.294664e-07 2.626287e-06 0.000000e+00 4.357828e-06
#> E:LD:1:AA 3.492950e-02 1.263458e-03 6.730191e-05 4.165374e-03
#> E:LD:2:AA 2.731261e-01 7.000716e-08 3.098093e-08 6.995294e-04
#> E:LD:2LOH:AA 2.093922e-03 7.770036e-02 2.762661e-06 1.018542e-02
#> E:LD:3:AA 7.586505e-04 1.056307e-01 3.946089e-05 1.690767e-02
#> E:LD:3:BB 7.971348e-05 5.838013e-03 8.331121e-03 7.217578e-04
#> E:LD:3+LOH:AA 1.394283e-07 6.811694e-04 1.697706e-08 4.997517e-04
#> E:LD:3+LOH:BB 3.263953e-08 7.661331e-06 5.413973e-09 2.387467e-05
#> E:LD:4:AA 5.185862e-08 9.177599e-04 3.533277e-09 1.161694e-03
#> E:LD:4:BB 4.567286e-07 1.795633e-04 1.815099e-03 6.157208e-04
#> E:LD:5-8:AA 1.088488e-07 1.326838e-04 3.978317e-10 1.934271e-04
#> E:LD:5-8:BB 1.022779e-07 3.123626e-05 3.832456e-08 1.166337e-04
#> E:LD:9+:AA 1.869865e-07 7.668151e-07 0.000000e+00 9.279371e-06
#> E:LD:9+:BB 7.155399e-06 2.806225e-06 4.203895e-47 4.491168e-05
#> E:LL:1:AA 6.000200e-04 1.167265e-04 5.508011e-05 3.733655e-04
#> E:LL:2:AA 2.858565e-03 8.116772e-04 7.006492e-47 2.437355e-03
#> E:LL:2LOH:AA 6.523346e-04 1.983793e-02 1.851240e-05 2.726330e-03
#> E:LL:3:AA 1.943546e-02 4.002305e-01 1.372682e-03 5.197645e-05
#> E:LL:3:BB 2.697510e-05 1.796323e-03 3.894187e-04 5.323140e-05
#> E:LL:3+LOH:AA 2.135276e-07 9.931985e-03 1.077996e-05 1.744368e-03
#> E:LL:3+LOH:BB 1.179953e-06 8.103836e-05 1.985914e-05 8.947907e-05
#> E:LL:4:AA 3.989982e-07 1.547897e-03 1.928438e-09 1.400570e-06
#> E:LL:4:BB 3.658173e-06 1.006798e-03 1.301340e-02 4.406824e-04
#> E:LL:5-8:AA 1.915464e-07 6.723702e-05 4.538941e-08 1.444972e-04
#> E:LL:5-8:BB 6.405094e-07 1.492376e-06 1.304488e-06 8.234853e-06
#> E:LL:9+:AA 1.826338e-07 1.213161e-06 3.453003e-06 5.757718e-06
#> E:LL:9+:BB 2.526067e-07 8.008120e-08 7.476245e-05 4.246163e-05
#> L:HH:0:AA 3.926997e-03 2.137965e-03 1.736899e-04 3.390476e-03
#> L:HH:0:BB 1.829571e-05 9.053849e-05 9.535037e-04 2.066897e-04
#> L:HH:1:AA 7.775572e-02 4.948603e-03 7.346156e-03 1.807968e-02
#> L:HH:1:BB 2.264785e-04 6.249034e-05 5.836552e-02 2.611428e-03
#> L:HH:2:AA 8.214185e-06 1.995208e-05 2.858250e-04 2.815776e-02
#> L:HH:2:BB 2.382008e-07 3.125527e-05 3.633391e-02 5.265381e-04
#> L:HH:2LOH:AA 6.188816e-09 3.020083e-03 7.191264e-10 6.770309e-03
#> L:HH:2LOH:BB 2.044607e-09 1.397351e-03 7.667435e-04 4.348263e-03
#> L:HH:3:AA 5.222878e-09 1.859001e-04 1.109514e-06 3.810651e-03
#> L:HH:3:BB 7.836384e-07 7.005328e-04 1.028325e-02 2.561129e-03
#> L:HH:3+LOH:AA 4.153565e-08 4.355553e-05 2.790987e-05 1.579061e-04
#> L:HH:3+LOH:BB 6.212991e-07 5.320000e-04 3.495399e-05 8.866419e-04
#> L:HH:4:AA 1.448806e-07 4.926169e-04 1.137599e-08 5.498535e-04
#> L:HH:4:BB 1.043333e-07 4.964449e-04 2.733463e-03 1.926312e-03
#> L:HH:5-8:AA 2.820352e-07 1.797537e-04 1.541428e-46 1.185326e-03
#> L:HH:5-8:BB 1.132351e-08 2.834744e-04 1.464004e-05 9.527990e-04
#> L:HH:9+:AA 3.892327e-07 2.072369e-06 0.000000e+00 4.435257e-05
#> L:HH:9+:BB 6.376447e-07 7.160714e-07 0.000000e+00 1.227421e-04
#> L:LD:1:AA 5.881691e-04 1.084186e-03 2.617099e-05 4.409310e-03
#> L:LD:2:AA 3.670790e-02 2.512592e-04 2.330112e-03 2.431186e-02
#> L:LD:2LOH:AA 2.331258e-03 9.103989e-03 5.765737e-05 9.257595e-03
#> L:LD:3:AA 4.484046e-06 3.083441e-03 5.469841e-03 2.153569e-02
#> L:LD:3:BB 1.275254e-06 1.746948e-04 1.105086e-02 8.709137e-04
#> L:LD:3+LOH:AA 7.370395e-08 1.792791e-04 1.687205e-08 1.655997e-04
#> L:LD:3+LOH:BB 1.948973e-07 5.041681e-04 4.352561e-05 7.851526e-04
#> L:LD:4:AA 2.425660e-06 6.526228e-04 1.719276e-03 2.400775e-03
#> L:LD:4:BB 1.863920e-07 3.444751e-04 1.093249e-02 1.615231e-03
#> L:LD:5-8:AA 2.521541e-07 4.237910e-04 8.162201e-05 2.112731e-03
#> L:LD:5-8:BB 7.179138e-08 9.451270e-04 1.122084e-02 3.892651e-03
#> L:LD:9+:AA 4.880088e-07 4.503081e-07 0.000000e+00 1.179577e-04
#> L:LD:9+:BB 5.367718e-07 3.350718e-07 2.278575e-04 4.524112e-04
#> L:LL:1:AA 2.527800e-06 1.205620e-04 5.755755e-05 6.559770e-04
#> L:LL:2:AA 3.429919e-05 1.465207e-07 6.532263e-07 8.045852e-06
#> L:LL:2LOH:AA 4.053517e-03 3.211198e-03 3.282384e-04 3.947732e-03
#> L:LL:3:AA 1.846066e-02 4.336672e-02 5.587777e-03 3.140709e-03
#> L:LL:3:BB 1.762565e-06 4.223879e-04 3.984046e-04 1.663471e-05
#> L:LL:3+LOH:AA 6.966588e-08 1.543824e-03 2.692340e-06 6.386028e-04
#> L:LL:3+LOH:BB 6.919314e-07 3.680958e-04 1.274169e-04 5.283537e-04
#> L:LL:4:AA 4.011792e-05 2.589984e-03 2.126499e-02 1.627174e-03
#> L:LL:4:BB 1.427479e-04 3.302965e-04 2.496254e-02 1.253580e-03
#> L:LL:5-8:AA 5.687242e-10 6.455988e-04 1.060599e-04 2.264417e-03
#> L:LL:5-8:BB 2.041861e-07 9.569515e-04 5.597941e-02 4.575256e-03
#> L:LL:9+:AA 3.137111e-07 1.004147e-05 1.125476e-05 1.116000e-04
#> L:LL:9+:BB 2.095847e-06 3.134088e-05 1.904273e-03 7.820085e-04
#> M:HH:0:AA 8.180645e-05 7.102645e-03 5.608434e-08 8.525830e-03
#> M:HH:0:BB 1.156304e-08 4.089817e-04 4.511516e-04 4.486714e-04
#> M:HH:1:AA 1.177597e-03 4.869381e-02 7.608700e-03 1.102655e-02
#> M:HH:1:BB 2.058310e-08 7.075466e-05 4.761804e-02 1.307473e-03
#> M:HH:2:AA 1.120909e-08 2.663068e-02 1.345679e-02 5.652205e-03
#> M:HH:2:BB 1.085766e-07 4.600164e-06 2.087440e-02 2.925944e-05
#> M:HH:2LOH:AA 0.000000e+00 7.384639e-03 3.836012e-04 3.321496e-03
#> M:HH:2LOH:BB 1.148761e-08 1.015832e-03 9.417171e-04 3.141222e-03
#> M:HH:3:AA 1.196354e-08 1.828309e-04 1.084488e-03 1.494098e-03
#> M:HH:3:BB 2.441628e-07 5.642169e-04 1.185533e-02 1.938740e-03
#> M:HH:3+LOH:AA 0.000000e+00 3.052934e-04 5.134831e-04 9.211971e-04
#> M:HH:3+LOH:BB 1.163441e-07 1.270149e-03 2.128321e-04 2.234989e-03
#> M:HH:4:AA 2.646561e-07 2.781308e-04 6.467321e-04 1.240567e-03
#> M:HH:4:BB 1.217881e-07 4.343638e-04 4.371470e-03 1.971235e-03
#> M:HH:5-8:AA 7.023030e-09 5.010818e-04 1.591959e-03 2.738697e-03
#> M:HH:5-8:BB 2.401406e-08 8.491643e-04 3.477333e-04 2.875019e-03
#> M:HH:9+:AA 4.931375e-07 5.720278e-07 0.000000e+00 1.206195e-04
#> M:HH:9+:BB 2.877675e-07 4.874315e-07 8.199254e-09 2.676405e-04
#> M:LD:1:AA 0.000000e+00 3.370799e-03 5.724932e-08 2.375012e-03
#> M:LD:2:AA 1.227152e-03 1.404356e-03 8.262150e-03 4.758633e-03
#> M:LD:2LOH:AA 1.144888e-05 2.929987e-03 1.752404e-03 2.632509e-03
#> M:LD:3:AA 3.319524e-08 6.560186e-05 1.602070e-02 1.179006e-03
#> M:LD:3:BB 4.428737e-07 2.938568e-05 9.328201e-03 3.719058e-04
#> M:LD:3+LOH:AA 0.000000e+00 4.782600e-04 4.011090e-05 9.692683e-04
#> M:LD:3+LOH:BB 7.061024e-07 1.729499e-03 5.373144e-04 2.571836e-03
#> M:LD:4:AA 8.417852e-09 2.653436e-04 7.383981e-03 1.698462e-03
#> M:LD:4:BB 1.164337e-07 2.532369e-04 1.502698e-02 1.217685e-03
#> M:LD:5-8:AA 1.544038e-08 9.327962e-04 2.420567e-03 4.247232e-03
#> M:LD:5-8:BB 2.059913e-08 1.999866e-03 1.772720e-02 7.202180e-03
#> M:LD:9+:AA 3.880000e-07 3.075502e-07 0.000000e+00 2.471221e-04
#> M:LD:9+:BB 4.313815e-07 4.800010e-07 1.331173e-06 6.797366e-04
#> M:LL:1:AA 2.273497e-08 2.240506e-04 2.425872e-09 4.517157e-04
#> M:LL:2:AA 9.739648e-09 2.073295e-08 1.336082e-07 8.412909e-04
#> M:LL:2LOH:AA 9.721433e-03 1.027683e-03 9.758731e-06 6.618616e-03
#> M:LL:3:AA 8.254436e-04 3.725039e-07 5.154359e-07 4.412340e-03
#> M:LL:3:BB 4.226028e-06 5.243495e-05 6.965419e-05 1.178827e-04
#> M:LL:3+LOH:AA 1.406240e-07 2.319996e-03 8.195268e-11 1.519035e-03
#> M:LL:3+LOH:BB 5.785400e-07 1.707470e-03 6.135694e-04 2.682212e-03
#> M:LL:4:AA 8.973821e-09 1.073498e-03 1.468999e-02 1.925001e-03
#> M:LL:4:BB 3.934122e-05 2.194289e-05 2.439360e-02 7.269889e-04
#> M:LL:5-8:AA 0.000000e+00 1.959714e-03 4.168747e-04 4.477849e-03
#> M:LL:5-8:BB 1.289871e-08 2.218012e-03 1.067678e-01 8.799317e-03
#> M:LL:9+:AA 1.672377e-07 1.870621e-05 4.203895e-47 3.415069e-04
#> M:LL:9+:BB 8.760272e-09 7.345674e-04 3.401775e-03 3.093679e-03
#> S:HH:0:AA 1.032452e-08 2.165668e-03 7.908474e-09 4.912834e-03
#> S:HH:0:BB 5.936430e-09 7.183285e-04 1.817793e-03 7.264665e-04
#> S:HH:1:AA 4.950888e-08 3.729891e-02 1.096096e-02 6.122803e-02
#> S:HH:1:BB 0.000000e+00 9.444657e-04 5.303327e-02 5.697986e-03
#> S:HH:2:AA 5.221467e-06 3.208046e-02 1.287652e-02 4.364980e-02
#> S:HH:2:BB 9.448572e-09 5.821841e-04 1.253353e-02 2.475804e-03
#> S:HH:2LOH:AA 8.407791e-47 2.580721e-03 2.159353e-04 3.257777e-03
#> S:HH:2LOH:BB 1.101644e-06 4.909800e-04 1.051543e-03 1.399208e-03
#> S:HH:3:AA 3.239472e-08 8.435891e-04 2.632253e-03 1.196214e-02
#> S:HH:3:BB 1.179331e-07 8.305120e-04 1.189751e-02 2.579793e-03
#> S:HH:3+LOH:AA 2.607622e-08 2.054018e-04 4.506911e-04 5.500629e-04
#> S:HH:3+LOH:BB 7.974138e-08 7.400379e-04 1.232814e-04 1.291933e-03
#> S:HH:4:AA 2.011125e-07 3.250200e-04 8.826981e-04 2.303833e-03
#> S:HH:4:BB 1.702112e-08 5.493063e-04 2.891432e-03 2.005607e-03
#> S:HH:5-8:AA 6.158919e-08 6.961506e-04 5.025265e-04 2.837903e-03
#> S:HH:5-8:BB 7.450184e-08 1.583017e-03 6.750174e-04 3.221672e-03
#> S:HH:9+:AA 6.488147e-07 6.980092e-06 2.802597e-47 1.284036e-04
#> S:HH:9+:BB 3.955271e-07 5.030039e-07 2.802597e-47 1.771316e-05
#> S:LD:1:AA 0.000000e+00 1.589549e-03 2.802597e-47 1.576814e-03
#> S:LD:2:AA 2.851664e-04 2.340603e-03 7.504884e-03 1.129216e-02
#> S:LD:2LOH:AA 1.338544e-06 9.037735e-04 7.967177e-04 2.977599e-03
#> S:LD:3:AA 1.044976e-08 4.083028e-04 1.577138e-02 1.652813e-02
#> S:LD:3:BB 1.885377e-09 1.586986e-04 5.665422e-03 9.660627e-04
#> S:LD:3+LOH:AA 7.873926e-09 2.127439e-04 2.093826e-04 6.267335e-04
#> S:LD:3+LOH:BB 2.553907e-06 1.178901e-03 2.320580e-04 1.819192e-03
#> S:LD:4:AA 2.611586e-08 3.779228e-04 6.230860e-03 2.419094e-03
#> S:LD:4:BB 4.791215e-06 3.802323e-04 7.110070e-03 1.208880e-03
#> S:LD:5-8:AA 2.414867e-07 8.272158e-04 2.954632e-03 3.241587e-03
#> S:LD:5-8:BB 3.085880e-07 2.124678e-03 1.107029e-02 5.636182e-03
#> S:LD:9+:AA 6.414695e-07 2.285531e-06 0.000000e+00 1.520315e-04
#> S:LD:9+:BB 5.453020e-07 2.909083e-04 1.232882e-06 5.317187e-04
#> S:LL:1:AA 1.568167e-10 4.012471e-04 2.533034e-05 4.674668e-04
#> S:LL:2:AA 1.127498e-06 1.739717e-05 1.971103e-05 2.073659e-02
#> S:LL:2LOH:AA 2.143985e-03 2.058006e-04 1.007444e-10 2.479216e-02
#> S:LL:3:AA 2.561222e-04 2.907908e-04 6.601225e-06 2.093587e-01
#> S:LL:3:BB 4.593698e-06 3.517612e-05 5.996073e-04 2.309156e-04
#> S:LL:3+LOH:AA 1.088061e-07 8.622115e-04 1.401298e-47 1.160365e-02
#> S:LL:3+LOH:BB 3.428596e-07 1.307089e-03 2.217090e-04 2.040694e-03
#> S:LL:4:AA 1.116791e-06 1.013069e-03 3.797860e-03 1.145820e-01
#> S:LL:4:BB 5.325334e-07 4.497923e-05 2.016414e-02 1.961281e-03
#> S:LL:5-8:AA 7.144094e-10 1.847544e-03 2.574731e-04 3.659589e-02
#> S:LL:5-8:BB 8.116111e-09 2.832223e-03 5.021806e-02 1.186275e-02
#> S:LL:9+:AA 4.639819e-08 3.490235e-04 3.847002e-05 1.071654e-03
#> S:LL:9+:BB 2.683919e-09 4.850287e-03 3.514505e-03 1.063494e-02
#>
#> $aetiology
#> aetiology
#> PCAWG_CNS1 See https://doi.org/10.1093/bib/bbad053
#> PCAWG_CNS2 See https://doi.org/10.1093/bib/bbad053
#> PCAWG_CNS3 See https://doi.org/10.1093/bib/bbad053
#> PCAWG_CNS4 See https://doi.org/10.1093/bib/bbad053
#> PCAWG_CNS5 See https://doi.org/10.1093/bib/bbad053
#> PCAWG_CNS6 See https://doi.org/10.1093/bib/bbad053
#> PCAWG_CNS7 See https://doi.org/10.1093/bib/bbad053
#> PCAWG_CNS8 See https://doi.org/10.1093/bib/bbad053
#> PCAWG_CNS9 See https://doi.org/10.1093/bib/bbad053
#> PCAWG_CNS10 See https://doi.org/10.1093/bib/bbad053
#> PCAWG_CNS11 See https://doi.org/10.1093/bib/bbad053
#> PCAWG_CNS12 See https://doi.org/10.1093/bib/bbad053
#> PCAWG_CNS13 See https://doi.org/10.1093/bib/bbad053
#> PCAWG_CNS14 See https://doi.org/10.1093/bib/bbad053
#>
#> $date
#> [1] "2023/03/17"
#>