These functions are combined to provide a best practice for optimally identifying mutational signatures and attributing their activities (exposures) in tumor samples. They are listed in order to use.

  • bp_extract_signatures() for extracting signatures.

  • bp_show_survey() for showing measures change under different signature numbers to help user select optimal signature number. At default, an aggregated score (named score) is generated to suggest the best solution.

  • bp_show_survey2() for showing simplified signature number survey like show_sig_number_survey().

  • bp_get_sig_obj() for get a (list of) Signature object which is common used in sigminer for analysis and visualization.

  • bp_attribute_activity() for optimizing signature activities (exposures). NOTE: the activities from extraction step may be better! You can also use sig_extract to get optimal NMF result from multiple NMF runs. Besides, you can use sig_fit to quantify exposures based on signatures extracted from bp_extract_signatures().

  • bp_extract_signatures_iter() for extracting signature in a iteration way.

  • bp_cluster_iter_list() for clustering (hclust with average linkage) iterated signatures to help collapse multiple signatures into one. The result cluster can be visualized by plot() or factoextra::fviz_dend().

  • bp_get_clustered_sigs() for getting clustered (grouped) mean signatures from signature clusters.

  • Extra: bp_get_stats() for obtaining stats for signatures and samples of a solution. These stats are aggregated (averaged) as the stats for a solution (specific signature number).

  • Extra: bp_get_rank_score() for obtaining rank score for all signature numbers.

bp_extract_signatures(
  nmf_matrix,
  range = 2:5,
  n_bootstrap = 20L,
  n_nmf_run = 50,
  RTOL = 0.001,
  min_contribution = 0,
  cores = min(4L, future::availableCores()),
  cores_solution = min(cores, length(range)),
  seed = 123456L,
  handle_hyper_mutation = TRUE,
  report_integer_exposure = FALSE,
  only_core_stats = nrow(nmf_matrix) > 100,
  cache_dir = file.path(tempdir(), "sigminer_bp"),
  keep_cache = FALSE,
  pynmf = FALSE,
  use_conda = TRUE,
  py_path = "/Users/wsx/anaconda3/bin/python"
)

bp_extract_signatures_iter(
  nmf_matrix,
  range = 2:5,
  sim_threshold = 0.95,
  max_iter = 10L,
  n_bootstrap = 20L,
  n_nmf_run = 50,
  RTOL = 0.001,
  min_contribution = 0,
  cores = min(4L, future::availableCores()),
  cores_solution = min(cores, length(range)),
  seed = 123456L,
  handle_hyper_mutation = TRUE,
  report_integer_exposure = FALSE,
  only_core_stats = nrow(nmf_matrix) > 100,
  cache_dir = file.path(tempdir(), "sigminer_bp"),
  keep_cache = FALSE,
  pynmf = FALSE,
  use_conda = FALSE,
  py_path = "/Users/wsx/anaconda3/bin/python"
)

bp_cluster_iter_list(x, k = NULL, include_final_iteration = TRUE)

bp_get_clustered_sigs(SigClusters, cluster_label)

bp_get_sig_obj(obj, signum = NULL)

bp_get_stats(obj)

bp_get_rank_score(obj)

bp_show_survey2(
  obj,
  x = "signature_number",
  left_y = "silhouette",
  right_y = "L2_error",
  left_name = left_y,
  right_name = right_y,
  left_color = "black",
  right_color = "red",
  left_shape = 16,
  right_shape = 18,
  shape_size = 4,
  highlight = NULL
)

bp_show_survey(
  obj,
  add_score = FALSE,
  scales = c("free_y", "free"),
  fixed_ratio = TRUE
)

bp_attribute_activity(
  input,
  sample_class = NULL,
  nmf_matrix = NULL,
  method = c("bt", "stepwise"),
  bt_use_prop = FALSE,
  return_class = c("matrix", "data.table"),
  use_parallel = FALSE,
  cache_dir = file.path(tempdir(), "sigminer_attribute_activity"),
  keep_cache = FALSE
)

Arguments

nmf_matrix

a matrix used for NMF decomposition with rows indicate samples and columns indicate components.

range

a numeric vector containing the ranks of factorization to try. Note that duplicates are removed and values are sorted in increasing order. The results are notably returned in this order.

n_bootstrap

number of bootstrapped (resampling) catalogs used. When it is 0, the original (input) mutation catalog is used for NMF decomposition, this is not recommended, just for testing, user should not set it to 0.

n_nmf_run

number of NMF runs for each bootstrapped or original catalog. At default, in total n_bootstrap x n_nmf_run (i.e. 1000) NMF runs are used for the task.

RTOL

a threshold proposed by Nature Cancer paper to control how to filter solutions of NMF. Default is 0.1% (from reference #2), only NMF solutions with KLD (KL deviance) <= 100.1% minimal KLD are kept.

min_contribution

a component contribution threshold to filer out small contributed components.

cores

number of cpu cores to run NMF.

cores_solution

cores for processing solutions, default is equal to argument cores.

seed

a random seed to make reproducible result.

handle_hyper_mutation

default is TRUE, handle hyper-mutant samples.

report_integer_exposure

if TRUE, report integer signature exposure by bootstrapping technique.

only_core_stats

if TRUE, only calculate the core stats for signatures and samples.

cache_dir

a directory for keep temp result files.

keep_cache

if TRUE, keep cache results.

pynmf

if TRUE, use Python NMF driver Nimfa. The seed currently is not used by this implementation, so the only way to reproduce your result is setting keep_cache = TRUE.

use_conda

if TRUE, create an independent conda environment to run NMF.

py_path

path to Python executable file, e.g. '/Users/wsx/anaconda3/bin/python'. In my test, it is more stable than use_conda=TRUE. You can install the Nimfa package by yourself or set use_conda to TRUE to install required Python environment, and then set this option.

sim_threshold

a similarity threshold for selecting samples to auto-rerun the extraction procedure (i.e. bp_extract_signatures()), default is 0.95.

max_iter

the maximum iteration size, default is 10, i.e., at most run the extraction procedure 10 times.

x

result from bp_extract_signatures_iter() or a list of Signature objects.

k

an integer sequence specifying the cluster number to get silhouette.

include_final_iteration

if FALSE, exclude final iteration result from clustering for input from bp_extract_signatures_iter(), not applied if input is a list of Signature objects.

SigClusters

result from bp_cluster_iter_list().

cluster_label

cluster labels for a specified cluster number, obtain it from SigClusters$sil_df.

obj

a ExtractionResult object from bp_extract_signatures().

signum

a integer vector to extract the corresponding Signature object(s). If it is NULL (default), all will be returned.

left_y

column name for left y axis.

right_y

column name for right y axis.

left_name

label name for left y axis.

right_name

label name for right y axis.

left_color

color for left axis.

right_color

color for right axis.

left_shape, right_shape, shape_size

shape setting.

highlight

a integer to highlight a x.

add_score

if FALSE, don't show score and label optimal points by rank score.

scales

one of "free_y" (default) and "free" to control the scales of plot facet.

fixed_ratio

if TRUE (default), make the x/y axis ratio fixed.

input

result from bp_extract_signatures() or a Signature object.

sample_class

a named string vector whose names are sample names and values are class labels (i.e. cancer subtype). If it is NULL (the default), treat all samples as one group.

method

one of 'bt' (use bootstrap exposure median, from reference #2, the most recommended way in my personal view) or stepwise' (stepwise reduce and update signatures then do signature fitting with last signature sets, from reference #2, the result tends to assign the contribution of removed signatures to the remaining signatures, maybe I misunderstand the paper method? PAY ATTENTION).

bt_use_prop

this parameter is only used for bt method to reset low contributing signature activity (relative activity <0.01). If TRUE, use empirical P value calculation way (i.e. proportion, used by reference #2), otherwise a t.test is applied.

return_class

string, 'matrix' or 'data.table'.

use_parallel

if TRUE, use parallel computation based on furrr package. It can also be an integer for specifying cores.

Value

It depends on the called function.

Details

The signature extraction approach is adopted from reference #1, #2, and the whole best practice is adopted from the pipeline used by reference #3. I implement the whole procedure with R code based on the method description of papers. The code is well organized, tested and documented so user will find it pretty simple and useful. Besides, the structure of the results is very clear to see and also visualize like other approaches provided by sigminer.

Measure Explanation in Survey Plot

The survey plot provides a pretty good way to facilitate the signature number selection. A score measure is calculated as the weighted mean of selected measures and visualized as the first sub-plot. The optimal number is highlighted with red color dot and the best values for each measures are also highlighted with orange color dots. The detail of 6 measures shown in plot are explained as below.

  • score - an aggregated score based on rank scores from selected measures below. The higher, the better. When two signature numbers have the same score, the larger signature number is preferred (this is a rare situation, you have to double check other measures).

  • silhouette - the average silhouette width for signatures, also named as ASW in reference #2. The signature number with silhouette decreases sharply is preferred.

  • distance - the average sample reconstructed cosine distance, the lower value is better.

  • error - the average sample reconstructed error calculated with L2 formula (i.e. L2 error). This lower value is better. This measure represents a similar concept like distance above, they are all used to quantify how well sample mutation profiles can be reconstructed from signatures, but distance cares the whole mutation profile similarity while error here cares value difference.

  • pos cor - the average positive signature exposure correlation coefficient. The lower value is better. This measure is constructed based on my understanding about signatures: mutational signatures are typically treated as independent recurrent patterns, so their activities are less correlated.

  • similarity - the average similarity within in a signature cluster. Like silhouette, the point decreases sharply is preferred. In the practice, results from multiple NMF runs are clustered with "clustering with match" algorithm proposed by reference #2. This value indicates if the signature profiles extracted from different NMF runs are similar.

References

Alexandrov, Ludmil B., et al. "Deciphering signatures of mutational processes operative in human cancer." Cell reports 3.1 (2013): 246-259.

Degasperi, Andrea, et al. "A practical framework and online tool for mutational signature analyses show intertissue variation and driver dependencies." Nature cancer 1.2 (2020): 249-263.

Alexandrov, Ludmil B., et al. “The repertoire of mutational signatures in human cancer.” Nature 578.7793 (2020): 94-101.

See also

Author

Shixiang Wang w_shixiang@163.com

Examples

data("simulated_catalogs")
# \donttest{
# Here I reduce the values for n_bootstrap and n_nmf_run
# for reducing the run time.
# In practice, you should keep default or increase the values
# for better estimation.
#
# The input data here is simulated from 10 mutational signatures

# e1 <- bp_extract_signatures(
#   t(simulated_catalogs$set1),
#   range = 8:12,
#   n_bootstrap = 5,
#   n_nmf_run = 10
# )
#
# To avoid computation in examples,
# Here just load the result
# (e1$signature and e1$exposure set to NA to reduce package size)
load(system.file("extdata", "e1.RData", package = "sigminer"))


# See the survey for different signature numbers
# The suggested solution is marked as red dot
# with highest integrated score.
p1 <- bp_show_survey(e1)
p1

# You can also exclude plotting and highlighting the score
p2 <- bp_show_survey(e1, add_score = FALSE)
p2


# You can also plot a simplified version
p3 <- bp_show_survey2(e1, highlight = 10)
#> Variables can be used: signature_number, silhouette, sample_cosine_distance, L1_error, L2_error, exposure_positive_correlation, signature_similarity_within_cluster, signature_similarity_across_cluster, silhouette_sample
p3


# Obtain the suggested solution from extraction result
obj_suggested <- bp_get_sig_obj(e1, e1$suggested)
obj_suggested
#> $Signature
#>                 Sig1       Sig2       Sig3       Sig4       Sig5         Sig6
#> A[C>A]A  364.6855115  346.94762  452.99236  692.34882  380.33725 1.324947e+03
#> A[C>A]C  144.9048999  252.82263  388.79723  440.77833  227.80360 1.328586e+03
#> A[C>A]G  101.9965735   56.31129   73.55796   77.30450   35.81481 7.254115e+01
#> A[C>A]T  228.2381304  215.37118  321.71075  477.84538  175.07128 1.261005e+03
#> C[C>A]A  453.0228668  373.09497  354.26747  877.39212  132.35013 9.321536e+02
#> C[C>A]C  352.2870235  356.88211  261.08852  585.38882  103.33427 9.466691e+02
#> C[C>A]G  139.5844540   77.21084   71.37286   89.08911   67.52359 5.770273e+00
#> C[C>A]T  206.6452684  325.06644  233.99811  449.18696  224.99675 9.577429e+02
#> G[C>A]A  262.9030436   93.42677  249.76023  671.83989  292.79971 6.752285e+02
#> G[C>A]C  234.4691391  203.94031  338.46614  341.08226  239.81114 5.328750e+02
#> G[C>A]G   77.2748163   38.76242   67.73828   55.54570   33.87816 2.079253e+01
#> G[C>A]T   25.1498022  147.95376  306.35190  471.88666  250.35555 6.924583e+02
#> T[C>A]A  707.9694364 1128.97194  915.45972  578.90913  425.73686 9.433380e+02
#> T[C>A]C  550.3665329  639.22968  560.35636  691.10963  363.64965 5.479057e+02
#> T[C>A]G  124.1977001   90.18331  156.15108  117.38406   93.80205 1.223391e+01
#> T[C>A]T  423.1960918  487.78631  622.24017  648.89415  477.28252 1.218222e+03
#> A[C>G]A  191.6864937  322.45523  599.97352  496.63443  220.62923 3.340177e+02
#> A[C>G]C   98.4509868  163.72693  305.70556  240.58008  192.32289 1.778502e+02
#> A[C>G]G   32.9514639   41.90439  110.29973  130.08351   51.99749 5.024744e-06
#> A[C>G]T  196.5392614  354.14978  543.65236  573.08529  259.68447 2.734687e+02
#> C[C>G]A  170.7588970  286.52200  405.42625  425.08854  151.77176 2.007334e+02
#> C[C>G]C  184.4906424  173.75603  306.77347  324.29104  135.08277 1.839090e+02
#> C[C>G]G   37.1196263   34.60268  108.73587   98.87709   47.68770 2.160016e+01
#> C[C>G]T  191.1959730  337.55583  526.49460  653.67282  177.24473 2.172862e+02
#> G[C>G]A  120.8305851  147.81819  245.41235  278.24330   94.40144 1.447409e+02
#> G[C>G]C   85.9454946  129.07501  248.42925  244.06828  203.54229 1.119571e+02
#> G[C>G]G   11.2368880   18.09011   48.93059   39.78653   18.81565 1.239872e+00
#> G[C>G]T   99.2539804  194.17868  318.01486  404.69066  119.83849 2.243552e+02
#> T[C>G]A 2304.8190218 5806.53390 2543.20013  827.06428    4.47700 8.045533e+01
#> T[C>G]C  649.4320013 1498.46533  908.51263  607.96705  148.26065 5.881513e+01
#> T[C>G]G   91.1666377  209.73580  147.99082   71.38912   23.82618 8.602967e-04
#> T[C>G]T 2761.4204889 6844.53103 3311.67302 1324.25369  108.29443 6.392960e+01
#> A[C>T]A  580.6367660  486.55883  771.14239  573.23727 1045.30267 8.209856e+02
#> A[C>T]C  336.8462426  166.00633  384.82160  259.72339  579.17288 2.279499e+02
#> A[C>T]G   41.2744554   48.63027 1095.73657  279.15822 5056.19068 7.232503e+02
#> A[C>T]T  365.5627960  320.98049  532.98918  433.35276  478.77227 7.802344e+02
#> C[C>T]A 1107.9997769  578.99821  714.60791  489.10670  828.90566 1.504848e+02
#> C[C>T]C  680.5296357  284.55116  583.37633  291.95102  705.17673 1.096355e+02
#> C[C>T]G  140.6997922  110.49878  608.69038  382.82184 2856.59934 9.769086e+01
#> C[C>T]T  899.7884560  535.31877  570.95299  596.89330  769.16400 7.430400e+02
#> G[C>T]A  740.5029427  445.50554  653.16343  432.39515 1022.83916 4.543718e+01
#> G[C>T]C  518.2147424  336.90086  473.33371  288.04137 1073.90995 8.017087e-01
#> G[C>T]G  151.0536663   97.06964  535.59679  111.37791 3150.67238 3.028044e+02
#> G[C>T]T  684.1239448  427.63207  522.89528  260.30904  744.80860 2.399426e+02
#> T[C>T]A 1935.5135649 2371.00890 1254.10598  184.58238  468.56327 2.016729e+02
#> T[C>T]C  808.7068291  534.84839  784.12753  396.90968  736.96715 7.805433e+01
#> T[C>T]G  174.8872796   75.86828  502.79237  130.24016 2179.16906 1.917718e+02
#> T[C>T]T  887.6696088  710.46176  664.34758  223.84417  452.25297 3.454048e+02
#> A[T>A]A  317.6552554  228.37936  246.26228  271.09229  168.31318 4.928755e+02
#> A[T>A]C  278.2529058  213.13425  260.76926  232.40386   98.31839 4.406474e+02
#> A[T>A]G  249.1917651  182.23415  340.62694  225.47731  185.96380 5.335190e+02
#> A[T>A]T  246.2567101  310.95073  335.99184  190.22561  288.31773 1.114181e+03
#> C[T>A]A  100.2452810   96.44490  181.15835  160.06344   66.32999 5.002986e+02
#> C[T>A]C  315.3312658  290.19171  210.47003  393.73526   34.30914 7.272778e+02
#> C[T>A]G  214.4139116  134.29338  313.33861  255.20058  152.95544 6.791202e+02
#> C[T>A]T  255.1055329  189.25835  347.36489  510.57007  130.67930 9.858692e+02
#> G[T>A]A   78.5708695   46.54815  181.40288  119.84166   92.06006 3.475210e+02
#> G[T>A]C  162.1735392  152.29781  122.00953  162.13346   53.23410 2.791327e+02
#> G[T>A]G  159.3889064  110.89872  247.32946  192.69463   94.97434 3.082144e+02
#> G[T>A]T  115.6398251  140.47073  153.38354  297.73054   26.48535 7.054885e+02
#> T[T>A]A  252.4670358  160.68865  305.17529  216.26710  228.23242 6.535623e+02
#> T[T>A]C  592.0449289  353.72488  228.79198  337.76826   55.16387 4.069120e+02
#> T[T>A]G  198.0755104  151.91335  256.84425  226.22452   62.18204 3.285117e+02
#> T[T>A]T  383.5737823  337.00589  351.72460  404.10447   88.98538 1.036281e+03
#> A[T>C]A 2214.2964522 1259.06003  851.26760  769.08597  645.92386 6.571294e+02
#> A[T>C]C 1296.4130889  789.71635  429.95798  612.10931  168.38083 3.339987e+02
#> A[T>C]G 2184.7595181 1231.70050  712.42662  866.79096  423.38503 3.059365e+02
#> A[T>C]T 1334.2884205  746.77707  823.13917  536.52760  381.41889 9.212770e+02
#> C[T>C]A 1368.4259217  768.78881  352.44770  550.53435  178.86216 1.540993e+02
#> C[T>C]C 1517.2716800  984.20451  361.66402  904.29318   97.95732 2.679858e+02
#> C[T>C]G 1890.4159043 1020.51180  435.96306  693.79180  283.74277 7.832913e+01
#> C[T>C]T 1419.4825104  789.41692  461.84585  894.63908  253.60587 3.501025e+02
#> G[T>C]A 2449.4241104 1446.44266  424.35425  906.38195  218.56288 1.170186e+02
#> G[T>C]C 1114.6078783  664.36882  219.30814  553.12788  124.96875 2.110529e+02
#> G[T>C]G 1737.5192128 1021.54590  349.01345  654.90212  130.34669 1.528999e+02
#> G[T>C]T 1758.5622876 1017.16814  477.82218  719.38885  245.19309 1.661486e+02
#> T[T>C]A 2185.6729708 1226.57228  480.33544  787.78432  208.84153 1.190451e+02
#> T[T>C]C 1490.7693030  863.31094  418.77913  676.08017  163.41359 1.798135e+02
#> T[T>C]G 1357.3556066  889.25467  370.53252  521.65067  232.69739 2.304677e+01
#> T[T>C]T 1684.7172024  939.72966  463.64985  665.37852  175.01269 3.423028e+02
#> A[T>G]A   94.4330523   63.49243  100.69104   64.50282   68.14202 1.959488e+02
#> A[T>G]C   30.4353615   40.74580   67.32443   66.49769   63.33256 2.948087e+01
#> A[T>G]G   83.6873843  128.33196  167.15785  235.83434  149.35654 2.825874e+02
#> A[T>G]T  127.1360117  105.47819  139.83909  220.61187  114.86815 7.451436e+01
#> C[T>G]A   70.5662971   29.27212   72.12039   57.89206   24.15968 1.131150e+02
#> C[T>G]C  210.8441666  150.24265  126.53264  252.93096   93.03145 6.693238e+01
#> C[T>G]G  232.3968048  173.22663  216.46656  294.16258  156.93625 2.150109e+02
#> C[T>G]T  150.3588432   66.59398  208.90862  985.23861  129.16472 6.238572e+01
#> G[T>G]A   17.0229495   29.80699   61.77359   90.96154   31.34418 1.800350e+01
#> G[T>G]C    0.8591066   27.85169   43.31172  134.02653   11.43404 5.874917e+00
#> G[T>G]G   69.6919626  179.41070  333.42242  428.18415  107.86656 1.859646e+02
#> G[T>G]T  105.2678056   98.08502   80.19119  381.34504   43.04977 1.704416e+02
#> T[T>G]A  121.6433012  111.73067  186.94694  146.40000   97.89894 5.773345e+01
#> T[T>G]C  149.5333411  116.51460  196.94210  192.20642  108.00836 8.684462e+01
#> T[T>G]G   92.4731954  109.25682  245.52028  297.37939  121.43337 1.981042e+02
#> T[T>G]T  154.2386196  137.23642  463.48903  453.32162  362.20483 3.207298e+02
#>                 Sig7       Sig8        Sig9       Sig10      Sig11
#> A[C>A]A 1.612108e+03  513.18466  370.426103  317.485977  301.03623
#> A[C>A]C 2.811969e+02  401.26021   92.737155  172.921734  284.52485
#> A[C>A]G 6.406936e+01   34.86885   21.922641   40.546934   54.23260
#> A[C>A]T 5.420044e+02  442.76085  179.626853  174.936185  239.09711
#> C[C>A]A 2.982074e+03  378.20672  661.929329  410.372295  352.30301
#> C[C>A]C 6.180518e+02  407.35946  144.713698  496.039327  282.01916
#> C[C>A]G 5.695139e+02   70.25062  137.061730  181.714287   84.90837
#> C[C>A]T 1.145804e+03  595.39775  242.674959 1254.882610  543.60381
#> G[C>A]A 4.307915e+03  201.90842 1045.442740  335.581323  189.36150
#> G[C>A]C 4.907381e+02  281.13290  147.213294  218.435173  218.83653
#> G[C>A]G 3.010680e+02   50.90646   93.143500   75.067089   27.98970
#> G[C>A]T 2.381946e+03  311.50351  598.580470  307.131262  223.18275
#> T[C>A]A 2.260020e+03  184.81599  809.740232  341.930871  351.10781
#> T[C>A]C 1.420839e+03  272.18579  422.915978  265.454149  331.98760
#> T[C>A]G 4.926154e+02   61.94453  155.534013   38.590677   48.86329
#> T[C>A]T 3.949891e+03  485.04643 1038.476495  528.723002  445.57556
#> A[C>G]A 3.520491e+01  422.58229   40.719413  213.294440  268.63571
#> A[C>G]C 7.537606e+01  226.12183   61.341091  110.981307  143.04307
#> A[C>G]G 8.863639e+01   78.61895   22.544953   51.641726   43.82139
#> A[C>G]T 9.105450e+01  366.43408   89.752984  211.646507  271.03210
#> C[C>G]A 1.972337e+01  248.53555   60.458058   88.425799  197.55635
#> C[C>G]C 9.389712e+01  260.05125   47.392917  117.524661  142.99773
#> C[C>G]G 1.663936e+02   53.56070   52.251455   32.427322   48.24376
#> C[C>G]T 1.706537e+02  393.61001  110.455586  149.326789  252.83704
#> G[C>G]A 2.172857e+01  172.11493   40.207808   83.289982  144.21200
#> G[C>G]C 4.494280e+00  178.13304   24.373164  102.997208   79.65155
#> G[C>G]G 1.405500e+01   24.57657    8.070140    9.880719   23.98459
#> G[C>G]T 4.908029e+01  278.74457   48.651901  116.891518  199.79989
#> T[C>G]A 1.165248e+02  174.16061 2103.156522   60.437995  636.17041
#> T[C>G]C 2.559735e+02  319.73340  537.274027  144.375587  254.02401
#> T[C>G]G 4.842660e+01   36.11222   90.435720   21.618406   42.63096
#> T[C>G]T 3.079238e+02  437.76949 2451.564561  107.446794 1076.02647
#> A[C>T]A 8.516367e+01  509.78431  164.680745  682.596751  368.57769
#> A[C>T]C 6.549977e+01  275.39037   93.548518  407.421365  194.61958
#> A[C>T]G 1.681590e+02  639.81418  192.171636  848.451511  219.49651
#> A[C>T]T 1.133526e+02  443.09742  116.301412  436.498259  353.52505
#> C[C>T]A 4.266475e+02  486.79212  382.866038  341.456923  281.63431
#> C[C>T]C 1.837298e+02  297.96180   93.103677  314.845399  149.63889
#> C[C>T]G 4.588847e+02  656.23660  223.766036 1160.824899  367.12010
#> C[C>T]T 2.099212e+02  473.19977  195.353006  375.259764  216.10874
#> G[C>T]A 4.583719e+01  634.10065   70.067798 1225.877730  446.60656
#> G[C>T]C 5.966043e+01  555.87383   11.390655 1446.161268  410.37815
#> G[C>T]G 1.952663e+02  865.03568  150.635721 1883.402702  485.25151
#> G[C>T]T 5.219121e+01  482.18963   15.358399 1077.792737  381.75646
#> T[C>T]A 1.546390e+03 1274.21386  867.813705  186.347428 3610.62119
#> T[C>T]C 5.496995e+02  581.97699  331.764668  389.736658  828.37489
#> T[C>T]G 4.305419e+02  429.02041  299.813014  416.334741  431.72765
#> T[C>T]T 7.084075e+02  938.68885  305.542684  154.768464 2052.27825
#> A[T>A]A 7.306582e+01  214.07703   40.380191  176.207375  120.52509
#> A[T>A]C 2.160929e+01  184.66354   35.452354  183.943184  164.97223
#> A[T>A]G 1.005536e+02  223.40107   57.061578  153.156016  158.48139
#> A[T>A]T 5.196649e+00  178.04216   72.976932  225.995616  198.19835
#> C[T>A]A 1.031591e+01  178.96767    4.101657   69.662794   91.91138
#> C[T>A]C 7.133643e+01  258.40038  146.588241  183.514312  188.51210
#> C[T>A]G 1.508386e+02  241.73351  104.706117  199.029485  186.53684
#> C[T>A]T 5.950672e+01  450.47718  448.413420  159.310090  200.94527
#> G[T>A]A 4.023947e+01  132.03257   15.449153  135.074786   84.25939
#> G[T>A]C 4.059007e+01  144.93827   41.140153  122.359928   73.99045
#> G[T>A]G 2.666966e+01  206.97926   58.077096  108.049975   95.89027
#> G[T>A]T 1.039028e+02  162.86845   96.512208  139.668975  110.51575
#> T[T>A]A 1.479951e+02  177.40016   59.351331  101.861911   83.66533
#> T[T>A]C 3.988944e+01  221.61403   76.704589   99.678627  156.37407
#> T[T>A]G 4.386895e+01  131.16375   13.215947  112.645471   70.52114
#> T[T>A]T 9.197887e+01  404.64818   62.262232  159.609253  246.15917
#> A[T>C]A 1.191110e+02  335.01932   65.429821  530.206594  227.30323
#> A[T>C]C 3.904971e+01  159.92207  171.022183  136.603821  200.82597
#> A[T>C]G 1.352414e+02  311.18862  113.133780  613.917569  265.01951
#> A[T>C]T 1.187246e+02  354.08441  101.227039  455.991338  259.04444
#> C[T>C]A 3.547481e+01  178.23633  131.679803  173.902849  159.88132
#> C[T>C]C 1.181216e+02  353.55559  565.016939  165.869156  199.39352
#> C[T>C]G 8.349381e+01  349.37968  411.872251  602.032977  266.30015
#> C[T>C]T 9.314132e+01  515.71853 1405.308433  205.208256  138.86411
#> G[T>C]A 2.096227e+01  129.66327   24.431083  236.377912  202.21432
#> G[T>C]C 8.448178e+01  136.57622  155.816136  185.699517  116.65866
#> G[T>C]G 2.165845e+02  111.21861  116.556976  262.845807  110.23349
#> G[T>C]T 1.712354e+02  184.11356  153.641728  162.856944  144.86920
#> T[T>C]A 3.227932e+01  142.89343   39.611581  187.313337  144.31734
#> T[T>C]C 2.064432e+02  238.07017  205.195362  115.366520  204.09146
#> T[T>C]G 4.401696e+01   96.63450  113.903142  192.806438  146.76799
#> T[T>C]T 4.759346e+01  169.16982  133.755945  196.920385  184.60302
#> A[T>G]A 4.033890e+00   40.36780   11.242104   66.646853   27.33252
#> A[T>G]C 6.087864e+01   48.52501  106.739107   55.313219   25.22731
#> A[T>G]G 5.545958e+01  158.65964   72.653213   85.767824  107.17091
#> A[T>G]T 7.122083e+01  237.06369  438.170763   63.674406   78.92264
#> C[T>G]A 1.443062e-12   44.97803    7.262841   16.753545   22.04673
#> C[T>G]C 5.585688e+01  169.31173  273.464660   81.668878   73.01694
#> C[T>G]G 1.619524e+02  222.54191  236.659074  181.248153  202.89875
#> C[T>G]T 1.808814e+02 1014.28261 3612.855255  162.959024   11.20453
#> G[T>G]A 5.097588e+01   67.23368   15.831875   26.673109   40.87270
#> G[T>G]C 1.208215e+00   88.11666  129.743115   32.569949   57.50406
#> G[T>G]G 3.286240e+02  240.69052  135.338848  109.371542  165.10136
#> G[T>G]T 1.089361e+02  326.61030  840.187207   82.431326   82.28797
#> T[T>G]A 9.813250e+00   97.48130   11.504350   83.856599   71.65787
#> T[T>G]C 9.185830e+01  123.56889  152.977572   86.260669  107.28512
#> T[T>G]G 3.350509e+01  226.00057   86.625452   88.302890  110.06536
#> T[T>G]T 3.225139e+01  521.83563  761.382232  264.138090  175.67229
#> 
#> $Signature.norm
#>                 Sig1         Sig2        Sig3        Sig4         Sig5
#> A[C>A]A 6.714744e-03 0.0070443097 0.011013137 0.017684877 0.0108444883
#> A[C>A]C 2.668050e-03 0.0051332270 0.009452426 0.011258936 0.0064953234
#> A[C>A]G 1.878004e-03 0.0011433259 0.001788339 0.001974612 0.0010211813
#> A[C>A]T 4.202417e-03 0.0043728252 0.007821422 0.012205750 0.0049917763
#> C[C>A]A 8.341249e-03 0.0075751968 0.008612940 0.022411495 0.0037736757
#> C[C>A]C 6.486458e-03 0.0072460163 0.006347576 0.014952765 0.0029463516
#> C[C>A]G 2.570088e-03 0.0015676634 0.001735215 0.002275630 0.0019252882
#> C[C>A]T 3.804840e-03 0.0066000415 0.005688955 0.011473720 0.0064152924
#> G[C>A]A 4.840682e-03 0.0018969062 0.006072163 0.017161012 0.0083485461
#> G[C>A]C 4.317145e-03 0.0041407367 0.008228778 0.008712368 0.0068376923
#> G[C>A]G 1.422817e-03 0.0007870193 0.001646851 0.001418821 0.0009659619
#> G[C>A]T 4.630688e-04 0.0030040043 0.007448018 0.012053545 0.0071383433
#> T[C>A]A 1.303543e-02 0.0229222728 0.022256629 0.014787253 0.0121389593
#> T[C>A]C 1.013358e-02 0.0129787080 0.013623367 0.017653224 0.0103686778
#> T[C>A]G 2.286781e-03 0.0018310520 0.003796340 0.002998377 0.0026745613
#> T[C>A]T 7.792065e-03 0.0099038519 0.015127884 0.016574901 0.0136086717
#> A[C>G]A 3.529413e-03 0.0065470243 0.014586538 0.012685685 0.0062907618
#> A[C>G]C 1.812721e-03 0.0033242574 0.007432304 0.006145210 0.0054836684
#> A[C>G]G 6.067163e-04 0.0008508129 0.002681604 0.003322763 0.0014825952
#> A[C>G]T 3.618764e-03 0.0071905401 0.013217260 0.014638493 0.0074043371
#> C[C>G]A 3.144085e-03 0.0058174479 0.009856711 0.010858166 0.0043274412
#> C[C>G]C 3.396920e-03 0.0035278849 0.007458267 0.008283465 0.0038515909
#> C[C>G]G 6.834623e-04 0.0007025615 0.002643583 0.002525648 0.0013597108
#> C[C>G]T 3.520381e-03 0.0068536218 0.012800121 0.016696964 0.0050537474
#> G[C>G]A 2.224784e-03 0.0030012516 0.005966458 0.007107254 0.0026916513
#> G[C>G]C 1.582465e-03 0.0026206963 0.006039804 0.006234311 0.0058035652
#> G[C>G]G 2.068983e-04 0.0003672956 0.001189599 0.001016280 0.0005364872
#> G[C>G]T 1.827506e-03 0.0039425397 0.007731568 0.010337137 0.0034169337
#> T[C>G]A 4.243730e-02 0.1178939434 0.061830204 0.021125956 0.0001276519
#> T[C>G]C 1.195762e-02 0.0304243444 0.022087731 0.015529488 0.0042273295
#> T[C>G]G 1.678599e-03 0.0042584064 0.003597948 0.001823514 0.0006793516
#> T[C>G]T 5.084444e-02 0.1389690939 0.080513294 0.033825817 0.0030877799
#> A[C>T]A 1.069093e-02 0.0098789295 0.018747990 0.014642375 0.0298045291
#> A[C>T]C 6.202155e-03 0.0033705377 0.009355771 0.006634194 0.0165138533
#> A[C>T]G 7.599627e-04 0.0009873728 0.026639514 0.007130624 0.1441662650
#> A[C>T]T 6.730897e-03 0.0065170816 0.012958017 0.011069262 0.0136511486
#> C[C>T]A 2.040096e-02 0.0117557881 0.017373526 0.012493402 0.0236344396
#> C[C>T]C 1.253020e-02 0.0057774325 0.014183028 0.007457394 0.0201065787
#> C[C>T]G 2.590624e-03 0.0022435307 0.014798462 0.009778535 0.0814497087
#> C[C>T]T 1.656729e-02 0.0108689351 0.013880992 0.015246628 0.0219310362
#> G[C>T]A 1.363445e-02 0.0090453971 0.015879689 0.011044801 0.0291640310
#> G[C>T]C 9.541589e-03 0.0068403236 0.011507675 0.007357529 0.0306202032
#> G[C>T]G 2.781264e-03 0.0019708699 0.013021413 0.002844960 0.0898345608
#> G[C>T]T 1.259638e-02 0.0086825002 0.012712614 0.006649153 0.0212365951
#> T[C>T]A 3.563749e-02 0.0481401803 0.030489786 0.004714844 0.0133600610
#> T[C>T]C 1.489025e-02 0.0108593848 0.019063685 0.010138385 0.0210130133
#> T[C>T]G 3.220099e-03 0.0015404044 0.012223873 0.003326764 0.0621342595
#> T[C>T]T 1.634415e-02 0.0144249805 0.016151598 0.005717720 0.0128950083
#> A[T>A]A 5.848803e-03 0.0046369389 0.005987121 0.006924593 0.0047990836
#> A[T>A]C 5.123310e-03 0.0043274074 0.006339814 0.005936363 0.0028033349
#> A[T>A]G 4.588224e-03 0.0037000218 0.008281312 0.005759436 0.0053023528
#> A[T>A]T 4.534183e-03 0.0063134407 0.008168623 0.004858991 0.0082207520
#> C[T>A]A 1.845759e-03 0.0019581853 0.004404316 0.004088549 0.0018912552
#> C[T>A]C 5.806013e-03 0.0058919565 0.005116941 0.010057300 0.0009782504
#> C[T>A]G 3.947880e-03 0.0027266485 0.007617879 0.006518666 0.0043611914
#> C[T>A]T 4.697111e-03 0.0038426390 0.008445125 0.013041647 0.0037260357
#> G[T>A]A 1.446680e-03 0.0009450981 0.004410261 0.003061152 0.0026248922
#> G[T>A]C 2.986008e-03 0.0030922044 0.002966292 0.004141425 0.0015178545
#> G[T>A]G 2.934736e-03 0.0022516508 0.006013066 0.004922058 0.0027079864
#> G[T>A]T 2.129209e-03 0.0028520713 0.003729056 0.007605022 0.0007551720
#> T[T>A]A 4.648530e-03 0.0032625691 0.007419412 0.005524177 0.0065075505
#> T[T>A]C 1.090098e-02 0.0071819130 0.005562384 0.008627718 0.0015728777
#> T[T>A]G 3.647050e-03 0.0030843984 0.006244390 0.005778522 0.0017729856
#> T[T>A]T 7.062523e-03 0.0068424561 0.008551118 0.010322164 0.0025372244
#> A[T>C]A 4.077056e-02 0.0255635383 0.020695992 0.019644998 0.0184171121
#> A[T>C]C 2.387011e-02 0.0160341395 0.010453125 0.015635295 0.0048010126
#> A[T>C]G 4.022672e-02 0.0250080395 0.017320494 0.022140706 0.0120719020
#> A[T>C]T 2.456748e-02 0.0151623147 0.020012135 0.013704688 0.0108753289
#> C[T>C]A 2.519604e-02 0.0156092336 0.008568698 0.014062467 0.0050998648
#> C[T>C]C 2.793665e-02 0.0199829629 0.008792765 0.023098637 0.0027930397
#> C[T>C]G 3.480714e-02 0.0207201340 0.010599121 0.017721736 0.0080903070
#> C[T>C]T 2.613611e-02 0.0160280599 0.011228382 0.022852039 0.0072310190
#> G[T>C]A 4.509983e-02 0.0293680932 0.010316888 0.023151991 0.0062318446
#> G[T>C]C 2.052263e-02 0.0134891247 0.005331813 0.014128714 0.0035632117
#> G[T>C]G 3.199194e-02 0.0207411301 0.008485204 0.016728365 0.0037165519
#> G[T>C]T 3.237939e-02 0.0206522455 0.011616798 0.018375569 0.0069911470
#> T[T>C]A 4.024354e-02 0.0249039178 0.011677901 0.020122616 0.0059546613
#> T[T>C]C 2.744867e-02 0.0175283797 0.010181346 0.017269322 0.0046593827
#> T[T>C]G 2.499221e-02 0.0180551327 0.009008375 0.013324682 0.0066348593
#> T[T>C]T 3.101973e-02 0.0190799601 0.011272241 0.016995967 0.0049901055
#> A[T>G]A 1.738741e-03 0.0012891294 0.002447997 0.001647615 0.0019429212
#> A[T>G]C 5.603887e-04 0.0008272892 0.001636789 0.001698571 0.0018057899
#> A[T>G]G 1.540888e-03 0.0026056097 0.004063937 0.006023988 0.0042585765
#> A[T>G]T 2.340882e-03 0.0021415944 0.003399764 0.005635156 0.0032752150
#> C[T>G]A 1.299297e-03 0.0005943313 0.001753389 0.001478755 0.0006888606
#> C[T>G]C 3.882152e-03 0.0030504770 0.003076258 0.006460693 0.0026525892
#> C[T>G]G 4.278988e-03 0.0035171361 0.005262728 0.007513885 0.0044746952
#> C[T>G]T 2.768471e-03 0.0013521020 0.005078980 0.025166251 0.0036828507
#> G[T>G]A 3.134337e-04 0.0006051913 0.001501838 0.002323458 0.0008937109
#> G[T>G]C 1.581823e-05 0.0005654915 0.001052993 0.003423481 0.0003260169
#> G[T>G]G 1.283198e-03 0.0036426955 0.008106156 0.010937239 0.0030755801
#> G[T>G]T 1.938235e-03 0.0019914858 0.001949606 0.009740813 0.0012274704
#> T[T>G]A 2.239748e-03 0.0022685426 0.004545048 0.003739540 0.0027913751
#> T[T>G]C 2.753271e-03 0.0023656739 0.004788050 0.004909587 0.0030796233
#> T[T>G]G 1.702656e-03 0.0022183143 0.005969082 0.007596053 0.0034624082
#> T[T>G]T 2.839907e-03 0.0027864029 0.011268331 0.011579332 0.0103274820
#>                 Sig6         Sig7         Sig8         Sig9        Sig10
#> A[C>A]A 3.826092e-02 4.724913e-02 0.0178120539 0.0134224026 0.0120391543
#> A[C>A]C 3.836599e-02 8.241573e-03 0.0139272839 0.0033603340 0.0065572390
#> A[C>A]G 2.094793e-03 1.877803e-03 0.0012102579 0.0007943677 0.0015375507
#> A[C>A]T 3.641442e-02 1.588556e-02 0.0153677237 0.0065087852 0.0066336276
#> C[C>A]A 2.691809e-02 8.740133e-02 0.0131271236 0.0239850321 0.0155614286
#> C[C>A]C 2.733726e-02 1.811442e-02 0.0141389819 0.0052437058 0.0188099457
#> C[C>A]G 1.666300e-04 1.669183e-02 0.0024383188 0.0049664365 0.0068906550
#> C[C>A]T 2.765704e-02 3.358228e-02 0.0206655765 0.0087933355 0.0475854887
#> G[C>A]A 1.949879e-02 1.262603e-01 0.0070080108 0.0378816538 0.0127253347
#> G[C>A]C 1.538800e-02 1.438300e-02 0.0097578021 0.0053342788 0.0082831210
#> G[C>A]G 6.004324e-04 8.823974e-03 0.0017669051 0.0033750579 0.0028465644
#> G[C>A]T 1.999634e-02 6.981223e-02 0.0108119313 0.0216895840 0.0116465007
#> T[C>A]A 2.724107e-02 6.623871e-02 0.0064147522 0.0293409653 0.0129661113
#> T[C>A]C 1.582204e-02 4.164323e-02 0.0094472583 0.0153243751 0.0100660933
#> T[C>A]G 3.532825e-04 1.443802e-02 0.0021500240 0.0056357803 0.0014633689
#> T[C>A]T 3.517898e-02 1.157670e-01 0.0168354080 0.0376292317 0.0200493195
#> A[C>G]A 9.645533e-03 1.031817e-03 0.0146673491 0.0014754693 0.0080881830
#> A[C>G]C 5.135836e-03 2.209190e-03 0.0078484306 0.0022226966 0.0042084412
#> A[C>G]G 1.451011e-10 2.597836e-03 0.0027287740 0.0008169172 0.0019582682
#> A[C>G]T 7.897040e-03 2.668708e-03 0.0127185089 0.0032522025 0.0080256929
#> C[C>G]A 5.796642e-03 5.780703e-04 0.0086263852 0.0021906998 0.0033531303
#> C[C>G]C 5.310799e-03 2.752022e-03 0.0090260821 0.0017172840 0.0044565670
#> C[C>G]G 6.237546e-04 4.876815e-03 0.0018590308 0.0018933333 0.0012296529
#> C[C>G]T 6.274642e-03 5.001674e-03 0.0136617543 0.0040023620 0.0056625123
#> G[C>G]A 4.179727e-03 6.368407e-04 0.0059739128 0.0014569313 0.0031583787
#> G[C>G]C 3.233020e-03 1.317224e-04 0.0061827944 0.0008831625 0.0039056820
#> G[C>G]G 3.580418e-05 4.119368e-04 0.0008530248 0.0002924218 0.0003746795
#> G[C>G]T 6.478774e-03 1.438490e-03 0.0096749059 0.0017629033 0.0044325580
#> T[C>G]A 2.323334e-03 3.415215e-03 0.0060449161 0.0762079493 0.0022918252
#> T[C>G]C 1.698423e-03 7.502304e-03 0.0110975814 0.0194681430 0.0054747614
#> T[C>G]G 2.484306e-08 1.419331e-03 0.0012534141 0.0032769414 0.0008197758
#> T[C>G]T 1.846115e-03 9.024908e-03 0.0151944796 0.0888325266 0.0040744115
#> A[C>T]A 2.370786e-02 2.496054e-03 0.0176940316 0.0059672125 0.0258842538
#> A[C>T]C 6.582582e-03 1.919727e-03 0.0095584856 0.0033897338 0.0154495286
#> A[C>T]G 2.088552e-02 4.928558e-03 0.0222072201 0.0069633459 0.0321735112
#> A[C>T]T 2.253107e-02 3.322242e-03 0.0153794057 0.0042141857 0.0165521323
#> C[C>T]A 4.345598e-03 1.250457e-02 0.0168959988 0.0138731641 0.0129481390
#> C[C>T]C 3.165979e-03 5.384920e-03 0.0103419142 0.0033736149 0.0119390229
#> C[C>T]G 2.821050e-03 1.344941e-02 0.0227772235 0.0081081701 0.0440187948
#> C[C>T]T 2.145700e-02 6.152561e-03 0.0164242241 0.0070786229 0.0142299520
#> G[C>T]A 1.312104e-03 1.343438e-03 0.0220089101 0.0025389091 0.0464856158
#> G[C>T]C 2.315119e-05 1.748582e-03 0.0192937463 0.0004127408 0.0548388272
#> G[C>T]G 8.744178e-03 5.723040e-03 0.0300244012 0.0054582906 0.0714191409
#> G[C>T]T 6.928898e-03 1.529667e-03 0.0167362519 0.0005565121 0.0408701927
#> T[C>T]A 5.823772e-03 4.532300e-02 0.0442265088 0.0314452596 0.0070663450
#> T[C>T]C 2.253999e-03 1.611109e-02 0.0201997571 0.0120215042 0.0147789197
#> T[C>T]G 5.537855e-03 1.261871e-02 0.0148908088 0.0108637349 0.0157875262
#> T[C>T]T 9.974362e-03 2.076265e-02 0.0325808186 0.0110713497 0.0058688621
#> A[T>A]A 1.423292e-02 2.141479e-03 0.0074303693 0.0014631776 0.0066818314
#> A[T>A]C 1.272471e-02 6.333448e-04 0.0064094606 0.0012846173 0.0069751754
#> A[T>A]G 1.540660e-02 2.947117e-03 0.0077539962 0.0020676282 0.0058077176
#> A[T>A]T 3.217455e-02 1.523081e-04 0.0061796402 0.0026443216 0.0085698150
#> C[T>A]A 1.444728e-02 3.023481e-04 0.0062117635 0.0001486237 0.0026416320
#> C[T>A]C 2.100183e-02 2.090793e-03 0.0089687822 0.0053116300 0.0069589124
#> C[T>A]G 1.961117e-02 4.420913e-03 0.0083902941 0.0037940298 0.0075472520
#> C[T>A]T 2.846925e-02 1.744077e-03 0.0156355488 0.0162482758 0.0060410818
#> G[T>A]A 1.003547e-02 1.179375e-03 0.0045826999 0.0005598006 0.0051220725
#> G[T>A]C 8.060601e-03 1.189650e-03 0.0050306421 0.0014907148 0.0046399216
#> G[T>A]G 8.900403e-03 7.816584e-04 0.0071840138 0.0021044256 0.0040972843
#> G[T>A]T 2.037261e-02 3.045276e-03 0.0056529781 0.0034971232 0.0052962854
#> T[T>A]A 1.887312e-02 4.337576e-03 0.0061573573 0.0021505975 0.0038626313
#> T[T>A]C 1.175052e-02 1.169116e-03 0.0076919701 0.0027793934 0.0037798405
#> T[T>A]G 9.486536e-03 1.285751e-03 0.0045525439 0.0004788803 0.0042715468
#> T[T>A]T 2.992503e-02 2.695800e-03 0.0140448765 0.0022560741 0.0060524261
#> A[T>C]A 1.897613e-02 3.491014e-03 0.0116281383 0.0023708518 0.0201055777
#> A[T>C]C 9.644984e-03 1.144504e-03 0.0055507127 0.0061969947 0.0051800539
#> A[T>C]G 8.834625e-03 3.963776e-03 0.0108010017 0.0040994064 0.0232799206
#> A[T>C]T 2.660401e-02 3.479688e-03 0.0122898657 0.0036679653 0.0172913151
#> C[T>C]A 4.449973e-03 1.039728e-03 0.0061863797 0.0047714222 0.0065944432
#> C[T>C]C 7.738710e-03 3.462014e-03 0.0122715112 0.0204734083 0.0062898033
#> C[T>C]G 2.261935e-03 2.447112e-03 0.0121265701 0.0149242053 0.0228292536
#> C[T>C]T 1.011002e-02 2.729870e-03 0.0179000016 0.0509213996 0.0077815527
#> G[T>C]A 3.379184e-03 6.143812e-04 0.0045004640 0.0008852611 0.0089635145
#> G[T>C]C 6.094640e-03 2.476069e-03 0.0047404046 0.0056460031 0.0070417760
#> G[T>C]G 4.415338e-03 6.347855e-03 0.0038602710 0.0042234461 0.0099671842
#> G[T>C]T 4.797926e-03 5.018722e-03 0.0063903717 0.0055672133 0.0061755795
#> T[T>C]A 3.437703e-03 9.460714e-04 0.0049596680 0.0014353270 0.0071029725
#> T[T>C]C 5.192531e-03 6.050624e-03 0.0082631437 0.0074352610 0.0043747297
#> T[T>C]G 6.655287e-04 1.290089e-03 0.0033540732 0.0041272843 0.0073112724
#> T[T>C]T 9.884785e-03 1.394912e-03 0.0058716913 0.0048466513 0.0074672744
#> A[T>G]A 5.658475e-03 1.182289e-04 0.0014011203 0.0004073580 0.0025272667
#> A[T>G]C 8.513284e-04 1.784286e-03 0.0016842477 0.0038676952 0.0020974923
#> A[T>G]G 8.160365e-03 1.625460e-03 0.0055068951 0.0026325917 0.0032523391
#> A[T>G]T 2.151774e-03 2.087405e-03 0.0082282101 0.0158771327 0.0024145507
#> C[T>G]A 3.266457e-03 4.229457e-17 0.0015611360 0.0002631693 0.0006352990
#> C[T>G]C 1.932827e-03 1.637104e-03 0.0058766170 0.0099090014 0.0030969060
#> C[T>G]G 6.208937e-03 4.746647e-03 0.0077241759 0.0085753497 0.0068729791
#> C[T>G]T 1.801532e-03 5.301436e-03 0.0352045920 0.1309119350 0.0061794503
#> G[T>G]A 5.198928e-04 1.494047e-03 0.0023336045 0.0005736685 0.0010114515
#> G[T>G]C 1.696518e-04 3.541146e-05 0.0030584286 0.0047012463 0.0012350613
#> G[T>G]G 5.370159e-03 9.631609e-03 0.0083540934 0.0049040078 0.0041473985
#> G[T>G]T 4.921895e-03 3.192798e-03 0.0113362707 0.0304442125 0.0031258182
#> T[T>G]A 1.667187e-03 2.876156e-04 0.0033834647 0.0004168605 0.0031798650
#> T[T>G]C 2.507839e-03 2.692266e-03 0.0042889353 0.0055431476 0.0032710279
#> T[T>G]G 5.720718e-03 9.819975e-04 0.0078442218 0.0031388763 0.0033484695
#> T[T>G]T 9.261816e-03 9.452530e-04 0.0181123193 0.0275887115 0.0100161880
#>                Sig11
#> A[C>A]A 0.0119643388
#> A[C>A]C 0.0113081129
#> A[C>A]G 0.0021554124
#> A[C>A]T 0.0095026398
#> C[C>A]A 0.0140018781
#> C[C>A]C 0.0112085274
#> C[C>A]G 0.0033745855
#> C[C>A]T 0.0216049082
#> G[C>A]A 0.0075259551
#> G[C>A]C 0.0086974062
#> G[C>A]G 0.0011124183
#> G[C>A]T 0.0088701419
#> T[C>A]A 0.0139543764
#> T[C>A]C 0.0131944655
#> T[C>A]G 0.0019420151
#> T[C>A]T 0.0177088881
#> A[C>G]A 0.0106766175
#> A[C>G]C 0.0056850823
#> A[C>G]G 0.0017416306
#> A[C>G]T 0.0107718592
#> C[C>G]A 0.0078516501
#> C[C>G]C 0.0056832804
#> C[C>G]G 0.0019173927
#> C[C>G]T 0.0100487174
#> G[C>G]A 0.0057315401
#> G[C>G]C 0.0031656594
#> G[C>G]G 0.0009532399
#> G[C>G]T 0.0079408169
#> T[C>G]A 0.0252838614
#> T[C>G]C 0.0100958922
#> T[C>G]G 0.0016943186
#> T[C>G]T 0.0427654345
#> A[C>T]A 0.0146486965
#> A[C>T]C 0.0077349315
#> A[C>T]G 0.0087236363
#> A[C>T]T 0.0140504467
#> C[C>T]A 0.0111932318
#> C[C>T]C 0.0059472256
#> C[C>T]G 0.0145907664
#> C[C>T]T 0.0085889933
#> G[C>T]A 0.0177498640
#> G[C>T]C 0.0163100076
#> G[C>T]G 0.0192857634
#> G[C>T]T 0.0151724714
#> T[C>T]A 0.1434999874
#> T[C>T]C 0.0329228076
#> T[C>T]G 0.0171585190
#> T[C>T]T 0.0815654393
#> A[T>A]A 0.0047901312
#> A[T>A]C 0.0065566317
#> A[T>A]G 0.0062986608
#> A[T>A]T 0.0078771656
#> C[T>A]A 0.0036529121
#> C[T>A]C 0.0074921966
#> C[T>A]G 0.0074136921
#> C[T>A]T 0.0079863388
#> G[T>A]A 0.0033487924
#> G[T>A]C 0.0029406654
#> G[T>A]G 0.0038110484
#> G[T>A]T 0.0043923215
#> T[T>A]A 0.0033251823
#> T[T>A]C 0.0062149076
#> T[T>A]G 0.0028027817
#> T[T>A]T 0.0097833133
#> A[T>C]A 0.0090339055
#> A[T>C]C 0.0079815971
#> A[T>C]G 0.0105328956
#> A[T>C]T 0.0102954236
#> C[T>C]A 0.0063542993
#> C[T>C]C 0.0079246661
#> C[T>C]G 0.0105837934
#> C[T>C]T 0.0055189942
#> G[T>C]A 0.0080367755
#> G[T>C]C 0.0046364642
#> G[T>C]G 0.0043811033
#> G[T>C]T 0.0057576598
#> T[T>C]A 0.0057357268
#> T[T>C]C 0.0081113805
#> T[T>C]G 0.0058331252
#> T[T>C]T 0.0073368347
#> A[T>G]A 0.0010862997
#> A[T>G]C 0.0010026306
#> A[T>G]G 0.0042593846
#> A[T>G]T 0.0031366896
#> C[T>G]A 0.0008762220
#> C[T>G]C 0.0029019742
#> C[T>G]G 0.0080639777
#> C[T>G]T 0.0004453111
#> G[T>G]A 0.0016244383
#> G[T>G]C 0.0022854326
#> G[T>G]G 0.0065617637
#> G[T>G]T 0.0032704409
#> T[T>G]A 0.0028479597
#> T[T>G]C 0.0042639236
#> T[T>G]G 0.0043744212
#> T[T>G]T 0.0069818933
#> 
#> $Exposure
#>        Sample_2   Sample_3  Sample_4     Sample_5  Sample_6   Sample_7
#> Sig1  2892.6085 1438.31588 2144.9114 3.666354e+02  99.63291 137.893150
#> Sig2  3513.9127 1630.36643 2593.6703 5.099705e+02  35.87441 206.990635
#> Sig3   883.1682  999.82449 1620.5006 2.200093e+02  62.56996 136.248454
#> Sig4   613.7551  381.77322 1432.5917 3.561856e+01  61.76187  47.319553
#> Sig5   681.6584  996.24499  258.9395 5.827967e+00  84.75080  85.340279
#> Sig6  2736.6553    5.33738  173.6779 2.305192e-11 129.05447   8.009669
#> Sig7   772.0221  414.59774  518.4493 5.527642e+02 273.26348 326.195505
#> Sig8  1427.0286  961.67686  411.5051 1.636235e+02 212.96144 108.651649
#> Sig9   816.6163  563.91365  748.6491 2.449189e+02  44.50443 238.489037
#> Sig10 1867.2844 2427.52364  369.7361 2.104454e-11 227.89468 237.757576
#> Sig11 2619.2959  950.43175  313.4014 5.956370e+02 380.72101  64.108139
#>         Sample_8    Sample_9 Sample_10 Sample_11 Sample_13  Sample_14 Sample_15
#> Sig1    89.93212  488.793291  905.4543  776.4751 348.97759 1016.18747 1460.2398
#> Sig2    31.35218  598.472660  472.9686  463.9699 479.85092  769.99088 1689.8349
#> Sig3   251.11465  861.183926  970.2283  720.3104 185.36715  355.95277 1666.7762
#> Sig4   108.58510 1235.038937  462.9401  119.2712 111.28595  196.68282  834.4780
#> Sig5  1009.90122  236.079620  436.4380 1091.2295  34.94721  145.36836  884.3407
#> Sig6    90.69113   60.886372 2410.8005  243.0323 273.73171   67.65131  310.1513
#> Sig7   440.48911    8.771324 1211.6532  130.4269 261.79152  225.22257  619.3689
#> Sig8    74.70018 1188.665460  938.4633  462.4500  75.00998  321.96583  766.1233
#> Sig9    79.56263 3007.538680  299.7510  167.8243 178.97157  160.12889 1782.2534
#> Sig10   57.18481  229.424132  464.3371  586.7409  50.61674  232.50772  572.2277
#> Sig11  158.47136  209.090714 1139.9931  494.2835 116.45055  719.36049  202.2660
#>       Sample_16 Sample_18 Sample_20 Sample_21  Sample_23  Sample_25  Sample_26
#> Sig1   934.2772  160.1461 480.89236  686.2181   98.51086  209.63011  151.50822
#> Sig2   879.5054  340.8865 280.00483 1764.4183   26.83737   19.20814  334.19769
#> Sig3   755.1573  241.5888  93.86510 1550.0272  129.18451  265.97631  305.58491
#> Sig4  1081.1668  404.8437 187.53047 1562.8443  175.31600  442.56548  199.63635
#> Sig5   130.6072  284.1178 302.04813  385.5179  214.21455 1262.10468 1358.37761
#> Sig6   205.8966 1624.0754  71.94879 3375.6279  446.89891   27.27933  516.71080
#> Sig7  2249.0159  115.2477 703.74847  214.4457 1509.37124 3176.21408   18.33754
#> Sig8   230.3227  615.8694 109.10612 1382.4526  320.41983  929.48746  662.46444
#> Sig9   588.9454 1461.3680 264.78930  525.8701  764.31524 2347.32498  506.38697
#> Sig10  317.4797  178.5133  92.59464  690.8966  603.39723  714.40765 1536.45567
#> Sig11  353.5959  145.2997  10.46747 1193.6668  123.51717  767.71390  355.27864
#>       Sample_27 Sample_28 Sample_29 Sample_30   Sample_1 Sample_12   Sample_17
#> Sig1  2128.2169 381.74682 441.29878 455.58574  6839.9396  7947.486 5275.766766
#> Sig2  2431.8323 147.91176 313.35221 316.96902  6459.2051  6858.115 3129.978687
#> Sig3   840.3103 286.50832 159.07111  21.13038  2722.7947  5464.118 1323.193417
#> Sig4   634.5028 206.81553 377.59857 245.44283  6487.6336  8892.051 2110.857319
#> Sig5   235.9003 186.55398 453.89135 150.34295   604.8369  1415.254 7304.314115
#> Sig6  1579.0797 194.60556 639.58753 560.70139 10107.1512  1325.049    4.146147
#> Sig7   667.4846 912.54872  66.25600  26.37378   952.4554  7312.888  559.804630
#> Sig8   408.5010 174.18293 384.03014 268.64216  3527.7995  2818.241 1671.982139
#> Sig9   604.7606 201.24096 709.88011 245.75308  1172.6965  2710.134 1397.714490
#> Sig10  257.2629 204.38831  54.05094 524.62055  1185.7381  1853.601 2977.616059
#> Sig11  302.2091  76.50792  48.95576 103.42140  2699.6698  3371.060 1916.421730
#>       Sample_19 Sample_22 Sample_24
#> Sig1  5949.4895 4440.5748  5563.813
#> Sig2  3715.5190 1911.4240  7325.591
#> Sig3  3370.2751 6739.2437  7930.720
#> Sig4  2583.7245 3218.1267  4697.443
#> Sig5  4702.6021 7760.7238  2369.467
#> Sig6  1899.4088 2889.8528  2651.562
#> Sig7  5755.0451  419.3292  3705.740
#> Sig8   986.0466 4175.0721  3033.644
#> Sig9  1901.6070  727.1271  3134.564
#> Sig10 1259.3749 3983.8709  2613.616
#> Sig11  768.9564 2090.7489  2870.124
#> 
#> $Exposure.norm
#>         Sample_2     Sample_3   Sample_4     Sample_5   Sample_6    Sample_7
#> Sig1  0.15366594 0.1335482891 0.20261712 1.360426e-01 0.06176910 0.086344919
#> Sig2  0.18667189 0.1513802711 0.24500872 1.892280e-01 0.02224094 0.129611874
#> Sig3  0.04691712 0.0928341628 0.15307913 8.163593e-02 0.03879130 0.085315055
#> Sig4  0.03260491 0.0354478183 0.13532848 1.321651e-02 0.03829031 0.029630210
#> Sig5  0.03621218 0.0925018045 0.02446049 2.162507e-03 0.05254269 0.053437748
#> Sig6  0.14538114 0.0004955782 0.01640633 8.553571e-15 0.08000949 0.005015436
#> Sig7  0.04101264 0.0384955900 0.04897485 2.051069e-01 0.16941430 0.204254703
#> Sig8  0.07580898 0.0892921373 0.03887246 6.071361e-02 0.13202903 0.068034691
#> Sig9  0.04338164 0.0523596412 0.07072046 9.087881e-02 0.02759127 0.149335311
#> Sig10 0.09919697 0.2253966837 0.03492679 7.808719e-15 0.14128715 0.148877291
#> Sig11 0.13914658 0.0882480240 0.02960518 2.210151e-01 0.23603441 0.040142763
#>         Sample_8    Sample_9  Sample_10  Sample_11  Sample_13  Sample_14
#> Sig1  0.03759728 0.060166986 0.09322060 0.14773080 0.16484527 0.24131628
#> Sig2  0.01310718 0.073667738 0.04869426 0.08827409 0.22666543 0.18285143
#> Sig3  0.10498172 0.106005631 0.09988938 0.13704499 0.08756121 0.08452889
#> Sig4  0.04539540 0.152024530 0.04766177 0.02269233 0.05256774 0.04670670
#> Sig5  0.42220225 0.029059726 0.04493326 0.20761541 0.01650789 0.03452094
#> Sig6  0.03791460 0.007494680 0.24820278 0.04623890 0.12930165 0.01606531
#> Sig7  0.18415216 0.001079688 0.12474517 0.02481480 0.12366151 0.05348410
#> Sig8  0.03122938 0.146316284 0.09661903 0.08798492 0.03543219 0.07645794
#> Sig9  0.03326219 0.370206671 0.03086071 0.03192996 0.08454015 0.03802616
#> Sig10 0.02390685 0.028240483 0.04780560 0.11163229 0.02390965 0.05521412
#> Sig11 0.06625100 0.025737583 0.11736744 0.09404151 0.05500732 0.17082812
#>        Sample_15  Sample_16  Sample_18   Sample_20  Sample_21   Sample_23
#> Sig1  0.13535703 0.12092684 0.02874144 0.185172566 0.05147156 0.022328024
#> Sig2  0.15663936 0.11383754 0.06117896 0.107818750 0.13234475 0.006082837
#> Sig3  0.15450194 0.09774272 0.04335799 0.036143725 0.11626379 0.029280375
#> Sig4  0.07735200 0.13993929 0.07265737 0.072210544 0.11722517 0.039736328
#> Sig5  0.08197403 0.01690496 0.05099067 0.116306752 0.02891677 0.048552896
#> Sig6  0.02874950 0.02664993 0.29147310 0.027704626 0.25319769 0.101292076
#> Sig7  0.05741244 0.29109818 0.02068352 0.270985615 0.01608505 0.342107228
#> Sig8  0.07101585 0.02981150 0.11053019 0.042012437 0.10369443 0.072624903
#> Sig9  0.16520610 0.07622931 0.26227197 0.101959855 0.03944424 0.173236219
#> Sig10 0.05304269 0.04109254 0.03203781 0.035654522 0.05182248 0.136763274
#> Sig11 0.01874906 0.04576719 0.02607697 0.004030609 0.08953406 0.027995840
#>         Sample_25   Sample_26  Sample_27  Sample_28  Sample_29   Sample_30
#> Sig1  0.020629002 0.025485244 0.21092211 0.12840412 0.12097097 0.156076860
#> Sig2  0.001890210 0.056215497 0.24101266 0.04975151 0.08589763 0.108588843
#> Sig3  0.026173844 0.051402532 0.08328100 0.09636975 0.04360535 0.007238951
#> Sig4  0.043551398 0.033580893 0.06288394 0.06956434 0.10350916 0.084085041
#> Sig5  0.124199527 0.228493118 0.02337948 0.06274918 0.12442291 0.051505245
#> Sig6  0.002684468 0.086916083 0.15649853 0.06545740 0.17532685 0.192087908
#> Sig7  0.312560672 0.003084564 0.06615268 0.30694430 0.01816242 0.009035262
#> Sig8  0.091467772 0.111433348 0.04048548 0.05858806 0.10527221 0.092032784
#> Sig9  0.230992450 0.085179509 0.05993627 0.06768928 0.19459580 0.084191330
#> Sig10 0.070302483 0.258447683 0.02549667 0.06874792 0.01481671 0.179727151
#> Sig11 0.075548174 0.059761530 0.02995117 0.02573415 0.01341999 0.035430625
#>         Sample_1  Sample_12   Sample_17  Sample_19  Sample_22  Sample_24
#> Sig1  0.15996147 0.15905152 0.190655021 0.18087926 0.11577234 0.12122579
#> Sig2  0.15105746 0.13725016 0.113110791 0.11296101 0.04983365 0.15961185
#> Sig3  0.06367633 0.10935234 0.047817404 0.10246473 0.17570203 0.17279656
#> Sig4  0.15172230 0.17795493 0.076281907 0.07855164 0.08390131 0.10234909
#> Sig5  0.01414495 0.02832321 0.263962420 0.14297078 0.20233353 0.05162655
#> Sig6  0.23636974 0.02651795 0.000149833 0.05774675 0.07534273 0.05777290
#> Sig7  0.02227449 0.14635143 0.020230152 0.17496767 0.01093253 0.08074162
#> Sig8  0.08250248 0.05640091 0.060421888 0.02997827 0.10885029 0.06609781
#> Sig9  0.02742513 0.05423740 0.050510437 0.05781358 0.01895728 0.06829669
#> Sig10 0.02773013 0.03709576 0.107604729 0.03828813 0.10386540 0.05694613
#> Sig11 0.06313552 0.06746439 0.069255417 0.02337818 0.05450891 0.06253499
#> 
#> $K
#> [1] 11
#> 
#> attr(,"class")
#> [1] "Signature"
#> attr(,"used_runs")
#> [1] 6
#> attr(,"method")
#> [1] "brunet"
#> attr(,"call_method")
#> [1] "NMF with best practice"
#> attr(,"nrun")
#> [1] 50
#> attr(,"seed")
#> [1] 123456
# If you think the suggested signature number is not right
# Just pick up the solution you want
obj_s8 <- bp_get_sig_obj(e1, 8)

# Track the reconstructed profile similarity
rec_sim <- get_sig_rec_similarity(obj_s8, t(simulated_catalogs$set1))
rec_sim
#>        sample similarity         rss unexplained_variance
#>        <char>      <num>       <num>                <num>
#>  1:  Sample_1  0.9997486 13230.30099         0.0005076483
#>  2:  Sample_2  0.9992611 20030.77983         0.0014806239
#>  3:  Sample_3  0.9903052 59263.95137         0.0196886410
#>  4:  Sample_4  0.9997825  1856.76699         0.0004676679
#>  5:  Sample_5  0.9992557  1019.54200         0.0015201050
#>  6:  Sample_6  0.9958607   721.60675         0.0083609296
#>  7:  Sample_7  0.9982163   261.63888         0.0036855218
#>  8:  Sample_8  0.9801222  7122.56156         0.0410276351
#>  9:  Sample_9  0.9992708  3331.53459         0.0014817779
#> 10: Sample_10  0.9989004  3735.70983         0.0022051099
#> 11: Sample_11  0.9993768   885.02187         0.0012459902
#> 12: Sample_12  0.9990641 77738.85426         0.0019042753
#> 13: Sample_13  0.9997332    87.78296         0.0005511132
#> 14: Sample_14  0.9995498   805.36015         0.0010261993
#> 15: Sample_15  0.9991823  5885.65491         0.0016497945
#> 16: Sample_16  0.9994722  1343.32088         0.0010669067
#> 17: Sample_17  0.9994158 24812.49173         0.0012580570
#> 18: Sample_18  0.9969664  4761.54340         0.0060580974
#> 19: Sample_19  0.9979704 77097.52442         0.0040672214
#> 20: Sample_20  0.9984978   397.72548         0.0030309129
#> 21: Sample_21  0.9995502  3540.17917         0.0009081402
#> 22: Sample_22  0.9996566 15566.63589         0.0006927896
#> 23: Sample_23  0.9973757  2453.12111         0.0052897034
#> 24: Sample_24  0.9999582  4645.77103         0.0000843955
#> 25: Sample_25  0.9996526  2058.53068         0.0006979333
#> 26: Sample_26  0.9950134 10587.56050         0.0100460865
#> 27: Sample_27  0.9992121  4574.39411         0.0015861921
#> 28: Sample_28  0.9983929   576.01938         0.0032494451
#> 29: Sample_29  0.9966799  1831.31566         0.0066974197
#> 30: Sample_30  0.9913698  2563.94388         0.0174160856
#>        sample similarity         rss unexplained_variance

# After extraction, you can assign the signatures
# to reference COSMIC signatures
# More see ?get_sig_similarity
sim <- get_sig_similarity(obj_suggested)
#> -Comparing against COSMIC signatures
#> ------------------------------------
#> --Found Sig1 most similar to SBS12
#>    Aetiology: Unknown [similarity: 0.827]
#> --Found Sig2 most similar to SBS13
#>    Aetiology: Activity of APOBEC family of cytidine deaminases [similarity: 0.881]
#> --Found Sig3 most similar to SBS40
#>    Aetiology: Unknown [similarity: 0.768]
#> --Found Sig4 most similar to SBS3
#>    Aetiology: Defective homologous recombination DNA damage repair [similarity: 0.901]
#> --Found Sig5 most similar to SBS1
#>    Aetiology: Spontaneous deamination of 5-methylcytosine (clock-like signature) [similarity: 0.917]
#> --Found Sig6 most similar to SBS8
#>    Aetiology: Unknown [similarity: 0.939]
#> --Found Sig7 most similar to SBS18
#>    Aetiology: Damage by reactive oxygen species [similarity: 0.975]
#> --Found Sig8 most similar to SBS40
#>    Aetiology: Unknown [similarity: 0.849]
#> --Found Sig9 most similar to SBS17b
#>    Aetiology: Unknown [similarity: 0.67]
#> --Found Sig10 most similar to SBS6
#>    Aetiology: Defective DNA mismatch repair [similarity: 0.828]
#> --Found Sig11 most similar to SBS2
#>    Aetiology: Activity of APOBEC family of cytidine deaminases [similarity: 0.872]
#> ------------------------------------
#> Return result invisiblely.
# Visualize the match result
if (require(pheatmap)) {
  pheatmap::pheatmap(sim$similarity)
}
#> Loading required package: pheatmap


# You already got the activities of signatures
# in obj_suggested, however, you can still
# try to optimize the result.
# NOTE: the optimization step may not truly optimize the result!
expo <- bp_attribute_activity(e1, return_class = "data.table")
#> Set cache dir: /tmp/RtmpADM14r/sigminer_attribute_activity
#> Handling sample: Sample_2
#>  [2024-08-04 14:37:02.094133]: Started.
#>  [2024-08-04 14:37:02.096051]: Checking catalog.
#>  [2024-08-04 14:37:02.097476]: Done.
#>  [2024-08-04 14:37:02.098822]: About to start bootstrap.
#> → Bootstrapping 100 times.
#> → Total 100 times, starting no.1.
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#> Bootstrap done.
#> 
#>  [2024-08-04 14:37:05.449819]: Signature exposures collected.
#>  [2024-08-04 14:37:05.451333]: Errors and similarity collected.
#>  [2024-08-04 14:37:05.452692]: Done.
#>  [2024-08-04 14:37:05.454095]: 3.36 secs elapsed.
#> Save expo result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_2_expo.rds
#> Save similarity result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_2_sim.rds
#> Handling sample: Sample_3
#>  [2024-08-04 14:37:05.611184]: Started.
#>  [2024-08-04 14:37:05.613196]: Checking catalog.
#>  [2024-08-04 14:37:05.614706]: Done.
#>  [2024-08-04 14:37:05.616109]: About to start bootstrap.
#> → Bootstrapping 100 times.
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#> Bootstrap done.
#> 
#>  [2024-08-04 14:37:08.79324]: Signature exposures collected.
#>  [2024-08-04 14:37:08.794703]: Errors and similarity collected.
#>  [2024-08-04 14:37:08.796002]: Done.
#>  [2024-08-04 14:37:08.79736]: 3.186 secs elapsed.
#> Save expo result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_3_expo.rds
#> Save similarity result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_3_sim.rds
#> Handling sample: Sample_4
#>  [2024-08-04 14:37:08.951332]: Started.
#>  [2024-08-04 14:37:08.95309]: Checking catalog.
#>  [2024-08-04 14:37:08.954588]: Done.
#>  [2024-08-04 14:37:08.955972]: About to start bootstrap.
#> → Bootstrapping 100 times.
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#> → Total 100 times, starting no.56.
#> → Total 100 times, starting no.57.
#> → Total 100 times, starting no.58.
#> → Total 100 times, starting no.59.
#> → Total 100 times, starting no.60.
#> → Total 100 times, starting no.61.
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#> → Total 100 times, starting no.63.
#> → Total 100 times, starting no.64.
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#> → Total 100 times, starting no.67.
#> → Total 100 times, starting no.68.
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#> → Total 100 times, starting no.70.
#> → Total 100 times, starting no.71.
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#> → Total 100 times, starting no.73.
#> → Total 100 times, starting no.74.
#> → Total 100 times, starting no.75.
#> → Total 100 times, starting no.76.
#> → Total 100 times, starting no.77.
#> → Total 100 times, starting no.78.
#> → Total 100 times, starting no.79.
#> → Total 100 times, starting no.80.
#> → Total 100 times, starting no.81.
#> → Total 100 times, starting no.82.
#> → Total 100 times, starting no.83.
#> → Total 100 times, starting no.84.
#> → Total 100 times, starting no.85.
#> → Total 100 times, starting no.86.
#> → Total 100 times, starting no.87.
#> → Total 100 times, starting no.88.
#> → Total 100 times, starting no.89.
#> → Total 100 times, starting no.90.
#> → Total 100 times, starting no.91.
#> → Total 100 times, starting no.92.
#> → Total 100 times, starting no.93.
#> → Total 100 times, starting no.94.
#> → Total 100 times, starting no.95.
#> → Total 100 times, starting no.96.
#> → Total 100 times, starting no.97.
#> → Total 100 times, starting no.98.
#> → Total 100 times, starting no.99.
#> → Total 100 times, starting no.100.
#> Bootstrap done.
#> 
#>  [2024-08-04 14:37:12.225574]: Signature exposures collected.
#>  [2024-08-04 14:37:12.22704]: Errors and similarity collected.
#>  [2024-08-04 14:37:12.228377]: Done.
#>  [2024-08-04 14:37:12.229755]: 3.278 secs elapsed.
#> Save expo result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_4_expo.rds
#> Save similarity result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_4_sim.rds
#> Handling sample: Sample_5
#>  [2024-08-04 14:37:12.383579]: Started.
#>  [2024-08-04 14:37:12.385382]: Checking catalog.
#>  [2024-08-04 14:37:12.386871]: Done.
#>  [2024-08-04 14:37:12.3883]: About to start bootstrap.
#> → Bootstrapping 100 times.
#> → Total 100 times, starting no.1.
#> → Total 100 times, starting no.2.
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#> → Total 100 times, starting no.11.
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#> → Total 100 times, starting no.21.
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#> → Total 100 times, starting no.27.
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#> → Total 100 times, starting no.31.
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#> → Total 100 times, starting no.37.
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#> → Total 100 times, starting no.41.
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#> → Total 100 times, starting no.44.
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#> → Total 100 times, starting no.46.
#> → Total 100 times, starting no.47.
#> → Total 100 times, starting no.48.
#> → Total 100 times, starting no.49.
#> → Total 100 times, starting no.50.
#> → Total 100 times, starting no.51.
#> → Total 100 times, starting no.52.
#> → Total 100 times, starting no.53.
#> → Total 100 times, starting no.54.
#> → Total 100 times, starting no.55.
#> → Total 100 times, starting no.56.
#> → Total 100 times, starting no.57.
#> → Total 100 times, starting no.58.
#> → Total 100 times, starting no.59.
#> → Total 100 times, starting no.60.
#> → Total 100 times, starting no.61.
#> → Total 100 times, starting no.62.
#> → Total 100 times, starting no.63.
#> → Total 100 times, starting no.64.
#> → Total 100 times, starting no.65.
#> → Total 100 times, starting no.66.
#> → Total 100 times, starting no.67.
#> → Total 100 times, starting no.68.
#> → Total 100 times, starting no.69.
#> → Total 100 times, starting no.70.
#> → Total 100 times, starting no.71.
#> → Total 100 times, starting no.72.
#> → Total 100 times, starting no.73.
#> → Total 100 times, starting no.74.
#> → Total 100 times, starting no.75.
#> → Total 100 times, starting no.76.
#> → Total 100 times, starting no.77.
#> → Total 100 times, starting no.78.
#> → Total 100 times, starting no.79.
#> → Total 100 times, starting no.80.
#> → Total 100 times, starting no.81.
#> → Total 100 times, starting no.82.
#> → Total 100 times, starting no.83.
#> → Total 100 times, starting no.84.
#> → Total 100 times, starting no.85.
#> → Total 100 times, starting no.86.
#> → Total 100 times, starting no.87.
#> → Total 100 times, starting no.88.
#> → Total 100 times, starting no.89.
#> → Total 100 times, starting no.90.
#> → Total 100 times, starting no.91.
#> → Total 100 times, starting no.92.
#> → Total 100 times, starting no.93.
#> → Total 100 times, starting no.94.
#> → Total 100 times, starting no.95.
#> → Total 100 times, starting no.96.
#> → Total 100 times, starting no.97.
#> → Total 100 times, starting no.98.
#> → Total 100 times, starting no.99.
#> → Total 100 times, starting no.100.
#> Bootstrap done.
#> 
#>  [2024-08-04 14:37:15.525238]: Signature exposures collected.
#>  [2024-08-04 14:37:15.526748]: Errors and similarity collected.
#>  [2024-08-04 14:37:15.528068]: Done.
#>  [2024-08-04 14:37:15.529441]: 3.146 secs elapsed.
#> Save expo result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_5_expo.rds
#> Save similarity result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_5_sim.rds
#> Handling sample: Sample_6
#>  [2024-08-04 14:37:15.682783]: Started.
#>  [2024-08-04 14:37:15.684881]: Checking catalog.
#>  [2024-08-04 14:37:15.686395]: Done.
#>  [2024-08-04 14:37:15.687801]: About to start bootstrap.
#> → Bootstrapping 100 times.
#> → Total 100 times, starting no.1.
#> → Total 100 times, starting no.2.
#> → Total 100 times, starting no.3.
#> → Total 100 times, starting no.4.
#> → Total 100 times, starting no.5.
#> → Total 100 times, starting no.6.
#> → Total 100 times, starting no.7.
#> → Total 100 times, starting no.8.
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#> → Total 100 times, starting no.10.
#> → Total 100 times, starting no.11.
#> → Total 100 times, starting no.12.
#> → Total 100 times, starting no.13.
#> → Total 100 times, starting no.14.
#> → Total 100 times, starting no.15.
#> → Total 100 times, starting no.16.
#> → Total 100 times, starting no.17.
#> → Total 100 times, starting no.18.
#> → Total 100 times, starting no.19.
#> → Total 100 times, starting no.20.
#> → Total 100 times, starting no.21.
#> → Total 100 times, starting no.22.
#> → Total 100 times, starting no.23.
#> → Total 100 times, starting no.24.
#> → Total 100 times, starting no.25.
#> → Total 100 times, starting no.26.
#> → Total 100 times, starting no.27.
#> → Total 100 times, starting no.28.
#> → Total 100 times, starting no.29.
#> → Total 100 times, starting no.30.
#> → Total 100 times, starting no.31.
#> → Total 100 times, starting no.32.
#> → Total 100 times, starting no.33.
#> → Total 100 times, starting no.34.
#> → Total 100 times, starting no.35.
#> → Total 100 times, starting no.36.
#> → Total 100 times, starting no.37.
#> → Total 100 times, starting no.38.
#> → Total 100 times, starting no.39.
#> → Total 100 times, starting no.40.
#> → Total 100 times, starting no.41.
#> → Total 100 times, starting no.42.
#> → Total 100 times, starting no.43.
#> → Total 100 times, starting no.44.
#> → Total 100 times, starting no.45.
#> → Total 100 times, starting no.46.
#> → Total 100 times, starting no.47.
#> → Total 100 times, starting no.48.
#> → Total 100 times, starting no.49.
#> → Total 100 times, starting no.50.
#> → Total 100 times, starting no.51.
#> → Total 100 times, starting no.52.
#> → Total 100 times, starting no.53.
#> → Total 100 times, starting no.54.
#> → Total 100 times, starting no.55.
#> → Total 100 times, starting no.56.
#> → Total 100 times, starting no.57.
#> → Total 100 times, starting no.58.
#> → Total 100 times, starting no.59.
#> → Total 100 times, starting no.60.
#> → Total 100 times, starting no.61.
#> → Total 100 times, starting no.62.
#> → Total 100 times, starting no.63.
#> → Total 100 times, starting no.64.
#> → Total 100 times, starting no.65.
#> → Total 100 times, starting no.66.
#> → Total 100 times, starting no.67.
#> → Total 100 times, starting no.68.
#> → Total 100 times, starting no.69.
#> → Total 100 times, starting no.70.
#> → Total 100 times, starting no.71.
#> → Total 100 times, starting no.72.
#> → Total 100 times, starting no.73.
#> → Total 100 times, starting no.74.
#> → Total 100 times, starting no.75.
#> → Total 100 times, starting no.76.
#> → Total 100 times, starting no.77.
#> → Total 100 times, starting no.78.
#> → Total 100 times, starting no.79.
#> → Total 100 times, starting no.80.
#> → Total 100 times, starting no.81.
#> → Total 100 times, starting no.82.
#> → Total 100 times, starting no.83.
#> → Total 100 times, starting no.84.
#> → Total 100 times, starting no.85.
#> → Total 100 times, starting no.86.
#> → Total 100 times, starting no.87.
#> → Total 100 times, starting no.88.
#> → Total 100 times, starting no.89.
#> → Total 100 times, starting no.90.
#> → Total 100 times, starting no.91.
#> → Total 100 times, starting no.92.
#> → Total 100 times, starting no.93.
#> → Total 100 times, starting no.94.
#> → Total 100 times, starting no.95.
#> → Total 100 times, starting no.96.
#> → Total 100 times, starting no.97.
#> → Total 100 times, starting no.98.
#> → Total 100 times, starting no.99.
#> → Total 100 times, starting no.100.
#> Bootstrap done.
#> 
#>  [2024-08-04 14:37:18.828753]: Signature exposures collected.
#>  [2024-08-04 14:37:18.830274]: Errors and similarity collected.
#>  [2024-08-04 14:37:18.831614]: Done.
#>  [2024-08-04 14:37:18.832978]: 3.15 secs elapsed.
#> Save expo result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_6_expo.rds
#> Save similarity result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_6_sim.rds
#> Handling sample: Sample_7
#>  [2024-08-04 14:37:18.985641]: Started.
#>  [2024-08-04 14:37:18.987449]: Checking catalog.
#>  [2024-08-04 14:37:18.988936]: Done.
#>  [2024-08-04 14:37:18.990403]: About to start bootstrap.
#> → Bootstrapping 100 times.
#> → Total 100 times, starting no.1.
#> → Total 100 times, starting no.2.
#> → Total 100 times, starting no.3.
#> → Total 100 times, starting no.4.
#> → Total 100 times, starting no.5.
#> → Total 100 times, starting no.6.
#> → Total 100 times, starting no.7.
#> → Total 100 times, starting no.8.
#> → Total 100 times, starting no.9.
#> → Total 100 times, starting no.10.
#> → Total 100 times, starting no.11.
#> → Total 100 times, starting no.12.
#> → Total 100 times, starting no.13.
#> → Total 100 times, starting no.14.
#> → Total 100 times, starting no.15.
#> → Total 100 times, starting no.16.
#> → Total 100 times, starting no.17.
#> → Total 100 times, starting no.18.
#> → Total 100 times, starting no.19.
#> → Total 100 times, starting no.20.
#> → Total 100 times, starting no.21.
#> → Total 100 times, starting no.22.
#> → Total 100 times, starting no.23.
#> → Total 100 times, starting no.24.
#> → Total 100 times, starting no.25.
#> → Total 100 times, starting no.26.
#> → Total 100 times, starting no.27.
#> → Total 100 times, starting no.28.
#> → Total 100 times, starting no.29.
#> → Total 100 times, starting no.30.
#> → Total 100 times, starting no.31.
#> → Total 100 times, starting no.32.
#> → Total 100 times, starting no.33.
#> → Total 100 times, starting no.34.
#> → Total 100 times, starting no.35.
#> → Total 100 times, starting no.36.
#> → Total 100 times, starting no.37.
#> → Total 100 times, starting no.38.
#> → Total 100 times, starting no.39.
#> → Total 100 times, starting no.40.
#> → Total 100 times, starting no.41.
#> → Total 100 times, starting no.42.
#> → Total 100 times, starting no.43.
#> → Total 100 times, starting no.44.
#> → Total 100 times, starting no.45.
#> → Total 100 times, starting no.46.
#> → Total 100 times, starting no.47.
#> → Total 100 times, starting no.48.
#> → Total 100 times, starting no.49.
#> → Total 100 times, starting no.50.
#> → Total 100 times, starting no.51.
#> → Total 100 times, starting no.52.
#> → Total 100 times, starting no.53.
#> → Total 100 times, starting no.54.
#> → Total 100 times, starting no.55.
#> → Total 100 times, starting no.56.
#> → Total 100 times, starting no.57.
#> → Total 100 times, starting no.58.
#> → Total 100 times, starting no.59.
#> → Total 100 times, starting no.60.
#> → Total 100 times, starting no.61.
#> → Total 100 times, starting no.62.
#> → Total 100 times, starting no.63.
#> → Total 100 times, starting no.64.
#> → Total 100 times, starting no.65.
#> → Total 100 times, starting no.66.
#> → Total 100 times, starting no.67.
#> → Total 100 times, starting no.68.
#> → Total 100 times, starting no.69.
#> → Total 100 times, starting no.70.
#> → Total 100 times, starting no.71.
#> → Total 100 times, starting no.72.
#> → Total 100 times, starting no.73.
#> → Total 100 times, starting no.74.
#> → Total 100 times, starting no.75.
#> → Total 100 times, starting no.76.
#> → Total 100 times, starting no.77.
#> → Total 100 times, starting no.78.
#> → Total 100 times, starting no.79.
#> → Total 100 times, starting no.80.
#> → Total 100 times, starting no.81.
#> → Total 100 times, starting no.82.
#> → Total 100 times, starting no.83.
#> → Total 100 times, starting no.84.
#> → Total 100 times, starting no.85.
#> → Total 100 times, starting no.86.
#> → Total 100 times, starting no.87.
#> → Total 100 times, starting no.88.
#> → Total 100 times, starting no.89.
#> → Total 100 times, starting no.90.
#> → Total 100 times, starting no.91.
#> → Total 100 times, starting no.92.
#> → Total 100 times, starting no.93.
#> → Total 100 times, starting no.94.
#> → Total 100 times, starting no.95.
#> → Total 100 times, starting no.96.
#> → Total 100 times, starting no.97.
#> → Total 100 times, starting no.98.
#> → Total 100 times, starting no.99.
#> → Total 100 times, starting no.100.
#> Bootstrap done.
#> 
#>  [2024-08-04 14:37:22.270242]: Signature exposures collected.
#>  [2024-08-04 14:37:22.271741]: Errors and similarity collected.
#>  [2024-08-04 14:37:22.273065]: Done.
#>  [2024-08-04 14:37:22.274429]: 3.289 secs elapsed.
#> Save expo result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_7_expo.rds
#> Save similarity result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_7_sim.rds
#> Handling sample: Sample_8
#>  [2024-08-04 14:37:22.423293]: Started.
#>  [2024-08-04 14:37:22.425076]: Checking catalog.
#>  [2024-08-04 14:37:22.426619]: Done.
#>  [2024-08-04 14:37:22.428046]: About to start bootstrap.
#> → Bootstrapping 100 times.
#> → Total 100 times, starting no.1.
#> → Total 100 times, starting no.2.
#> → Total 100 times, starting no.3.
#> → Total 100 times, starting no.4.
#> → Total 100 times, starting no.5.
#> → Total 100 times, starting no.6.
#> → Total 100 times, starting no.7.
#> → Total 100 times, starting no.8.
#> → Total 100 times, starting no.9.
#> → Total 100 times, starting no.10.
#> → Total 100 times, starting no.11.
#> → Total 100 times, starting no.12.
#> → Total 100 times, starting no.13.
#> → Total 100 times, starting no.14.
#> → Total 100 times, starting no.15.
#> → Total 100 times, starting no.16.
#> → Total 100 times, starting no.17.
#> → Total 100 times, starting no.18.
#> → Total 100 times, starting no.19.
#> → Total 100 times, starting no.20.
#> → Total 100 times, starting no.21.
#> → Total 100 times, starting no.22.
#> → Total 100 times, starting no.23.
#> → Total 100 times, starting no.24.
#> → Total 100 times, starting no.25.
#> → Total 100 times, starting no.26.
#> → Total 100 times, starting no.27.
#> → Total 100 times, starting no.28.
#> → Total 100 times, starting no.29.
#> → Total 100 times, starting no.30.
#> → Total 100 times, starting no.31.
#> → Total 100 times, starting no.32.
#> → Total 100 times, starting no.33.
#> → Total 100 times, starting no.34.
#> → Total 100 times, starting no.35.
#> → Total 100 times, starting no.36.
#> → Total 100 times, starting no.37.
#> → Total 100 times, starting no.38.
#> → Total 100 times, starting no.39.
#> → Total 100 times, starting no.40.
#> → Total 100 times, starting no.41.
#> → Total 100 times, starting no.42.
#> → Total 100 times, starting no.43.
#> → Total 100 times, starting no.44.
#> → Total 100 times, starting no.45.
#> → Total 100 times, starting no.46.
#> → Total 100 times, starting no.47.
#> → Total 100 times, starting no.48.
#> → Total 100 times, starting no.49.
#> → Total 100 times, starting no.50.
#> → Total 100 times, starting no.51.
#> → Total 100 times, starting no.52.
#> → Total 100 times, starting no.53.
#> → Total 100 times, starting no.54.
#> → Total 100 times, starting no.55.
#> → Total 100 times, starting no.56.
#> → Total 100 times, starting no.57.
#> → Total 100 times, starting no.58.
#> → Total 100 times, starting no.59.
#> → Total 100 times, starting no.60.
#> → Total 100 times, starting no.61.
#> → Total 100 times, starting no.62.
#> → Total 100 times, starting no.63.
#> → Total 100 times, starting no.64.
#> → Total 100 times, starting no.65.
#> → Total 100 times, starting no.66.
#> → Total 100 times, starting no.67.
#> → Total 100 times, starting no.68.
#> → Total 100 times, starting no.69.
#> → Total 100 times, starting no.70.
#> → Total 100 times, starting no.71.
#> → Total 100 times, starting no.72.
#> → Total 100 times, starting no.73.
#> → Total 100 times, starting no.74.
#> → Total 100 times, starting no.75.
#> → Total 100 times, starting no.76.
#> → Total 100 times, starting no.77.
#> → Total 100 times, starting no.78.
#> → Total 100 times, starting no.79.
#> → Total 100 times, starting no.80.
#> → Total 100 times, starting no.81.
#> → Total 100 times, starting no.82.
#> → Total 100 times, starting no.83.
#> → Total 100 times, starting no.84.
#> → Total 100 times, starting no.85.
#> → Total 100 times, starting no.86.
#> → Total 100 times, starting no.87.
#> → Total 100 times, starting no.88.
#> → Total 100 times, starting no.89.
#> → Total 100 times, starting no.90.
#> → Total 100 times, starting no.91.
#> → Total 100 times, starting no.92.
#> → Total 100 times, starting no.93.
#> → Total 100 times, starting no.94.
#> → Total 100 times, starting no.95.
#> → Total 100 times, starting no.96.
#> → Total 100 times, starting no.97.
#> → Total 100 times, starting no.98.
#> → Total 100 times, starting no.99.
#> → Total 100 times, starting no.100.
#> Bootstrap done.
#> 
#>  [2024-08-04 14:37:25.584566]: Signature exposures collected.
#>  [2024-08-04 14:37:25.586081]: Errors and similarity collected.
#>  [2024-08-04 14:37:25.587415]: Done.
#>  [2024-08-04 14:37:25.588778]: 3.165 secs elapsed.
#> Save expo result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_8_expo.rds
#> Save similarity result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_8_sim.rds
#> Handling sample: Sample_9
#>  [2024-08-04 14:37:25.742712]: Started.
#>  [2024-08-04 14:37:25.744498]: Checking catalog.
#>  [2024-08-04 14:37:25.746011]: Done.
#>  [2024-08-04 14:37:25.747409]: About to start bootstrap.
#> → Bootstrapping 100 times.
#> → Total 100 times, starting no.1.
#> → Total 100 times, starting no.2.
#> → Total 100 times, starting no.3.
#> → Total 100 times, starting no.4.
#> → Total 100 times, starting no.5.
#> → Total 100 times, starting no.6.
#> → Total 100 times, starting no.7.
#> → Total 100 times, starting no.8.
#> → Total 100 times, starting no.9.
#> → Total 100 times, starting no.10.
#> → Total 100 times, starting no.11.
#> → Total 100 times, starting no.12.
#> → Total 100 times, starting no.13.
#> → Total 100 times, starting no.14.
#> → Total 100 times, starting no.15.
#> → Total 100 times, starting no.16.
#> → Total 100 times, starting no.17.
#> → Total 100 times, starting no.18.
#> → Total 100 times, starting no.19.
#> → Total 100 times, starting no.20.
#> → Total 100 times, starting no.21.
#> → Total 100 times, starting no.22.
#> → Total 100 times, starting no.23.
#> → Total 100 times, starting no.24.
#> → Total 100 times, starting no.25.
#> → Total 100 times, starting no.26.
#> → Total 100 times, starting no.27.
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#> → Total 100 times, starting no.37.
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#> → Total 100 times, starting no.41.
#> → Total 100 times, starting no.42.
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#> → Total 100 times, starting no.46.
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#> → Total 100 times, starting no.48.
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#> → Total 100 times, starting no.51.
#> → Total 100 times, starting no.52.
#> → Total 100 times, starting no.53.
#> → Total 100 times, starting no.54.
#> → Total 100 times, starting no.55.
#> → Total 100 times, starting no.56.
#> → Total 100 times, starting no.57.
#> → Total 100 times, starting no.58.
#> → Total 100 times, starting no.59.
#> → Total 100 times, starting no.60.
#> → Total 100 times, starting no.61.
#> → Total 100 times, starting no.62.
#> → Total 100 times, starting no.63.
#> → Total 100 times, starting no.64.
#> → Total 100 times, starting no.65.
#> → Total 100 times, starting no.66.
#> → Total 100 times, starting no.67.
#> → Total 100 times, starting no.68.
#> → Total 100 times, starting no.69.
#> → Total 100 times, starting no.70.
#> → Total 100 times, starting no.71.
#> → Total 100 times, starting no.72.
#> → Total 100 times, starting no.73.
#> → Total 100 times, starting no.74.
#> → Total 100 times, starting no.75.
#> → Total 100 times, starting no.76.
#> → Total 100 times, starting no.77.
#> → Total 100 times, starting no.78.
#> → Total 100 times, starting no.79.
#> → Total 100 times, starting no.80.
#> → Total 100 times, starting no.81.
#> → Total 100 times, starting no.82.
#> → Total 100 times, starting no.83.
#> → Total 100 times, starting no.84.
#> → Total 100 times, starting no.85.
#> → Total 100 times, starting no.86.
#> → Total 100 times, starting no.87.
#> → Total 100 times, starting no.88.
#> → Total 100 times, starting no.89.
#> → Total 100 times, starting no.90.
#> → Total 100 times, starting no.91.
#> → Total 100 times, starting no.92.
#> → Total 100 times, starting no.93.
#> → Total 100 times, starting no.94.
#> → Total 100 times, starting no.95.
#> → Total 100 times, starting no.96.
#> → Total 100 times, starting no.97.
#> → Total 100 times, starting no.98.
#> → Total 100 times, starting no.99.
#> → Total 100 times, starting no.100.
#> Bootstrap done.
#> 
#>  [2024-08-04 14:37:28.953845]: Signature exposures collected.
#>  [2024-08-04 14:37:28.955323]: Errors and similarity collected.
#>  [2024-08-04 14:37:28.956671]: Done.
#>  [2024-08-04 14:37:28.958074]: 3.215 secs elapsed.
#> Save expo result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_9_expo.rds
#> Save similarity result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_9_sim.rds
#> Handling sample: Sample_10
#>  [2024-08-04 14:37:29.11065]: Started.
#>  [2024-08-04 14:37:29.112443]: Checking catalog.
#>  [2024-08-04 14:37:29.113982]: Done.
#>  [2024-08-04 14:37:29.115422]: About to start bootstrap.
#> → Bootstrapping 100 times.
#> → Total 100 times, starting no.1.
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#> → Total 100 times, starting no.11.
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#> → Total 100 times, starting no.14.
#> → Total 100 times, starting no.15.
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#> → Total 100 times, starting no.20.
#> → Total 100 times, starting no.21.
#> → Total 100 times, starting no.22.
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#> → Total 100 times, starting no.25.
#> → Total 100 times, starting no.26.
#> → Total 100 times, starting no.27.
#> → Total 100 times, starting no.28.
#> → Total 100 times, starting no.29.
#> → Total 100 times, starting no.30.
#> → Total 100 times, starting no.31.
#> → Total 100 times, starting no.32.
#> → Total 100 times, starting no.33.
#> → Total 100 times, starting no.34.
#> → Total 100 times, starting no.35.
#> → Total 100 times, starting no.36.
#> → Total 100 times, starting no.37.
#> → Total 100 times, starting no.38.
#> → Total 100 times, starting no.39.
#> → Total 100 times, starting no.40.
#> → Total 100 times, starting no.41.
#> → Total 100 times, starting no.42.
#> → Total 100 times, starting no.43.
#> → Total 100 times, starting no.44.
#> → Total 100 times, starting no.45.
#> → Total 100 times, starting no.46.
#> → Total 100 times, starting no.47.
#> → Total 100 times, starting no.48.
#> → Total 100 times, starting no.49.
#> → Total 100 times, starting no.50.
#> → Total 100 times, starting no.51.
#> → Total 100 times, starting no.52.
#> → Total 100 times, starting no.53.
#> → Total 100 times, starting no.54.
#> → Total 100 times, starting no.55.
#> → Total 100 times, starting no.56.
#> → Total 100 times, starting no.57.
#> → Total 100 times, starting no.58.
#> → Total 100 times, starting no.59.
#> → Total 100 times, starting no.60.
#> → Total 100 times, starting no.61.
#> → Total 100 times, starting no.62.
#> → Total 100 times, starting no.63.
#> → Total 100 times, starting no.64.
#> → Total 100 times, starting no.65.
#> → Total 100 times, starting no.66.
#> → Total 100 times, starting no.67.
#> → Total 100 times, starting no.68.
#> → Total 100 times, starting no.69.
#> → Total 100 times, starting no.70.
#> → Total 100 times, starting no.71.
#> → Total 100 times, starting no.72.
#> → Total 100 times, starting no.73.
#> → Total 100 times, starting no.74.
#> → Total 100 times, starting no.75.
#> → Total 100 times, starting no.76.
#> → Total 100 times, starting no.77.
#> → Total 100 times, starting no.78.
#> → Total 100 times, starting no.79.
#> → Total 100 times, starting no.80.
#> → Total 100 times, starting no.81.
#> → Total 100 times, starting no.82.
#> → Total 100 times, starting no.83.
#> → Total 100 times, starting no.84.
#> → Total 100 times, starting no.85.
#> → Total 100 times, starting no.86.
#> → Total 100 times, starting no.87.
#> → Total 100 times, starting no.88.
#> → Total 100 times, starting no.89.
#> → Total 100 times, starting no.90.
#> → Total 100 times, starting no.91.
#> → Total 100 times, starting no.92.
#> → Total 100 times, starting no.93.
#> → Total 100 times, starting no.94.
#> → Total 100 times, starting no.95.
#> → Total 100 times, starting no.96.
#> → Total 100 times, starting no.97.
#> → Total 100 times, starting no.98.
#> → Total 100 times, starting no.99.
#> → Total 100 times, starting no.100.
#> Bootstrap done.
#> 
#>  [2024-08-04 14:37:32.328388]: Signature exposures collected.
#>  [2024-08-04 14:37:32.329886]: Errors and similarity collected.
#>  [2024-08-04 14:37:32.331222]: Done.
#>  [2024-08-04 14:37:32.332583]: 3.222 secs elapsed.
#> Save expo result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_10_expo.rds
#> Save similarity result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_10_sim.rds
#> Handling sample: Sample_11
#>  [2024-08-04 14:37:32.485459]: Started.
#>  [2024-08-04 14:37:32.487276]: Checking catalog.
#>  [2024-08-04 14:37:32.488806]: Done.
#>  [2024-08-04 14:37:32.4903]: About to start bootstrap.
#> → Bootstrapping 100 times.
#> → Total 100 times, starting no.1.
#> → Total 100 times, starting no.2.
#> → Total 100 times, starting no.3.
#> → Total 100 times, starting no.4.
#> → Total 100 times, starting no.5.
#> → Total 100 times, starting no.6.
#> → Total 100 times, starting no.7.
#> → Total 100 times, starting no.8.
#> → Total 100 times, starting no.9.
#> → Total 100 times, starting no.10.
#> → Total 100 times, starting no.11.
#> → Total 100 times, starting no.12.
#> → Total 100 times, starting no.13.
#> → Total 100 times, starting no.14.
#> → Total 100 times, starting no.15.
#> → Total 100 times, starting no.16.
#> → Total 100 times, starting no.17.
#> → Total 100 times, starting no.18.
#> → Total 100 times, starting no.19.
#> → Total 100 times, starting no.20.
#> → Total 100 times, starting no.21.
#> → Total 100 times, starting no.22.
#> → Total 100 times, starting no.23.
#> → Total 100 times, starting no.24.
#> → Total 100 times, starting no.25.
#> → Total 100 times, starting no.26.
#> → Total 100 times, starting no.27.
#> → Total 100 times, starting no.28.
#> → Total 100 times, starting no.29.
#> → Total 100 times, starting no.30.
#> → Total 100 times, starting no.31.
#> → Total 100 times, starting no.32.
#> → Total 100 times, starting no.33.
#> → Total 100 times, starting no.34.
#> → Total 100 times, starting no.35.
#> → Total 100 times, starting no.36.
#> → Total 100 times, starting no.37.
#> → Total 100 times, starting no.38.
#> → Total 100 times, starting no.39.
#> → Total 100 times, starting no.40.
#> → Total 100 times, starting no.41.
#> → Total 100 times, starting no.42.
#> → Total 100 times, starting no.43.
#> → Total 100 times, starting no.44.
#> → Total 100 times, starting no.45.
#> → Total 100 times, starting no.46.
#> → Total 100 times, starting no.47.
#> → Total 100 times, starting no.48.
#> → Total 100 times, starting no.49.
#> → Total 100 times, starting no.50.
#> → Total 100 times, starting no.51.
#> → Total 100 times, starting no.52.
#> → Total 100 times, starting no.53.
#> → Total 100 times, starting no.54.
#> → Total 100 times, starting no.55.
#> → Total 100 times, starting no.56.
#> → Total 100 times, starting no.57.
#> → Total 100 times, starting no.58.
#> → Total 100 times, starting no.59.
#> → Total 100 times, starting no.60.
#> → Total 100 times, starting no.61.
#> → Total 100 times, starting no.62.
#> → Total 100 times, starting no.63.
#> → Total 100 times, starting no.64.
#> → Total 100 times, starting no.65.
#> → Total 100 times, starting no.66.
#> → Total 100 times, starting no.67.
#> → Total 100 times, starting no.68.
#> → Total 100 times, starting no.69.
#> → Total 100 times, starting no.70.
#> → Total 100 times, starting no.71.
#> → Total 100 times, starting no.72.
#> → Total 100 times, starting no.73.
#> → Total 100 times, starting no.74.
#> → Total 100 times, starting no.75.
#> → Total 100 times, starting no.76.
#> → Total 100 times, starting no.77.
#> → Total 100 times, starting no.78.
#> → Total 100 times, starting no.79.
#> → Total 100 times, starting no.80.
#> → Total 100 times, starting no.81.
#> → Total 100 times, starting no.82.
#> → Total 100 times, starting no.83.
#> → Total 100 times, starting no.84.
#> → Total 100 times, starting no.85.
#> → Total 100 times, starting no.86.
#> → Total 100 times, starting no.87.
#> → Total 100 times, starting no.88.
#> → Total 100 times, starting no.89.
#> → Total 100 times, starting no.90.
#> → Total 100 times, starting no.91.
#> → Total 100 times, starting no.92.
#> → Total 100 times, starting no.93.
#> → Total 100 times, starting no.94.
#> → Total 100 times, starting no.95.
#> → Total 100 times, starting no.96.
#> → Total 100 times, starting no.97.
#> → Total 100 times, starting no.98.
#> → Total 100 times, starting no.99.
#> → Total 100 times, starting no.100.
#> Bootstrap done.
#> 
#>  [2024-08-04 14:37:35.667874]: Signature exposures collected.
#>  [2024-08-04 14:37:35.669393]: Errors and similarity collected.
#>  [2024-08-04 14:37:35.670739]: Done.
#>  [2024-08-04 14:37:35.672103]: 3.187 secs elapsed.
#> Save expo result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_11_expo.rds
#> Save similarity result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_11_sim.rds
#> Handling sample: Sample_13
#>  [2024-08-04 14:37:35.825502]: Started.
#>  [2024-08-04 14:37:35.827305]: Checking catalog.
#>  [2024-08-04 14:37:35.828799]: Done.
#>  [2024-08-04 14:37:35.830251]: About to start bootstrap.
#> → Bootstrapping 100 times.
#> → Total 100 times, starting no.1.
#> → Total 100 times, starting no.2.
#> → Total 100 times, starting no.3.
#> → Total 100 times, starting no.4.
#> → Total 100 times, starting no.5.
#> → Total 100 times, starting no.6.
#> → Total 100 times, starting no.7.
#> → Total 100 times, starting no.8.
#> → Total 100 times, starting no.9.
#> → Total 100 times, starting no.10.
#> → Total 100 times, starting no.11.
#> → Total 100 times, starting no.12.
#> → Total 100 times, starting no.13.
#> → Total 100 times, starting no.14.
#> → Total 100 times, starting no.15.
#> → Total 100 times, starting no.16.
#> → Total 100 times, starting no.17.
#> → Total 100 times, starting no.18.
#> → Total 100 times, starting no.19.
#> → Total 100 times, starting no.20.
#> → Total 100 times, starting no.21.
#> → Total 100 times, starting no.22.
#> → Total 100 times, starting no.23.
#> → Total 100 times, starting no.24.
#> → Total 100 times, starting no.25.
#> → Total 100 times, starting no.26.
#> → Total 100 times, starting no.27.
#> → Total 100 times, starting no.28.
#> → Total 100 times, starting no.29.
#> → Total 100 times, starting no.30.
#> → Total 100 times, starting no.31.
#> → Total 100 times, starting no.32.
#> → Total 100 times, starting no.33.
#> → Total 100 times, starting no.34.
#> → Total 100 times, starting no.35.
#> → Total 100 times, starting no.36.
#> → Total 100 times, starting no.37.
#> → Total 100 times, starting no.38.
#> → Total 100 times, starting no.39.
#> → Total 100 times, starting no.40.
#> → Total 100 times, starting no.41.
#> → Total 100 times, starting no.42.
#> → Total 100 times, starting no.43.
#> → Total 100 times, starting no.44.
#> → Total 100 times, starting no.45.
#> → Total 100 times, starting no.46.
#> → Total 100 times, starting no.47.
#> → Total 100 times, starting no.48.
#> → Total 100 times, starting no.49.
#> → Total 100 times, starting no.50.
#> → Total 100 times, starting no.51.
#> → Total 100 times, starting no.52.
#> → Total 100 times, starting no.53.
#> → Total 100 times, starting no.54.
#> → Total 100 times, starting no.55.
#> → Total 100 times, starting no.56.
#> → Total 100 times, starting no.57.
#> → Total 100 times, starting no.58.
#> → Total 100 times, starting no.59.
#> → Total 100 times, starting no.60.
#> → Total 100 times, starting no.61.
#> → Total 100 times, starting no.62.
#> → Total 100 times, starting no.63.
#> → Total 100 times, starting no.64.
#> → Total 100 times, starting no.65.
#> → Total 100 times, starting no.66.
#> → Total 100 times, starting no.67.
#> → Total 100 times, starting no.68.
#> → Total 100 times, starting no.69.
#> → Total 100 times, starting no.70.
#> → Total 100 times, starting no.71.
#> → Total 100 times, starting no.72.
#> → Total 100 times, starting no.73.
#> → Total 100 times, starting no.74.
#> → Total 100 times, starting no.75.
#> → Total 100 times, starting no.76.
#> → Total 100 times, starting no.77.
#> → Total 100 times, starting no.78.
#> → Total 100 times, starting no.79.
#> → Total 100 times, starting no.80.
#> → Total 100 times, starting no.81.
#> → Total 100 times, starting no.82.
#> → Total 100 times, starting no.83.
#> → Total 100 times, starting no.84.
#> → Total 100 times, starting no.85.
#> → Total 100 times, starting no.86.
#> → Total 100 times, starting no.87.
#> → Total 100 times, starting no.88.
#> → Total 100 times, starting no.89.
#> → Total 100 times, starting no.90.
#> → Total 100 times, starting no.91.
#> → Total 100 times, starting no.92.
#> → Total 100 times, starting no.93.
#> → Total 100 times, starting no.94.
#> → Total 100 times, starting no.95.
#> → Total 100 times, starting no.96.
#> → Total 100 times, starting no.97.
#> → Total 100 times, starting no.98.
#> → Total 100 times, starting no.99.
#> → Total 100 times, starting no.100.
#> Bootstrap done.
#> 
#>  [2024-08-04 14:37:38.958806]: Signature exposures collected.
#>  [2024-08-04 14:37:38.960295]: Errors and similarity collected.
#>  [2024-08-04 14:37:38.961659]: Done.
#>  [2024-08-04 14:37:38.963022]: 3.138 secs elapsed.
#> Save expo result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_13_expo.rds
#> Save similarity result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_13_sim.rds
#> Handling sample: Sample_14
#>  [2024-08-04 14:37:39.114997]: Started.
#>  [2024-08-04 14:37:39.116826]: Checking catalog.
#>  [2024-08-04 14:37:39.118389]: Done.
#>  [2024-08-04 14:37:39.119812]: About to start bootstrap.
#> → Bootstrapping 100 times.
#> → Total 100 times, starting no.1.
#> → Total 100 times, starting no.2.
#> → Total 100 times, starting no.3.
#> → Total 100 times, starting no.4.
#> → Total 100 times, starting no.5.
#> → Total 100 times, starting no.6.
#> → Total 100 times, starting no.7.
#> → Total 100 times, starting no.8.
#> → Total 100 times, starting no.9.
#> → Total 100 times, starting no.10.
#> → Total 100 times, starting no.11.
#> → Total 100 times, starting no.12.
#> → Total 100 times, starting no.13.
#> → Total 100 times, starting no.14.
#> → Total 100 times, starting no.15.
#> → Total 100 times, starting no.16.
#> → Total 100 times, starting no.17.
#> → Total 100 times, starting no.18.
#> → Total 100 times, starting no.19.
#> → Total 100 times, starting no.20.
#> → Total 100 times, starting no.21.
#> → Total 100 times, starting no.22.
#> → Total 100 times, starting no.23.
#> → Total 100 times, starting no.24.
#> → Total 100 times, starting no.25.
#> → Total 100 times, starting no.26.
#> → Total 100 times, starting no.27.
#> → Total 100 times, starting no.28.
#> → Total 100 times, starting no.29.
#> → Total 100 times, starting no.30.
#> → Total 100 times, starting no.31.
#> → Total 100 times, starting no.32.
#> → Total 100 times, starting no.33.
#> → Total 100 times, starting no.34.
#> → Total 100 times, starting no.35.
#> → Total 100 times, starting no.36.
#> → Total 100 times, starting no.37.
#> → Total 100 times, starting no.38.
#> → Total 100 times, starting no.39.
#> → Total 100 times, starting no.40.
#> → Total 100 times, starting no.41.
#> → Total 100 times, starting no.42.
#> → Total 100 times, starting no.43.
#> → Total 100 times, starting no.44.
#> → Total 100 times, starting no.45.
#> → Total 100 times, starting no.46.
#> → Total 100 times, starting no.47.
#> → Total 100 times, starting no.48.
#> → Total 100 times, starting no.49.
#> → Total 100 times, starting no.50.
#> → Total 100 times, starting no.51.
#> → Total 100 times, starting no.52.
#> → Total 100 times, starting no.53.
#> → Total 100 times, starting no.54.
#> → Total 100 times, starting no.55.
#> → Total 100 times, starting no.56.
#> → Total 100 times, starting no.57.
#> → Total 100 times, starting no.58.
#> → Total 100 times, starting no.59.
#> → Total 100 times, starting no.60.
#> → Total 100 times, starting no.61.
#> → Total 100 times, starting no.62.
#> → Total 100 times, starting no.63.
#> → Total 100 times, starting no.64.
#> → Total 100 times, starting no.65.
#> → Total 100 times, starting no.66.
#> → Total 100 times, starting no.67.
#> → Total 100 times, starting no.68.
#> → Total 100 times, starting no.69.
#> → Total 100 times, starting no.70.
#> → Total 100 times, starting no.71.
#> → Total 100 times, starting no.72.
#> → Total 100 times, starting no.73.
#> → Total 100 times, starting no.74.
#> → Total 100 times, starting no.75.
#> → Total 100 times, starting no.76.
#> → Total 100 times, starting no.77.
#> → Total 100 times, starting no.78.
#> → Total 100 times, starting no.79.
#> → Total 100 times, starting no.80.
#> → Total 100 times, starting no.81.
#> → Total 100 times, starting no.82.
#> → Total 100 times, starting no.83.
#> → Total 100 times, starting no.84.
#> → Total 100 times, starting no.85.
#> → Total 100 times, starting no.86.
#> → Total 100 times, starting no.87.
#> → Total 100 times, starting no.88.
#> → Total 100 times, starting no.89.
#> → Total 100 times, starting no.90.
#> → Total 100 times, starting no.91.
#> → Total 100 times, starting no.92.
#> → Total 100 times, starting no.93.
#> → Total 100 times, starting no.94.
#> → Total 100 times, starting no.95.
#> → Total 100 times, starting no.96.
#> → Total 100 times, starting no.97.
#> → Total 100 times, starting no.98.
#> → Total 100 times, starting no.99.
#> → Total 100 times, starting no.100.
#> Bootstrap done.
#> 
#>  [2024-08-04 14:37:42.246326]: Signature exposures collected.
#>  [2024-08-04 14:37:42.24782]: Errors and similarity collected.
#>  [2024-08-04 14:37:42.249192]: Done.
#>  [2024-08-04 14:37:42.250589]: 3.136 secs elapsed.
#> Save expo result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_14_expo.rds
#> Save similarity result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_14_sim.rds
#> Handling sample: Sample_15
#>  [2024-08-04 14:37:42.406652]: Started.
#>  [2024-08-04 14:37:42.408442]: Checking catalog.
#>  [2024-08-04 14:37:42.409972]: Done.
#>  [2024-08-04 14:37:42.411401]: About to start bootstrap.
#> → Bootstrapping 100 times.
#> → Total 100 times, starting no.1.
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#> → Total 100 times, starting no.78.
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#> → Total 100 times, starting no.80.
#> → Total 100 times, starting no.81.
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#> → Total 100 times, starting no.84.
#> → Total 100 times, starting no.85.
#> → Total 100 times, starting no.86.
#> → Total 100 times, starting no.87.
#> → Total 100 times, starting no.88.
#> → Total 100 times, starting no.89.
#> → Total 100 times, starting no.90.
#> → Total 100 times, starting no.91.
#> → Total 100 times, starting no.92.
#> → Total 100 times, starting no.93.
#> → Total 100 times, starting no.94.
#> → Total 100 times, starting no.95.
#> → Total 100 times, starting no.96.
#> → Total 100 times, starting no.97.
#> → Total 100 times, starting no.98.
#> → Total 100 times, starting no.99.
#> → Total 100 times, starting no.100.
#> Bootstrap done.
#> 
#>  [2024-08-04 14:37:45.633027]: Signature exposures collected.
#>  [2024-08-04 14:37:45.634573]: Errors and similarity collected.
#>  [2024-08-04 14:37:45.635923]: Done.
#>  [2024-08-04 14:37:45.637316]: 3.231 secs elapsed.
#> Save expo result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_15_expo.rds
#> Save similarity result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_15_sim.rds
#> Handling sample: Sample_16
#>  [2024-08-04 14:37:45.795764]: Started.
#>  [2024-08-04 14:37:45.797636]: Checking catalog.
#>  [2024-08-04 14:37:45.79918]: Done.
#>  [2024-08-04 14:37:45.800596]: About to start bootstrap.
#> → Bootstrapping 100 times.
#> → Total 100 times, starting no.1.
#> → Total 100 times, starting no.2.
#> → Total 100 times, starting no.3.
#> → Total 100 times, starting no.4.
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#> → Total 100 times, starting no.11.
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#> → Total 100 times, starting no.15.
#> → Total 100 times, starting no.16.
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#> → Total 100 times, starting no.18.
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#> → Total 100 times, starting no.20.
#> → Total 100 times, starting no.21.
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#> → Total 100 times, starting no.25.
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#> → Total 100 times, starting no.27.
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#> → Total 100 times, starting no.37.
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#> → Total 100 times, starting no.41.
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#> → Total 100 times, starting no.45.
#> → Total 100 times, starting no.46.
#> → Total 100 times, starting no.47.
#> → Total 100 times, starting no.48.
#> → Total 100 times, starting no.49.
#> → Total 100 times, starting no.50.
#> → Total 100 times, starting no.51.
#> → Total 100 times, starting no.52.
#> → Total 100 times, starting no.53.
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#> → Total 100 times, starting no.56.
#> → Total 100 times, starting no.57.
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#> → Total 100 times, starting no.63.
#> → Total 100 times, starting no.64.
#> → Total 100 times, starting no.65.
#> → Total 100 times, starting no.66.
#> → Total 100 times, starting no.67.
#> → Total 100 times, starting no.68.
#> → Total 100 times, starting no.69.
#> → Total 100 times, starting no.70.
#> → Total 100 times, starting no.71.
#> → Total 100 times, starting no.72.
#> → Total 100 times, starting no.73.
#> → Total 100 times, starting no.74.
#> → Total 100 times, starting no.75.
#> → Total 100 times, starting no.76.
#> → Total 100 times, starting no.77.
#> → Total 100 times, starting no.78.
#> → Total 100 times, starting no.79.
#> → Total 100 times, starting no.80.
#> → Total 100 times, starting no.81.
#> → Total 100 times, starting no.82.
#> → Total 100 times, starting no.83.
#> → Total 100 times, starting no.84.
#> → Total 100 times, starting no.85.
#> → Total 100 times, starting no.86.
#> → Total 100 times, starting no.87.
#> → Total 100 times, starting no.88.
#> → Total 100 times, starting no.89.
#> → Total 100 times, starting no.90.
#> → Total 100 times, starting no.91.
#> → Total 100 times, starting no.92.
#> → Total 100 times, starting no.93.
#> → Total 100 times, starting no.94.
#> → Total 100 times, starting no.95.
#> → Total 100 times, starting no.96.
#> → Total 100 times, starting no.97.
#> → Total 100 times, starting no.98.
#> → Total 100 times, starting no.99.
#> → Total 100 times, starting no.100.
#> Bootstrap done.
#> 
#>  [2024-08-04 14:37:49.104651]: Signature exposures collected.
#>  [2024-08-04 14:37:49.10617]: Errors and similarity collected.
#>  [2024-08-04 14:37:49.107512]: Done.
#>  [2024-08-04 14:37:49.108879]: 3.313 secs elapsed.
#> Save expo result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_16_expo.rds
#> Save similarity result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_16_sim.rds
#> Handling sample: Sample_18
#>  [2024-08-04 14:37:49.262846]: Started.
#>  [2024-08-04 14:37:49.26466]: Checking catalog.
#>  [2024-08-04 14:37:49.266156]: Done.
#>  [2024-08-04 14:37:49.267558]: About to start bootstrap.
#> → Bootstrapping 100 times.
#> → Total 100 times, starting no.1.
#> → Total 100 times, starting no.2.
#> → Total 100 times, starting no.3.
#> → Total 100 times, starting no.4.
#> → Total 100 times, starting no.5.
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#> → Total 100 times, starting no.10.
#> → Total 100 times, starting no.11.
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#> → Total 100 times, starting no.13.
#> → Total 100 times, starting no.14.
#> → Total 100 times, starting no.15.
#> → Total 100 times, starting no.16.
#> → Total 100 times, starting no.17.
#> → Total 100 times, starting no.18.
#> → Total 100 times, starting no.19.
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#> → Total 100 times, starting no.21.
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#> → Total 100 times, starting no.27.
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#> → Total 100 times, starting no.31.
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#> → Total 100 times, starting no.36.
#> → Total 100 times, starting no.37.
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#> → Total 100 times, starting no.39.
#> → Total 100 times, starting no.40.
#> → Total 100 times, starting no.41.
#> → Total 100 times, starting no.42.
#> → Total 100 times, starting no.43.
#> → Total 100 times, starting no.44.
#> → Total 100 times, starting no.45.
#> → Total 100 times, starting no.46.
#> → Total 100 times, starting no.47.
#> → Total 100 times, starting no.48.
#> → Total 100 times, starting no.49.
#> → Total 100 times, starting no.50.
#> → Total 100 times, starting no.51.
#> → Total 100 times, starting no.52.
#> → Total 100 times, starting no.53.
#> → Total 100 times, starting no.54.
#> → Total 100 times, starting no.55.
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#> → Total 100 times, starting no.57.
#> → Total 100 times, starting no.58.
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#> → Total 100 times, starting no.61.
#> → Total 100 times, starting no.62.
#> → Total 100 times, starting no.63.
#> → Total 100 times, starting no.64.
#> → Total 100 times, starting no.65.
#> → Total 100 times, starting no.66.
#> → Total 100 times, starting no.67.
#> → Total 100 times, starting no.68.
#> → Total 100 times, starting no.69.
#> → Total 100 times, starting no.70.
#> → Total 100 times, starting no.71.
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#> → Total 100 times, starting no.73.
#> → Total 100 times, starting no.74.
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#> → Total 100 times, starting no.77.
#> → Total 100 times, starting no.78.
#> → Total 100 times, starting no.79.
#> → Total 100 times, starting no.80.
#> → Total 100 times, starting no.81.
#> → Total 100 times, starting no.82.
#> → Total 100 times, starting no.83.
#> → Total 100 times, starting no.84.
#> → Total 100 times, starting no.85.
#> → Total 100 times, starting no.86.
#> → Total 100 times, starting no.87.
#> → Total 100 times, starting no.88.
#> → Total 100 times, starting no.89.
#> → Total 100 times, starting no.90.
#> → Total 100 times, starting no.91.
#> → Total 100 times, starting no.92.
#> → Total 100 times, starting no.93.
#> → Total 100 times, starting no.94.
#> → Total 100 times, starting no.95.
#> → Total 100 times, starting no.96.
#> → Total 100 times, starting no.97.
#> → Total 100 times, starting no.98.
#> → Total 100 times, starting no.99.
#> → Total 100 times, starting no.100.
#> Bootstrap done.
#> 
#>  [2024-08-04 14:37:52.44333]: Signature exposures collected.
#>  [2024-08-04 14:37:52.444838]: Errors and similarity collected.
#>  [2024-08-04 14:37:52.446218]: Done.
#>  [2024-08-04 14:37:52.447587]: 3.185 secs elapsed.
#> Save expo result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_18_expo.rds
#> Save similarity result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_18_sim.rds
#> Handling sample: Sample_20
#>  [2024-08-04 14:37:52.603029]: Started.
#>  [2024-08-04 14:37:52.604837]: Checking catalog.
#>  [2024-08-04 14:37:52.60639]: Done.
#>  [2024-08-04 14:37:52.607829]: About to start bootstrap.
#> → Bootstrapping 100 times.
#> → Total 100 times, starting no.1.
#> → Total 100 times, starting no.2.
#> → Total 100 times, starting no.3.
#> → Total 100 times, starting no.4.
#> → Total 100 times, starting no.5.
#> → Total 100 times, starting no.6.
#> → Total 100 times, starting no.7.
#> → Total 100 times, starting no.8.
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#> → Total 100 times, starting no.10.
#> → Total 100 times, starting no.11.
#> → Total 100 times, starting no.12.
#> → Total 100 times, starting no.13.
#> → Total 100 times, starting no.14.
#> → Total 100 times, starting no.15.
#> → Total 100 times, starting no.16.
#> → Total 100 times, starting no.17.
#> → Total 100 times, starting no.18.
#> → Total 100 times, starting no.19.
#> → Total 100 times, starting no.20.
#> → Total 100 times, starting no.21.
#> → Total 100 times, starting no.22.
#> → Total 100 times, starting no.23.
#> → Total 100 times, starting no.24.
#> → Total 100 times, starting no.25.
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#> → Total 100 times, starting no.27.
#> → Total 100 times, starting no.28.
#> → Total 100 times, starting no.29.
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#> → Total 100 times, starting no.31.
#> → Total 100 times, starting no.32.
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#> → Total 100 times, starting no.35.
#> → Total 100 times, starting no.36.
#> → Total 100 times, starting no.37.
#> → Total 100 times, starting no.38.
#> → Total 100 times, starting no.39.
#> → Total 100 times, starting no.40.
#> → Total 100 times, starting no.41.
#> → Total 100 times, starting no.42.
#> → Total 100 times, starting no.43.
#> → Total 100 times, starting no.44.
#> → Total 100 times, starting no.45.
#> → Total 100 times, starting no.46.
#> → Total 100 times, starting no.47.
#> → Total 100 times, starting no.48.
#> → Total 100 times, starting no.49.
#> → Total 100 times, starting no.50.
#> → Total 100 times, starting no.51.
#> → Total 100 times, starting no.52.
#> → Total 100 times, starting no.53.
#> → Total 100 times, starting no.54.
#> → Total 100 times, starting no.55.
#> → Total 100 times, starting no.56.
#> → Total 100 times, starting no.57.
#> → Total 100 times, starting no.58.
#> → Total 100 times, starting no.59.
#> → Total 100 times, starting no.60.
#> → Total 100 times, starting no.61.
#> → Total 100 times, starting no.62.
#> → Total 100 times, starting no.63.
#> → Total 100 times, starting no.64.
#> → Total 100 times, starting no.65.
#> → Total 100 times, starting no.66.
#> → Total 100 times, starting no.67.
#> → Total 100 times, starting no.68.
#> → Total 100 times, starting no.69.
#> → Total 100 times, starting no.70.
#> → Total 100 times, starting no.71.
#> → Total 100 times, starting no.72.
#> → Total 100 times, starting no.73.
#> → Total 100 times, starting no.74.
#> → Total 100 times, starting no.75.
#> → Total 100 times, starting no.76.
#> → Total 100 times, starting no.77.
#> → Total 100 times, starting no.78.
#> → Total 100 times, starting no.79.
#> → Total 100 times, starting no.80.
#> → Total 100 times, starting no.81.
#> → Total 100 times, starting no.82.
#> → Total 100 times, starting no.83.
#> → Total 100 times, starting no.84.
#> → Total 100 times, starting no.85.
#> → Total 100 times, starting no.86.
#> → Total 100 times, starting no.87.
#> → Total 100 times, starting no.88.
#> → Total 100 times, starting no.89.
#> → Total 100 times, starting no.90.
#> → Total 100 times, starting no.91.
#> → Total 100 times, starting no.92.
#> → Total 100 times, starting no.93.
#> → Total 100 times, starting no.94.
#> → Total 100 times, starting no.95.
#> → Total 100 times, starting no.96.
#> → Total 100 times, starting no.97.
#> → Total 100 times, starting no.98.
#> → Total 100 times, starting no.99.
#> → Total 100 times, starting no.100.
#> Bootstrap done.
#> 
#>  [2024-08-04 14:37:55.750282]: Signature exposures collected.
#>  [2024-08-04 14:37:55.751774]: Errors and similarity collected.
#>  [2024-08-04 14:37:55.753127]: Done.
#>  [2024-08-04 14:37:55.754528]: 3.151 secs elapsed.
#> Save expo result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_20_expo.rds
#> Save similarity result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_20_sim.rds
#> Handling sample: Sample_21
#>  [2024-08-04 14:37:55.910704]: Started.
#>  [2024-08-04 14:37:55.912526]: Checking catalog.
#>  [2024-08-04 14:37:55.914066]: Done.
#>  [2024-08-04 14:37:55.915576]: About to start bootstrap.
#> → Bootstrapping 100 times.
#> → Total 100 times, starting no.1.
#> → Total 100 times, starting no.2.
#> → Total 100 times, starting no.3.
#> → Total 100 times, starting no.4.
#> → Total 100 times, starting no.5.
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#> → Total 100 times, starting no.7.
#> → Total 100 times, starting no.8.
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#> → Total 100 times, starting no.11.
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#> → Total 100 times, starting no.13.
#> → Total 100 times, starting no.14.
#> → Total 100 times, starting no.15.
#> → Total 100 times, starting no.16.
#> → Total 100 times, starting no.17.
#> → Total 100 times, starting no.18.
#> → Total 100 times, starting no.19.
#> → Total 100 times, starting no.20.
#> → Total 100 times, starting no.21.
#> → Total 100 times, starting no.22.
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#> → Total 100 times, starting no.28.
#> → Total 100 times, starting no.29.
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#> → Total 100 times, starting no.31.
#> → Total 100 times, starting no.32.
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#> → Total 100 times, starting no.35.
#> → Total 100 times, starting no.36.
#> → Total 100 times, starting no.37.
#> → Total 100 times, starting no.38.
#> → Total 100 times, starting no.39.
#> → Total 100 times, starting no.40.
#> → Total 100 times, starting no.41.
#> → Total 100 times, starting no.42.
#> → Total 100 times, starting no.43.
#> → Total 100 times, starting no.44.
#> → Total 100 times, starting no.45.
#> → Total 100 times, starting no.46.
#> → Total 100 times, starting no.47.
#> → Total 100 times, starting no.48.
#> → Total 100 times, starting no.49.
#> → Total 100 times, starting no.50.
#> → Total 100 times, starting no.51.
#> → Total 100 times, starting no.52.
#> → Total 100 times, starting no.53.
#> → Total 100 times, starting no.54.
#> → Total 100 times, starting no.55.
#> → Total 100 times, starting no.56.
#> → Total 100 times, starting no.57.
#> → Total 100 times, starting no.58.
#> → Total 100 times, starting no.59.
#> → Total 100 times, starting no.60.
#> → Total 100 times, starting no.61.
#> → Total 100 times, starting no.62.
#> → Total 100 times, starting no.63.
#> → Total 100 times, starting no.64.
#> → Total 100 times, starting no.65.
#> → Total 100 times, starting no.66.
#> → Total 100 times, starting no.67.
#> → Total 100 times, starting no.68.
#> → Total 100 times, starting no.69.
#> → Total 100 times, starting no.70.
#> → Total 100 times, starting no.71.
#> → Total 100 times, starting no.72.
#> → Total 100 times, starting no.73.
#> → Total 100 times, starting no.74.
#> → Total 100 times, starting no.75.
#> → Total 100 times, starting no.76.
#> → Total 100 times, starting no.77.
#> → Total 100 times, starting no.78.
#> → Total 100 times, starting no.79.
#> → Total 100 times, starting no.80.
#> → Total 100 times, starting no.81.
#> → Total 100 times, starting no.82.
#> → Total 100 times, starting no.83.
#> → Total 100 times, starting no.84.
#> → Total 100 times, starting no.85.
#> → Total 100 times, starting no.86.
#> → Total 100 times, starting no.87.
#> → Total 100 times, starting no.88.
#> → Total 100 times, starting no.89.
#> → Total 100 times, starting no.90.
#> → Total 100 times, starting no.91.
#> → Total 100 times, starting no.92.
#> → Total 100 times, starting no.93.
#> → Total 100 times, starting no.94.
#> → Total 100 times, starting no.95.
#> → Total 100 times, starting no.96.
#> → Total 100 times, starting no.97.
#> → Total 100 times, starting no.98.
#> → Total 100 times, starting no.99.
#> → Total 100 times, starting no.100.
#> Bootstrap done.
#> 
#>  [2024-08-04 14:37:59.165813]: Signature exposures collected.
#>  [2024-08-04 14:37:59.167321]: Errors and similarity collected.
#>  [2024-08-04 14:37:59.168673]: Done.
#>  [2024-08-04 14:37:59.170108]: 3.259 secs elapsed.
#> Save expo result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_21_expo.rds
#> Save similarity result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_21_sim.rds
#> Handling sample: Sample_23
#>  [2024-08-04 14:37:59.323509]: Started.
#>  [2024-08-04 14:37:59.325694]: Checking catalog.
#>  [2024-08-04 14:37:59.327213]: Done.
#>  [2024-08-04 14:37:59.328642]: About to start bootstrap.
#> → Bootstrapping 100 times.
#> → Total 100 times, starting no.1.
#> → Total 100 times, starting no.2.
#> → Total 100 times, starting no.3.
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#> → Total 100 times, starting no.10.
#> → Total 100 times, starting no.11.
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#> → Total 100 times, starting no.13.
#> → Total 100 times, starting no.14.
#> → Total 100 times, starting no.15.
#> → Total 100 times, starting no.16.
#> → Total 100 times, starting no.17.
#> → Total 100 times, starting no.18.
#> → Total 100 times, starting no.19.
#> → Total 100 times, starting no.20.
#> → Total 100 times, starting no.21.
#> → Total 100 times, starting no.22.
#> → Total 100 times, starting no.23.
#> → Total 100 times, starting no.24.
#> → Total 100 times, starting no.25.
#> → Total 100 times, starting no.26.
#> → Total 100 times, starting no.27.
#> → Total 100 times, starting no.28.
#> → Total 100 times, starting no.29.
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#> → Total 100 times, starting no.31.
#> → Total 100 times, starting no.32.
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#> → Total 100 times, starting no.35.
#> → Total 100 times, starting no.36.
#> → Total 100 times, starting no.37.
#> → Total 100 times, starting no.38.
#> → Total 100 times, starting no.39.
#> → Total 100 times, starting no.40.
#> → Total 100 times, starting no.41.
#> → Total 100 times, starting no.42.
#> → Total 100 times, starting no.43.
#> → Total 100 times, starting no.44.
#> → Total 100 times, starting no.45.
#> → Total 100 times, starting no.46.
#> → Total 100 times, starting no.47.
#> → Total 100 times, starting no.48.
#> → Total 100 times, starting no.49.
#> → Total 100 times, starting no.50.
#> → Total 100 times, starting no.51.
#> → Total 100 times, starting no.52.
#> → Total 100 times, starting no.53.
#> → Total 100 times, starting no.54.
#> → Total 100 times, starting no.55.
#> → Total 100 times, starting no.56.
#> → Total 100 times, starting no.57.
#> → Total 100 times, starting no.58.
#> → Total 100 times, starting no.59.
#> → Total 100 times, starting no.60.
#> → Total 100 times, starting no.61.
#> → Total 100 times, starting no.62.
#> → Total 100 times, starting no.63.
#> → Total 100 times, starting no.64.
#> → Total 100 times, starting no.65.
#> → Total 100 times, starting no.66.
#> → Total 100 times, starting no.67.
#> → Total 100 times, starting no.68.
#> → Total 100 times, starting no.69.
#> → Total 100 times, starting no.70.
#> → Total 100 times, starting no.71.
#> → Total 100 times, starting no.72.
#> → Total 100 times, starting no.73.
#> → Total 100 times, starting no.74.
#> → Total 100 times, starting no.75.
#> → Total 100 times, starting no.76.
#> → Total 100 times, starting no.77.
#> → Total 100 times, starting no.78.
#> → Total 100 times, starting no.79.
#> → Total 100 times, starting no.80.
#> → Total 100 times, starting no.81.
#> → Total 100 times, starting no.82.
#> → Total 100 times, starting no.83.
#> → Total 100 times, starting no.84.
#> → Total 100 times, starting no.85.
#> → Total 100 times, starting no.86.
#> → Total 100 times, starting no.87.
#> → Total 100 times, starting no.88.
#> → Total 100 times, starting no.89.
#> → Total 100 times, starting no.90.
#> → Total 100 times, starting no.91.
#> → Total 100 times, starting no.92.
#> → Total 100 times, starting no.93.
#> → Total 100 times, starting no.94.
#> → Total 100 times, starting no.95.
#> → Total 100 times, starting no.96.
#> → Total 100 times, starting no.97.
#> → Total 100 times, starting no.98.
#> → Total 100 times, starting no.99.
#> → Total 100 times, starting no.100.
#> Bootstrap done.
#> 
#>  [2024-08-04 14:38:02.493806]: Signature exposures collected.
#>  [2024-08-04 14:38:02.495323]: Errors and similarity collected.
#>  [2024-08-04 14:38:02.496673]: Done.
#>  [2024-08-04 14:38:02.498093]: 3.175 secs elapsed.
#> Save expo result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_23_expo.rds
#> Save similarity result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_23_sim.rds
#> Handling sample: Sample_25
#>  [2024-08-04 14:38:02.652782]: Started.
#>  [2024-08-04 14:38:02.65463]: Checking catalog.
#>  [2024-08-04 14:38:02.65615]: Done.
#>  [2024-08-04 14:38:02.657622]: About to start bootstrap.
#> → Bootstrapping 100 times.
#> → Total 100 times, starting no.1.
#> → Total 100 times, starting no.2.
#> → Total 100 times, starting no.3.
#> → Total 100 times, starting no.4.
#> → Total 100 times, starting no.5.
#> → Total 100 times, starting no.6.
#> → Total 100 times, starting no.7.
#> → Total 100 times, starting no.8.
#> → Total 100 times, starting no.9.
#> → Total 100 times, starting no.10.
#> → Total 100 times, starting no.11.
#> → Total 100 times, starting no.12.
#> → Total 100 times, starting no.13.
#> → Total 100 times, starting no.14.
#> → Total 100 times, starting no.15.
#> → Total 100 times, starting no.16.
#> → Total 100 times, starting no.17.
#> → Total 100 times, starting no.18.
#> → Total 100 times, starting no.19.
#> → Total 100 times, starting no.20.
#> → Total 100 times, starting no.21.
#> → Total 100 times, starting no.22.
#> → Total 100 times, starting no.23.
#> → Total 100 times, starting no.24.
#> → Total 100 times, starting no.25.
#> → Total 100 times, starting no.26.
#> → Total 100 times, starting no.27.
#> → Total 100 times, starting no.28.
#> → Total 100 times, starting no.29.
#> → Total 100 times, starting no.30.
#> → Total 100 times, starting no.31.
#> → Total 100 times, starting no.32.
#> → Total 100 times, starting no.33.
#> → Total 100 times, starting no.34.
#> → Total 100 times, starting no.35.
#> → Total 100 times, starting no.36.
#> → Total 100 times, starting no.37.
#> → Total 100 times, starting no.38.
#> → Total 100 times, starting no.39.
#> → Total 100 times, starting no.40.
#> → Total 100 times, starting no.41.
#> → Total 100 times, starting no.42.
#> → Total 100 times, starting no.43.
#> → Total 100 times, starting no.44.
#> → Total 100 times, starting no.45.
#> → Total 100 times, starting no.46.
#> → Total 100 times, starting no.47.
#> → Total 100 times, starting no.48.
#> → Total 100 times, starting no.49.
#> → Total 100 times, starting no.50.
#> → Total 100 times, starting no.51.
#> → Total 100 times, starting no.52.
#> → Total 100 times, starting no.53.
#> → Total 100 times, starting no.54.
#> → Total 100 times, starting no.55.
#> → Total 100 times, starting no.56.
#> → Total 100 times, starting no.57.
#> → Total 100 times, starting no.58.
#> → Total 100 times, starting no.59.
#> → Total 100 times, starting no.60.
#> → Total 100 times, starting no.61.
#> → Total 100 times, starting no.62.
#> → Total 100 times, starting no.63.
#> → Total 100 times, starting no.64.
#> → Total 100 times, starting no.65.
#> → Total 100 times, starting no.66.
#> → Total 100 times, starting no.67.
#> → Total 100 times, starting no.68.
#> → Total 100 times, starting no.69.
#> → Total 100 times, starting no.70.
#> → Total 100 times, starting no.71.
#> → Total 100 times, starting no.72.
#> → Total 100 times, starting no.73.
#> → Total 100 times, starting no.74.
#> → Total 100 times, starting no.75.
#> → Total 100 times, starting no.76.
#> → Total 100 times, starting no.77.
#> → Total 100 times, starting no.78.
#> → Total 100 times, starting no.79.
#> → Total 100 times, starting no.80.
#> → Total 100 times, starting no.81.
#> → Total 100 times, starting no.82.
#> → Total 100 times, starting no.83.
#> → Total 100 times, starting no.84.
#> → Total 100 times, starting no.85.
#> → Total 100 times, starting no.86.
#> → Total 100 times, starting no.87.
#> → Total 100 times, starting no.88.
#> → Total 100 times, starting no.89.
#> → Total 100 times, starting no.90.
#> → Total 100 times, starting no.91.
#> → Total 100 times, starting no.92.
#> → Total 100 times, starting no.93.
#> → Total 100 times, starting no.94.
#> → Total 100 times, starting no.95.
#> → Total 100 times, starting no.96.
#> → Total 100 times, starting no.97.
#> → Total 100 times, starting no.98.
#> → Total 100 times, starting no.99.
#> → Total 100 times, starting no.100.
#> Bootstrap done.
#> 
#>  [2024-08-04 14:38:05.87948]: Signature exposures collected.
#>  [2024-08-04 14:38:05.881034]: Errors and similarity collected.
#>  [2024-08-04 14:38:05.882453]: Done.
#>  [2024-08-04 14:38:05.883848]: 3.231 secs elapsed.
#> Save expo result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_25_expo.rds
#> Save similarity result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_25_sim.rds
#> Handling sample: Sample_26
#>  [2024-08-04 14:38:06.039642]: Started.
#>  [2024-08-04 14:38:06.041602]: Checking catalog.
#>  [2024-08-04 14:38:06.043191]: Done.
#>  [2024-08-04 14:38:06.044637]: About to start bootstrap.
#> → Bootstrapping 100 times.
#> → Total 100 times, starting no.1.
#> → Total 100 times, starting no.2.
#> → Total 100 times, starting no.3.
#> → Total 100 times, starting no.4.
#> → Total 100 times, starting no.5.
#> → Total 100 times, starting no.6.
#> → Total 100 times, starting no.7.
#> → Total 100 times, starting no.8.
#> → Total 100 times, starting no.9.
#> → Total 100 times, starting no.10.
#> → Total 100 times, starting no.11.
#> → Total 100 times, starting no.12.
#> → Total 100 times, starting no.13.
#> → Total 100 times, starting no.14.
#> → Total 100 times, starting no.15.
#> → Total 100 times, starting no.16.
#> → Total 100 times, starting no.17.
#> → Total 100 times, starting no.18.
#> → Total 100 times, starting no.19.
#> → Total 100 times, starting no.20.
#> → Total 100 times, starting no.21.
#> → Total 100 times, starting no.22.
#> → Total 100 times, starting no.23.
#> → Total 100 times, starting no.24.
#> → Total 100 times, starting no.25.
#> → Total 100 times, starting no.26.
#> → Total 100 times, starting no.27.
#> → Total 100 times, starting no.28.
#> → Total 100 times, starting no.29.
#> → Total 100 times, starting no.30.
#> → Total 100 times, starting no.31.
#> → Total 100 times, starting no.32.
#> → Total 100 times, starting no.33.
#> → Total 100 times, starting no.34.
#> → Total 100 times, starting no.35.
#> → Total 100 times, starting no.36.
#> → Total 100 times, starting no.37.
#> → Total 100 times, starting no.38.
#> → Total 100 times, starting no.39.
#> → Total 100 times, starting no.40.
#> → Total 100 times, starting no.41.
#> → Total 100 times, starting no.42.
#> → Total 100 times, starting no.43.
#> → Total 100 times, starting no.44.
#> → Total 100 times, starting no.45.
#> → Total 100 times, starting no.46.
#> → Total 100 times, starting no.47.
#> → Total 100 times, starting no.48.
#> → Total 100 times, starting no.49.
#> → Total 100 times, starting no.50.
#> → Total 100 times, starting no.51.
#> → Total 100 times, starting no.52.
#> → Total 100 times, starting no.53.
#> → Total 100 times, starting no.54.
#> → Total 100 times, starting no.55.
#> → Total 100 times, starting no.56.
#> → Total 100 times, starting no.57.
#> → Total 100 times, starting no.58.
#> → Total 100 times, starting no.59.
#> → Total 100 times, starting no.60.
#> → Total 100 times, starting no.61.
#> → Total 100 times, starting no.62.
#> → Total 100 times, starting no.63.
#> → Total 100 times, starting no.64.
#> → Total 100 times, starting no.65.
#> → Total 100 times, starting no.66.
#> → Total 100 times, starting no.67.
#> → Total 100 times, starting no.68.
#> → Total 100 times, starting no.69.
#> → Total 100 times, starting no.70.
#> → Total 100 times, starting no.71.
#> → Total 100 times, starting no.72.
#> → Total 100 times, starting no.73.
#> → Total 100 times, starting no.74.
#> → Total 100 times, starting no.75.
#> → Total 100 times, starting no.76.
#> → Total 100 times, starting no.77.
#> → Total 100 times, starting no.78.
#> → Total 100 times, starting no.79.
#> → Total 100 times, starting no.80.
#> → Total 100 times, starting no.81.
#> → Total 100 times, starting no.82.
#> → Total 100 times, starting no.83.
#> → Total 100 times, starting no.84.
#> → Total 100 times, starting no.85.
#> → Total 100 times, starting no.86.
#> → Total 100 times, starting no.87.
#> → Total 100 times, starting no.88.
#> → Total 100 times, starting no.89.
#> → Total 100 times, starting no.90.
#> → Total 100 times, starting no.91.
#> → Total 100 times, starting no.92.
#> → Total 100 times, starting no.93.
#> → Total 100 times, starting no.94.
#> → Total 100 times, starting no.95.
#> → Total 100 times, starting no.96.
#> → Total 100 times, starting no.97.
#> → Total 100 times, starting no.98.
#> → Total 100 times, starting no.99.
#> → Total 100 times, starting no.100.
#> Bootstrap done.
#> 
#>  [2024-08-04 14:38:09.226263]: Signature exposures collected.
#>  [2024-08-04 14:38:09.227786]: Errors and similarity collected.
#>  [2024-08-04 14:38:09.229151]: Done.
#>  [2024-08-04 14:38:09.230568]: 3.191 secs elapsed.
#> Save expo result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_26_expo.rds
#> Save similarity result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_26_sim.rds
#> Handling sample: Sample_27
#>  [2024-08-04 14:38:09.38452]: Started.
#>  [2024-08-04 14:38:09.386347]: Checking catalog.
#>  [2024-08-04 14:38:09.387841]: Done.
#>  [2024-08-04 14:38:09.389286]: About to start bootstrap.
#> → Bootstrapping 100 times.
#> → Total 100 times, starting no.1.
#> → Total 100 times, starting no.2.
#> → Total 100 times, starting no.3.
#> → Total 100 times, starting no.4.
#> → Total 100 times, starting no.5.
#> → Total 100 times, starting no.6.
#> → Total 100 times, starting no.7.
#> → Total 100 times, starting no.8.
#> → Total 100 times, starting no.9.
#> → Total 100 times, starting no.10.
#> → Total 100 times, starting no.11.
#> → Total 100 times, starting no.12.
#> → Total 100 times, starting no.13.
#> → Total 100 times, starting no.14.
#> → Total 100 times, starting no.15.
#> → Total 100 times, starting no.16.
#> → Total 100 times, starting no.17.
#> → Total 100 times, starting no.18.
#> → Total 100 times, starting no.19.
#> → Total 100 times, starting no.20.
#> → Total 100 times, starting no.21.
#> → Total 100 times, starting no.22.
#> → Total 100 times, starting no.23.
#> → Total 100 times, starting no.24.
#> → Total 100 times, starting no.25.
#> → Total 100 times, starting no.26.
#> → Total 100 times, starting no.27.
#> → Total 100 times, starting no.28.
#> → Total 100 times, starting no.29.
#> → Total 100 times, starting no.30.
#> → Total 100 times, starting no.31.
#> → Total 100 times, starting no.32.
#> → Total 100 times, starting no.33.
#> → Total 100 times, starting no.34.
#> → Total 100 times, starting no.35.
#> → Total 100 times, starting no.36.
#> → Total 100 times, starting no.37.
#> → Total 100 times, starting no.38.
#> → Total 100 times, starting no.39.
#> → Total 100 times, starting no.40.
#> → Total 100 times, starting no.41.
#> → Total 100 times, starting no.42.
#> → Total 100 times, starting no.43.
#> → Total 100 times, starting no.44.
#> → Total 100 times, starting no.45.
#> → Total 100 times, starting no.46.
#> → Total 100 times, starting no.47.
#> → Total 100 times, starting no.48.
#> → Total 100 times, starting no.49.
#> → Total 100 times, starting no.50.
#> → Total 100 times, starting no.51.
#> → Total 100 times, starting no.52.
#> → Total 100 times, starting no.53.
#> → Total 100 times, starting no.54.
#> → Total 100 times, starting no.55.
#> → Total 100 times, starting no.56.
#> → Total 100 times, starting no.57.
#> → Total 100 times, starting no.58.
#> → Total 100 times, starting no.59.
#> → Total 100 times, starting no.60.
#> → Total 100 times, starting no.61.
#> → Total 100 times, starting no.62.
#> → Total 100 times, starting no.63.
#> → Total 100 times, starting no.64.
#> → Total 100 times, starting no.65.
#> → Total 100 times, starting no.66.
#> → Total 100 times, starting no.67.
#> → Total 100 times, starting no.68.
#> → Total 100 times, starting no.69.
#> → Total 100 times, starting no.70.
#> → Total 100 times, starting no.71.
#> → Total 100 times, starting no.72.
#> → Total 100 times, starting no.73.
#> → Total 100 times, starting no.74.
#> → Total 100 times, starting no.75.
#> → Total 100 times, starting no.76.
#> → Total 100 times, starting no.77.
#> → Total 100 times, starting no.78.
#> → Total 100 times, starting no.79.
#> → Total 100 times, starting no.80.
#> → Total 100 times, starting no.81.
#> → Total 100 times, starting no.82.
#> → Total 100 times, starting no.83.
#> → Total 100 times, starting no.84.
#> → Total 100 times, starting no.85.
#> → Total 100 times, starting no.86.
#> → Total 100 times, starting no.87.
#> → Total 100 times, starting no.88.
#> → Total 100 times, starting no.89.
#> → Total 100 times, starting no.90.
#> → Total 100 times, starting no.91.
#> → Total 100 times, starting no.92.
#> → Total 100 times, starting no.93.
#> → Total 100 times, starting no.94.
#> → Total 100 times, starting no.95.
#> → Total 100 times, starting no.96.
#> → Total 100 times, starting no.97.
#> → Total 100 times, starting no.98.
#> → Total 100 times, starting no.99.
#> → Total 100 times, starting no.100.
#> Bootstrap done.
#> 
#>  [2024-08-04 14:38:12.757006]: Signature exposures collected.
#>  [2024-08-04 14:38:12.758554]: Errors and similarity collected.
#>  [2024-08-04 14:38:12.759908]: Done.
#>  [2024-08-04 14:38:12.761307]: 3.377 secs elapsed.
#> Save expo result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_27_expo.rds
#> Save similarity result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_27_sim.rds
#> Handling sample: Sample_28
#>  [2024-08-04 14:38:12.915554]: Started.
#>  [2024-08-04 14:38:12.917435]: Checking catalog.
#>  [2024-08-04 14:38:12.918985]: Done.
#>  [2024-08-04 14:38:12.920444]: About to start bootstrap.
#> → Bootstrapping 100 times.
#> → Total 100 times, starting no.1.
#> → Total 100 times, starting no.2.
#> → Total 100 times, starting no.3.
#> → Total 100 times, starting no.4.
#> → Total 100 times, starting no.5.
#> → Total 100 times, starting no.6.
#> → Total 100 times, starting no.7.
#> → Total 100 times, starting no.8.
#> → Total 100 times, starting no.9.
#> → Total 100 times, starting no.10.
#> → Total 100 times, starting no.11.
#> → Total 100 times, starting no.12.
#> → Total 100 times, starting no.13.
#> → Total 100 times, starting no.14.
#> → Total 100 times, starting no.15.
#> → Total 100 times, starting no.16.
#> → Total 100 times, starting no.17.
#> → Total 100 times, starting no.18.
#> → Total 100 times, starting no.19.
#> → Total 100 times, starting no.20.
#> → Total 100 times, starting no.21.
#> → Total 100 times, starting no.22.
#> → Total 100 times, starting no.23.
#> → Total 100 times, starting no.24.
#> → Total 100 times, starting no.25.
#> → Total 100 times, starting no.26.
#> → Total 100 times, starting no.27.
#> → Total 100 times, starting no.28.
#> → Total 100 times, starting no.29.
#> → Total 100 times, starting no.30.
#> → Total 100 times, starting no.31.
#> → Total 100 times, starting no.32.
#> → Total 100 times, starting no.33.
#> → Total 100 times, starting no.34.
#> → Total 100 times, starting no.35.
#> → Total 100 times, starting no.36.
#> → Total 100 times, starting no.37.
#> → Total 100 times, starting no.38.
#> → Total 100 times, starting no.39.
#> → Total 100 times, starting no.40.
#> → Total 100 times, starting no.41.
#> → Total 100 times, starting no.42.
#> → Total 100 times, starting no.43.
#> → Total 100 times, starting no.44.
#> → Total 100 times, starting no.45.
#> → Total 100 times, starting no.46.
#> → Total 100 times, starting no.47.
#> → Total 100 times, starting no.48.
#> → Total 100 times, starting no.49.
#> → Total 100 times, starting no.50.
#> → Total 100 times, starting no.51.
#> → Total 100 times, starting no.52.
#> → Total 100 times, starting no.53.
#> → Total 100 times, starting no.54.
#> → Total 100 times, starting no.55.
#> → Total 100 times, starting no.56.
#> → Total 100 times, starting no.57.
#> → Total 100 times, starting no.58.
#> → Total 100 times, starting no.59.
#> → Total 100 times, starting no.60.
#> → Total 100 times, starting no.61.
#> → Total 100 times, starting no.62.
#> → Total 100 times, starting no.63.
#> → Total 100 times, starting no.64.
#> → Total 100 times, starting no.65.
#> → Total 100 times, starting no.66.
#> → Total 100 times, starting no.67.
#> → Total 100 times, starting no.68.
#> → Total 100 times, starting no.69.
#> → Total 100 times, starting no.70.
#> → Total 100 times, starting no.71.
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#> → Total 100 times, starting no.73.
#> → Total 100 times, starting no.74.
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#> → Total 100 times, starting no.76.
#> → Total 100 times, starting no.77.
#> → Total 100 times, starting no.78.
#> → Total 100 times, starting no.79.
#> → Total 100 times, starting no.80.
#> → Total 100 times, starting no.81.
#> → Total 100 times, starting no.82.
#> → Total 100 times, starting no.83.
#> → Total 100 times, starting no.84.
#> → Total 100 times, starting no.85.
#> → Total 100 times, starting no.86.
#> → Total 100 times, starting no.87.
#> → Total 100 times, starting no.88.
#> → Total 100 times, starting no.89.
#> → Total 100 times, starting no.90.
#> → Total 100 times, starting no.91.
#> → Total 100 times, starting no.92.
#> → Total 100 times, starting no.93.
#> → Total 100 times, starting no.94.
#> → Total 100 times, starting no.95.
#> → Total 100 times, starting no.96.
#> → Total 100 times, starting no.97.
#> → Total 100 times, starting no.98.
#> → Total 100 times, starting no.99.
#> → Total 100 times, starting no.100.
#> Bootstrap done.
#> 
#>  [2024-08-04 14:38:16.057013]: Signature exposures collected.
#>  [2024-08-04 14:38:16.058567]: Errors and similarity collected.
#>  [2024-08-04 14:38:16.059939]: Done.
#>  [2024-08-04 14:38:16.061359]: 3.146 secs elapsed.
#> Save expo result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_28_expo.rds
#> Save similarity result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_28_sim.rds
#> Handling sample: Sample_29
#>  [2024-08-04 14:38:16.218087]: Started.
#>  [2024-08-04 14:38:16.219818]: Checking catalog.
#>  [2024-08-04 14:38:16.221188]: Done.
#>  [2024-08-04 14:38:16.222585]: About to start bootstrap.
#> → Bootstrapping 100 times.
#> → Total 100 times, starting no.1.
#> → Total 100 times, starting no.2.
#> → Total 100 times, starting no.3.
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#> → Total 100 times, starting no.11.
#> → Total 100 times, starting no.12.
#> → Total 100 times, starting no.13.
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#> → Total 100 times, starting no.16.
#> → Total 100 times, starting no.17.
#> → Total 100 times, starting no.18.
#> → Total 100 times, starting no.19.
#> → Total 100 times, starting no.20.
#> → Total 100 times, starting no.21.
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#> → Total 100 times, starting no.23.
#> → Total 100 times, starting no.24.
#> → Total 100 times, starting no.25.
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#> → Total 100 times, starting no.27.
#> → Total 100 times, starting no.28.
#> → Total 100 times, starting no.29.
#> → Total 100 times, starting no.30.
#> → Total 100 times, starting no.31.
#> → Total 100 times, starting no.32.
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#> → Total 100 times, starting no.36.
#> → Total 100 times, starting no.37.
#> → Total 100 times, starting no.38.
#> → Total 100 times, starting no.39.
#> → Total 100 times, starting no.40.
#> → Total 100 times, starting no.41.
#> → Total 100 times, starting no.42.
#> → Total 100 times, starting no.43.
#> → Total 100 times, starting no.44.
#> → Total 100 times, starting no.45.
#> → Total 100 times, starting no.46.
#> → Total 100 times, starting no.47.
#> → Total 100 times, starting no.48.
#> → Total 100 times, starting no.49.
#> → Total 100 times, starting no.50.
#> → Total 100 times, starting no.51.
#> → Total 100 times, starting no.52.
#> → Total 100 times, starting no.53.
#> → Total 100 times, starting no.54.
#> → Total 100 times, starting no.55.
#> → Total 100 times, starting no.56.
#> → Total 100 times, starting no.57.
#> → Total 100 times, starting no.58.
#> → Total 100 times, starting no.59.
#> → Total 100 times, starting no.60.
#> → Total 100 times, starting no.61.
#> → Total 100 times, starting no.62.
#> → Total 100 times, starting no.63.
#> → Total 100 times, starting no.64.
#> → Total 100 times, starting no.65.
#> → Total 100 times, starting no.66.
#> → Total 100 times, starting no.67.
#> → Total 100 times, starting no.68.
#> → Total 100 times, starting no.69.
#> → Total 100 times, starting no.70.
#> → Total 100 times, starting no.71.
#> → Total 100 times, starting no.72.
#> → Total 100 times, starting no.73.
#> → Total 100 times, starting no.74.
#> → Total 100 times, starting no.75.
#> → Total 100 times, starting no.76.
#> → Total 100 times, starting no.77.
#> → Total 100 times, starting no.78.
#> → Total 100 times, starting no.79.
#> → Total 100 times, starting no.80.
#> → Total 100 times, starting no.81.
#> → Total 100 times, starting no.82.
#> → Total 100 times, starting no.83.
#> → Total 100 times, starting no.84.
#> → Total 100 times, starting no.85.
#> → Total 100 times, starting no.86.
#> → Total 100 times, starting no.87.
#> → Total 100 times, starting no.88.
#> → Total 100 times, starting no.89.
#> → Total 100 times, starting no.90.
#> → Total 100 times, starting no.91.
#> → Total 100 times, starting no.92.
#> → Total 100 times, starting no.93.
#> → Total 100 times, starting no.94.
#> → Total 100 times, starting no.95.
#> → Total 100 times, starting no.96.
#> → Total 100 times, starting no.97.
#> → Total 100 times, starting no.98.
#> → Total 100 times, starting no.99.
#> → Total 100 times, starting no.100.
#> Bootstrap done.
#> 
#>  [2024-08-04 14:38:19.353896]: Signature exposures collected.
#>  [2024-08-04 14:38:19.355422]: Errors and similarity collected.
#>  [2024-08-04 14:38:19.356789]: Done.
#>  [2024-08-04 14:38:19.358199]: 3.14 secs elapsed.
#> Save expo result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_29_expo.rds
#> Save similarity result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_29_sim.rds
#> Handling sample: Sample_30
#>  [2024-08-04 14:38:19.517917]: Started.
#>  [2024-08-04 14:38:19.519818]: Checking catalog.
#>  [2024-08-04 14:38:19.521333]: Done.
#>  [2024-08-04 14:38:19.522713]: About to start bootstrap.
#> → Bootstrapping 100 times.
#> → Total 100 times, starting no.1.
#> → Total 100 times, starting no.2.
#> → Total 100 times, starting no.3.
#> → Total 100 times, starting no.4.
#> → Total 100 times, starting no.5.
#> → Total 100 times, starting no.6.
#> → Total 100 times, starting no.7.
#> → Total 100 times, starting no.8.
#> → Total 100 times, starting no.9.
#> → Total 100 times, starting no.10.
#> → Total 100 times, starting no.11.
#> → Total 100 times, starting no.12.
#> → Total 100 times, starting no.13.
#> → Total 100 times, starting no.14.
#> → Total 100 times, starting no.15.
#> → Total 100 times, starting no.16.
#> → Total 100 times, starting no.17.
#> → Total 100 times, starting no.18.
#> → Total 100 times, starting no.19.
#> → Total 100 times, starting no.20.
#> → Total 100 times, starting no.21.
#> → Total 100 times, starting no.22.
#> → Total 100 times, starting no.23.
#> → Total 100 times, starting no.24.
#> → Total 100 times, starting no.25.
#> → Total 100 times, starting no.26.
#> → Total 100 times, starting no.27.
#> → Total 100 times, starting no.28.
#> → Total 100 times, starting no.29.
#> → Total 100 times, starting no.30.
#> → Total 100 times, starting no.31.
#> → Total 100 times, starting no.32.
#> → Total 100 times, starting no.33.
#> → Total 100 times, starting no.34.
#> → Total 100 times, starting no.35.
#> → Total 100 times, starting no.36.
#> → Total 100 times, starting no.37.
#> → Total 100 times, starting no.38.
#> → Total 100 times, starting no.39.
#> → Total 100 times, starting no.40.
#> → Total 100 times, starting no.41.
#> → Total 100 times, starting no.42.
#> → Total 100 times, starting no.43.
#> → Total 100 times, starting no.44.
#> → Total 100 times, starting no.45.
#> → Total 100 times, starting no.46.
#> → Total 100 times, starting no.47.
#> → Total 100 times, starting no.48.
#> → Total 100 times, starting no.49.
#> → Total 100 times, starting no.50.
#> → Total 100 times, starting no.51.
#> → Total 100 times, starting no.52.
#> → Total 100 times, starting no.53.
#> → Total 100 times, starting no.54.
#> → Total 100 times, starting no.55.
#> → Total 100 times, starting no.56.
#> → Total 100 times, starting no.57.
#> → Total 100 times, starting no.58.
#> → Total 100 times, starting no.59.
#> → Total 100 times, starting no.60.
#> → Total 100 times, starting no.61.
#> → Total 100 times, starting no.62.
#> → Total 100 times, starting no.63.
#> → Total 100 times, starting no.64.
#> → Total 100 times, starting no.65.
#> → Total 100 times, starting no.66.
#> → Total 100 times, starting no.67.
#> → Total 100 times, starting no.68.
#> → Total 100 times, starting no.69.
#> → Total 100 times, starting no.70.
#> → Total 100 times, starting no.71.
#> → Total 100 times, starting no.72.
#> → Total 100 times, starting no.73.
#> → Total 100 times, starting no.74.
#> → Total 100 times, starting no.75.
#> → Total 100 times, starting no.76.
#> → Total 100 times, starting no.77.
#> → Total 100 times, starting no.78.
#> → Total 100 times, starting no.79.
#> → Total 100 times, starting no.80.
#> → Total 100 times, starting no.81.
#> → Total 100 times, starting no.82.
#> → Total 100 times, starting no.83.
#> → Total 100 times, starting no.84.
#> → Total 100 times, starting no.85.
#> → Total 100 times, starting no.86.
#> → Total 100 times, starting no.87.
#> → Total 100 times, starting no.88.
#> → Total 100 times, starting no.89.
#> → Total 100 times, starting no.90.
#> → Total 100 times, starting no.91.
#> → Total 100 times, starting no.92.
#> → Total 100 times, starting no.93.
#> → Total 100 times, starting no.94.
#> → Total 100 times, starting no.95.
#> → Total 100 times, starting no.96.
#> → Total 100 times, starting no.97.
#> → Total 100 times, starting no.98.
#> → Total 100 times, starting no.99.
#> → Total 100 times, starting no.100.
#> Bootstrap done.
#> 
#>  [2024-08-04 14:38:22.698183]: Signature exposures collected.
#>  [2024-08-04 14:38:22.699703]: Errors and similarity collected.
#>  [2024-08-04 14:38:22.701059]: Done.
#>  [2024-08-04 14:38:22.70246]: 3.185 secs elapsed.
#> Save expo result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_30_expo.rds
#> Save similarity result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_30_sim.rds
#> Handling sample: Sample_1
#>  [2024-08-04 14:38:22.858709]: Started.
#>  [2024-08-04 14:38:22.860537]: Checking catalog.
#>  [2024-08-04 14:38:22.862093]: Done.
#>  [2024-08-04 14:38:22.863616]: About to start bootstrap.
#> → Bootstrapping 100 times.
#> → Total 100 times, starting no.1.
#> → Total 100 times, starting no.2.
#> → Total 100 times, starting no.3.
#> → Total 100 times, starting no.4.
#> → Total 100 times, starting no.5.
#> → Total 100 times, starting no.6.
#> → Total 100 times, starting no.7.
#> → Total 100 times, starting no.8.
#> → Total 100 times, starting no.9.
#> → Total 100 times, starting no.10.
#> → Total 100 times, starting no.11.
#> → Total 100 times, starting no.12.
#> → Total 100 times, starting no.13.
#> → Total 100 times, starting no.14.
#> → Total 100 times, starting no.15.
#> → Total 100 times, starting no.16.
#> → Total 100 times, starting no.17.
#> → Total 100 times, starting no.18.
#> → Total 100 times, starting no.19.
#> → Total 100 times, starting no.20.
#> → Total 100 times, starting no.21.
#> → Total 100 times, starting no.22.
#> → Total 100 times, starting no.23.
#> → Total 100 times, starting no.24.
#> → Total 100 times, starting no.25.
#> → Total 100 times, starting no.26.
#> → Total 100 times, starting no.27.
#> → Total 100 times, starting no.28.
#> → Total 100 times, starting no.29.
#> → Total 100 times, starting no.30.
#> → Total 100 times, starting no.31.
#> → Total 100 times, starting no.32.
#> → Total 100 times, starting no.33.
#> → Total 100 times, starting no.34.
#> → Total 100 times, starting no.35.
#> → Total 100 times, starting no.36.
#> → Total 100 times, starting no.37.
#> → Total 100 times, starting no.38.
#> → Total 100 times, starting no.39.
#> → Total 100 times, starting no.40.
#> → Total 100 times, starting no.41.
#> → Total 100 times, starting no.42.
#> → Total 100 times, starting no.43.
#> → Total 100 times, starting no.44.
#> → Total 100 times, starting no.45.
#> → Total 100 times, starting no.46.
#> → Total 100 times, starting no.47.
#> → Total 100 times, starting no.48.
#> → Total 100 times, starting no.49.
#> → Total 100 times, starting no.50.
#> → Total 100 times, starting no.51.
#> → Total 100 times, starting no.52.
#> → Total 100 times, starting no.53.
#> → Total 100 times, starting no.54.
#> → Total 100 times, starting no.55.
#> → Total 100 times, starting no.56.
#> → Total 100 times, starting no.57.
#> → Total 100 times, starting no.58.
#> → Total 100 times, starting no.59.
#> → Total 100 times, starting no.60.
#> → Total 100 times, starting no.61.
#> → Total 100 times, starting no.62.
#> → Total 100 times, starting no.63.
#> → Total 100 times, starting no.64.
#> → Total 100 times, starting no.65.
#> → Total 100 times, starting no.66.
#> → Total 100 times, starting no.67.
#> → Total 100 times, starting no.68.
#> → Total 100 times, starting no.69.
#> → Total 100 times, starting no.70.
#> → Total 100 times, starting no.71.
#> → Total 100 times, starting no.72.
#> → Total 100 times, starting no.73.
#> → Total 100 times, starting no.74.
#> → Total 100 times, starting no.75.
#> → Total 100 times, starting no.76.
#> → Total 100 times, starting no.77.
#> → Total 100 times, starting no.78.
#> → Total 100 times, starting no.79.
#> → Total 100 times, starting no.80.
#> → Total 100 times, starting no.81.
#> → Total 100 times, starting no.82.
#> → Total 100 times, starting no.83.
#> → Total 100 times, starting no.84.
#> → Total 100 times, starting no.85.
#> → Total 100 times, starting no.86.
#> → Total 100 times, starting no.87.
#> → Total 100 times, starting no.88.
#> → Total 100 times, starting no.89.
#> → Total 100 times, starting no.90.
#> → Total 100 times, starting no.91.
#> → Total 100 times, starting no.92.
#> → Total 100 times, starting no.93.
#> → Total 100 times, starting no.94.
#> → Total 100 times, starting no.95.
#> → Total 100 times, starting no.96.
#> → Total 100 times, starting no.97.
#> → Total 100 times, starting no.98.
#> → Total 100 times, starting no.99.
#> → Total 100 times, starting no.100.
#> Bootstrap done.
#> 
#>  [2024-08-04 14:38:26.375695]: Signature exposures collected.
#>  [2024-08-04 14:38:26.37725]: Errors and similarity collected.
#>  [2024-08-04 14:38:26.378732]: Done.
#>  [2024-08-04 14:38:26.380135]: 3.521 secs elapsed.
#> Save expo result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_1_expo.rds
#> Save similarity result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_1_sim.rds
#> Handling sample: Sample_12
#>  [2024-08-04 14:38:26.539569]: Started.
#>  [2024-08-04 14:38:26.541453]: Checking catalog.
#>  [2024-08-04 14:38:26.543005]: Done.
#>  [2024-08-04 14:38:26.544495]: About to start bootstrap.
#> → Bootstrapping 100 times.
#> → Total 100 times, starting no.1.
#> → Total 100 times, starting no.2.
#> → Total 100 times, starting no.3.
#> → Total 100 times, starting no.4.
#> → Total 100 times, starting no.5.
#> → Total 100 times, starting no.6.
#> → Total 100 times, starting no.7.
#> → Total 100 times, starting no.8.
#> → Total 100 times, starting no.9.
#> → Total 100 times, starting no.10.
#> → Total 100 times, starting no.11.
#> → Total 100 times, starting no.12.
#> → Total 100 times, starting no.13.
#> → Total 100 times, starting no.14.
#> → Total 100 times, starting no.15.
#> → Total 100 times, starting no.16.
#> → Total 100 times, starting no.17.
#> → Total 100 times, starting no.18.
#> → Total 100 times, starting no.19.
#> → Total 100 times, starting no.20.
#> → Total 100 times, starting no.21.
#> → Total 100 times, starting no.22.
#> → Total 100 times, starting no.23.
#> → Total 100 times, starting no.24.
#> → Total 100 times, starting no.25.
#> → Total 100 times, starting no.26.
#> → Total 100 times, starting no.27.
#> → Total 100 times, starting no.28.
#> → Total 100 times, starting no.29.
#> → Total 100 times, starting no.30.
#> → Total 100 times, starting no.31.
#> → Total 100 times, starting no.32.
#> → Total 100 times, starting no.33.
#> → Total 100 times, starting no.34.
#> → Total 100 times, starting no.35.
#> → Total 100 times, starting no.36.
#> → Total 100 times, starting no.37.
#> → Total 100 times, starting no.38.
#> → Total 100 times, starting no.39.
#> → Total 100 times, starting no.40.
#> → Total 100 times, starting no.41.
#> → Total 100 times, starting no.42.
#> → Total 100 times, starting no.43.
#> → Total 100 times, starting no.44.
#> → Total 100 times, starting no.45.
#> → Total 100 times, starting no.46.
#> → Total 100 times, starting no.47.
#> → Total 100 times, starting no.48.
#> → Total 100 times, starting no.49.
#> → Total 100 times, starting no.50.
#> → Total 100 times, starting no.51.
#> → Total 100 times, starting no.52.
#> → Total 100 times, starting no.53.
#> → Total 100 times, starting no.54.
#> → Total 100 times, starting no.55.
#> → Total 100 times, starting no.56.
#> → Total 100 times, starting no.57.
#> → Total 100 times, starting no.58.
#> → Total 100 times, starting no.59.
#> → Total 100 times, starting no.60.
#> → Total 100 times, starting no.61.
#> → Total 100 times, starting no.62.
#> → Total 100 times, starting no.63.
#> → Total 100 times, starting no.64.
#> → Total 100 times, starting no.65.
#> → Total 100 times, starting no.66.
#> → Total 100 times, starting no.67.
#> → Total 100 times, starting no.68.
#> → Total 100 times, starting no.69.
#> → Total 100 times, starting no.70.
#> → Total 100 times, starting no.71.
#> → Total 100 times, starting no.72.
#> → Total 100 times, starting no.73.
#> → Total 100 times, starting no.74.
#> → Total 100 times, starting no.75.
#> → Total 100 times, starting no.76.
#> → Total 100 times, starting no.77.
#> → Total 100 times, starting no.78.
#> → Total 100 times, starting no.79.
#> → Total 100 times, starting no.80.
#> → Total 100 times, starting no.81.
#> → Total 100 times, starting no.82.
#> → Total 100 times, starting no.83.
#> → Total 100 times, starting no.84.
#> → Total 100 times, starting no.85.
#> → Total 100 times, starting no.86.
#> → Total 100 times, starting no.87.
#> → Total 100 times, starting no.88.
#> → Total 100 times, starting no.89.
#> → Total 100 times, starting no.90.
#> → Total 100 times, starting no.91.
#> → Total 100 times, starting no.92.
#> → Total 100 times, starting no.93.
#> → Total 100 times, starting no.94.
#> → Total 100 times, starting no.95.
#> → Total 100 times, starting no.96.
#> → Total 100 times, starting no.97.
#> → Total 100 times, starting no.98.
#> → Total 100 times, starting no.99.
#> → Total 100 times, starting no.100.
#> Bootstrap done.
#> 
#>  [2024-08-04 14:38:30.105448]: Signature exposures collected.
#>  [2024-08-04 14:38:30.106986]: Errors and similarity collected.
#>  [2024-08-04 14:38:30.10836]: Done.
#>  [2024-08-04 14:38:30.109788]: 3.57 secs elapsed.
#> Save expo result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_12_expo.rds
#> Save similarity result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_12_sim.rds
#> Handling sample: Sample_17
#>  [2024-08-04 14:38:30.266732]: Started.
#>  [2024-08-04 14:38:30.26862]: Checking catalog.
#>  [2024-08-04 14:38:30.270199]: Done.
#>  [2024-08-04 14:38:30.271692]: About to start bootstrap.
#> → Bootstrapping 100 times.
#> → Total 100 times, starting no.1.
#> → Total 100 times, starting no.2.
#> → Total 100 times, starting no.3.
#> → Total 100 times, starting no.4.
#> → Total 100 times, starting no.5.
#> → Total 100 times, starting no.6.
#> → Total 100 times, starting no.7.
#> → Total 100 times, starting no.8.
#> → Total 100 times, starting no.9.
#> → Total 100 times, starting no.10.
#> → Total 100 times, starting no.11.
#> → Total 100 times, starting no.12.
#> → Total 100 times, starting no.13.
#> → Total 100 times, starting no.14.
#> → Total 100 times, starting no.15.
#> → Total 100 times, starting no.16.
#> → Total 100 times, starting no.17.
#> → Total 100 times, starting no.18.
#> → Total 100 times, starting no.19.
#> → Total 100 times, starting no.20.
#> → Total 100 times, starting no.21.
#> → Total 100 times, starting no.22.
#> → Total 100 times, starting no.23.
#> → Total 100 times, starting no.24.
#> → Total 100 times, starting no.25.
#> → Total 100 times, starting no.26.
#> → Total 100 times, starting no.27.
#> → Total 100 times, starting no.28.
#> → Total 100 times, starting no.29.
#> → Total 100 times, starting no.30.
#> → Total 100 times, starting no.31.
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#> → Total 100 times, starting no.100.
#> Bootstrap done.
#> 
#>  [2024-08-04 14:38:33.635939]: Signature exposures collected.
#>  [2024-08-04 14:38:33.637494]: Errors and similarity collected.
#>  [2024-08-04 14:38:33.638875]: Done.
#>  [2024-08-04 14:38:33.640272]: 3.374 secs elapsed.
#> Save expo result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_17_expo.rds
#> Save similarity result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_17_sim.rds
#> Handling sample: Sample_19
#>  [2024-08-04 14:38:33.796468]: Started.
#>  [2024-08-04 14:38:33.798341]: Checking catalog.
#>  [2024-08-04 14:38:33.799874]: Done.
#>  [2024-08-04 14:38:33.801368]: About to start bootstrap.
#> → Bootstrapping 100 times.
#> → Total 100 times, starting no.1.
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#> → Total 100 times, starting no.91.
#> → Total 100 times, starting no.92.
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#> → Total 100 times, starting no.94.
#> → Total 100 times, starting no.95.
#> → Total 100 times, starting no.96.
#> → Total 100 times, starting no.97.
#> → Total 100 times, starting no.98.
#> → Total 100 times, starting no.99.
#> → Total 100 times, starting no.100.
#> Bootstrap done.
#> 
#>  [2024-08-04 14:38:37.245344]: Signature exposures collected.
#>  [2024-08-04 14:38:37.246896]: Errors and similarity collected.
#>  [2024-08-04 14:38:37.248278]: Done.
#>  [2024-08-04 14:38:37.249726]: 3.453 secs elapsed.
#> Save expo result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_19_expo.rds
#> Save similarity result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_19_sim.rds
#> Handling sample: Sample_22
#>  [2024-08-04 14:38:37.405367]: Started.
#>  [2024-08-04 14:38:37.407255]: Checking catalog.
#>  [2024-08-04 14:38:37.408854]: Done.
#>  [2024-08-04 14:38:37.410403]: About to start bootstrap.
#> → Bootstrapping 100 times.
#> → Total 100 times, starting no.1.
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#> → Total 100 times, starting no.67.
#> → Total 100 times, starting no.68.
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#> → Total 100 times, starting no.70.
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#> → Total 100 times, starting no.78.
#> → Total 100 times, starting no.79.
#> → Total 100 times, starting no.80.
#> → Total 100 times, starting no.81.
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#> → Total 100 times, starting no.84.
#> → Total 100 times, starting no.85.
#> → Total 100 times, starting no.86.
#> → Total 100 times, starting no.87.
#> → Total 100 times, starting no.88.
#> → Total 100 times, starting no.89.
#> → Total 100 times, starting no.90.
#> → Total 100 times, starting no.91.
#> → Total 100 times, starting no.92.
#> → Total 100 times, starting no.93.
#> → Total 100 times, starting no.94.
#> → Total 100 times, starting no.95.
#> → Total 100 times, starting no.96.
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#> → Total 100 times, starting no.100.
#> Bootstrap done.
#> 
#>  [2024-08-04 14:38:41.019572]: Signature exposures collected.
#>  [2024-08-04 14:38:41.021148]: Errors and similarity collected.
#>  [2024-08-04 14:38:41.022574]: Done.
#>  [2024-08-04 14:38:41.023981]: 3.619 secs elapsed.
#> Save expo result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_22_expo.rds
#> Save similarity result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_22_sim.rds
#> Handling sample: Sample_24
#>  [2024-08-04 14:38:41.177841]: Started.
#>  [2024-08-04 14:38:41.179695]: Checking catalog.
#>  [2024-08-04 14:38:41.181249]: Done.
#>  [2024-08-04 14:38:41.182809]: About to start bootstrap.
#> → Bootstrapping 100 times.
#> → Total 100 times, starting no.1.
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#> → Total 100 times, starting no.17.
#> → Total 100 times, starting no.18.
#> → Total 100 times, starting no.19.
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#> → Total 100 times, starting no.46.
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#> → Total 100 times, starting no.58.
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#> → Total 100 times, starting no.66.
#> → Total 100 times, starting no.67.
#> → Total 100 times, starting no.68.
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#> → Total 100 times, starting no.70.
#> → Total 100 times, starting no.71.
#> → Total 100 times, starting no.72.
#> → Total 100 times, starting no.73.
#> → Total 100 times, starting no.74.
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#> → Total 100 times, starting no.76.
#> → Total 100 times, starting no.77.
#> → Total 100 times, starting no.78.
#> → Total 100 times, starting no.79.
#> → Total 100 times, starting no.80.
#> → Total 100 times, starting no.81.
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#> → Total 100 times, starting no.84.
#> → Total 100 times, starting no.85.
#> → Total 100 times, starting no.86.
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#> → Total 100 times, starting no.88.
#> → Total 100 times, starting no.89.
#> → Total 100 times, starting no.90.
#> → Total 100 times, starting no.91.
#> → Total 100 times, starting no.92.
#> → Total 100 times, starting no.93.
#> → Total 100 times, starting no.94.
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#> → Total 100 times, starting no.96.
#> → Total 100 times, starting no.97.
#> → Total 100 times, starting no.98.
#> → Total 100 times, starting no.99.
#> → Total 100 times, starting no.100.
#> Bootstrap done.
#> 
#>  [2024-08-04 14:38:44.693877]: Signature exposures collected.
#>  [2024-08-04 14:38:44.69542]: Errors and similarity collected.
#>  [2024-08-04 14:38:44.696807]: Done.
#>  [2024-08-04 14:38:44.698233]: 3.52 secs elapsed.
#> Save expo result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_24_expo.rds
#> Save similarity result to temp file /tmp/RtmpADM14r/sigminer_attribute_activity/Sample_24_sim.rds
#> 
#> Reading result files...
#> Clean cache files when exits.
#> Done.
expo$abs_activity
#>        sample       Sig1       Sig2        Sig3        Sig4        Sig5
#>        <char>      <num>      <num>       <num>       <num>       <num>
#>  1:  Sample_2     0.0000  8324.3129     0.00000     0.00000   836.23229
#>  2:  Sample_3     0.0000  5134.2448     0.00000     0.00000  1711.02871
#>  3:  Sample_4     0.0000  7628.7041  1523.89284     0.00000     0.00000
#>  4:  Sample_5     0.0000  1033.6448     0.00000     0.00000     0.00000
#>  5:  Sample_6     0.0000     0.0000     0.00000     0.00000   181.69335
#>  6:  Sample_7     0.0000   582.8461     0.00000     0.00000   172.01602
#>  7:  Sample_8     0.0000     0.0000     0.00000     0.00000  1369.45498
#>  8:  Sample_9     0.0000     0.0000     0.00000     0.00000     0.00000
#>  9: Sample_10  1143.1114     0.0000     0.00000     0.00000     0.00000
#> 10: Sample_11     0.0000  1432.9232     0.00000     0.00000  1600.13559
#> 11: Sample_13     0.0000  1570.0646     0.00000     0.00000    56.91541
#> 12: Sample_14     0.0000  1331.7105     0.00000     0.00000     0.00000
#> 13: Sample_15     0.0000  3713.2011  2380.78415     0.00000   551.04363
#> 14: Sample_16   673.5523  1095.9283     0.00000  2397.98433     0.00000
#> 15: Sample_18     0.0000     0.0000     0.00000     0.00000   178.07434
#> 16: Sample_20   440.5282     0.0000     0.00000   822.08119   416.87212
#> 17: Sample_21     0.0000  3630.3894  4917.63789     0.00000     0.00000
#> 18: Sample_23     0.0000     0.0000     0.00000    33.20335   243.22641
#> 19: Sample_25     0.0000     0.0000     0.00000     0.00000  2141.32871
#> 20: Sample_26     0.0000   429.4069     0.00000     0.00000  2491.68582
#> 21: Sample_27     0.0000  6699.1632    76.18949     0.00000   194.17338
#> 22: Sample_28   302.2635     0.0000     0.00000   818.94743     0.00000
#> 23: Sample_29     0.0000     0.0000     0.00000  1097.81229   578.42602
#> 24: Sample_30   400.9180     0.0000     0.00000   826.83399   238.78021
#> 25:  Sample_1  9138.4848     0.0000     0.00000 18252.04649     0.00000
#> 26: Sample_12  8847.7116  2860.9798  5597.61520 18490.61967     0.00000
#> 27: Sample_17  8282.3148     0.0000     0.00000     0.00000 12385.06731
#> 28: Sample_19 10367.8524  1558.8368     0.00000  4600.13526  5734.80507
#> 29: Sample_22  3572.9161     0.0000     0.00000 11095.51018  8944.23850
#> 30: Sample_24     0.0000 15548.7912 22224.83696     0.00000     0.00000
#>        sample       Sig1       Sig2        Sig3        Sig4        Sig5
#>            Sig6      Sig7      Sig8       Sig9     Sig10     Sig11
#>           <num>     <num>     <num>      <num>     <num>     <num>
#>  1:     0.00000    0.0000    0.0000    0.00000    0.0000 9633.1075
#>  2:     0.00000  199.5056    0.0000  247.33530 3412.1065    0.0000
#>  3:     0.00000 1005.7703    0.0000  330.72220    0.0000  135.6430
#>  4:     0.00000    0.0000    0.0000    0.00000    0.0000 1661.3552
#>  5:     0.00000  226.9018    0.0000    0.00000    0.0000 1197.6510
#>  6:     0.00000  307.6999    0.0000  367.55856  149.6321    0.0000
#>  7:     0.00000  482.2529    0.0000    0.00000    0.0000  537.6053
#>  8:     0.00000    0.0000 2783.9792 5340.02083    0.0000    0.0000
#>  9:  2541.17025 1129.0811 1701.7448    0.00000    0.0000 3136.6450
#> 10:     0.00000    0.0000    0.0000   81.98904  192.4109 1940.1209
#> 11:    13.19321  401.8427    0.0000   46.59928    0.0000    0.0000
#> 12:     0.00000    0.0000    0.0000    0.00000    0.0000 2879.2895
#> 13:     0.00000    0.0000    0.0000 3589.13531    0.0000  524.3026
#> 14:   430.87300 2892.9436    0.0000    0.00000  238.9572    0.0000
#> 15:   405.92264    0.0000 2134.3934 2835.14250    0.0000    0.0000
#> 16:    40.38733  728.0084    0.0000    0.00000  148.8330    0.0000
#> 17:  3540.94597  502.9650    0.0000  561.13782    0.0000    0.0000
#> 18:   532.02063 1582.7356    0.0000  847.56904 1161.9916    0.0000
#> 19:     0.00000 2796.0676 1904.0547 2645.43897    0.0000  698.4211
#> 20:     0.00000    0.0000    0.0000  926.44717 2092.5266    0.0000
#> 21:  1587.79622  906.3852    0.0000  212.54317    0.0000    0.0000
#> 22:   362.25152 1080.0412    0.0000    0.00000  402.3160    0.0000
#> 23:   176.34483    0.0000  965.4548  830.89664    0.0000    0.0000
#> 24:   253.43957    0.0000  223.5043  100.89195  882.4947    0.0000
#> 25: 13782.50908    0.0000    0.0000    0.00000 1493.6083    0.0000
#> 26:  3816.65478 9141.6032    0.0000    0.00000 1195.2922    0.0000
#> 27:     0.00000    0.0000 1629.9891    0.00000 2218.2940 3163.1918
#> 28:  1724.13326 7400.3912    0.0000    0.00000 1469.2849    0.0000
#> 29:  5109.09700    0.0000 3655.6147    0.00000 6016.8222    0.0000
#> 30:   679.65994 5732.9665    0.0000 1757.38556    0.0000    0.0000
#>            Sig6      Sig7      Sig8       Sig9     Sig10     Sig11
# }

if (FALSE) { # \dontrun{
# Iterative extraction:
# This procedure will rerun extraction step
# for those samples with reconstructed catalog similarity
# lower than a threshold (default is 0.95)
e2 <- bp_extract_signatures_iter(
  t(simulated_catalogs$set1),
  range = 9:11,
  n_bootstrap = 5,
  n_nmf_run = 5,
  sim_threshold = 0.99
)
e2
# When the procedure run multiple rounds
# you can cluster the signatures from different rounds by
# the following command
# bp_cluster_iter_list(e2)

## Extra utilities
rank_score <- bp_get_rank_score(e1)
rank_score
stats <- bp_get_stats(e2$iter1)
# Get the mean reconstructed similarity
1 - stats$stats_sample$cosine_distance_mean
} # }